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Chromatin Accessibility Reveals Potential Prognostic Value of the Peak Set Associated with Smoking History in Patients with Lung Adenocarcinoma

Han Liang, Jianlian Deng, Tian Luo, Huijuan Luo, Xuan Wu, Yiwang Ye, Shubin Wang, Fuqiang Li, Kui Wu, Cong Lin,

Abstract Considerable differences in molecular characteristics have been defined between non-smoker and smokers in patients with lung adenocarcinoma (LUAD), yet study of open chromatin patterns associated with LUAD progression caused by smoking is still lacking. Here, we constructed a novel network based on correlations between each ATAC-seq peak from TCGA ... Read more >>

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An NHC-CuCl functionalized metal-organic framework for catalyzing β-boration of α,β-unsaturated carbonyl compounds.

Qingxia Yao, Xiufang Lu, Kaili Liu, Chao Ma, Jie Su, Cong Lin, Dacheng Li, Jianmin Dou, Junliang Sun, Wenzeng Duan,

A microporous metal-organic framework functionalized with in situ generated NHC-CuCl units (1) has been successfully synthesized from a novel imidazolium-containing ligand. In particular, the MOF 1 can catalyze β-boration of α,β-unsaturated carbonyl compounds, while the isoreticular version of 1 (1-im) modified with only imidazolium moiety cannot. This work demonstrates for ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(16):5144-5148]

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Rapid implementation of SARS-CoV-2 emergency use authorization RT-PCR testing and experience at an academic medical institution

Priya Velu, Arryn Craney, Phyllis Ruggiero, John Sipley, Lin Cong, Erika Hissong, Massimo Loda, Lars Westblade, Melissa Cushing, Hanna Rennert,

An epidemic caused by an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China in December 2019 has since rapidly spread internationally, requiring urgent response from the clinical diagnostics community. We present a detailed overview of the clinical validation and implementation of the first laboratory-developed real-time reverse-transcription-PCR (rRT-PCR) ... Read more >>

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Continuous association of total bile acid levels with the risk of small for gestational age infants.

Li Li, Wei Chen, Li Ma, Zhi Bing Liu, Xue Lu, Xing Xing Gao, Yan Liu, Hua Wang, Mei Zhao, Xiao Lan Li, Lin Cong, De Xiang Xu, Yuan Hua Chen,

The association between maternal serum total bile acid (TBA) levels and small-for-gestational-age (SGA) infants is unclear. We investigated the association between various degrees of serum TBA levels and the risk of SGA infants in a Chinese population. The current study performed a cohort study among 11811 mothers with singleton pregnancy. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9257]

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Type I astrocytes and microglia induce a cytokine response in an encephalitic murine coronavirus infection.

Ehud Lavi, Lin Cong,

The pathogenesis of viral infections involves an immune response by cytokines, causing a deleterious effect on organ function, in addition to tissue destruction due to viral replication. Clinical symptoms and laboratory findings of the human coronavirus disease COVID-19, caused by the novel coronavirus SARS CoV-2, indicate cytokine involvement. Our laboratory ... Read more >>

Exp. Mol. Pathol. (Experimental and molecular pathology)
[2020, 115:104474]

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Arginine hypomethylation-mediated proteasomal degradation of histone H4-an early biomarker of cellular senescence.

Cong Lin, Hongxin Li, Jiwei Liu, Qianying Hu, Shuai Zhang, Na Zhang, Lingxia Liu, Yingjie Dai, Donghui Cao, Xiaoxue Li, Baiqu Huang, Jun Lu, Yu Zhang,

Senescence is accompanied with histones level alteration; however, the roles and the mechanisms of histone reduction in cellular senescence are largely unknown. Protein arginine methyltransferase 1 (PRMT1) is the major enzyme that generates monomethyl and asymmetrical dimethyl arginine. Here we showed that abrogation of PRMT1-mediated senescence was accompanied with decreasing ... Read more >>

Cell Death Differ. (Cell death and differentiation)
[2020, :]

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Genetic analysis and screening of detoxification-related genes in an amitraz-resistant strain of Panonychus citri.

Shi-Jiang Yu, Lin Cong, Hao-Qiang Liu, Chun Ran,

Panonychus citri (McGregor) is the most common pest in citrus-producing regions. Special low-toxicity acaricides, such as spirocyclic tetronic acids and mite growth inhibitors, have been used for a long time in China. However, pesticide resistance in mites is a growing problem due to the lack of new acaricide development. Wide-spectrum ... Read more >>

Bull. Entomol. Res. (Bulletin of entomological research)
[2020, :1-13]

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Laparoscopic treatment of a large cystic adenomyosis of the uterus: A case report.

Congqing Li, Youjiang Xu, Lin Cong,

INTRODUCTION:We describe a patient with a large cystic adenomyosis of the uterus who was treated by a laparoscopic approach. CASE PRESENTATION:A 38-year-old woman presented with dysmenorrhoea for 4 months. A 104 mm × 55 mm × 60 mm cystic mass was detected on the right side of the posterior wall of the uterus by ultrasound. Laparoscopy was ... Read more >>

Int J Surg Case Rep (International journal of surgery case reports)
[2020, 71:179-182]

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Expression and Potential Role of MMP-9 in Intrauterine Adhesion

Congqing Li, Lin Cong, Youjiang Xu, Wenyan Wang,

Abstract Background: Intrauterine adhesions will affect the amount of menstrual and fertility, endometrial fibrosis is the last manifestation of the IUA. MMP-9 is closely related to fibrosis. The purpose of the study was to assess the role of MMP-9 in intrauterine adhesion (IUA) rats and patients.Methods:40 female rats and 24 ... Read more >>

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The association between neutrophil-to-albumin ratio and mortality in patients with cardiogenic shock: a cohort study

Yangpei Peng, Yangjing Xue, Jinsheng Wang, Huaqiang Xiang, Kangting Ji, Jie Wang, Cong Lin,

Abstract The authors have withdrawn this preprint due to author disagreement. ... Read more >>

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HPM-14, a New Germanosilicate Zeolite with Interconnected Extra-Large Pores Plus Odd-Membered and Small Pores

Zihao Gao, Jian Li, Cong Lin, Alvaro Mayoral, Junliang Sun, Miguel Camblor,

We describe HPM-14, a new extra-large pore zeolite synthesized using imidazolium-based organic structure-directing agents, fluoride anions and germanium and silicon as tetrahedral components of the framework. Due to the presence of stacking disorder, the structure elucidation of HPM-14 was challenging, and different techniques were necessary to clarify the details of ... Read more >>

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Shotgun Transcriptome and Isothermal Profiling of SARS-CoV-2 Infection Reveals Unique Host Responses, Viral Diversification, and Drug Interactions

Daniel Butler, Christopher Mozsary, Cem Meydan, David Danko, Jonathan Foox, Joel Rosiene, Alon Shaiber, Ebrahim Afshinnekoo, Matthew MacKay, Fritz Sedlazeck, Nikolay Ivanov, Maria Sierra, Diana Pohle, Michael Zietz, Undina Gisladottir, Vijendra Ramlall, Craig Westover, Krista Ryon, Benjamin Young, Chandrima Bhattacharya, Phyllis Ruggiero, Bradley Langhorst, Nathan Tanner, Justyna Gawrys, Dmitry Meleshko, Dong Xu, Peter Steel, Amos Shemesh, Jenny Xiang, Jean Thierry-Mieg, Danielle Thierry-Mieg, Robert Schwartz, Angelika Iftner, Daniela Bezdan, John Sipley, Lin Cong, Arryn Craney, Priya Velu, Ari Melnick, Iman Hajirasouliha, Stacy Horner, Thomas Iftner, Mirella Salvatore, Massimo Loda, Lars Westblade, Melissa Cushing, Shawn Levy, Shixiu Wu, Nicholas Tatonetti, Marcin Imielinski, Hanna Rennert, Christopher Mason,

Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused thousands of deaths worldwide, including >18,000 in New York City (NYC) alone. The sudden emergence of this pandemic has highlighted a pressing clinical need for rapid, scalable diagnostics that can detect infection, interrogate strain evolution, and identify novel patient ... Read more >>

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Hydroxyl free radical route to the stable siliceous Ti-UTL with extra-large pores for oxidative desulfurization.

Dier Shi, Le Xu, Pohua Chen, Tianqiong Ma, Cong Lin, Xiaoge Wang, Diming Xu, Junliang Sun,

A facile and mild method was successfully developed to prepare the stable, highly siliceous Ti-UTL zeolite with extra-large pores. The hydroxyl free radical (˙OH) was introduced for the first time to effectively promote the isomorphous substitution of Si for framework Ge under room temperature and neutral conditions, resulting in a ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(10):1390-1393]

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Electrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation.

Lin Cong, Ziyu Gao, Yinghong Zheng, Ting Ye, Zitong Wang, Pengyu Wang, Manman Li, Bowen Dong, Wei Yang, Quanfeng Li, Shupei Qiao, Cao Wang, Yijun Shen, Hong Li, Weiming Tian, Liming Yang,

The incidence of atherosclerosis (AS), a major contributor to cardiovascular disease, is steadily rising along with an increasingly older population worldwide. Pyroptosis, a form of inflammatory programmed cell death, determines the release of pro-inflammatory mediators by endothelial cells, smooth muscle cells, and atheroma-associated macrophages and foam cells, thereby playing a ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(7):6415-6435]

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Long non‑coding RNA PRNCR1 exerts oncogenic effects in tongue squamous cell carcinoma in vitro and in vivo by sponging microRNA‑944 and thereby increasing HOXB5 expression.

Cong Lin, Yanan Zou, Ruijing Li, Daofeng Liu,

A long non‑coding RNA (lncRNA) called prostate cancer‑associated non‑coding RNA 1 (PRNCR1) serves crucial roles in the aggressive phenotypes of colorectal cancer and non‑small cell lung cancer. However, there is little research on the expression profile, clinical value and detailed functions of PRNCR1 in tongue squamous cell carcinoma (TSCC). The ... Read more >>

Int. J. Mol. Med. (International journal of molecular medicine)
[2020, 46(1):119-130]

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Identification of the associated expression patterns as potential predictive markers for cancer prognosis

Han Liang, Cong Lin, Yong Hou, Fuqiang Li, Kui Wu,

Abstract Dysregulated gene expression can develop as a consequence of uncontrolled alterations of tumor cells. Analysis of these abnormal alterations will improve our understanding of the tumor development and reveal the corresponding clinical associations. It is well known that multiple genetic abnormalities could be observed in the same tumor, however, ... Read more >>

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Dynamic curve analysis of indicators related to lumbar cistern drainage for postoperative meningitis

Weining Ma, Chun Li, Lin Cong,

Abstract Background Lumbar cisterna drainage (LCD) is widely used in neurosurgery as an effective treatment for postoperative meningitis, vasospasm of subarachnoid hemorrhage and ventricular system hemorrhage, and for reducing intracranial pressure in patients with severe craniocerebral trauma. The purpose of this work was two-fold: to analyze the dynamic curve ... Read more >>

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Prognostic Relationship Between Peripheral Red Cell Distribution Width and Acute Cerebral Infarction in Patients with rtPA Thrombolysis.

Lin Cong, Han Gao, Weining Ma,

Neurotox Res (Neurotoxicity research)
[2020, 38(1):211-218]

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Microwave Ablation-Aided Curettage for Treatment of Aggressive Benign Bone Tumors in the Extremities: Preliminary Report and Technical Points

Lin Cong, Yu Chen,

Abstract The authors have withdrawn this preprint from Research Square ... Read more >>

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Mixed-Dimensional Vertical Point p-n Junctions.

Jin Zhang, Lin Cong, Ke Zhang, Xiang Jin, Xuanzhang Li, Yang Wei, Qunqing Li, Kaili Jiang, Yi Luo, Shoushan Fan,

Mixed-dimensional van der Waals (vdW) heterostructures composed of one-dimensional (1D) and two-dimensional (2D) materials have exhibited great potential in nanoelectronics and nano-optoelectronics. In this study, we present a vertical point p-n junction (VPpnJ), in which a vertical stacked molybdenum disulfide/tungsten diselenide p-n junction is sandwiched between two cross-stacked metallic carbon nanotubes ... Read more >>

ACS Nano (ACS nano)
[2020, 14(3):3181-3189]

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Glasgow Coma Scale is a better delayed neurological sequelae risk factor than neurological examination abnormalities in carbon monoxide poisoning.

Ping Xu, Yushu Wang, Linghong Cao, Wenbin Huang, Jianjun Zhang, Xia Gao, Cong Lin,

Am J Emerg Med (The American Journal of Emergency Medicine)
[2020, :]

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Citron Rho-Interacting Serine/Threonine Kinase Promotes HIF1a-CypA Signaling and Growth of Human Pancreatic Adenocarcinoma.

Lin Cong, Zhile Bai, Yang Du, Yong Cheng,

In human pancreatic ductal adenocarcinoma (PDAC), the cyclophilin A (CypA) is overexpressed and promotes the development of PDAC. However, the mechanism underlying cyclophilin A expression remains elusive. Here, we reported that the citron Rho-interacting serine/threonine kinase (CIT) promotes the HIF1a-CypA signaling and growth of PDAC cells. CIT expression was higher ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:9210891]

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The power of the Functional Activities Questionnaire for screening dementia in rural-dwelling older adults at high-risk of cognitive impairment.

Ling Yin, Yifei Ren, Xiang Wang, Yunxia Li, Tingting Hou, Keke Liu, Lin Cong, Qinghua Zhang, Yongxiang Wang, Ziying Jiang, Yifeng Du,

AIM:A simple approach to detecting dementia in its early stages may help improve patient care. We therefore aimed to assess the power of the Functional Activities Questionnaire (FAQ) for screening dementia among rural-dwelling older adults who are at high-risk for cognitive impairment. METHODS:This study included 961 participants at a high-risk ... Read more >>

Psychogeriatrics (Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society)
[2020, :]

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Catechin relieves hypoxia/reoxygenation-induced myocardial cell apoptosis via down-regulating lncRNA MIAT.

Lin Cong, Yisheng Su, Dazhen Wei, Lu Qian, Dawei Xing, Jialin Pan, Ye Chen, Mingyuan Huang,

BACKGROUND:Catechin protects heart from myocardial ischaemia/reperfusion (MI/R) injury. However, whether catechin inhibits H/R-induced myocardial cell apoptosis is largely unknown. OBJECTIVE:This study aims to investigate the underlying mechanism of catechin in inhibiting the apoptosis of H/R-induced myocardial cells. METHODS:LncRNA MIAT expression was detected by qRT-PCR. Cell viability of H9C2 cells was ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, 24(3):2356-2368]

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Life cycle assessment of anaerobic digestion of pig manure coupled with different digestate treatment technologies.

Na Duan, Benyamin Khoshnevisan, Cong Lin, Zhidan Liu, Hongbin Liu,

The direct use of digestate on farmlands as soil amendment is becoming an uneconomic option for farmers. Moreover, there are serious environmental concerns about its oversupply in regions with intensive biogas plants. Downstream technologies, offering innovative upcycling methods to handle huge amounts of digestate, have absorbed great interest in this ... Read more >>

Environ Int (Environment international)
[2020, 137:105522]

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