Full Text Journal Articles by
Author Colin Seymour

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A pilot study of radiation-induced bystander effect in radio-adapting frogs at a radiologically contaminated site located on the chalk river laboratories property.

Nguyen T K Vo, Harleen Singh, Marilyne Stuart, Colin B Seymour, Carmel E Mothersill,

<h4>Purpose</h4>To measure medium borne bystander effects, to study the influence of radioadaptive response (RAR) on bystander response, and to discover reliable radioresponsive biomarkers in radio-adapting frogs from Duke Swamp contaminated with an above-background radiation level and in naïve frogs from Twin Lake as the background control site.<h4>Materials and methods</h4>Frogs were ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2021, :1-8]

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Copper uptake in adult rainbow trout irradiated during early life stages and in non-irradiated bystander trout which swam with the irradiated fish.

Richard Smith, Sunita Nadella, Richard Moccia, Colin Seymour, Carmel Mothersill,

<h4>Purpose</h4>This investigation forms part of a wider study into the legacy effects of exposure of rainbow trout eggs 38 h after fertilization, eyed eggs, yolk sac larvae (YSL) or first feeders to a single 0.5 Gy X-ray dose, including the induction of a bystander effect, by the irradiated fish, to non-irradiated fish. ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2021, :1-9]

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Low dose ionizing radiation and the immune response: what is the role of non-targeted effects?

Annum Dawood, Carmel Mothersill, Colin Seymour,

<h4>Objectives</h4>This review aims to trace the historical narrative surrounding the low dose effects of radiation on the immune system and how our understanding has changed from the beginning of the 20th century to now. The particular focus is on the non-targeted effects (NTEs) of low dose ionizing radiation (LDIR) which ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2021, 97(10):1368-1382]

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Radiation exposure and mitochondrial insufficiency in chronic fatigue and immune dysfunction syndrome.

Andrej Rusin, Megan Li, Alan Cocchetto, Colin Seymour, Carmel Mothersill,

Chronic fatigue and Immune Dysfunction Syndrome (CFIDS) is a heterogeneous disease that may be promoted by various environmental stressors, including viral infection, toxin uptake, and ionizing radiation exposure. Previous studies have identified mitochondrial dysfunction in CFIDS patients, including modulation of mitochondrial respiratory chain activity, deletions in the mitochondrial genome, and ... Read more >>

Med Hypotheses (Medical hypotheses)
[2021, 154:110647]

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X-ray induced bio-acoustic emissions from cultured cells

Bruno F.E. Matarèse, Hassan Rahmoune, Nguyen Vo, Colin Seymour, Paul Schofield, Carmel Mothersill,

<h4>Purpose</h4> We characterise for the first time the emission of bio-acoustic waves from cultured cells irradiated at doses of X-ray photon radiation relevant to medical and accidental exposure. <h4>Methods and materials</h4> Human cancer cell lines (MCF-7, HL-60) and control cell-free media were exposed to 1 Gy X-ray photons while recording ... Read more >>

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Relative Biological Effectiveness and Non-Poissonian Distribution of Dicentric Chromosome Aberrations following Californium-252 Neutron Exposures of Human Peripheral Blood Lymphocytes.

Laura C Paterson, Andre Yonkeu, Fawaz Ali, Nicholas D Priest, Douglas R Boreham, Colin B Seymour, Farrah Norton, Richard B Richardson,

Cells exposed to fast neutrons often exhibit a non-Poisson distribution of chromosome aberrations due to the high ionization density of the secondary reaction products. However, it is unknown whether lymphocytes exposed to californium-252 (252Cf) spectrum neutrons, of mean energy 2.1 MeV, demonstrate this same dispersion effect at low doses. Furthermore, ... Read more >>

Radiat Res (Radiation research)
[2021, 195(2):211-217]

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Influence of common dietary supplements (curcumin, andrographolide, and d-limonene) on the radiobiological responses of p53-competent colonic cancer epithelial cells.

Dusan Vukmirovic, Nguyen T K Vo, Colin Seymour, Dave Rollo, Carmel Mothersill,

<h4>Purpose</h4>The main goal of the research was to determine whether commercially available common dietary phytochemical supplements (curcumin, andrographolide, and d-limonene) have radiomodulatory effects on p53-competent human colonic epithelial cells.<h4>Methods</h4>Clonogenic survival assays were used to characterize effects of the phytochemicals on cultured colonic epithelial cells (HCT116 p53<sup>+/+</sup>) in direct irradiation or ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2021, 97(3):341-347]

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Relative Biological Effectiveness and Non-Poissonian Distribution of Dicentric Chromosome Aberrations after Californium-252 Neutron Exposures of Human Peripheral Blood Lymphocytes.

Laura C Paterson, Andre Yonkeu, Fawaz Ali, Nicholas D Priest, Douglas R Boreham, Colin B Seymour, Farrah Norton, Richard B Richardson,

Cells exposed to fast neutrons often exhibit a non-Poisson distribution of chromosome aberrations due to the high ionization density of the secondary reaction products. However, it is unknown whether lymphocytes exposed to californium-252 (252Cf) spectrum neutrons, of mean energy 2.1 MeV, demonstrate this same dispersion effect at low doses. Furthermore, ... Read more >>

Radiat Res (Radiation research)
[2020, :]

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Bio-acoustic signaling; exploring the potential of sound as a mediator of low-dose radiation and stress responses in the environment.

Bruno F E Matarèse, Jigar Lad, Colin Seymour, Paul N Schofield, Carmel Mothersill,

<h4>Objectives</h4>This commentary reviews and evaluates the role of sound signals as part of the infosome of cells and organisms. Emission and receipt of sound has recently been identified as a potentially important universal signaling mechanism invoked when organisms are stressed. Recent evidence from plants, animals and microbes suggests that it ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2020, :1-15]

Cited: 1 time

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Environmental radiation on large Japanese field mice in Fukushima reduced colony forming potential in hematopoietic progenitor cells without inducing genomic instability.

Kentaro Ariyoshi, Tomisato Miura, Kosuke Kasai, Valerie Swee Ting Goh, Yohei Fujishima, Akifumi Nakata, Atsushi Takahashi, Yoshinaka Shimizu, Hisashi Shinoda, Hideaki Yamashiro, Colin Seymour, Carmel Mothersill, Mitsuaki A Yoshida,

<h4>Purpose</h4>To study the environmental radiation effects of wild animals after the Fukushima Dai-ichi nuclear power plant accident, we assessed effects on hematopoietic progenitor cells (HPCs) in large Japanese field mice (<i>Apodemus speciosus</i>).<h4>Materials and methods</h4>A. speciosus were collected from three contaminated sites and control area. The air dose-rates at the control ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2020, :1-12]

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Environmental and industrial developments in radiation cataractogenesis.

Lukasz Laskowski, David Williams, Colin Seymour, Carmel Mothersill,

Purpose: This review discusses recent developments in our understanding of biological and physiological mechanisms underlying radiation cataractogenesis. The areas discussed include effects of low-dose exposures to the lens including potential relevance of non-targeted effects, the development of new personal-protective equipment (PPE) and standards in clinical and nuclear settings motivated by ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2020, :1-9]

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From tangled banks to toxic bunnies; a reflection on the issues involved in developing an ecosystem approach for environmental radiation protection.

Carmel E Mothersill, Deborah H Oughton, Paul N Schofield, Michael Abend, Christelle Adam-Guillermin, Kentaro Ariyoshi, Nicholas A Beresford, Andrea Bonisoli-Alquati, Jason Cohen, Yuri Dubrova, Stanislav A Geras'kin, Tanya Helena Hevrøy, Kathryn A Higley, Nele Horemans, Awadhesh N Jha, Lawrence A Kapustka, Juliann G Kiang, Balázs G Madas, Gibin Powathil, Elena I Sarapultseva, Colin B Seymour, Nguyen T K Vo, Michael D Wood,

The objective of this paper is to present the results of discussions at a workshop held as part of the International Congress of Radiation Research (Environmental Health stream) in Manchester UK, 2019. The main objective of the workshop was to provide a platform for radioecologists to engage with radiobiologists to ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2020, :1-16]

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Reprint of: Deciphering and simulating models of radiation genotoxicity with CRISPR/Cas9 systems.

Dusan Vukmirovic, Colin Seymour, Carmel Mothersill,

This short review explores the utility and applications of CRISPR/Cas9 systems in radiobiology. Specifically, in the context of experimentally simulating genotoxic effects of Ionizing Radiation (IR) to determine the contributions from DNA targets and 'Complex Double-Stranded Breaks' (complex DSBs) to the IR response. To elucidate this objective, this review considers ... Read more >>

Mutat Res Rev Mutat Res (Mutation research. Reviews in mutation research)
[2020, 785:108318]

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Integration of ecosystem science into radioecology: A consensus perspective.

Olin E Rhodes, Francois Bréchignac, Clare Bradshaw, Thomas G Hinton, Carmel Mothersill, John A Arnone, Doug P Aubrey, Lawrence W Barnthouse, James C Beasley, Andrea Bonisoli-Alquati, Lindsay R Boring, Albert L Bryan, Krista A Capps, Bernard Clément, Austin Coleman, Caitlin Condon, Fanny Coutelot, Timothy DeVol, Guha Dharmarajan, Dean Fletcher, Wes Flynn, Garth Gladfelder, Travis C Glenn, Susan Hendricks, Ken Ishida, Tim Jannik, Larry Kapustka, Ulrik Kautsky, Robert Kennamer, Wendy Kuhne, Stacey Lance, Gennadiy Laptyev, Cara Love, Lisa Manglass, Nicole Martinez, Teresa Mathews, Arthur McKee, William McShea, Steve Mihok, Gary Mills, Ben Parrott, Brian Powell, Evgeny Pryakhin, Ann Rypstra, David Scott, John Seaman, Colin Seymour, Maryna Shkvyria, Amelia Ward, David White, Michael D Wood, Jess K Zimmerman,

In the Fall of 2016 a workshop was held which brought together over 50 scientists from the ecological and radiological fields to discuss feasibility and challenges of reintegrating ecosystem science into radioecology. There is a growing desire to incorporate attributes of ecosystem science into radiological risk assessment and radioecological research ... Read more >>

Sci Total Environ (The Science of the total environment)
[2020, 740:140031]

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5-HT2A and 5-HT3 receptors contribute to the exacerbation of targeted and non-targeted effects of ionizing radiation-induced cell death in human colon carcinoma cells.

Jacob J Curtis, Nguyen T K Vo, Colin B Seymour, Carmel E Mothersill,

<b>Purpose:</b> Serotonin (5-HT) is implicated in the underlying mechanisms which mediate cell death following ionizing radiation exposure, however, effects appear to be cell type-dependent. We sought to further characterize the role of 5-HT and 5-HT receptors (5-HTRs) in the exacerbation of cell death following ionizing radiation exposure in human colon ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2020, 96(4):482-490]

Cited: 1 time

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Deciphering and simulating models of radiation genotoxicity with CRISPR/Cas9 systems.

Dusan Vukmirovic, Colin Seymour, Carmel Mothersill,

This short review explores the utility and applications of CRISPR/Cas9 systems in radiobiology. Specifically, in the context of experimentally simulating genotoxic effects of Ionizing Radiation (IR) to determine the contributions from DNA targets and 'Complex Double-Stranded Breaks' (complex DSBs) to the IR response. To elucidate this objective, this review considers ... Read more >>

Mutat Res Rev Mutat Res (Mutation research. Reviews in mutation research)
[2020, 783:108298]

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Serotonin and 5-HT3 receptors sensitize human skin cells to direct irradiation cell death but not to soluble radiation-induced bystander signals.

Jacob J Curtis, Nguyen T K Vo, Colin B Seymour, Carmel E Mothersill,

Ionizing radiation (IR) is an environmental carcinogen and the biological damages it elicits are mechanistically distinct between high and low doses. Non-targeted effects occurring in nonirradiated cells such as the radiation-induced bystander effect predominate at low doses of IR. However, the role of non-targeted effects in environmental radiation protection is ... Read more >>

Environ Res (Environmental research)
[2020, 180:108807]

Cited: 2 times

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One-Decade-Spanning transgenerational effects of historic radiation dose in wild populations of bank voles exposed to radioactive contamination following the chernobyl nuclear disaster.

Samuel Hancock, Nguyen T K Vo, Roza I Goncharova, Colin B Seymour, Soo Hyun Byun, Carmel E Mothersill,

The concept of historic radiation doses associated with accidental radioactive releases and their role in leading to radiation-induced non-targeted effects on affected wild animals are currently being evaluated. Previous research studying Fukushima butterfly, Chernobyl bird and fruit fly populations shows that the effects are transgenerational, underlined by the principles of ... Read more >>

Environ Res (Environmental research)
[2020, 180:108816]

Cited: 3 times

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Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology

Carmel Mothersill, Andrej Rusin, Colin Seymour,

Non-targeted effects (NTE) such as bystander effects or genomic instability have been known for many years but their significance for radiotherapy or medical diagnostic radiology are far from clear. Central to the issue are reported differences in response of normal and tumour tissues to signals from directly irradiated cells. This ... Read more >>

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Towards a New Concept of Low Dose.

Carmel Mothersill, Andrej Rusin, Colin Seymour,

When people discuss the risks associated with low doses of ionizing radiation, central to the discussion is the definition of a low dose and the nature of harm. Standard answers such as "doses below 0.1 Gy are low" or "cancer is the most sensitive measure of harm" obscure the complexity ... Read more >>

Health Phys (Health physics)
[2019, 117(3):330-336]

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An investigation into neutron-induced bystander effects: How low can you go?

Jigar Lad, Andrej Rusin, Colin Seymour, Carmel Mothersill,

Neutron radiation is very harmful to both individual organisms and the environment. A n understanding of all aspects of both direct and indirect effects of radiation is necessary to accurately assess the risk of neutron radiation exposure. This review seeks to review current evidence in the literature for radiation-induced bystander ... Read more >>

Environ Res (Environmental research)
[2019, 175:84-99]

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Characterization of Radioprotective, Radiomitigative and Bystander Signaling Modulating Effects of Endogenous Metabolites - Phenylacetate, Ursodeoxycholate and Tauroursodeoxycholate - on HCT116 Human Colon Carcinoma Cell Line.

Dusan Vukmirovic, Nguyen T K Vo, Colin Seymour, David Rollo, Carmel Mothersill,

Exposures to ionizing radiation can cause depletion in stem cell reservoirs and lead to chronic injury processes that exacerbate carcinogenic and inflammatory responses. Therefore, radioprotective measures, against both acute and chronic biological effects of radiation, require frequent intake of nontoxic natural products, which have practical oral administration. The goal of ... Read more >>

Radiat Res (Radiation research)
[2019, 192(1):28-39]

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BIOPHOTONS IN RADIOBIOLOGY: INHIBITORS, COMMUNICATORS AND REACTORS.

Carmel Mothersill, Michelle Le, Andrej Rusin, Colin Seymour,

Radiation-induced bystander effects refer to the production of signals from irradiated cells which induce responses in unirradiated, or bystander, cells. There has been a recent resurgence of interest in low-energy photon biology. This is due to concerns about health effects, increased use of biophoton imaging techniques, and the fact that ... Read more >>

Radiat Prot Dosimetry (Radiation protection dosimetry)
[2019, 183(1-2):136-141]

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Targets, pools, shoulders, and communication - a reflection on the evolution of low-dose radiobiology.

Carmel Mothersill, Colin Seymour,

This reflection aims to look at the evolution of thinking about radiation dose response relationships from the early years of the journal when target theory prevailed to the present day when dose response is seen as a more holistic process involving multiple levels of organization and communication. The review is ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2019, 95(7):851-860]

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Effects of historic radiation dose on the frequency of sex-linked recessive lethals in Drosophila populations following the Chernobyl nuclear accident.

Samuel Hancock, Nguyen T K Vo, Soo Hyun Byun, Vladimir G Zainullin, Colin B Seymour, Carmel Mothersill,

Contrary to the effects of high doses of radiation, the effects of low doses of radiation are still being investigated. Low doses and their non-targeted effects in particular are of special interest for researchers. The accident that occurred at the Chernobyl Nuclear Power Plant (NPP) gives researchers the opportunity to ... Read more >>

Environ Res (Environmental research)
[2019, 172:333-337]

Cited: 3 times

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