Full Text Journal Articles by
Author Colin Dykes


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Comparative whole-genome mapping to determine Staphylococcus aureus genome size, virulence motifs, and clonality.

Sanjay K Shukla, Madhulatha Pantrangi, Buffy Stahl, Adam M Briska, Mary E Stemper, Trevor K Wagner, Emily B Zentz, Steven M Callister, Steven D Lovrich, John K Henkhaus, Colin W Dykes,

Despite being a clonal pathogen, Staphylococcus aureus continues to acquire virulence and antibiotic-resistant genes located on mobile genetic elements such as genomic islands, prophages, pathogenicity islands, and the staphylococcal chromosomal cassette mec (SCCmec) by horizontal gene transfer from other staphylococci. The potential virulence of a S. aureus strain is often ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2012, 50(11):3526-3533]

Cited: 15 times

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Use of optical mapping to sort uropathogenic Escherichia coli strains into distinct subgroups.

William R Schwan, Adam Briska, Buffy Stahl, Trevor K Wagner, Emily Zentz, John Henkhaus, Steven D Lovrich, William A Agger, Steven M Callister, Brian DuChateau, Colin W Dykes,

Optical maps were generated for 33 uropathogenic Escherichia coli (UPEC) isolates. For individual genomes, the NcoI restriction fragments aligned into a unique chromosome map for each individual isolate, which was then compared with the in silico restriction maps of all of the sequenced E. coli and Shigella strains. All of ... Read more >>

Microbiology (Reading) (Microbiology (Reading, England))
[2010, 156(Pt 7):2124-2135]

Cited: 18 times

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Optical mapping reveals a large genetic inversion between two methicillin-resistant Staphylococcus aureus strains.

Sanjay K Shukla, Jennifer Kislow, Adam Briska, John Henkhaus, Colin Dykes,

Staphylococcus aureus is a highly versatile and evolving bacterium of great clinical importance. S. aureus can evolve by acquiring single nucleotide polymorphisms and mobile genetic elements and by recombination events. Identification and location of novel genomic elements in a bacterial genome are not straightforward, unless the whole genome is sequenced. ... Read more >>

J Bacteriol (Journal of bacteriology)
[2009, 191(18):5717-5723]

Cited: 21 times

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Genes, disease and medicine.

C W Dykes,

1. Information and technologies derived from genomic research are beginning to revolutionize the study of disease. It is now being predicted that the human genome sequencing project will be more than 90% complete by the end of this decade and that most of the major genes involved in common diseases ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[1996, 42(6):683-695]

Cited: 10 times

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