Full Text Journal Articles by
Author Colin P N Dinney

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WHAT WOMEN WANT: RADICAL CYSTECTOMY AND PERIOPERATIVE SEXUAL FUNCTION EDUCATIONAL NEEDS.

Mary E Westerman, Kelly K Bree, Andrea Kokorovic, Jane Frank, Xin Shelly Wang, Ashish M Kamat, Colin P N Dinney, Neema Navai,

<h4>Objective</h4>To assess the extent and adequacy of pre-operative sexual function (SF) counseling in females undergoing radical cystectomy (RC) and develop educational material to improve identified deficits.<h4>Methods</h4>A 10-question survey was electronically delivered to all females who underwent RC at a single institution between 2015 and 2020. 23 of 145 patients responded ... Read more >>

Urology (Urology)
[2021, :]

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Revisiting an Old Conundrum: A Systematic Review and Meta-Analysis of Intravesical Therapy for Treatment of Urothelial Carcinoma of the Prostate.

Andrea Kokorovic, Mary E Westerman, Kate Krause, Mike Hernandez, Nathan Brooks, Colin P N Dinney, Ashish M Kamat, Neema Navai,

<h4>Background</h4>The optimal management of non-invasive (mucosal and/or ductal) urothelial carcinoma of the prostate remains elusive and there is a paucity of data to guide treatment.<h4>Objective</h4>Our objective was to systematically review and synthesize treatment responses to conservative management of non-invasive prostatic urothelial carcinoma using intravesical therapy.<h4>Methods</h4>A systematic literature search using MEDLINE, ... Read more >>

Bladder Cancer (Bladder cancer (Amsterdam, Netherlands))
[2021, 7(2):243-252]

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Justin T Matulay, Roger Li, Patrick J Hensley, Nathan A Brooks, Vikram M Narayan, H Barton Grossman, Neema Navai, Colin P N Dinney, Ashish M Kamat,

J Urol (The Journal of urology)
[2021, 205(6):1620-1621]

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Contemporary Outcomes of Patients with Nonmuscle-Invasive Bladder Cancer Treated with bacillus Calmette-Guérin: Implications for Clinical Trial Design.

Justin T Matulay, Roger Li, Patrick J Hensley, Nathan A Brooks, Vikram M Narayan, H Barton Grossman, Neema Navai, Colin P N Dinney, Ashish M Kamat,

<h4>Purpose</h4>Recurrent disease after bacillus Calmette-Guérin treatment presents a therapeutic challenge. To aid trial development, the U.S. Food and Drug Administration defined "adequate bacillus Calmette-Guérin" therapy and adopted the "bacillus Calmette-Guérin unresponsive" disease state. Available data for efficacy benchmark comparison are outdated, leading to concerns about appropriate control arms and sample ... Read more >>

J Urol (The Journal of urology)
[2021, 205(6):1612-1621]

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Impact of upper tract urothelial carcinoma on response to BCG in patients with non-muscle-invasive bladder cancer.

Kelly K Bree, Patrick J Hensley, Nathan A Brooks, Justin Matulay, Roger Li, Graciela M Nogueras Gonzalez, Neema Navai, Herbert Barton Grossman, Surena F Matin, Colin P N Dinney, Ashish M Kamat,

<h4>Objective</h4>To evaluate the impact of upper tract urothelial carcinoma (UTUC) on bacillus Calmette-Guerin (BCG) response and progression in patients with non-muscle-invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>We performed an institutional review board-approved review of patients with NMIBC treated with adequate intravesical BCG, as defined by the US Food and Drug Administration, ... Read more >>

BJU Int (BJU international)
[2021, :]

Cited: 1 time

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The obesity paradox: defining the impact of body mass index and diabetes mellitus for patients with non-muscle-invasive bladder cancer treated with bacillus Calmette-Guérin.

Nathan A Brooks, Andrea Kokorovic, Lianchen Xiao, Justin T Matulay, Roger Li, Weranja K B Ranasinghe, Supriya Nagaraju, Yu Shen, Jianjun Gao, Neema Navai, Colin P N Dinney, H Barton Grossman, Ashish M Kamat,

<h4>Objectives</h4>To evaluate if the obesity paradox, wherein obesity portends worse overall prognosis for a disease but improved outcomes for patients receiving immunotherapy, exists for patients receiving bacillus Calmette-Guérin (BCG) in a contemporary cohort.<h4>Patients and methods</h4>We performed an Institutional Review Board-approved database review to identify patients with non-muscle-invasive bladder cancer (NMIBC) ... Read more >>

BJU Int (BJU international)
[2021, 128(1):65-71]

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Genomic Predictors of Good Outcome, Recurrence, or Progression in High-Grade T1 Non-Muscle-Invasive Bladder Cancer.

Anirban P Mitra, Tanner Miest, Colin P N Dinney,

Eur Urol (European urology)
[2021, 79(3):428-429]

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Radical Cystectomy and Perioperative Sexual Function: A Cross-Sectional Analysis.

Mary E Westerman, Andrea Kokorovic, Xin Shelly Wang, Amy Lim, Araceli Garcia-Gonzalez, Mohamed Seif, Run Wang, Ashish M Kamat, Colin P N Dinney, Neema Navai,

<h4>Background</h4>Cancer-related changes in sexual function (SF) negatively impact quality of life and intimate partner relationships. There is a lack of data regarding SF among patients who underwent radical cystectomy (RC).<h4>Aim</h4>To comparatively evaluate perioperative SF among patients who underwent RC.<h4>Methods</h4>A prospective cohort of 150 patients undergoing RC for bladder cancer and ... Read more >>

J Sex Med (The journal of sexual medicine)
[2020, 17(10):1995-2004]

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TCF21 Promotes Luminal-Like Differentiation and Suppresses Metastasis in Bladder Cancer.

Sharada Mokkapati, Sima P Porten, Vikram M Narayan, Amy H Lim, Isuru S Jayaratna, Beat Roth, Tiewei Cheng, Neema Navai, Matthew Wszolek, Jonathan Melquist, Ganiraju Manyam, Woonyoung Choi, Bradley Broom, Shanna Pretzsch, Bogdan Czerniak, David J McConkey, Colin P N Dinney,

Little is known regarding the subclone evolution process in advanced bladder cancer, particularly with respect to the genomic alterations that lead to the development of metastatic lesions. In this project, we identify gene expression signatures associated with metastatic bladder cancer through mRNA expression profiling of RNA isolated from 33 primary ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2020, 18(6):811-821]

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Bacillus Calmette-Guérin Salvage Therapy: Definitions and Context.

Badrinath R Konety, Vikram M Narayan, Colin P N Dinney,

High-risk non-muscle invasive bladder cancer is marked by frequent disease recurrences and risk of stage progression, contributing to high surveillance, treatment-related costs, and patient anxiety. Although the mainstay of high-risk non-muscle invasive bladder cancer clinical management remains transurethral resection followed by intravesical bacillus Calmette-Guérin (BCG), patients who develop BCG-unresponsive disease ... Read more >>

Urol Clin North Am (The Urologic clinics of North America)
[2020, 47(1):1-4]

Cited: 1 time

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Should chemotherapy still be used to treat all muscle invasive bladder cancer in the "era of immunotherapy"?

Jonathan J Duplisea, Colin P N Dinney,

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2019, 19(7):543-545]

Cited: 1 time

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Re: Impact of Immune and Stromal Infiltration on Outcomes Following Bladder-sparing Trimodality Therapy for Muscle-invasive Bladder Cancer.

Vikram M Narayan, Amy H Lim, Colin P N Dinney,

Eur Urol (European urology)
[2019, 75(6):1034-1035]

Cited: 1 time

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Outcomes of nonmetastatic micropapillary variant upper tract urothelial carcinoma.

Jonathan J Duplisea, Firas G Petros, Roger Li, Bryan Fellman, Charles C Guo, Bogdan A Czerniak, Arlene O Siefker-Radtke, John C Araujo, Colin P N Dinney, Surena F Matin,

<h4>Purpose</h4>Micropapillary variant upper tract urothelial cancer (MP-UTUC) is a rare malignancy with little known regarding its clinical course and/or optimal treatment. In this case series, we describe patient characteristics, surgical treatment, oncologic outcomes, and response to perioperative chemotherapy.<h4>Materials and methods</h4>We conducted a review to identify patients with MP-UTUC treated at ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(6):354.e19-354.e26]

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Cost-Effectiveness of Robot-assisted Radical Cystectomy Using a Propensity-matched Cohort.

Janet Baack Kukreja, Michael J Metcalfe, Wei Qiao, Ashish M Kamat, Colin P N Dinney, Neema Navai,

<h4>Background</h4>Health-related quality of life is important for patients undergoing radical cystectomy (RC).<h4>Objective</h4>To determine the cost-effectiveness of robotic-assisted RC (RARC) compared to open cystectomy (OC) for bladder cancer and factors that contribute to cost-effectiveness.<h4>Design, setting, and participants</h4>A decision analytic model was used to compare health-related quality of life and medical costs ... Read more >>

Eur Urol Focus (European urology focus)
[2020, 6(1):88-94]

Cited: 4 times

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Absence of Tumor on Repeat Transurethral Resection of Bladder Tumor Does Not Predict Final Pathologic T0 Stage in Bladder Cancer Treated with Radical Cystectomy.

Janet Baack Kukreja, Sima Porten, Vishnukamal Golla, Philip Levy Ho, Graciela Noguera-Gonzalez, Neema Navai, Ashish M Kamat, Colin P N Dinney, Jay B Shah,

<h4>Background</h4>For patients with bladder cancer (BC) receiving neoadjuvant chemotherapy (NAC), complete pathologic absence of tumor (pT0) at radical cystectomy (RC) is associated with better survival. It is unclear if pT0 status can be attributed to the absence of residual disease (cT0) on transurethral resection of bladder tumor (TURBT) or to ... Read more >>

Eur Urol Focus (European urology focus)
[2018, 4(5):720-724]

Cited: 1 time

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Clinical risk stratification in patients with surgically resectable micropapillary bladder cancer.

Mario I Fernández, Stephen B Williams, Daniel L Willis, Rebecca S Slack, Rian J Dickstein, Sahil Parikh, Edmund Chiong, Arlene O Siefker-Radtke, Charles C Guo, Bogdan A Czerniak, David J McConkey, Jay B Shah, Louis L Pisters, H Barton Grossman, Colin P N Dinney, Ashish M Kamat,

<h4>Objective</h4>To analyse survival in patients with clinically localised, surgically resectable micropapillary bladder cancer (MPBC) undergoing radical cystectomy (RC) with and without neoadjuvant chemotherapy (NAC) and develop risk strata based on outcome data.<h4>Patients and methods</h4>A review of our database identified 103 patients with surgically resectable (≤cT4acN0 cM0) MPBC who underwent RC. ... Read more >>

BJU Int (BJU international)
[2017, 119(5):684-691]

Cited: 7 times

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Intrinsic subtypes and bladder cancer metastasis.

David J McConkey, Woonyoung Choi, Andrea Ochoa, Colin P N Dinney,

Recent studies demonstrated that bladder cancers can be grouped into basal and luminal molecular subtypes that possess distinct biological and clinical characteristics. Basal bladder cancers express biomarkers characteristic of cancer stem cells and epithelial-to-mesenchymal transition (EMT). Patients with basal cancers tend have more advanced stage and metastatic disease at presentation. ... Read more >>

Asian J Urol (Asian journal of urology)
[2016, 3(4):260-267]

Cited: 12 times

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Non-seminomatous germ cell tumor with bone metastasis only at diagnosis: A rare clinical presentation.

K C Biebighauser, Jianjun Gao, Priya Rao, Gene Landon, Lance Pagliaro, Colin P N Dinney, Jose Karam, Neema Navai,

Bone metastasis of non-seminomatous germ cell tumors (NSGCT) of the testes is a rare event and even more uncommon at initial presentation. Generally, bone lesions are discovered in the presence of concurrent retroperitoneal lymph node or visceral disease. However, in this case, a 37 years old male complaining of a ... Read more >>

Asian J Urol (Asian journal of urology)
[2017, 4(2):124-127]

Cited: 0 times

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Underutilization of Radical Cystectomy Among Patients Diagnosed with Clinical Stage T2 Muscle-invasive Bladder Cancer.

Stephen B Williams, Jinhai Huo, Karim Chamie, Jim C Hu, Sharon H Giordano, Karen E Hoffman, Colin P N Dinney, Ashish M Kamat, Ya-Chen Tina Shih,

<h4>Background</h4>Radical cystectomy is the standard surgical treatment for muscle-invasive bladder cancer (MIBC).<h4>Objective</h4>We sought to identify population-based factors predicting the use of radical cystectomy.<h4>Design, setting, and patients</h4>Analysis of Surveillance, Epidemiology, and End Results (SEER)-Medicare data for 3922 patients aged ≥66 yr diagnosed with clinical stage T2 MIBC from January 1, 2002 ... Read more >>

Eur Urol Focus (European urology focus)
[2017, 3(2-3):258-264]

Cited: 14 times

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Oncologic Equivalence between Laparoscopic/Robotic and Open Radical Cystectomy.

Neema Navai, Colin P N Dinney,

J Urol (The Journal of urology)
[2016, 195(6):1646-1647]

Cited: 1 time

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Genetic subtypes of invasive bladder cancer.

David J McConkey, Woonyoung Choi, Colin P N Dinney,

<h4>Purpose of review</h4>Recently completed cancer genomics projects identified intrinsic subtypes in muscle-invasive bladder cancers. Here we will describe the studies that led to their discovery and review their biological and clinical properties.<h4>Recent findings</h4>Whole genome mRNA expression profiling and unsupervised hierarchical cluster analyses identified intrinsic basal and luminal subtypes in muscle-invasive ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2015, 25(5):449-458]

Cited: 24 times

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Risk based neoadjuvant chemotherapy in muscle invasive bladder cancer.

Isuru S Jayaratna, Neema Navai, Colin P N Dinney,

Muscle invasive bladder cancer (MIBC) is an aggressive disease that frequently requires radical cystectomy (RC) to achieve durable cure rates. Surgery is most effective when performed in organ-confined disease, with the best outcomes for those patients with a pT0 result. The goals of neoadjuvant chemotherapy (NC) are to optimize surgical ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2015, 4(3):273-282]

Cited: 3 times

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Genetic Variants in the Wnt/β-Catenin Signaling Pathway as Indicators of Bladder Cancer Risk.

Jeanne A Pierzynski, Michelle A Hildebrandt, Ashish M Kamat, Jie Lin, Yuanqing Ye, Colin P N Dinney, Xifeng Wu,

<h4>Purpose</h4>Genetic factors that influence bladder cancer risk remain largely unknown. Previous research has suggested that there is a strong genetic component underlying the risk of bladder cancer. The Wnt/β-catenin signaling pathway is a key modulator of cellular proliferation through its regulation of stem cell homeostasis. Furthermore, variants in the Wnt/β-catenin ... Read more >>

J Urol (The Journal of urology)
[2015, 194(6):1771-1776]

Cited: 23 times

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Therapeutic opportunities in the intrinsic subtypes of muscle-invasive bladder cancer.

David J McConkey, Woonyoung Choi, Andrea Ochoa, Arlene Siefker-Radtke, Bogdan Czerniak, Colin P N Dinney,

Recent studies revealed that muscle-invasive bladder cancers segregate into intrinsic basal and luminal subtypes that are similar to those described for breast cancer. Each subtype is enriched with potentially clinically actionable genomic alterations and epigenetic signatures; there are associations between tumor subtype and sensitivity to conventional cisplatin-based chemotherapy. The authors ... Read more >>

Hematol Oncol Clin North Am (Hematology/oncology clinics of North America)
[2015, 29(2):377-94, x-xi]

Cited: 25 times

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Novel neoadjuvant therapy paradigms for bladder cancer: results from the National Cancer Center Institute Forum.

Colin P N Dinney, Donna Hansel, David McConkey, William Shipley, Michael Hagan, Robert Dreicer, Seth Lerner, Bogdan Czerniak, Fred Waldman, Susan Groshen, Lawrence D True, Emanuel Petricoin, Dan Theodorescu, Andrew Hruszkewycz, Dean Bajorin,

<h4>Objective</h4>To bridge gaps in translational science and develop the concepts for 2 novel biomarker-driven clinical trials: one in the presurgical setting and the other in the setting of bladder preservation with chemoradiation.<h4>Methods and materials</h4>The National Cancer Institute sponsored a forum, "Novel Neoadjuvant Therapy for Bladder Cancer," which brought leading clinical ... Read more >>

Urol Oncol (Urologic oncology)
[2014, 32(8):1108-1115]

Cited: 14 times

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