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Author Claus Peter Heussel

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Versatile workflow for cell-type resolved transcriptional and epigenetic profiles from cryopreserved human lung.

Maria Llamazares Prada, Elisa Espinet, Vedrana Mijošek, Uwe Schwartz, Pavlo Lutsik, Raluca Tamas, Mandy Richter, Annika Behrendt, Stephanie T Pohl, Naja P Benz, Thomas Muley, Arne Warth, Claus Peter Heußel, Hauke Winter, Jonathan J M Landry, Felix Jf Herth, Tinne Cj Mertens, Harry Karmouty-Quintana, Ina Koch, Vladimir Benes, Jan O Korbel, Sebastian M Waszak, Andreas Trumpp, David M Wyatt, Heiko F Stahl, Christoph Plass, Renata Z Jurkowska,

Complexity of lung microenvironment and changes in cellular composition during disease make it exceptionally hard to understand molecular mechanisms driving development of chronic lung diseases. Although recent advances in cell-type resolved approaches hold great promise for studying complex diseases, their implementation relies on local access to fresh tissue, as traditional ... Read more >>

JCI Insight (JCI insight)
[2021, :]

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The Diagnosis and Treatment of Pulmonary Fibrosis.

Michael Kreuter, Ulf Müller Ladner, Ulrich Costabel, Danny Jonigk, Claus Peter Heussel,

<h4>Background</h4>The different types of pulmonary fibrosis are a subgroup of the interstitial lung diseases (ILDs). They are associated with a chronic and often progressive course.<h4>Methods</h4>This review is based on pertinent publications retrieved by a selective search in the EMBASE and PubMed databases, with an emphasis on articles published from 2000 ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Lung cancer prediction by Deep Learning to identify benign lung nodules.

Marjolein A Heuvelmans, Peter M A van Ooijen, Sarim Ather, Carlos Francisco Silva, Daiwei Han, Claus Peter Heussel, William Hickes, Hans-Ulrich Kauczor, Petr Novotny, Heiko Peschl, Mieneke Rook, Roman Rubtsov, Oyunbileg von Stackelberg, Maria T Tsakok, Carlos Arteta, Jerome Declerck, Timor Kadir, Lyndsey Pickup, Fergus Gleeson, Matthijs Oudkerk,

<h4>Introduction</h4>Deep Learning has been proposed as promising tool to classify malignant nodules. Our aim was to retrospectively validate our Lung Cancer Prediction Convolutional Neural Network (LCP-CNN), which was trained on US screening data, on an independent dataset of indeterminate nodules in an European multicentre trial, to rule out benign nodules ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2021, 154:1-4]

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Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: First clinical experience.

Florian Eichhorn, Laura V Klotz, Mark Kriegsmann, Helge Bischoff, Marc A Schneider, Thomas Muley, Katharina Kriegsmann, Uwe Haberkorn, Claus Peter Heussel, Rajkumar Savai, Inka Zoernig, Dirk Jaeger, Michael Thomas, Hans Hoffmann, Hauke Winter, Martin E Eichhorn,

<h4>Objectives</h4>A phase II trial investigating the therapeutic effect of neoadjuvant programmed cell death 1 (PD-1) inhibitor pembrolizumab (MK-3475, KEYTRUDA®) administered prior to surgery for the treatment of non-small cell lung cancer (NSCLC) has been conducted (NCT03197467). We report the first clinical results of a planned interim safety analysis after 15 ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2021, 153:150-157]

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Residual symptoms and lower lung function in patients recovering from SARS-CoV-2 infection.

Frederik Trinkmann, Michael Müller, Alexandra Reif, Nicolas Kahn, Michael Kreuter, Franziska Trudzinski, Monika Eichinger, Claus-Peter Heussel, Felix J F Herth, ,

Eur Respir J (The European respiratory journal)
[2021, :]

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A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma.

Jan Budczies, Martina Kirchner, Klaus Kluck, Daniel Kazdal, Julia Glade, Michael Allgäuer, Mark Kriegsmann, Claus-Peter Heußel, Felix J Herth, Hauke Winter, Michael Meister, Thomas Muley, Stefan Fröhling, Solange Peters, Barbara Seliger, Peter Schirmacher, Michael Thomas, Petros Christopoulos, Albrecht Stenzinger,

Immune checkpoint blockade (ICB) expands the therapeutic options for metastatic lung cancer nowadays representing a standard frontline strategy as monotherapy or combination therapy, as well as an option in oncogene-addicted NSCLC after exhaustion of targeted therapies. Predictive markers are urgently needed, since only a minority of patients benefits from ICB, ... Read more >>

Oncoimmunology (Oncoimmunology)
[2021, 10(1):1860586]

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Joint Statement of the German Respiratory Society and German Society of Thoracic Surgery in Cooperation with the German Radiological Society: Structural Prerequisites of Centres for Interventional Treatment of Emphysema.

Wolfgang Johannes Gesierich, Kaid Darwiche, Felix Döllinger, Ralf Eberhardt, Stephan Eisenmann, Christian Grah, Claus Peter Heußel, Ralf-Harto Huebner, Julia Ley-Zaporozhan, Franz Stanzel, Stefan Welter, Hans Hoffmann,

Interventional treatment of emphysema offers a wide range of surgical and endoscopic options for patients with advanced disease. Multidisciplinary collaboration of pulmonology, thoracic surgery, and imaging disciplines in patient selection, therapy, and follow-up ensures treatment quality. The present joint statement describes the required structural and quality prerequisites of treatment centres. ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2021, 100(1):52-58]

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Transbronchial cryobiopsy increases diagnostic confidence in interstitial lung disease: a prospective multicentre trial.

Jürgen Hetzel, Athol U Wells, Ulrich Costabel, Thomas V Colby, Simon L F Walsh, Johny Verschakelen, Alberto Cavazza, Sara Tomassetti, Claudia Ravaglia, Michael Böckeler, Werner Spengler, Michael Kreuter, Ralf Eberhardt, Kaid Darwiche, Alfons Torrego, Virginia Pajares, Rainer Muche, Regina Musterle, Marius Horger, Falko Fend, Arne Warth, Claus Peter Heußel, Sara Piciucchi, Alessandra Dubini, Dirk Theegarten, Tomas Franquet, Enrique Lerma, Venerino Poletti, Maik Häntschel,

<h4>Introduction</h4>The accurate diagnosis of individual interstitial lung diseases (ILD) is often challenging, but is a critical determinant of appropriate management. If a diagnosis cannot be made after multidisciplinary team discussion (MDTD), surgical lung biopsy is the current recommended tissue sampling technique according to the most recent guidelines. Transbronchial lung cryobiopsy ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 56(6):]

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Consolidation Immunotherapy After Platinum-Based Chemoradiotherapy in Patients With Unresectable Stage III Non-Small Cell Lung Cancer-Cross-Sectional Study of Eligibility and Administration Rates.

Tanja Eichkorn, Farastuk Bozorgmehr, Sebastian Regnery, Lisa A Dinges, Andreas Kudak, Nina Bougatf, Dorothea Weber, Petros Christopoulos, Thomas Muley, Sonja Kobinger, Laila König, Juliane Hörner-Rieber, Sebastian Adeberg, Claus Peter Heussel, Michael Thomas, Jürgen Debus, Rami A El Shafie,

<h4>Introduction</h4>The PACIFC trial demonstrated a significant benefit of durvalumab consolidation immunotherapy (CIT) after definitive platinum-based chemoradiotherapy (P-CRT) for survival in stage III non-small cell lung cancer (NSCLC). It is unknown how many patients are eligible in clinical practice to receive CIT according to PACIFIC criteria compared to real administration rates ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:586449]

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Overdiagnosis in lung cancer screening: Estimates from the German Lung Cancer Screening Intervention Trial.

Sandra González Maldonado, Erna Motsch, Anke Trotter, Hans-Ulrich Kauczor, Claus-Peter Heussel, Silke Hermann, Sylke Ruth Zeissig, Stefan Delorme, Rudolf Kaaks,

Overdiagnosis is a major potential harm of lung cancer screening; knowing its potential magnitude helps to optimize screening eligibility criteria. The German Lung Screening Intervention Trial ("LUSI") is a randomized trial among 4052 long-term smokers (2622 men), 50.3 to 71.9 years of age from the general population around Heidelberg, Germany, comparing ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 148(5):1097-1105]

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Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.

J Peter Donnelly, Sharon C Chen, Carol A Kauffman, William J Steinbach, John W Baddley, Paul E Verweij, Cornelius J Clancy, John R Wingard, Shawn R Lockhart, Andreas H Groll, Tania C Sorrell, Matteo Bassetti, Hamdi Akan, Barbara D Alexander, David Andes, Elie Azoulay, Ralf Bialek, Robert W Bradsher, Stephane Bretagne, Thierry Calandra, Angela M Caliendo, Elio Castagnola, Mario Cruciani, Manuel Cuenca-Estrella, Catherine F Decker, Sujal R Desai, Brian Fisher, Thomas Harrison, Claus Peter Heussel, Henrik E Jensen, Christopher C Kibbler, Dimitrios P Kontoyiannis, Bart-Jan Kullberg, Katrien Lagrou, Frédéric Lamoth, Thomas Lehrnbecher, Jurgen Loeffler, Olivier Lortholary, Johan Maertens, Oscar Marchetti, Kieren A Marr, Henry Masur, Jacques F Meis, C Orla Morrisey, Marcio Nucci, Luis Ostrosky-Zeichner, Livio Pagano, Thomas F Patterson, John R Perfect, Zdenek Racil, Emmanuel Roilides, Marcus Ruhnke, Cornelia Schaefer Prokop, Shmuel Shoham, Monica A Slavin, David A Stevens, George R Thompson, Jose A Vazquez, Claudio Viscoli, Thomas J Walsh, Adilia Warris, L Joseph Wheat, P Lewis White, Theoklis E Zaoutis, Peter G Pappas,

<h4>Background</h4>Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(6):1367-1376]

Cited: 66 times

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Comprehensive serial biobanking in advanced NSCLC: feasibility, challenges and perspectives.

Sabine Wessels, Thomas Muley, Petros Christopoulos, Michael Meister, Ingrid Heinzmann-Groth, Arne Warth, Esther Herpel, Simone Hummler, Ursula Klingmüller, Jonas Kuon, Claus-Peter Heussel, Ralf Eberhardt, Felix J F Herth, Hauke Winter, Helge Bischoff, Albrecht Stenzinger, Martin Reck, Rudolf Maria Huber, Michael Thomas, Marc A Schneider,

<h4>Background</h4>Availability of tumor material at baseline and disease progression is increasingly important for patient management in non-small-cell lung cancer (NSCLC), especially for the application of targeted therapies like tyrosine kinase inhibitors and for immune checkpoint inhibitor treatment. Here we report the experience of prospective biomaterial acquisition in advanced NSCLC from ... Read more >>

Transl Lung Cancer Res (Translational lung cancer research)
[2020, 9(4):1000-1014]

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No Changes in T1 Relaxometry After a Mean of 11 Administrations of Gadobutrol.

Katerina Deike-Hofmann, Julia Reuter, Robert Haase, Tristan Kuder, Daniel Paech, Sebastian Bickelhaupt, Michael Forsting, Heinz-Peter Schlemmer, Claus Peter Heußel, Alexander Radbruch,

<h4>Objectives</h4>Quantitative T1 relaxometry is the benchmark in imaging potential gadolinium deposition and known to be superior to semiquantitative signal intensity ratio analyses. However, T1 relaxometry studies are rare, commonly limited to a few target structures, and reported results are inconsistent.We systematically investigated quantitative T1 relaxation times (qT1) of a variety ... Read more >>

Invest Radiol (Investigative radiology)
[2020, 55(6):381-386]

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Delayed contrast dynamics as marker of regional impairment in pulmonary fibrosis using 5D MRI - a pilot study.

Maria Ta Buzan, Andreas Wetscherek, Christopher M Rank, Michael Kreuter, Claus Peter Heussel, Marc Kachelrieß, Julien Dinkel,

<h4>Objective</h4>To analyse delayed contrast dynamics of fibrotic lesions in interstitial lung disease (ILD) using five dimensional (5D) MRI and to correlate contrast dynamics with disease severity.<h4>Methods</h4>20 patients (mean age: 71 years; M:F, 13:7), with chronic fibrosing ILD: <i>n</i> = 12 idiopathic pulmonary fibrosis (IPF) and <i>n</i> = 8 non-IPF, underwent ... Read more >>

Br J Radiol (The British journal of radiology)
[2020, 93(1113):20190121]

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Deep Learning for the Classification of Small-Cell and Non-Small-Cell Lung Cancer.

Mark Kriegsmann, Christian Haag, Cleo-Aron Weis, Georg Steinbuss, Arne Warth, Christiane Zgorzelski, Thomas Muley, Hauke Winter, Martin E Eichhorn, Florian Eichhorn, Joerg Kriegsmann, Petros Christopoulos, Michael Thomas, Mathias Witzens-Harig, Peter Sinn, Moritz von Winterfeld, Claus Peter Heussel, Felix J F Herth, Frederick Klauschen, Albrecht Stenzinger, Katharina Kriegsmann,

Reliable entity subtyping is paramount for therapy stratification in lung cancer. Morphological evaluation remains the basis for entity subtyping and directs the application of additional methods such as immunohistochemistry (IHC). The decision of whether to perform IHC for subtyping is subjective, and access to IHC is not available worldwide. Thus, ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(6):]

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CT features in amyloidosis of the respiratory system - Comprehensive analysis in a tertiary referral center cohort.

Simone Christine Brandelik, Claus Peter Heussel, Hans-Ulrich Kauczor, Christoph Röcken, Laura Huber, Marco Basset, Christoph Kimmich, Stefan Olaf Schönland, Ute Hegenbart, Johanna Nattenmüller,

<h4>Purpose</h4>Amyloidosis of the respiratory system is rare and challenging since imaging findings have several more prevalent alternative diagnoses. We analyze and quantify chest CT findings in a large tertiary referral center patient cohort with confirmed amyloidosis of the respiratory system.<h4>Methods</h4>67 patients with histology-proven amyloidosis of the respiratory system and with ... Read more >>

Eur J Radiol (European journal of radiology)
[2020, 129:109123]

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Comparison of MRI and VQ-SPECT as a Screening Test for Patients With Suspected CTEPH: CHANGE-MRI Study Design and Rationale.

Florian Lasch, Annika Karch, Armin Koch, Thorsten Derlin, Andreas Voskrebenzev, Tawfik Moher Alsady, Marius M Hoeper, Henning Gall, Fritz Roller, Sebastian Harth, Dagmar Steiner, Gabriele Krombach, Hossein Ardeschir Ghofrani, Fabian Rengier, Claus Peter Heußel, Ekkehard Grünig, Dietrich Beitzke, Marcus Hacker, Irene M Lang, Jürgen Behr, Peter Bartenstein, Julien Dinkel, Kai-Helge Schmidt, Karl-Friedrich Kreitner, Thomas Frauenfelder, Silvia Ulrich, Okka W Hamer, Michael Pfeifer, Christopher S Johns, David G Kiely, Andrew James Swift, Jim Wild, Jens Vogel-Claussen,

The diagnostic strategy for chronic thromboembolic pulmonary hypertension (CTEPH) is composed of two components required for a diagnosis of CTEPH: the presence of chronic pulmonary embolism and an elevated pulmonary artery pressure. The current guidelines require that ventilation-perfusion single-photon emission computed tomography (VQ-SPECT) is used for the first step diagnosis ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2020, 7:51]

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[Evolution of CT manifestations in a Coronavirus (2019-nCoV) pneumonia patient].

Qianna Jin, Claus Peter Heußel, Hans-Ulrich Kauczor, Wei Cui, Guoyi Lv,

Med Klin Intensivmed Notfmed (Medizinische Klinik, Intensivmedizin und Notfallmedizin)
[2020, 115(5):412-413]

Cited: 1 time

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Oligoprogressive Non-Small-Cell Lung Cancer under Treatment with PD-(L)1 Inhibitors.

Stephan Rheinheimer, Claus-Peter Heussel, Philipp Mayer, Lena Gaissmaier, Farastuk Bozorgmehr, Hauke Winter, Felix J Herth, Thomas Muley, Stephan Liersch, Helge Bischoff, Mark Kriegsmann, Rami A El Shafie, Albrecht Stenzinger, Michael Thomas, Hans-Ulrich Kauczor, Petros Christopoulos,

Oligoprogression (OPD) of non-small-cell lung cancer (NSCLC) occurs in approximately half of patients under targeted compounds (TKI) and facilitates use of regional therapies that can prolong survival. In order to characterize OPD in immunotherapy (IO)-treated NSCLC, we analyzed the failure pattern under PD-1/PD-L1 inhibitors (<i>n</i> = 297) or chemoimmunotherapy (<i>n</i> ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(4):]

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Evaluation of Prediction Models for Identifying Malignancy in Pulmonary Nodules Detected via Low-Dose Computed Tomography.

Sandra González Maldonado, Stefan Delorme, Anika Hüsing, Erna Motsch, Hans-Ulrich Kauczor, Claus-Peter Heussel, Rudolf Kaaks,

Importance:Malignancy prediction models based on participant-related characteristics and imaging parameters from low-dose computed tomography (CT) may improve decision-making regarding nodule management and diagnosis in lung cancer screening. Objective:To externally validate 5 malignancy prediction models that were developed in screening settings, compared with 3 models that were developed in clinical settings, ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(2):e1921221]

Cited: 2 times

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Gradual enhancement pattern of tracheobronchial adenoid cystic carcinoma on multiphasic dynamic computed tomography : a case series.

Shinsaku Matsumoto, Shogo Fukuma, Takayoshi Shinya, Takahiro Kitayama, Soichiro Kajita, Yoshihisa Masaoka, Shinji Hashimura, Claus Peter Heussel, Hans-Ulrich Kauczor, Susumu Kanazawa,

Tracheobronchial adenoid cystic carcinoma is a rare malignancy. To the best of our knowledge, its enhancement pattern on multiphasic contrast-enhanced multidetector computed tomography has not been reported. Herein, we report the computed tomography findings of three consecutive cases of tracheobronchial adenoid cystic carcinoma. All lesions presented a gradual enhancement pattern ... Read more >>

J Med Invest (The journal of medical investigation : JMI)
[2020, 67(3.4):378-381]

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Impact of FDG-PET on the Detection of Patients with Lung Cancer at High Risk for ILD.

Paul Flechsig, Olena Hural, Michael Kreuter, Martin Eichhorn, Gudula HEUßEL, Christos Sachpekidis, Hans-Ulrich Kauczor, Uwe Haberkorn, Claus Peter Heussel, Monika Eichinger,

<h4>Background/aim</h4>Idiopathic pulmonary fibrosis IPF is a type of interstitial lung disease (ILD) with poor prognosis. Lung cancer (LC) is a frequent complication in IPF, where all therapeutic options are potential triggers for acute exacerbation of IPF.<h4>Patients and methods</h4>Patients with 2-deoxy-2-fluoro-D-glucose-positron emission tomography/computer tomography (FDG-PET/CT) results before lobectomy for LC with ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2018, 32(6):1457-1462]

Cited: 1 time

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Serial liquid biopsies for detection of treatment failure and profiling of resistance mechanisms in KLC1-ALK-rearranged lung cancer.

Steffen Dietz, Petros Christopoulos, Lisa Gu, Anna-Lena Volckmar, Volker Endris, Zhao Yuan, Simon J Ogrodnik, Tomasz Zemojtel, Claus-Peter Heussel, Marc A Schneider, Michael Meister, Thomas Muley, Martin Reck, Matthias Schlesner, Michael Thomas, Albrecht Stenzinger, Holger Sültmann,

Genetic rearrangements involving the anaplastic lymphoma kinase (ALK) gene confer sensitivity to ALK tyrosine kinase inhibitors (TKIs) and superior outcome in non-small-cell lung cancer (NSCLC). However, clinical courses vary widely, and recent studies suggest that molecular profiling of ALK+ NSCLC can provide additional predictors of therapy response that could assist ... Read more >>

Cold Spring Harb Mol Case Stud (Cold Spring Harbor molecular case studies)
[2019, 5(6):]

Cited: 3 times

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Primary pulmonary myxoid sarcoma with an unusual gene fusion between exon 7 of EWSR1 and exon 5 of CREB1.

Christian Koelsche, Luca Tavernar, Olaf Neumann, Claus Peter Heußel, Ralf Eberhardt, Hauke Winter, Albrecht Stenzinger, Gunhild Mechtersheimer,

Primary pulmonary mesenchymal tumors are rare, yet they compromise a variety of entities. A novel low-grade malignant neoplasm coined primary pulmonary myxoid sarcoma (PPMS) has been introduced in the WHO classification of lung tumors. Molecular analysis in PPMS revealed recurrent gene fusions between EWSR1 and CREB1, a member of the ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2020, 476(5):787-791]

Cited: 2 times

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Comment on: Diagnostic Reference Levels for Diagnostic and Interventional X-Ray Procedures in Germany: Update and Handling/Diagnostische Referenzwerte für diagnostische und interventionelle Röntgenanwendungen in Deutschland: Aktualisierung und Handhabung (Alexander Schegerer, Reinhard Loose, Lothar J. Heuser, Gunnar Brix).

Jürgen Biederer, Okka W Hamer, Claus-Peter Heussel, Hans-Ulrich Kauczor, Hilmar Kühl, Sebastian Ley, Julia Ley-Zaporozhan, Ullrich G Müller-Lisse, Jens Vogel-Claussen, Dag Wormanns, ,

Rofo (RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin)
[2020, 192(1):82]

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