Full Text Journal Articles by
Author Colin D Funk

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Perivascular adipose tissue-derived extracellular vesicle miR-221-3p mediates vascular remodeling.

Xinzhi Li, Laurel L Ballantyne, Ying Yu, Colin D Funk,

Adipose tissue-secreted extracellular vesicles (EVs) containing microRNAs (miRNAs) convey intercellular message signaling. The biogenesis of EV-miRNAs from perivascular adipose tissue (PVAT) and their roles in intercellular communication in response to obesity-associated inflammation have not yet been fully explored. By feeding mice a high-fat diet for 16 wk, we established obesity-associated, ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(11):12704-12722]

Cited: 0 times

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Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy.

Xinzhi Li, Laurel L Ballantyne, Mackenzie C Crawford, Garret A FitzGerald, Colin D Funk,

The participation of cyclooxygenase (COX) in embryo implantation and parturition has been studied extensively. However, the distinct role of the two COX isoforms in these processes still remains unclear. Using three characterized mouse lines where the Ptgs1 and Ptgs2 genes substitute for one another, this study focused on the reproductive ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):12097]

Cited: 0 times

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Erratum: Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.

Xinzhi Li, Liudmila L Mazaleuskaya, Chong Yuan, Laurel L Ballantyne, Hu Meng, William L Smith, Garret A FitzGerald, Colin D Funk,

J. Lipid Res. (Journal of lipid research)
[2018, 59(10):2035]

Cited: 0 times

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Resolvin E1 attenuates injury-induced vascular neointimal formation by inhibition of inflammatory responses and vascular smooth muscle cell migration.

Guizhu Liu, Yanjun Gong, Rui Zhang, Lingjuan Piao, Xinzhi Li, Qian Liu, Shuai Yan, Yujun Shen, Shumin Guo, Mingjiang Zhu, Huiyong Yin, Colin D Funk, Jian Zhang, Ying Yu,

Mechanical insults, such as stent implantation, can induce endothelial injury, vascular inflammation, and ultimately lead to vascular neointimal hyperplasia. Resolvin E1 (RvE1), derived from the ω3 fatty acid eicosapentaenoic acid, can facilitate the resolution of inflammation in many settings. We therefore aimed to determine if there was a role for ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2018, 32(10):5413-5425]

Cited: 8 times

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Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions.

Xinzhi Li, Liudmila L Mazaleuskaya, Laurel L Ballantyne, Hu Meng, Garret A FitzGerald, Colin D Funk,

The distinct functions of each cyclooxygenase (COX) isoform in renal homeostasis have been the subject of intense investigation for many years. We took the novel approach of using 3 characterized mouse lines, where the prostaglandin (PG)-endoperoxide synthase genes 1 and 2 ( Ptgs1 and Ptgs2) substitute for one another to ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2018, 32(10):5326-5337]

Cited: 1 time

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Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice.

Yuan Yan Sin, Laurel L Ballantyne, Christopher R Richmond, Colin D Funk,

Progress in gene editing research has been accelerated by utilizing engineered nucleases in combination with induced pluripotent stem cell (iPSC) technology. Here, we report transcription activator-like effector nuclease (TALEN)-mediated reincorporation of Arg1 exons 7 and 8 in iPSCs derived from arginase-1-deficient mice possessing Arg1Δ alleles lacking these terminal exons. The ... Read more >>

Mol Ther Nucleic Acids (Molecular therapy. Nucleic acids)
[2018, 10:122-130]

Cited: 0 times

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Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.

Xinzhi Li, Liudmila L Mazaleuskaya, Chong Yuan, Laurel L Ballantyne, Hu Meng, William L Smith, Garret A FitzGerald, Colin D Funk,

Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2, the precursor of the major prostanoids. To address the functional interchangeability of these two isoforms and their distinct roles, we have generated COX-2>COX-1 mice whereby Ptgs2 is ... Read more >>

J. Lipid Res. (Journal of lipid research)
[2018, 59(1):89-101]

Cited: 4 times

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Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice.

Xinzhi Li, Liudmila L Mazaleuskaya, Laurel L Ballantyne, Hu Meng, Garret A FitzGerald, Colin D Funk,

Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2, function coordinately during inflammation. But the relative contributions and compensations of COX-1 and COX-2 to inflammatory responses remain unanswered. We used three engineered mouse lines where the Ptgs1 and Ptgs2 genes substitute for one another to discriminate the distinct roles ... Read more >>

J. Lipid Res. (Journal of lipid research)
[2018, 59(1):102-112]

Cited: 4 times

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Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice.

Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D Funk, Jian Zhang, Ying Yu,

BACKGROUND AND PURPOSE:An appropriate inflammatory response is necessary for cardiac healing after acute myocardial infarction (MI). Resolvin E1 (RvE1) is an anti-inflammatory and pro-resolution lipid mediator derived from eicosapentaenoic acid. Here we have investigated the effects of RvE1 on the recovery of cardiac function after MI in mice. EXPERIMENTAL APPROACH:Acute ... Read more >>

Br. J. Pharmacol. (British journal of pharmacology)
[2018, 175(8):1205-1216]

Cited: 8 times

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Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency.

Yuan Yan Sin, Phillipe R Price, Laurel L Ballantyne, Colin D Funk,

Arginase-1 deficiency in humans is a rare genetic disorder of metabolism resulting from a loss of arginase-1, leading to impaired ureagenesis, hyperargininemia and neurological deficits. Previously, we generated a tamoxifen-inducible arginase-1 deficient mouse model harboring a deletion of Arg1 exons 7 and 8 that leads to similar biochemical defects, along ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):2585]

Cited: 4 times

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Effects of p53-knockout in vascular smooth muscle cells on atherosclerosis in mice.

Richard Yang Cao, Robert Eves, Lilly Jia, Colin D Funk, Zongchao Jia, Alan S Mak,

In vitro and in vivo evidence has indicated that the tumor suppressor, p53, may play a significant role in the regulation of atherosclerotic plaque formation. In vivo studies using global knockout mice models, however, have generated inconclusive results that do not address the roles of p53 in various cell types ... Read more >>

PLoS ONE (PloS one)
[2017, 12(3):e0175061]

Cited: 1 time

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Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency.

Laurel L Ballantyne, Yuan Yan Sin, Osama Y Al-Dirbashi, Xinzhi Li, David J Hurlbut, Colin D Funk,

Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver. We previously generated a tamoxifen-inducible Arg1 deficient mouse model (Arg1-Cre) that disrupts Arg1 expression throughout the whole body and leads to lethality ≈ 2 weeks after gene disruption. Here, we evaluate if liver-selective Arg1 ... Read more >>

Mol Genet Metab Rep (Molecular genetics and metabolism reports)
[2016, 9:54-60]

Cited: 6 times

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Thromboxane Governs the Differentiation of Adipose-Derived Stromal Cells Toward Endothelial Cells In Vitro and In Vivo.

Yujun Shen, Shengkai Zuo, Yuanyang Wang, Hongfei Shi, Shuai Yan, Di Chen, Bing Xiao, Jian Zhang, Yanjun Gong, Maohua Shi, Juan Tang, Deping Kong, Luheng Lu, Yu Yu, Bin Zhou, Sheng-Zhong Duan, Claudio Schneider, Colin D Funk, Ying Yu,

Autologous adipose-derived stromal cells (ASCs) offer great promise as angiogenic cell therapy for ischemic diseases. Because of their limited self-renewal capacity and pluripotentiality, the therapeutic efficacy of ASCs is still relatively low. Thromboxane has been shown to play an important role in the maintenance of vascular homeostasis. However, little is ... Read more >>

Circ. Res. (Circulation research)
[2016, 118(8):1194-1207]

Cited: 6 times

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Arginase-1 deficiency.

Yuan Yan Sin, Garrett Baron, Andreas Schulze, Colin D Funk,

Arginase-1 (ARG1) deficiency is a rare autosomal recessive disorder that affects the liver-based urea cycle, leading to impaired ureagenesis. This genetic disorder is caused by 40+ mutations found fairly uniformly spread throughout the ARG1 gene, resulting in partial or complete loss of enzyme function, which catalyzes the hydrolysis of arginine ... Read more >>

J. Mol. Med. (Journal of molecular medicine (Berlin, Germany))
[2015, 93(12):1287-1296]

Cited: 12 times

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Endogenously generated omega-3 fatty acids attenuate vascular inflammation and neointimal hyperplasia by interaction with free fatty acid receptor 4 in mice.

Xinzhi Li, Laurel L Ballantyne, Xinghui Che, Jeffrey D Mewburn, Jing X Kang, Robert M Barkley, Robert C Murphy, Ying Yu, Colin D Funk,

Omega-3 polyunsaturated fatty acids (ω3 PUFAs) suppress inflammation through activation of free fatty acid receptor 4 (FFAR4), but this pathway has not been explored in the context of cardiovascular disease. We aimed to elucidate the involvement of FFAR4 activation by ω3 PUFAs in the process of vascular inflammation and neointimal ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2015, 4(4):]

Cited: 10 times

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Aspirin enhances protective effect of fish oil against thrombosis and injury-induced vascular remodelling.

Yanjun Gong, Minghui Lin, Lingjuan Piao, Xinzhi Li, Fei Yang, Jian Zhang, Bing Xiao, Qingli Zhang, Wen-Liang Song, Huiyong Yin, Li Zhu, Colin D Funk, Ying Yu,

Although aspirin (acetylsalicylic acid) is commonly used to prevent ischaemic events in patients with coronary artery disease, many patients fail to respond to aspirin treatment. Dietary fish oil (FO), containing ω3 polyunsaturated fatty acids (PUFAs), has anti-inflammatory and cardio-protective properties, such as lowering cholesterol and modulating platelet activity. The objective ... Read more >>

Br. J. Pharmacol. (British journal of pharmacology)
[2015, 172(23):5647-5660]

Cited: 12 times

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EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling.

Ankang Lu, Caojian Zuo, Yuhu He, Guilin Chen, Lingjuan Piao, Jian Zhang, Bing Xiao, Yujun Shen, Juan Tang, Deping Kong, Sara Alberti, Di Chen, Shenkai Zuo, Qianqian Zhang, Shuai Yan, Xiaochun Fei, Fei Yuan, Bin Zhou, Shengzhong Duan, Yu Yu, Michael Lazarus, Yunchao Su, Richard M Breyer, Colin D Funk, Ying Yu,

Pulmonary arterial hypertension (PAH) is commonly associated with chronic hypoxemia in disorders such as chronic obstructive pulmonary disease (COPD). Prostacyclin analogs are widely used in the management of PAH patients; however, clinical efficacy and long-term tolerability of some prostacyclin analogs may be compromised by concomitant activation of the E-prostanoid 3 ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2015, 125(3):1228-1242]

Cited: 26 times

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Strategies to rescue the consequences of inducible arginase-1 deficiency in mice.

Laurel L Ballantyne, Yuan Yan Sin, Tim St Amand, Joshua Si, Steven Goossens, Lieven Haenebalcke, Jody J Haigh, Lianna Kyriakopoulou, Andreas Schulze, Colin D Funk,

Arginase-1 catalyzes the conversion of arginine to ornithine and urea, which is the final step of the urea cycle used to remove excess ammonia from the body. Arginase-1 deficiency leads to hyperargininemia in mice and man with severe lethal consequences in the former and progressive neurological impairment to varying degrees ... Read more >>

PLoS ONE (PloS one)
[2015, 10(5):e0125967]

Cited: 5 times

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Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyperresponsiveness in mice.

Maohua Shi, Guochao Shi, Juan Tang, Deping Kong, Yao Bao, Bing Xiao, Caojian Zuo, Tai Wang, Qingsong Wang, Yujun Shen, Hui Wang, Colin D Funk, Jie Zhou, Ying Yu,

BACKGROUND: Myeloid-derived suppressor cells (MDSCs) have recently been implicated in the pathogenesis of asthma, but their regulation in patients with aspirin-intolerant asthma (AIA) remains unclear. OBJECTIVE: We sought to characterize MDSC accumulation and pathogenic functions in allergic airway inflammation mediated by COX-1 deficiency or aspirin treatment in mice. METHODS: Allergic ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2014, 134(5):1163-74.e16]

Cited: 14 times

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Whole blood transcriptomics and urinary metabolomics to define adaptive biochemical pathways of high-intensity exercise in 50-60 year old masters athletes.

Kamalika Mukherjee, Brittany A Edgett, Harrison W Burrows, Cecilia Castro, Julian L Griffin, Adel Giaid Schwertani, Brendon J Gurd, Colin D Funk,

Exercise is beneficial for a variety of age-related disorders. However, the molecular mechanisms mediating the beneficial adaptations to exercise in older adults are not well understood. The aim of the current study was to utilize a dual approach to characterize the genetic and metabolic adaptive pathways altered by exercise in ... Read more >>

PLoS ONE (PloS one)
[2014, 9(3):e92031]

Cited: 16 times

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A mutation interfering with 5-lipoxygenase domain interaction leads to increased enzyme activity.

Marija Rakonjac Ryge, Michiharu Tanabe, Patrick Provost, Bengt Persson, Xinsheng Chen, Colin D Funk, Agnes Rinaldo-Matthis, Bettina Hofmann, Dieter Steinhilber, Takashi Watanabe, Bengt Samuelsson, Olof Rådmark,

5-Lipoxygenase (5-LOX) catalyzes two steps in conversion of arachidonic acid to proinflammatory leukotrienes. Lipoxygenases, including human 5-LOX, consist of an N-terminal C2-like β-sandwich and a catalytic domain. We expressed the 5-LOX domains separately, these were found to interact in the yeast two-hybrid system. The 5-LOX structure suggested association between Arg(101) ... Read more >>

Arch. Biochem. Biophys. (Archives of biochemistry and biophysics)
[2014, 545:179-185]

Cited: 4 times

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Multiple-site activation of the cysteinyl leukotriene receptor 2 is required for exacerbation of ischemia/reperfusion injury.

Nathan C Ni, Laurel L Ballantyne, Jeffrey D Mewburn, Colin D Funk,

OBJECTIVE: Transgenic overexpression of the human cysteinyl leukotriene receptor 2 (CysLT2R) in murine endothelium exacerbates vascular permeability and ischemia/reperfusion injury. Here, we explore the underlying mechanisms of CysLT2R activation-mediated inflammation and delineate the relative contributions of endogenous murine CysLT2R and the transgene-derived receptor. APPROACH AND RESULTS: We created a novel ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2014, 34(2):321-330]

Cited: 6 times

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Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism.

Yuan Yan Sin, Laurel L Ballantyne, Kamalika Mukherjee, Tim St Amand, Lianna Kyriakopoulou, Andreas Schulze, Colin D Funk,

Arginase deficiency is a rare autosomal recessive disorder resulting from a loss of the liver arginase isoform, arginase 1 (ARG1), which is the final step in the urea cycle for detoxifying ammonia. ARG1 deficiency leads to hyperargininemia, characterized by progressive neurological impairment, persistent growth retardation and infrequent episodes of hyperammonemia. ... Read more >>

PLoS ONE (PloS one)
[2013, 8(11):e80001]

Cited: 15 times

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Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4).

Xinzhi Li, Ying Yu, Colin D Funk,

Cyclooxygenase-2 (COX-2)-derived prostaglandins are implicated in numerous inflammatory disorders. The purpose of these studies was to examine previously unexplored interactions between COX-2 induction and docosahexaenoic acid (DHA) via the free fatty acid receptor 4 (FFA4) signaling pathway in murine RAW 264.7 cells and peritoneal macrophages challenged with lipopolysaccharide (LPS). DHA ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2013, 27(12):4987-4997]

Cited: 38 times

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Cyclooxygenase-2-derived prostaglandin E₂ promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor.

Jian Zhang, Fangfang Zou, Juan Tang, Qianqian Zhang, Yanjun Gong, Qingsong Wang, Yujun Shen, Lixia Xiong, Richard M Breyer, Michael Lazarus, Colin D Funk, Ying Yu,

Vascular smooth muscle cell (VSMC) migration and proliferation are the hallmarks of restenosis pathogenesis after angioplasty. Cyclooxygenase (COX)-derived prostaglandin (PG) E₂ is implicated in the vascular remodeling response to injury. However, its precise molecular role remains unknown.This study investigates the impact of COX-2-derived PGE₂ on neointima formation after injury.Vascular remodeling ... Read more >>

Circ. Res. (Circulation research)
[2013, 113(2):104-114]

Cited: 37 times

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