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Heterologous Hyperimmune Polyclonal Antibodies Against SARS-CoV-2: A Broad Coverage, Affordable, and Scalable Potential Immunotherapy for COVID-19.

Alberto Alape-Girón, Andrés Moreira-Soto, Mauricio Arguedas, Hebleen Brenes, Willem Buján, Eugenia Corrales-Aguilar, Cecilia Díaz, Ann Echeverri, Marietta Flores-Díaz, Aarón Gómez, Andrés Hernández, María Herrera, Guillermo León, Román Macaya, José Arturo Molina-Mora, Javier Mora, Aarthi Narayanan, Alfredo Sanabria, Andrés Sánchez, Laura Sánchez, Álvaro Segura, Eduardo Segura, Daniela Solano, Claudio Soto, Jennifer L Stynoski, Mariángela Vargas, Mauren Villalta, Jan Felix Drexler, José María Gutiérrez,

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:743325]

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Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.

Claudio Hetz, Milene Russelakis-Carneiro, Kinsey Maundrell, Joaquin Castilla, Claudio Soto,

EMBO J (The EMBO journal)
[2021, 40(18):e109151]

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High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern.

Andres Moreira-Soto, Mauricio Arguedas, Hebleen Brenes, Willem Buján, Eugenia Corrales-Aguilar, Cecilia Díaz, Ann Echeverri, Marietta Flores-Díaz, Aarón Gómez, Andrés Hernández, María Herrera, Guillermo León, Román Macaya, Arne Kühne, José Arturo Molina-Mora, Javier Mora, Alfredo Sanabria, Andrés Sánchez, Laura Sánchez, Álvaro Segura, Eduardo Segura, Daniela Solano, Claudio Soto, Jennifer L Stynoski, Mariángela Vargas, Mauren Villalta, Chantal B E M Reusken, Christian Drosten, José María Gutiérrez, Alberto Alape-Girón, Jan Felix Drexler,

SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) that are being assessed in clinical trials in Costa Rica against five globally circulating variants of concern: alpha, beta, epsilon, gamma and delta, using plaque ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:735853]

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Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease

Natalia Salvadores, Inés Moreno-Gonzalez, Nazaret Gamez Ruiz, Gabriel Quiroz, Laura Vegas, Marcela Escandón, Sebastian Jimenez, Javier Vitorica, Antonia Gutierrez, Claudio Soto, Felipe Court,

Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports point amyloid-β (Aβ) as the main etiologic agent that triggers AD. Although there is extensive evidence of a detrimental crosstalk between Aβ and microglia that contributes to neuroinflammation in AD, the exact mechanism leading to ... Read more >>

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Prion Dissemination through the Environment and Medical Practices: Facts and Risks for Human Health.

Sandra Pritzkow, Damian Gorski, Frank Ramirez, Claudio Soto,

Prion diseases are a group of fatal, infectious neurodegenerative disorders affecting various species of mammals, including humans. The infectious agent in these diseases, termed prion, is composed exclusively of a misfolded protein that can spread and multiply in the absence of genetic materials. In this article, we provide an overview ... Read more >>

Clin Microbiol Rev (Clinical microbiology reviews)
[2021, :e0005919]

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Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein.

Jifeng Bian, Sehun Kim, Sarah J Kane, Jenna Crowell, Julianna L Sun, Jeffrey Christiansen, Eri Saijo, Julie A Moreno, James DiLisio, Emily Burnett, Sandra Pritzkow, Damian Gorski, Claudio Soto, Terry J Kreeger, Aru Balachandran, Gordon Mitchell, Michael W Miller, Romolo Nonno, Turid Vikøren, Jørn Våge, Knut Madslien, Linh Tran, Tram Thu Vuong, Sylvie L Benestad, Glenn C Telling,

Prions are infectious proteins causing fatal, transmissible neurodegenerative diseases of animals and humans. Replication involves template-directed refolding of host encoded prion protein, PrPC, by its infectious conformation, PrPSc. Following its discovery in captive Colorado deer in 1967, uncontrollable contagious transmission of chronic wasting disease (CWD) led to an expanded geographic ... Read more >>

PLoS Pathog (PLoS pathogens)
[2021, 17(7):e1009748]

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Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer's Disease.

Enrique Armijo, George Edwards, Andrea Flores, Jorge Vera, Mohammad Shahnawaz, Fabio Moda, Cesar Gonzalez, Magdalena Sanhueza, Claudio Soto,

Alzheimer's disease (AD) is the most common type of dementia in the elderly population. The disease is characterized by progressive memory loss, cerebral atrophy, extensive neuronal loss, synaptic alterations, brain inflammation, extracellular accumulation of amyloid-β (Aβ) plaques, and intracellular accumulation of hyper-phosphorylated tau (p-tau) protein. Many recent clinical trials have ... Read more >>

Cells (Cells)
[2021, 10(7):]

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North American and Norwegian Chronic Wasting Disease prions exhibit different potential for interspecies transmission and zoonotic risk.

Sandra Pritzkow, Damian Gorski, Frank Ramirez, Glenn C Telling, Sylvie L Benestad, Claudio Soto,

Chronic wasting disease (CWD) is a rapidly spreading prion disorder affecting various species of wild and captive cervids. The risk that CWD poses to co-habiting animals or more importantly to humans is largely unknown. In this study we investigated differences in the capacity of CWD isolates obtained from six different ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2021, :]

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Seed Amplification Assay to Diagnose Early Parkinson's and Predict Dopaminergic Deficit Progression.

Luis Concha-Marambio, Carly M Farris, Bret Holguin, Yihua Ma, John Seibyl, Marco J Russo, Un J Kang, Samantha J Hutten, Kalpana Merchant, Mohammad Shahnawaz, Claudio Soto,

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2021, :]

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Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming.

Qingfen Qiang, Jeanne M Manalo, Hong Sun, Yujin Zhang, Anren Song, Alexander Q Wen, Y Edward Wen, Changhan Chen, Hong Liu, Ying Cui, Travis Nemkov, Julie A Reisz, George Edwards Iii, Fred A Perreira, Rodney E Kellems, Claudio Soto, Angelo D'Alessandro, Yang Xia,

Hypoxia drives aging and promotes age-related cognition and hearing functional decline. Despite the role of erythrocytes in oxygen (O2) transport, their role in the onset of aging and age-related cognitive decline and hearing loss (HL) remains undetermined. Recent studies revealed that signaling through the erythrocyte adenosine A2B receptor (ADORA2B) promotes ... Read more >>

PLoS Biol (PLoS biology)
[2021, 19(6):e3001239]

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High efficacy of therapeutic equine hyperimmune antibodies against SARS-CoV-2 variants of concern

Andres Moreira-Soto, Mauricio Arguedas, Hebleen Brenes, Willem Buján, Eugenia Corrales-Aguilar, Cecilia Díaz, Ann Echeverri, Marietta Flores-Díaz, Aarón Gómez, Andrés Hernández, María Herrera, Guillermo León, Román Macaya, Arne Kühne, José Arturo Molina-Mora, Javier Mora, Alfredo Sanabria, Andrés Sánchez, Laura Sánchez, Álvaro Segura, Eduardo Segura, Daniela Solano, Claudio Soto, Jennifer Stynoski, Mariángela Vargas, Mauren Villalta, Chantal Reusken, Christian Drosten, José María Gutiérrez, Alberto Alape-Girón, Jan Felix Drexler,

SARS-CoV-2 variants of concern (VoC) show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies. We tested therapeutic equine polyclonal antibodies (pAbs) against four VoC (alpha, beta, epsilon and gamma). We show that equine pAbs efficiently neutralize VoC, suggesting they are an effective, broad coverage, low-cost and a scalable COVID-19 treatment. ... Read more >>

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Transmission of cerebral amyloid pathology by peripheral administration of misfolded Aβ aggregates.

Rodrigo Morales, Javiera Bravo-Alegria, Ines Moreno-Gonzalez, Claudia Duran-Aniotz, Nazaret Gamez, George Edwards Iii, Claudio Soto,

Previous reports showed that brain Aβ amyloidosis can be induced in animal models by exogenous administration of pre-formed aggregates. To date, only intra-peritoneal and intra-venous administrations are described as effective means to peripherally accelerate brain Aβ amyloidosis by seeding. Here, we show that cerebral accumulation of Aβ can be accelerated ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2021, :]

Cited: 1 time

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Multi-scale modeling for systematically understanding the key roles of microglia in AD development.

Zhiwei Ji, Changan Liu, Weiling Zhao, Claudio Soto, Xiaobo Zhou,

Alzheimer's disease (AD) is the leading cause of age-related dementia, affecting over 5 million people in the United States. Unfortunately, current therapies are largely palliative and several potential drug candidates have failed in late-stage clinical trials. Studies suggest that microglia-mediated neuroinflammation might be responsible for the failures of various therapies. ... Read more >>

Comput Biol Med (Computers in biology and medicine)
[2021, 133:104374]

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Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure.

Wolfgang Singer, Ann M Schmeichel, Mohammad Shahnawaz, James D Schmelzer, David M Sletten, Tonette L Gehrking, Jade A Gehrking, Anita D Olson, Mariana D Suarez, Pinaki P Misra, Claudio Soto, Phillip A Low,

<h4>Objective</h4>To explore the role of alpha-synuclein (αSyn) oligomers and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) of patients with pure autonomic failure (PAF) as markers of future phenoconversion to multiple system atrophy (MSA).<h4>Methods</h4>Well-characterized patients with PAF (n = 32) were enrolled between June 2016 and February 2019 at Mayo Clinic Rochester ... Read more >>

Ann Neurol (Annals of neurology)
[2021, 89(6):1212-1220]

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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.

David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P Matheos, Xinyi Ma, Celia Da Cunha, Ken C Walls, Rahasson R Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J Tenner, Grant R MacGregor, Marcelo Wood, Kim N Green, Frank M LaFerla,

The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2421]

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Amyloid pathology arrangements in Alzheimer's disease brains modulate in vivo seeding capability.

Claudia Duran-Aniotz, Ines Moreno-Gonzalez, Nazaret Gamez, Nelson Perez-Urrutia, Laura Vegas-Gomez, Claudio Soto, Rodrigo Morales,

Amyloid-β (Aβ) misfolding is one of the hallmark pathological features of Alzheimer's disease (AD). AD can manifest with diverse symptomatology including variable rates of cognitive decline, duration of clinical disease, and other detrimental changes. Several reports suggest that conformational diversity in misfolded Aβ is a leading factor for clinical variability ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2021, 9(1):56]

Cited: 1 time

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High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern

Andres Moreira-Soto, Mauricio Arguedas, Hebleen Brenes, Willem Buján, Eugenia Corrales-Aguilar, Cecilia Díaz, Ann Echeverri, Marietta Flores-Díaz, Aarón Gómez, Andrés Hernández, María Herrera, Guillermo León, Román Macaya, Arne Kühne, José Arturo Molina-Mora, Javier Mora, Alfredo Sanabria, Andrés Sánchez, Laura Sánchez, Álvaro Segura, Eduardo Segura, Daniela Solano, Claudio Soto, Jennifer L. Stynoski, Mariángela Vargas, Mauren Villalta, Chantal B. E. M. Reusken, Christian Drosten, José María Gutiérrez, Alberto Alape-Girón, Jan Felix Drexler,

SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) that are being assessed in clinical trials in Costa Rica against five globally circulating variants of concern: alpha, beta, epsilon, gamma and delta, using plaque ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:]

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Comparison of a Novel Sonic Toothbrush to Manual Brushing on Plaque Control and Gingival Inflammation: A Multicenter, Randomized, Controlled Clinical Trial.

Myron Nevins, Chia-Yu Chen, Eric Kerr, Gerardo Mendoza-Azpur, Gaetano Isola, Claudio P Soto, Claudio Stacchi, Teresa Lombardi, David Kim, Isabella Rocchietta,

The goal of this multicenter randomized controlled study was to evaluate the effectiveness of a newly developed ionic-sonic electric toothbrush in terms of plaque removal and reduction of gingival inflammation. A total of 78 subjects from three dental centers were invited to join the study. They were randomized to receive ... Read more >>

Int J Periodontics Restorative Dent (The International journal of periodontics & restorative dentistry)
[2021, 41(1):99-104]

Cited: 1 time

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Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer's disease.

Rodrigo Morales, Claudia Duran-Aniotz, Javiera Bravo-Alegria, Lisbell D Estrada, Mohammad Shahnawaz, Ping-Ping Hu, Carlos Kramm, Diego Morales-Scheihing, Akihiko Urayama, Claudio Soto,

Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer's disease (AD) through prion-like mechanisms. In this study, we evaluated whether brain amyloidosis could be accelerated by blood infusions, procedures that have been shown to transmit prion ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):213]

Cited: 1 time

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Mitochondrial transplant to replenish damaged mitochondria: A novel therapeutic strategy for neurodegenerative diseases?

Abhisek Mukherjee, Andrea D Becerra Calixto, Melissa Chavez, Jean Paul Delgado, Claudio Soto,

Neurodegenerative diseases are currently some of the most debilitating and incurable illness, including highly prevalent disorders, such as Alzheimer's and Parkinson's disease. Despite impressive advances in understanding the molecular basis of neurodegenerative diseases, several clinical trials have failed in identifying drugs that successfully delay or stop disease progression. New targets ... Read more >>

Prog Mol Biol Transl Sci (Progress in molecular biology and translational science)
[2021, 177:49-63]

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Platelet activation after withdrawal of life support in donation after circulatory death donors.

Sarah E Scheuer, Claudio Soto, Joanne Joseph, Paul C Jansz, Peter S Macdonald,

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2020, 39(12):1494-1496]

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Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies.

Wolfgang Singer, Ann M Schmeichel, Mohammad Shahnawaz, James D Schmelzer, Bradley F Boeve, David M Sletten, Tonette L Gehrking, Jade A Gehrking, Anita D Olson, Rodolfo Savica, Mariana D Suarez, Claudio Soto, Phillip A Low,

<h4>Objective</h4>To explore the role of alpha-synuclein (αSyn) oligomers and neurofilament light chain (NFL) in cerebrospinal fluid (CSF) as markers of early multiple system atrophy (MSA) and to contrast findings with Lewy body synucleinopathies.<h4>Methods</h4>In a discovery cohort of well-characterized early MSA patients (n = 24) and matched healthy controls (CON, n ... Read more >>

Ann Neurol (Annals of neurology)
[2020, 88(3):503-512]

Cited: 10 times

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Correction: The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease.

Maritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz, Felipe A Court,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Cell Death Differ (Cell death and differentiation)
[2020, 27(7):2294]

Cited: 1 time

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Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis?

Kenia Mendes Rodrigues Castro, Rodrigo Leal de Paiva Carvalho, Geraldo Marco Rosa Junior, Beatriz Antoniassi Tavares, Luis Henrique Simionato, Carlos Henrique Fachin Bortoluci, Claudio Alberto Tellez Soto, Cleber Ferraresi,

Photobiomodulation therapy (PBMT) has many effects on the energy metabolism of musculoskeletal tissue, such as increased glycogen and adenosine triphosphate synthesis. In addition, these effects may be due to a systemic blood glucose control. Twenty-four Wistar rats were randomly and equally allocated into four groups: sham, PBMT 10 J/cm<sup>2</sup>, PBMT 30 J/cm<sup>2</sup> ... Read more >>

J Photochem Photobiol B (Journal of photochemistry and photobiology. B, Biology)
[2020, 207:111877]

Cited: 1 time

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Preclinical Detection of Prions in Blood of Nonhuman Primates Infected with Variant Creutzfeldt-Jakob Disease.

Luis Concha-Marambio, Marcelo A Chacon, Claudio Soto,

Variant Creutzfeldt-Jakob disease (vCJD) is caused by prion infection with bovine spongiform encephalopathy and can be transmitted by blood transfusion. Protein misfolding cyclic amplification (PMCA) can detect prions in blood from vCJD patients with 100% sensitivity and specificity. To determine whether PMCA enables prion detection in blood during the preclinical ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2020, 26(1):34-43]

Cited: 5 times

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