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α-Hederin Inhibits the Growth of Lung Cancer A549 Cells in vitro and in vivo by Increasing SIRT6 Dependent Glycolysis

cong fang, Yahui Liu, Lanying Chen, Yingying Luo, Yaru Cui, Ni Zhang, Peng Liu, Mengjing Zhou, Yongyan Xie,

Abstract Background: α-hederin an effective component of Pulsatilla chinensis (Bunge) Regel, Studies showed that α-hederin exert many pharmacological activities, However, the effect of α-hederin on metabolism is still unclear. This study aimed to illuminate the role of α-hederin in glucose metabolism in lung cancer cells and investigate the molecular mechanism ... Read more >>

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CT quantification of pneumonia lesions in early days predicts progression to severe illness in a cohort of COVID-19 patients.

Fengjun Liu, Qi Zhang, Chao Huang, Chunzi Shi, Lin Wang, Nannan Shi, Cong Fang, Fei Shan, Xue Mei, Jing Shi, Fengxiang Song, Zhongcheng Yang, Zezhen Ding, Xiaoming Su, Hongzhou Lu, Tongyu Zhu, Zhiyong Zhang, Lei Shi, Yuxin Shi,

Rationale: Some patients with coronavirus disease 2019 (COVID-19) rapidly develop respiratory failure or even die, underscoring the need for early identification of patients at elevated risk of severe illness. This study aims to quantify pneumonia lesions by computed tomography (CT) in the early days to predict progression to severe illness ... Read more >>

Theranostics (Theranostics)
[2020, 10(12):5613-5622]

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Predicting COVID-19 malignant progression with AI techniques

Xiang Bai, Cong Fang, Yu Zhou, Song Bai, Zaiyi Liu, Qianlan Chen, Yongchao Xu, Tian Xia, Shi Gong, Xudong Xie, Dejia Song, Ronghui Du, Chunhua Zhou, Chengyang Chen, Dianer Nie, Dandan Tu, Changzheng Zhang, Xiaowu Liu, Lixin Qin, Weiwei Chen,

Background: The coronavirus disease 2019 (COVID-19) has become a worldwide pandemic since mid-December 2019, which greatly challenge public medical systems. With limited medical resources, it is a natural strategy, while adopted, to access the severity of patients then determine the treatment priority. However, our work observes the fact that the ... Read more >>

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Diosmin for the prevention of ovarian hyperstimulation syndrome.

Tingting Li, Wanshan Zhu, Guihua Liu, Cong Fang, Song Quan,

OBJECTIVE:To evaluate the effect of oral diosmin on the incidence and severity of ovarian hyperstimulation syndrome (OHSS) and explore the value of diosmin in preventing and treating OHSS. METHOD:A retrospective study of women attending a reproductive center in Guangzhou, China, between September and December 2016. The inclusion criterion was previous ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, 149(2):166-170]

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Plasmonics of Diffused Silver Nanoparticles in Silver/Nitride Optical Thin Films.

Yufeng Ye, Joel Y Y Loh, Andrew Flood, Cong Y Fang, Joshua Chang, Ruizhi Zhao, Peter Brodersen, Nazir P Kherani,

Metal-dielectric multilayers are versatile optical devices that can be designed to combine the visible transmittance of dielectrics with the electronic properties of metals for plasmonic and meta-material applications. However, their performances are limited by an interfacial optical absorption often attributed entirely to the metal surface roughness. Here, we show that ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):20227]

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Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats.

Cong Fang, Lanying Chen, Mingzhen He, Yingying Luo, Mengjing Zhou, Ni Zhang, Jinfeng Yuan, Huiling Wang, Yongyan Xie,

CONTEXT:Eucommia ulmoides Oliver (Eucommiaceae) has various medicinal properties. Our previous studies revealed that Eucommia ulmoides has a protective effect on hyperuricaemia. OBJECTIVE:This study investigates the effect of Eucommia ulmoides cortex ethanol extract (EU) on hyperuricaemia and explores the underlying mechanism in Kunming mice and Sprague-Dawley rats. MATERIAL AND METHODS:Sixty mice ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2019, 57(1):112-119]

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A dynamic model and some strategies on how to prevent and control hepatitis c in mainland China.

Wanru Jia, Jie Weng, Cong Fang, Yong Li,

BACKGROUND:Hepatitis C virus (HCV) is a leading cause of chronic liver disease. As yet there is no approved vaccine protects against contracting hepatitis C. HCV seriously affects many people's health in the world. METHODS:In this article, an epidemiological model is proposed and discussed to understand the transmission and prevalence of ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2019, 19(1):724]

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The role of galectin-3 in spermatozoa-zona pellucida binding and its association with fertilization in vitro.

Si Mei, Panyu Chen, Cheuk-Lun Lee, Weie Zhao, Ying Wang, Kevin K W Lam, Pak-Chung Ho, William S B Yeung, Cong Fang, Philip C N Chiu,

Human spermatozoa can fertilize an oocyte only after post-testicular maturation and capacitation. These processes involve dynamic modification and reorganization of the sperm plasma membrane, which allow them to bind to the zona pellucida (ZP) of the oocyte. Defective sperm-ZP binding is one of the major causes of male subfertility. Galectin-3 ... Read more >>

Mol. Hum. Reprod. (Molecular human reproduction)
[2019, 25(8):458-470]

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Different progestin-primed ovarian stimulation protocols in infertile women undergoing in vitro fertilization/intracytoplasmic sperm injection: an analysis of 1188 cycles.

Ying-Chun Guo, Pan-Yu Chen, Ting-Ting Li, Lei Jia, Peng Sun, Wan-Shan Zhu, Cun-Can Deng, Cong Fang, Xiao-Yan Liang,

PURPOSE:To evaluate the efficacy in suppressing the premature LH surge, embryo quality and pregnancy outcomes of progestin-primed ovarian stimulation (PPOS) protocols using medroxyprogesterone acetate versus utrogestan in women of all ages undergoing in vitro fertilization or intracytoplasmic sperm injection. METHODS:1188 patients were enrolled in the retrospective study, of which 1002 ... Read more >>

Arch. Gynecol. Obstet. (Archives of gynecology and obstetrics)
[2019, 299(4):1201-1212]

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Basal Serum Anti-Müllerian Hormone Level as a Predictor of Clinical Outcomes in Freezing-all Embryo Transfer Program.

Xiao-Lan Li, Rui Huang, Cong Fang, Xiao-Yan Liang,

As a novel biomarker, there is inconsistent evidence regarding the association between anti-Müllerian hormone (AMH) and live birth rate in freezing-all embryo transfer cycles. We aim to assess the prognostic effect of baseline AMH on clinical outcomes, especially live birth rate in freezing-all embryo transfer cycles. A total of 828 ... Read more >>

Curr Med Sci (Current medical science)
[2018, 38(5):861-867]

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[Micro-dissection testicular sperm extraction for non-obstructive azoospermia patients with the history of secondary testicular injury].

Gui-Hua Liu, Jing Zhang, Gui-Hua Sun, Jia-Hui Pang, Yi-da Wang, Cong Fang, Min-Fang Zhang, Xiao Gao, Hong Chen, Xiao-Mei Kang, Ya-Lu Zheng, De-Juan Sun, Hai-Tao Zeng, Lu-Gang Zhao, Zhong-Yang Wang, Xiao-Yan Liang,

Objective:To investigate the value of micro- dissection testicular sperm extraction (micro-TESE) in the treatment of non-obstructive azoospermia (NOA) in patients with the history of secondary testicular injury. METHODS:Totally, 121 NOA patients with the history of secondary testicular injury underwent micro-TESE in our hospital from September 2014 to December 2017. We ... Read more >>

Zhonghua Nan Ke Xue (Zhonghua nan ke xue = National journal of andrology)
[2018, 24(8):681-685]

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Enhancing Catalyzed Decomposition of Na2CO3 with Co2MnO x Nanowire-Decorated Carbon Fibers for Advanced Na-CO2 Batteries.

Cong Fang, Jianmin Luo, Chengbin Jin, Huadong Yuan, Ouwei Sheng, Hui Huang, Yongping Gan, Yang Xia, Chu Liang, Jun Zhang, Wenkui Zhang, Xinyong Tao,

The metal-CO2 batteries, especially Na-CO2, batteries come into sight owing to their high energy density, ability for CO2 capture, and the abundance of sodium resource. Besides the sluggish electrochemical reactions at the gas cathodes and the instability of the electrolyte at a high voltage, the final discharge product Na2CO3 is ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2018, 10(20):17240-17248]

Cited: 1 time

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Correction to: Ultrasound enhanced activation of peroxydisulfate by activated carbon fiber for decolorization of azo dye.

Tianyin Huang, Ke Zhang, Yajie Qian, Cong Fang, Jiabin Chen,

The correct name of the 5th Author is Jiabin Chen. ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2018, 25(15):14415]

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Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model.

Lijie Liu, Yi Huang, Cong Fang, Hongyu Zhang, Jing Yang, Chuanying Xuan, Fanfan Wang, Haiying Lu, Shuangfeng Cao, Yongfang Wang, Shengwei Li, Jun Sha, Mingming Zha, Min Guo, Jian Wang,

Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the development of T2DM in combination ... Read more >>

PLoS ONE (PloS one)
[2018, 13(3):e0195411]

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Should all embryos be cultured to blastocyst for advanced maternal age women with low ovarian reserve: a single center retrospective study.

Panyu Chen, Tingting Li, Lei Jia, Cong Fang, Xiaoyan Liang,

The purpose of this study is to determine whether all-blastocyst-culture can benefit advanced maternal age (AMA) patients with low ovarian reserve. We retrospectively analyze AMA patients with low ovarian reserve undergoing IVF/ICSI in Reproductive Medicine Research Center of the Sixth Affiliated Hospital of Sun Yat-sen University from May 2016 to ... Read more >>

Gynecol. Endocrinol. (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology)
[2018, 34(9):761-765]

Cited: 1 time

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Selective Transformation of β-Lactam Antibiotics by Peroxymonosulfate: Reaction Kinetics and Nonradical Mechanism.

Jiabin Chen, Cong Fang, Wenjun Xia, Tianyin Huang, Ching-Hua Huang,

While the β-lactam antibiotics are known to be susceptible to oxidative degradation by sulfate radical (SO4•-), here we report that peroxymonosulfate (PMS) exhibits specific high reactivity toward β-lactam antibiotics without SO4•- generation for the first time. Apparent second-order reaction constants (k2,app) were determined for the reaction of PMS with three ... Read more >>

Environ. Sci. Technol. (Environmental science & technology)
[2018, 52(3):1461-1470]

Cited: 1 time

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The effect of noise exposure on insulin sensitivity in mice may be mediated by the JNK/IRS1 pathway.

Lijie Liu, Cong Fang, Jing Yang, Hongyu Zhang, Yi Huang, Chuanying Xuan, Yongfang Wang, Shengwei Li, Jun Sha, Mingming Zha, Min Guo,

Epidemiological studies have suggested that noise exposure may increase the risk of type 2 diabetes mellitus (T2DM), and experimental studies have demonstrated that noise exposure can induce insulin resistance in rodents. The aim of the present study was to explore noise-induced processes underlying impaired insulin sensitivity in mice.Male ICR mice ... Read more >>

Environ Health Prev Med (Environmental health and preventive medicine)
[2018, 23(1):6]

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Ultrasound enhanced activation of peroxydisulfate by activated carbon fiber for decolorization of azo dye.

Tianyin Huang, Ke Zhang, Yajie Qian, Cong Fang, Jiabin Chen,

Activated carbon fiber (ACF) has become an emerging activator for peroxydisulfate (PDS) to generate sulfate radical (SO4•-). However, the relative low activation efficiency and poor contaminant mineralization limited its widespread application. Herein, ultrasound (US) was introduced to the ACF activated PDS system, and the synergistic effect of US and ACF ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2018, 25(15):14407-14414]

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Expression of CD24 and B7-H3 in breast cancer and the clinical significance.

Fang Cong, Haitao Yu, Xiuhua Gao,

This study aimed to investigate the correlation between the expression of CD24 and B7-H3 in breast cancer tissues and the clinical significance. Expression of CD24 and B7-H3 in breast cancer and adjacent tissues were detected by immunohistochemistry. Quantitative PCR was used to detect the expression of CD24 and B7-H3 mRNA ... Read more >>

Oncol Lett (Oncology letters)
[2017, 14(6):7185-7190]

Cited: 2 times

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A mumps model with seasonality in China.

Qianqian Qu, Cong Fang, Le Zhang, Wanru Jia, Jie Weng, Yong Li,

Mumps, an infectious viral disease, classically manifested by inflammation of salivary glands and is best known as a common childhood viral disease with no specific treatment. Although it can be protected by vaccine, there are more than 100,000 reported mumps cases according to the Chinese Center for Disease Control and ... Read more >>

Infect Dis Model (Infectious Disease Modelling)
[2017, 2(1):1-11]

Cited: 1 time

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Pregnancy outcomes of blastocysts cultured overnight after thawing.

Cong Fang, Chao-Min Yue, Rui Huang, Li-Na Wei, Lei Jia,

To compare embryo quality and outcomes of blastocysts thawed and transferred the same day with those thawed and cultured overnight before transfer.In this retrospective study, patients with infertility who underwent thawed embryo transfer (TET) the same day as thawing (0TET group) and those that received TET after embryos were thawed ... Read more >>

Arch. Gynecol. Obstet. (Archives of gynecology and obstetrics)
[2016, 293(6):1347-1356]

Cited: 2 times

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Mirror neuron system based therapy for aphasia rehabilitation.

Wenli Chen, Qian Ye, Xiangtong Ji, Sicong Zhang, Xi Yang, Qiumin Zhou, Fang Cong, Wei Chen, Xin Zhang, Bing Zhang, Yang Xia, Ti-Fei Yuan, Chunlei Shan,

To investigate the effect of hand action observation training, i.e., mirror neuron system (MNS) based training, on language function of aphasic patients after stroke. In addition, to reveal the tentative mechanism underlying this effect.Six aphasic patients after stroke, meeting the criteria, undergo 3 weeks' training protocol (30 min per day, ... Read more >>

Front Psychol (Frontiers in psychology)
[2015, 6:1665]

Cited: 8 times

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Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.

Pamela Y Ting, Christian W Johnson, Cong Fang, Xiaoqing Cao, Thomas G Graeber, Carla Mattos, John Colicelli,

RAS proteins are signal transduction gatekeepers that mediate cell growth, survival, and differentiation through interactions with multiple effector proteins. The RAS effector RAS- and RAB-interacting protein 1 (RIN1) activates its own downstream effectors, the small GTPase RAB5 and the tyrosine kinase Abelson tyrosine-protein kinase (ABL), to modulate endocytosis and cytoskeleton ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2015, 29(9):3750-3761]

Cited: 8 times

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Frozen-thawed day 5 blastocyst transfer is associated with a lower risk of ectopic pregnancy than day 3 transfer and fresh transfer.

Cong Fang, Rui Huang, Li-Na Wei, Lei Jia,

To determine the ectopic pregnancy rate with fresh versus frozen-thawed embryo transfers, and factors associated with ectopic pregnancy in patients undergoing IVF-ET.Retrospective analysis.Institutional IVF center.A total of 3,183 patients who received 3,340 blastocysts transfers: 1,994 fresh transfers and 1,346 frozen-thawed transfers.Patients received fresh day 3 embryos (F-D3 group), fresh day ... Read more >>

Fertil. Steril. (Fertility and sterility)
[2015, 103(3):655-61.e3]

Cited: 22 times

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[Apelin/APJ system--the important targets for the regulation of energy metabolism].

Fang Cong, Yun-lin Wei, Xiu-Ling Ji,

Sheng Li Ke Xue Jin Zhan (Sheng li ke xue jin zhan [Progress in physiology])
[2015, 46(1):49-51]

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