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Author Corinna Lang

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Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.

Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert,

The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into a 2-tiered system. So far it remains largely unexplored how these parameters interact with each other and whether they truly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):969-978]

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Correction to: Intracerebral Hemorrhage in COVID-19 Patients with Pulmonary Failure: A Propensity Score-Matched Registry Study.

Corinna N Lang, Johanna S Dettinger, Michael Berchtold-Herz, Stefan Utzolino, Xavier Bemtgen, Viviane Zotzmann, Bonaventura Schmid, Paul M Biever, Christoph Bode, Katharina Müller-Peltzer, Daniel Duerschmied, Tobias Wengenmayer, Wolf-Dirk Niesen, Dawid L Staudacher,

Neurocrit Care (Neurocritical care)
[2021, 34(3):1112]

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Utilization of transfusions and coagulation products in cardiogenic shock with and without mechanical circulatory support.

Corinna N Lang, Viviane Zotzmann, Bonaventura Schmid, Klaus Kaier, Christoph Bode, Tobias Wengenmayer, Dawid L Staudacher,

J Crit Care (Journal of critical care)
[2021, 65:62-64]

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[How can an emergency department be strengthened against a pandemic?]

Bonaventura Schmid, Corinna N Lang, Timo Danner, Katharina Kramer, Felix P Hans, Hans-Jörg Busch,

The emergency department (ED) is one of the crucial parts of the hospital infrastructure during all phases of the pandemic. The ED plays an important part in detecting an increasing number of new contagious diseases, which could potentially lead to an epidemic or pandemic.During a pandemic, the ED's main task ... Read more >>

Dtsch Med Wochenschr (Deutsche medizinische Wochenschrift (1946))
[2021, 146(10):657-666]

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Mode of Death after Extracorporeal Cardiopulmonary Resuscitation.

Viviane Zotzmann, Corinna N Lang, Xavier Bemtgen, Markus Jaeckel, Annabelle Fluegler, Jonathan Rilinger, Christoph Benk, Christoph Bode, Alexander Supady, Tobias Wengenmayer, Dawid L Staudacher,

<h4>Introduction</h4>Extracorporeal cardiopulmonary resuscitation (ECPR) might be a lifesaving therapy for patients with cardiac arrest and no return of spontaneous circulation during advanced life support. However, even with ECPR, mortality of these severely sick patients is high. Little is known on the exact mode of death in these patients.<h4>Methods</h4>Retrospective registry analysis ... Read more >>

Membranes (Basel) (Membranes)
[2021, 11(4):]

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The Tissue Renin-Angiotensin System and Its Role in the Pathogenesis of Major Human Diseases: Quo Vadis?

Babak Saravi, Zhen Li, Corinna N Lang, Bonaventura Schmid, Frauke K Lang, Sibylle Grad, Mauro Alini, Robert Geoffrey Richards, Hagen Schmal, Norbert Südkamp, Gernot M Lang,

Evidence has arisen in recent years suggesting that a tissue renin-angiotensin system (tRAS) is involved in the progression of various human diseases. This system contains two regulatory pathways: a pathological pro-inflammatory pathway containing the Angiotensin Converting Enzyme (ACE)/Angiotensin II (AngII)/Angiotensin II receptor type 1 (AGTR1) axis and a protective anti-inflammatory ... Read more >>

Cells (Cells)
[2021, 10(3):]

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Cytokine Adsorption in Severe Acute Respiratory Failure Requiring Veno-Venous Extracorporeal Membrane Oxygenation.

Marina Rieder, Daniel Duerschmied, Timm Zahn, Corinna Lang, Christoph Benk, Achim Lother, Paul Biever, Christoph Bode, Tobias Wengenmayer, Dawid Staudacher, Alexander Supady,

Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is a last resort treatment option for patients with acute respiratory failure (acute respiratory distress syndrome [ARDS]). Cytokine adsorption has been incorporated in the management of some of these patients on an individual basis to control the imbalance of danger-associated molecular patterns and proinflammatory ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(3):332-338]

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Case Report: Refusal of an Veno-Arterial Extracorporeal Membrane Oxygenation Due to Malignant Disease? - An Extremely Rare Form of Cardiac Involvement in Acute Myeloid Leukemia.

Viviane Zotzmann, Tobias Wengenmayer, Corinna N Lang, Dawid L Staudacher, Katharina Mueller-Peltzer, Fabian Bamberg, Reinhard Marks, Christoph Bode, Ralph Wäsch,

We report here on a 61-year-old patient with acute right heart failure of unclear etiology. Echocardiography revealed a myocardial mass infiltrating the heart, though, we assumed a cardiac lymphoma. A VA-ECMO was implanted as bridging for diagnosis and therapy. Our patient received chemotherapy, under which the tumor (of unknown etiology ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:584507]

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Intracerebral Hemorrhage in COVID-19 Patients with Pulmonary Failure: A Propensity Score-Matched Registry Study.

Corinna N Lang, Johanna S Dettinger, Michael Berchtold-Herz, Stefan Utzolino, Xavier Bemtgen, Viviane Zotzmann, Bonaventura Schmid, Paul M Biever, Christoph Bode, Katharina Müller-Peltzer, Daniel Duerschmied, Tobias Wengenmayer, Wolf-Dirk Niesen, Dawid L Staudacher,

<h4>Background</h4>Hypercoagulability in Coronavirus Disease 2019 (COVID-19) causes deep vein thrombosis and pulmonary embolism necessitating systemic anticoagulation. Case reports of intracerebral hemorrhages in ventilated COVID-19 patients warrant precaution. It is unclear, however, if COVID-19 patients with acute respiratory distress syndrome (ARDS) with or without veno-venous extracorporeal membrane oxygenation therapy (VV-ECMO) have ... Read more >>

Neurocrit Care (Neurocritical care)
[2021, 34(3):739-747]

Cited: 3 times

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Intensive Care Resources and 60-Day Survival of Critically-Ill COVID-19 Patients.

Corinna N Lang, Viviane Zotzmann, Bonaventura Schmid, Michael Berchtold-Herz, Stefan Utzolino, Paul Biever, Daniel Duerschmied, Christoph Bode, Tobias Wengenmayer, Dawid L Staudacher,

<h4>Background</h4>Germany reported sufficient intensive care unit (ICU) resources throughout the first wave of coronavirus disease 2019 (COVID-19). The treatment of critically ill COVID-19 patients without rationing may improve the outcome. We therefore analyzed ICU resources allocated to COVID-19 patients with respiratory failure and their outcomes.<h4>Methods</h4>Retrospectively, we enrolled severe acute respiratory ... Read more >>

Cureus (Cureus)
[2021, 13(2):e13210]

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Bronchoalveolar Lavage and Blood Markers of Infection in Critically Ill Patients-A Single Center Registry Study.

Jarno F Kronberger, Thomas C Köhler, Corinna N Lang, Markus Jäckel, Xavier Bemtgen, Tobias Wengenmayer, Alexander Supady, Wolfram Meschede, Christoph Bode, Viviane Zotzmann, Dawid L Staudacher,

Microbiological sampling is an indispensable targeted antibiotic therapy for critically ill patients. Invasive respiratory sampling by bronchoalveolar lavage (BAL) can be performed to obtain samples from the lower respiratory tract. It is debated as to whether blood markers of infection can predict the outcome of BAL in a medical intensive ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(3):]

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Outcome of acute respiratory distress syndrome requiring extracorporeal membrane oxygenation in Covid-19 or influenza: A single-center registry study.

Markus Jäckel, Jonathan Rilinger, Corinna Nadine Lang, Viviane Zotzmann, Klaus Kaier, Peter Stachon, Paul Marc Biever, Tobias Wengenmayer, Daniel Duerschmied, Christoph Bode, Dawid Leander Staudacher, Alexander Supady,

Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is used to sustain blood oxygenation and decarboxylation in severe acute respiratory distress syndrome (ARDS). It is under debate if V-V ECMO is as appropriate for coronavirus disease 2019 (Covid-19) ARDS as it is for influenza. In this retrospective study, we analyzed all patients ... Read more >>

Artif Organs (Artificial organs)
[2021, 45(6):593-601]

Cited: 4 times

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Lung ultrasound in the emergency department - a valuable tool in the management of patients presenting with respiratory symptoms during the SARS-CoV-2 pandemic.

Bonaventura Schmid, Doreen Feuerstein, Corinna N Lang, Katrin Fink, Rebecca Steger, Marina Rieder, Daniel Duerschmied, Hans-Jörg Busch, Domagoj Damjanovic,

<h4>Background</h4>Typical lung ultrasound (LUS) findings in patients with a COVID-19 infection were reported early on. During the global SARS-CoV-2 pandemic, LUS was propagated as a useful instrument in triage and monitoring. We evaluated LUS as a rapid diagnostic triage tool for the management of patients with suspected COVID-19 in the ... Read more >>

BMC Emerg Med (BMC emergency medicine)
[2020, 20(1):96]

Cited: 2 times

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Cardiogenic shock: incidence, survival and mechanical circulatory support usage 2007-2017-insights from a national registry.

Corinna N Lang, Klaus Kaier, Viviane Zotzmann, Peter Stachon, Torben Pottgiesser, Constantin von Zur Muehlen, Manfred Zehender, Daniel Duerschmied, Bonaventura Schmid, Christoph Bode, Tobias Wengenmayer, Dawid L Staudacher,

<h4>Background</h4>A central element in the management of cardiogenic shock (CS) comprises mechanical circulatory support (MCS) systems to maintain cardiac output (CO). This study aims to quantify incidence, outcome and influence of MCS in CS over the last decade.<h4>Methods</h4>All patients hospitalized with CS in a tertiary university hospital in Germany between ... Read more >>

Clin Res Cardiol (Clinical research in cardiology : official journal of the German Cardiac Society)
[2020, :]

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Angiotensin II Type 1 Receptor Antagonist Losartan Inhibits TNF-α Induced Inflammation and Degeneration Processes in Human Nucleus Pulposus Cells

Babak Saravi, Zhen Li, Judith Pfannkuche, Laura Wystrach, Christoph E. Albers, Sibylle Grad, Mauro Alini, Geoff Richards, Corinna Lang, Norbert Südkamp, Hagen Schmal, Gernot Lang,

Our recent study detected the expression of a tissue Renin-Angiotensin System (tRAS) in human intervertebral discs (IVDs). The present study sought to investigate the impact of angiotensin II receptor type 1 (AGTR1) antagonist losartan on human nucleus pulposus (NP) cell inflammation and degeneration induced by tumor necrosis factor-&alpha; (TNF-&alpha;). Human ... Read more >>

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COVID-19 in-hospital mortality and mode of death in a dynamic and non-restricted tertiary care model in Germany.

Siegbert Rieg, Maja von Cube, Johannes Kalbhenn, Stefan Utzolino, Katharina Pernice, Lena Bechet, Johanna Baur, Corinna N Lang, Dirk Wagner, Martin Wolkewitz, Winfried V Kern, Paul Biever, ,

<h4>Background</h4>Reported mortality of hospitalised Coronavirus Disease-2019 (COVID-19) patients varies substantially, particularly in critically ill patients. So far COVID-19 in-hospital mortality and modes of death under state of the art care have not been systematically studied.<h4>Methods</h4>This retrospective observational monocenter cohort study was performed after implementation of a non-restricted, dynamic tertiary care ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0242127]

Cited: 8 times

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Combining lung ultrasound and Wells score for diagnosing pulmonary embolism in critically ill COVID-19 patients.

Viviane Zotzmann, Corinna N Lang, Tobias Wengenmayer, Xavier Bemtgen, Bonaventura Schmid, Katharina Mueller-Peltzer, Alexander Supady, Christoph Bode, Daniel Duerschmied, Dawid L Staudacher,

Subpleural consolidations have been found in lung ultrasound in patients with COVID-19, possibly deriving from pulmonary embolism (PE). The diagnostic utility of impact of lung ultrasound in critical-ill patients with COVID-19 for PE diagnostics however is unclear. We retrospectively evaluated all SARS-CoV2-associated ARDS patients admitted to our ICU between March ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, :]

Cited: 4 times

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Incidence of Barotrauma in Patients With COVID-19 Pneumonia During Prolonged Invasive Mechanical Ventilation - A Case-Control Study.

Josefina Udi, Corinna N Lang, Viviane Zotzmann, Kirsten Krueger, Annabelle Fluegler, Fabian Bamberg, Christoph Bode, Daniel Duerschmied, Tobias Wengenmayer, Dawid L Staudacher,

<h4>Background</h4>SARS-CoV2 can cause pulmonary failure requiring prolonged invasive mechanical ventilation (MV). Lung protective ventilation strategies are recommended in order to minimize ventilator induced lung injury. Whether patients with COVID-19 have the same risk for complications including barotrauma is still unknown. Therefore, we investigated barotrauma in patients with COVID-19 pneumonia requiring ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2021, 36(4):477-483]

Cited: 3 times

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Combining lung ultrasound and wells score for diagnosing pulmonary embolism in critically ill COVID-19 patients

Viviane Zotzmann, Corinna Nadine Lang, Tobias Wengenmayer, Xavier Bemtgen, Bonaventura Schmid, Katharina Mueller-Peltzer, Alexander Supady, Christoph Bode, Daniel Duerschmied, Dawid Staudacher,

<h4>Introduction: </h4> Subpleural consolidations have been found in lung ultrasound in patients with COVID-19, possibly deriving from pulmonary embolism (PE). The diagnostic utility of impact of lung ultrasound in critical-ill patients with COVID-19 for PE diagnostics however is unclear. <h4>Methods: </h4> We retrospectively evaluated all SARS-CoV2-associated ARDS patients admitted to ... Read more >>

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Pulmonary artery thrombi are co-located with opacifications in SARS-CoV2 induced ARDS.

Katharina Mueller-Peltzer, Tobias Krauss, Matthias Benndorf, Corinna N Lang, Fabian Bamberg, Christoph Bode, Daniel Duerschmied, Dawid L Staudacher, Viviane Zotzmann,

<h4>Purpose</h4>Patients hospitalized for infection with SARS-CoV-2 typically present with pneumonia. The respiratory failure is frequently complicated by pulmonary embolism in segmental pulmonary arteries. The distribution of pulmonary embolism in regard to lung parenchymal opacifications has not been investigated yet.<h4>Methods</h4>All patients with COVID-19 treated at a medical intensive care unit between ... Read more >>

Respir Med (Respiratory medicine)
[2020, 172:106135]

Cited: 6 times

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Intracerebral hemorrhage in COVID-19 patients with pulmonary failure – a propensity score matched registry study

Corinna Lang, Johanna Dettinger, Michael Berchtold-Herz, Stefan Utzolino, Xavier Bemtgen, Viviane Zotzmann, Bonaventura Schmid, Paul Biever, Christoph Bode, Katharina Müller-Peltzer, Daniel Duerschmied, Tobias Wengenmayer, Wolf-Dirk Niesen, Dawid Staudacher,

<h4>Background: </h4> Hypercoagulopathy in coronavirus disease 2019 (COVID-19) causing deep vein thrombosis and pulmonary artery embolism necessitate systemic anticoagulation. Case reports of intracerebral hemorrhages in ventilated COVID-19 patients warrant precaution. It is unclear however, if COVID-19 patients with acute respiratory distress syndrome (ARDS) with and without extracorporeal membrane oxygenation therapy ... Read more >>

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COVID-19 in-hospital mortality and mode of death in a dynamic and non-restricted tertiary care model in Germany

Siegbert Rieg, Maja von Cube, Johannes Kalbhenn, Stefan Utzolino, Katharina Pernice, Lena Bechet, Johanna Baur, Corinna Lang, Dirk Wagner, Martin Wolkewitz, Winfried Kern, Paul Biever,

<h4>Background: </h4> Reported mortality of hospitalised COVID-19 patients varies substantially, particularly in critically ill patients. So far COVID-19 in-hospital mortality and modes of death under optimised care conditions have not been systematically studied.MethodsThis retrospective observational monocenter cohort study was performed after implementation of a non-restricted, dynamic tertiary care model at ... Read more >>

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60-day survival of critically ill COVID-19 first comers

Corinna Lang, Zotzmann, Schmid, Berchtold-Herz, Utzolino, P.M. Biever, Pottgießer, Duerschmied, Bode, Wengenmayer, D.L. Staudacher,

<h4>Background: </h4> Germany reported sufficient intensive care unit (ICU) resources throughout the first wave of coronavirus disease 2019 (COVID-19). The treatment of critically ill COVID-19 patients without rationing may improve the outcome. We therefore analyzed resources allocated to critically ill COVID-19 patients and their outcomes. <h4>Methods: </h4>: Retrospectively, we enrolled ... Read more >>

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COVID-19 in-hospital mortality and mode of death in a dynamic and non-restricted tertiary care model in Germany

Siegbert Rieg, Maja von Cube, Johannes Kalbhenn, Stefan Utzolino, Katharina Pernice, Lena Bechet, Johanna Baur, Corinna Lang, Dirk Wagner, Martin Wolkewitz, Winfried Kern, Paul Biever,

<h4>Background</h4> Reported mortality of hospitalised COVID-19 patients varies substantially, particularly in critically ill patients. So far COVID-19 in-hospital mortality and modes of death under optimised care conditions have not been systematically studied. <h4>Methods</h4> This retrospective observational monocenter cohort study was performed after implementation of a non-restricted, dynamic tertiary care model ... Read more >>

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Use of the CytoSorb adsorption device in MDMA intoxication: a first-in-man application and in vitro study.

Corinna N Lang, Michaela J Sommer, Merja A Neukamm, Dawid L Staudacher, Alexander Supady, Christoph Bode, Daniel Duerschmied, Achim Lother,

<h4>Background</h4>3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") abuse is frequent, and overdosing might cause severe and eventually lethal multi-organ failure. To date, there is no causal therapy of MDMA intoxication and removal of MDMA from the circulation might be a reasonable measure to prevent adverse courses after overdosing. We present here first-in-man experience and ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2020, 8(1):21]

Cited: 3 times

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