Full Text Journal Articles by
Author Claus G Roehrborn

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Kevin T McVary, Marc C Gittelman, Kenneth A Goldberg, Kalpesh Patel, Neal D Shore, Richard M Levin, Marc Pliskin, J Randolf Beahrs, David Prall, Jed Kaminetsky, Barrett E Cowan, Christopher H Cantrill, Lance A Mynderse, James C Ulchaker, Nicholas N Tadros, Steven N Gange, Claus G Roehrborn,

J Urol (The Journal of urology)
[2021, :101097JU000000000000177803]

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Final 5-Year Outcomes of the Multicenter Randomized Sham-Controlled Trial of a Water Vapor Thermal Therapy for Treatment of Moderate to Severe Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia.

Kevin T McVary, Marc C Gittelman, Kenneth A Goldberg, Kalpesh Patel, Neal D Shore, Richard M Levin, Marc Pliskin, J Randolf Beahrs, David Prall, Jed Kaminetsky, Barrett E Cowan, Christopher H Cantrill, Lance A Mynderse, James C Ulchaker, Nicholas N Tadros, Steven N Gange, Claus G Roehrborn,

<h4>Purpose</h4>We present final 5-year outcomes of the multicenter randomized sham-controlled trial of a water vapor therapy (Rezūm™) for treatment of moderate to severe lower urinary tract symptoms due to benign prostatic hyperplasia.<h4>Materials and methods</h4>A total of 197 subjects <u>></u>50 years of age with International Prostate Symptom Score ≥13, maximum flow ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001778]

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Gleason Grade Group Concordance between Preoperative Targeted Biopsy and Radical Prostatectomy Histopathologic Analysis: A Comparison Between In-Bore MRI-guided and MRI-Transrectal US Fusion Prostate Biopsies.

Daniel N Costa, Qi Cai, Yin Xi, Debora Z Recchimuzzi, Naveen Subramanian, Aditya Bagrodia, Neil M Rofsky, Claus G Roehrborn, Brad Hornberger, Rajal B Shah, Kenneth Goldberg, Alberto Diaz de Leon, Ivan Pedrosa,

<h4>Purpose</h4>To determine and compare rates of grade group (GG) discrepancies between different targeted biopsy techniques (in-bore vs fusion) after propensity score weighting using whole-mount radical prostatectomy (RP) histopathologic analysis as the reference standard.<h4>Materials and methods</h4>This retrospective study evaluated men who underwent targeted (fusion or in-bore) biopsy between April 2017 and ... Read more >>

Radiol Imaging Cancer (Radiology. Imaging cancer)
[2021, 3(2):e200123]

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Placebo Response in Patients with Oral Therapy for Overactive Bladder: A Systematic Review and Meta-analysis.

Hadi Mostafaei, Florian Janisch, Keiichiro Mori, Fahad Quhal, Benjamin Pradere, Sakineh Hajebrahimi, Claus G Roehrborn, Shahrokh F Shariat,

<h4>Context</h4>The role of a placebo response in the management of overactive bladder (OAB) remains unclear.<h4>Objective</h4>The aim of this review is to methodically study the placebo response extracted from the control arms of randomized clinical trials assessing therapy in patients with OAB.<h4>Evidence acquisition</h4>Medline (PubMed), The Cochrane Library, EMBASE, and Scopus were ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Dutasteride Improves Nocturia but Does Not Lead to Better Sleep: Results from the REDUCE Clinical Trial.

Paige K Kuhlmann, Sean C Fischer, Lauren E Howard, Daniel M Moreira, Gerald L Andriole, Martin L Hopp, Claus G Roehrborn, Donald L Bliwise, Stephen J Freedland,

<h4>Purpose</h4>In men, complaints of nocturia causing poor sleep are often attributed to benign prostatic hyperplasia and treated with benign prostatic hyperplasia medications. We assessed whether treating lower urinary tract symptoms with dutasteride altered either nocturia or sleep quality using data from REDUCE.<h4>Materials and methods</h4>REDUCE was a 4-year randomized, multicenter trial ... Read more >>

J Urol (The Journal of urology)
[2021, 205(6):1733-1739]

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Prostatic Urethral Lift Versus Medical Therapy: Examining the Impact on Sexual Function in Men with Benign Prostatic Hyperplasia.

Claus G Roehrborn, Daniel B Rukstalis,

<h4>Background</h4>Sexual dysfunction is a common side effect of medical therapy for benign prostatic hyperplasia (BPH), whereas prostatic urethral lift (PUL) offers safe and effective relief of lower urinary tract symptoms while preserving sexual function.<h4>Objective</h4>To compare the long-term impact on sexual health of PUL or daily medical therapy of doxazosin or ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Impact of early vs. delayed initiation of dutasteride/tamsulosin combination therapy on the risk of acute urinary retention or BPH-related surgery in LUTS/BPH patients with moderate-to-severe symptoms at risk of disease progression.

Salvatore D'Agate, Chandrashekhar Chavan, Michael Manyak, Juan Manuel Palacios-Moreno, Matthias Oelke, Martin C Michel, Claus G Roehrborn, Oscar Della Pasqua,

<h4>Purpose</h4>To evaluate the effect of delayed start of combination therapy (CT) with dutasteride 0.5 mg and tamsulosin 0.4 mg on the risk of acute urinary retention or benign prostatic hyperplasia (BPH)-related surgery (AUR/S) in patients with moderate-to-severe lower urinary tract symptoms (LUTS) at risk of disease progression.<h4>Methods</h4>Using a time-to-event model based on ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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Model-based meta-analysis of the time to first acute urinary retention or benign prostatic hyperplasia-related surgery in patients with moderate or severe symptoms.

Salvatore D'Agate, Chandrashekhar Chavan, Michael Manyak, Juan Manuel Palacios-Moreno, Matthias Oelke, Martin C Michel, Claus G Roehrborn, Oscar Della Pasqua,

<h4>Aims</h4>Combination therapy of 5α-reductase inhibitor and α-blocker is a guideline-endorsed therapeutic approach for patients with moderate-to-severe lower urinary tract symptoms or benign prostatic hyperplasia (LUTS/BPH) who are at risk of disease progression. We aimed to disentangle the contribution of clinical and demographic baseline characteristics affecting the risk of acute urinary ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2020, :]

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The role of novel minimally invasive treatments for lower urinary tract symptoms associated with benign prostatic hyperplasia.

Stephan Madersbacher, Claus G Roehrborn, Matthias Oelke,

<h4>Objectives</h4>To provide an update on novel minimally invasive lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) treatments in a non-systematic review. To define potential target populations for the various new minimally invasive treatments.<h4>Methods</h4>Recent literature, meta-analyses and guideline recommendations for aquablation (AquaBeam<sup>®</sup> ; PROCEPT BioRobotics, Redwood City, CA, USA), ... Read more >>

BJU Int (BJU international)
[2020, 126(3):317-326]

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Benign prostatic hyperplasia: an update on minimally invasive therapy including Aquablation.

Akhil K Das, Timothy M Han, Alex Uhr, Claus G Roehrborn,

<h4>Introduction</h4>Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) is a common condition affecting older men. New interventional treatments have emerged and evolved over the years, each with their own distinct efficacy and safety profiles. While some have fallen out of favor, new options continue to be explored.<h4>Materials ... Read more >>

Can J Urol (The Canadian journal of urology)
[2020, 27(S3):2-10]

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Reasons to overthrow TURP: bring on Aquablation.

Iman Sadri, Adel Arezki, Félix Couture, David-Dan Nguyen, Russell Schwartz, Ahmed S Zakaria, Dean Elterman, Enrique Rijo, Vincent Misrai, Thorsten Bach, Claus G Roehrborn, Kevin C Zorn,

<h4>Purpose</h4>In this review, we will discuss the state of the literature regarding Aquablation, its limitations, and opportunities for its application in the treatment of benign prostatic enlargement (BPE).<h4>Methods</h4>A comprehensive review of original research on Aquablation was conducted. Articles related to transurethral resection of the prostate, holmium laser enucleation of the ... Read more >>

World J Urol (World journal of urology)
[2020, :]

Cited: 1 time

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Urethral luminal epithelia are castration-insensitive cells of the proximal prostate.

Diya B Joseph, Gervaise H Henry, Alicia Malewska, Nida S Iqbal, Hannah M Ruetten, Anne E Turco, Lisa L Abler, Simran K Sandhu, Mark T Cadena, Venkat S Malladi, Jeffrey C Reese, Ryan J Mauck, Jeffrey C Gahan, Ryan C Hutchinson, Claus G Roehrborn, Linda A Baker, Chad M Vezina, Douglas W Strand,

<h4>Background</h4>Castration-insensitive epithelial progenitors capable of regenerating the prostate have been proposed to be concentrated in the proximal region based on facultative assays. Functional characterization of prostate epithelial populations isolated with individual cell surface markers has failed to provide a consensus on the anatomical and transcriptional identity of proximal prostate progenitors.<h4>Methods</h4>Here, ... Read more >>

Prostate (The Prostate)
[2020, 80(11):872-884]

Cited: 8 times

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Aquablation for benign prostatic hyperplasia in large prostates (80-150 cc): 2-year results.

Mihir Desai, Mo Bidair, Naeem Bhojani, Andrew Trainer, Andrew Arther, Eugene Kramolowsky, Leo Doumanian, Dean Elterman, Ronald P Kaufman, James Lingeman, Amy Krambeck, Gregg Eure, Gopal Badlani, Mark Plante, Edward Uchio, Greg Gin, Larry Goldenberg, Ryan Paterson, Alan So, Mitchell R Humphreys, Claus G Roehrborn, Steven Kaplan, Jay Motola, Kevin C Zorn,

<h4>Introduction</h4>To report 2-year safety and effectiveness of the Aquablation procedure for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) and large-volume 80-150 cc prostates.<h4>Materials and methods</h4>Between September-December 2017, 101 men with moderate-to-severe BPH symptoms and prostate volumes of 80-150 cc underwent an ultrasound-guided robotically executed Aquablation procedure in ... Read more >>

Can J Urol (The Canadian journal of urology)
[2020, 27(2):10147-10153]

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Clinical Efficacy of Silodosin in Patients with Severe Lower Urinary Tract Symptoms Related to Benign Prostatic Obstruction: A Pooled Analysis of Phase 3 and 4 Trials.

Massimiliano Creta, Jean-Nicolas Cornu, Claus G Roehrborn, Enrico Finazzi Agrò, Francesco Montorsi, Nicola Longo, Vittorio Imperatore, Marco De Sio, Davide Arcaniolo, Vincenzo Mirone, Ferdinando Fusco,

We performed a post hoc analysis of data from phase 3 and 4 studies to evaluate the efficacy of silodosin 8mg in patients with severe lower urinary tract symptoms (LUTS) related to benign prostatic obstruction (BPO). The presence of two or more of the following criteria was adopted to define ... Read more >>

Eur Urol Focus (European urology focus)
[2021, 7(2):440-443]

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Men's Sexual Health Questionnaire score changes vs spontaneous sexual adverse event reporting in men treated with dutasteride/tamsulosin combination therapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia: A post hoc analysis of a prospective, randomised, placebo-controlled study.

Claus G Roehrborn, Raymond C Rosen, Michael J Manyak, Juan Manuel Palacios-Moreno, Timothy H Wilson, Zrinka Lulic, François Giuliano,

AIM:To assess the impact of baseline characteristics on Men's Sexual Health Questionnaire (MSHQ) total scores and to evaluate the clinical relevance of MSHQ changes and their association with spontaneously reported sexual adverse events (SexAEs) in patients with benign prostatic hyperplasia. METHODS:This was a post hoc analysis of the Phase 4 ... Read more >>

Int J Clin Pract (International journal of clinical practice)
[2020, 74(5):e13480]

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Statin use and longitudinal changes in prostate volume; results from the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial.

Emma H Allott, Ilona Csizmadi, Lauren E Howard, Roberto L Muller, Daniel M Moreira, Gerald L Andriole, Claus G Roehrborn, Stephen J Freedland,

<h4>Objective</h4>To test the association between statin use and prostate volume (PV) change over time using data from the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial, a 4-year randomised controlled trial testing dutasteride for prostate cancer chemoprevention.<h4>Subjects/patients and methods</h4>We identified men with a baseline negative prostate biopsy from REDUCE ... Read more >>

BJU Int (BJU international)
[2020, 125(2):226-233]

Cited: 1 time

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Aquablation of the prostate: a review and update.

Claus G Roehrborn, Seth Teplitsky, Akhil K Das,

INTRODUCTION:Invasive procedures, such as transurethral resection of the prostate (TURP), have long been the gold standard therapy for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). In recent years, newer treatment modalities have arisen, such as Aquablation, with similar efficacy and improved adverse event ... Read more >>

Can J Urol (The Canadian journal of urology)
[2019, 26(4 Suppl 1):20-24]

Cited: 3 times

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Office-based therapies for benign prostatic hyperplasia: a review and update.

Akhil K Das, Joon Yau Leong, Claus G Roehrborn,

INTRODUCTION:Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) is one of the most common conditions affecting the aging man. Over the years, various treatment modalities with distinct efficacy and safety profiles have emerged in experimental and clinical use. However, only a handful have gained in popularity and ... Read more >>

Can J Urol (The Canadian journal of urology)
[2019, 26(4 Suppl 1):2-7]

Cited: 2 times

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Characteristics of men with untreated LUTS interested in over-the-counter tamsulosin.

Claus G Roehrborn, Franklin C Lowe, Marc Gittelman, Jan M Wruck, Anna E Verbeek,

<h4>Introduction</h4>Treatment for lower urinary tract symptoms (LUTS) is often delayed, as it is considered a natural progression of aging. We described baseline demographic and clinical characteristics of men currently not using prescription medications for benign prostatic hyperplasia (BPH) but interested in self-directed use of over-the-counter (OTC) tamsulosin and who had ... Read more >>

Can J Urol (The Canadian journal of urology)
[2019, 26(4):9821-9828]

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AUTHOR REPLY.

Kevin T McVary, Tyson Rogers, Claus G Roehrborn,

Urology (Urology)
[2019, 126:179]

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Management of Male Lower Urinary Tract Symptoms in a Simulated, Over-the-Counter Setting: An Exploratory Study of Tamsulosin.

Claus G Roehrborn, Franklin C Lowe, Marc Gittelman, Jan M Wruck, Anna E Verbeek,

<h4>Background</h4>Lower urinary tract symptoms (LUTS) attributed to benign prostatic hyperplasia (BPH) are common in men, considerably affecting quality of life.<h4>Aims</h4>The self-directed use of over-the-counter (OTC) tamsulosin (0.4 mg) and potential safety risks were evaluated in an open-label, uncontrolled, exploratory, 8-week OTC-simulated study.<h4>Methods</h4>Men (≥ 18 years) were recruited via mass advertising about bothersome LUTS. ... Read more >>

Drugs Aging (Drugs & aging)
[2019, 36(2):179-188]

Cited: 1 time

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Rezūm Water Vapor Thermal Therapy for Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: 4-Year Results From Randomized Controlled Study.

Kevin T McVary, Tyson Rogers, Claus G Roehrborn,

OBJECTIVE:To report 4-year outcomes of the randomized controlled trial of water vapor thermal therapy for treatment of moderate to severe lower urinary tract symptoms due to benign prostatic hyperplasia. MATERIALS AND METHODS:Total 188 subjects; 135 men ≥50years old, International Prostate Symptom Score ≥ 13, maximum flow rate (Qmax) ≤15 mL/s ... Read more >>

Urology (Urology)
[2019, 126:171-179]

Cited: 16 times

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Efficacy and safety of fexapotide triflutate in outpatient medical treatment of male lower urinary tract symptoms associated with benign prostatic hyperplasia.

Neal Shore, Ronald Tutrone, Claus G Roehrborn,

Male lower urinary tract symptoms (LUTS) is an increasingly important problem for the majority of late middle aged and elderly men. Fexapotide triflutate (FT) is a first in-class compound given by local injection via the transrectal intraprostatic route under ultrasound guidance. Data from >1700 FT and control injections in prospective ... Read more >>

Ther Adv Urol (Therapeutic advances in urology)
[2019, 11:1756287218820807]

Cited: 1 time

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Does proximity of positive prostate biopsy core to capsular margin help predict side-specific extracapsular extension at prostatectomy?

Nirmish Singla, Jordon T Walker, Solomon L Woldu, Karen De La Fuente, Ellen Araj, Brandon Swartz, Payal Kapur, Claus G Roehrborn,

<h4>Introduction</h4>To determine whether quantifying the proximity of positive prostate biopsy cores to the capsular edge may aid in identifying patients at risk for extracapsular extension (ECE) at the time of radical prostatectomy (RP).<h4>Materials and methods</h4>We reviewed a single-surgeon experience of 429 systematic transrectal prostate biopsies from 2010-2014. Marking ink was ... Read more >>

Can J Urol (The Canadian journal of urology)
[2019, 26(1):9634-9643]

Cited: 0 times

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Diagnostic Performance of Prospectively Assigned Likert Scale Scores to Determine Extraprostatic Extension and Seminal Vesicle Invasion With Multiparametric MRI of the Prostate.

Yuval Freifeld, Alberto Diaz de Leon, Yin Xi, Ivan Pedrosa, Claus G Roehrborn, Yair Lotan, Franto Francis, Daniel N Costa,

<h4>Objective</h4>The objective of this study was to determine the diagnostic performance of a prospectively assigned 5-point Likert scale for determination of extraprostatic extension (EPE) and seminal vesicle invasion (SVI).<h4>Materials and methods</h4>This study was a single-center, retrospective analysis of prospectively collected data including all men with abnormal 3-T multiparametric MRI and ... Read more >>

AJR Am J Roentgenol (AJR. American journal of roentgenology)
[2019, 212(3):576-581]

Cited: 2 times

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