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Wound Closure After Port Implantation-a Randomized Controlled Trial Comparing Tissue Adhesive and Intracutaneous Suturing.

Saskia Witting, Maja Ingwersen, Thomas Lehmann, René Aschenbach, Niklas Eckardt, Jürgen Zanow, René Fahrner, Stephan Lotze, Reinhard Friedel, Mark Lenz, Claudia Schmidt, Diana Miguel, Laine Ludriksone, Ulf Teichgräber,

<h4>Background</h4>Wound healing after pectoral port implantation is a major factor determining the success or failure of the procedure. Infection and wound dehiscence can endanger the functionality of the port system and impede chemotherapy. The cosmetic result is important for patient satisfaction as well.<h4>Methods</h4>From August 2015 to July 2017, adult patients ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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Intensity of mycophenolate mofetil treatment is associated with an impaired immune response to SARS-CoV-2 vaccination in kidney transplant recipients.

Marta Kantauskaite, Lisa Müller, Thilo Kolb, Svenja Fischer, Jonas Hillebrandt, Katrin Ivens, Marcel Andree, Tom Luedde, Hans Martin Orth, Ortwin Adams, Heiner Schaal, Claudia Schmidt, Eva Königshausen, Lars C Rump, Jörg Timm, Johannes Stegbauer,

Kidney transplant recipients (KTRs) are extremely vulnerable to SARS-CoV-2 infection and show an impaired immune response to SARS-CoV-2 vaccination. We analyzed factors related to vaccination efficiency in KTRs. In a multicenter prospective observational study (NCT04743947), IgG antibodies levels against SARS-CoV-2 spike S1 subunit and their neutralization capacity after SARS-CoV-2 vaccination ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, :]

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MEOX2 homeobox gene promotes growth of malignant gliomas

Anna Schönrock, Elisa Heinzelmann, Bianca Steffl, Ashwin Narayanan, Damir Krunic, Marion Bähr, Jong-Whi Park, Claudia Schmidt, Koray Özduman, Necmettin Pamir, Wolfgang Wick, Felix Bestvater, Dieter Weichenhan, Christoph Plass, Julian Taranda, Moritz Mall, Şevin Turcan,

Glioblastoma (GBM) is an aggressive tumor that frequently exhibits gain of chromosome 7, loss of chromosome 10 and aberrantly activated receptor tyrosine kinase signaling pathways. Here, we identify mesenchyme homeobox 2 (MEOX2) on chromosome 7 with increased expression in GBM as a salient oncogenic transcription factor. Specifically, we show that ... Read more >>

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Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity.

Anja Busemann, Ingrid Flaspohler, Xue-Quan Zhou, Claudia Schmidt, Sina K Goetzfried, Vincent H S van Rixel, Ingo Ott, Maxime A Siegler, Sylvestre Bonnet,

The known ruthenium complex [Ru(tpy)(bpy)(Hmte)](PF<sub>6</sub>)<sub>2</sub> ([1](PF<sub>6</sub>)<sub>2</sub>, where tpy = 2,2':6',2″-terpyridine, bpy = 2,2'-bipyridine, Hmte = 2-(methylthio)ethanol) is photosubstitutionally active but non-toxic to cancer cells even upon light irradiation. In this work, the two analogs complexes [Ru(tpy)(NN)(Hmte)](PF<sub>6</sub>)<sub>2</sub>, where NN = 3,3'-biisoquinoline (i-biq, [2](PF<sub>6</sub>)<sub>2</sub>) and di(isoquinolin-3-yl)amine (i-Hdiqa, [3](PF<sub>6</sub>)<sub>2</sub>), were synthesized and their photochemistry and phototoxicity evaluated to assess their suitability ... Read more >>

J Biol Inorg Chem (Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry)
[2021, 26(6):667-674]

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Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs?

Claudia Schmidt, Tomer Babu, Hana Kostrhunova, Annika Timm, Uttara Basu, Ingo Ott, Valentina Gandin, Viktor Brabec, Dan Gibson,

"Multi-action" Pt(IV) derivatives of cisplatin with combretastatin A4 (CA4) bioactive ligands that are conjugated to Pt(IV) by carbonate are unique because the ligand (IC<sub>50</sub> < 10 nM) is dramatically 1000-folds more cytotoxic than cisplatin <i>in vitro</i>. The Pt(IV)-CA4 prodrugs were as cytotoxic as CA4 itself, indicating that the platinum moiety ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2021, 64(15):11364-11378]

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Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma.

Shruti G Dighe, Jianhong Chen, Li Yan, Qianchuan He, Puya Gharahkhani, Lynn Onstad, David M Levine, Claire Palles, Weimin Ye, Marilie D Gammon, Prasad G Iyer, Lesley A Anderson, Geoffrey Liu, Anna H Wu, James Y Dai, Wong-Ho Chow, Harvey A Risch, Jesper Lagergren, Nicholas J Shaheen, Leslie Bernstein, Douglas A Corley, Hans Prenen, John deCaestecker, David MacDonald, Paul Moayyedi, Hugh Barr, Sharon B Love, Laura Chegwidden, Stephen Attwood, Peter Watson, Rebecca Harrison, Katja Ott, Susanne Moebus, Marino Venerito, Hauke Lang, Rupert Mayershofer, Michael Knapp, Lothar Veits, Christian Gerges, Josef Weismüller, Ines Gockel, Yogesh Vashist, Markus M Nöthen, Jakob R Izbicki, Hendrik Manner, Horst Neuhaus, Thomas Rösch, Anne C Böhmer, Arnulf H Hölscher, Mario Anders, Oliver Pech, Brigitte Schumacher, Claudia Schmidt, Thomas Schmidt, Tania Noder, Dietmar Lorenz, Michael Vieth, Andrea May, Timo Hess, Nicole Kreuser, Jessica Becker, Christian Ell, Christine B Ambrosone, Kirsten B Moysich, Stuart MacGregor, Ian Tomlinson, David C Whiteman, Janusz Jankowski, Johannes Schumacher, Thomas L Vaughan, Margaret M Madeleine, Laura J Hardie, Matthew F Buas,

Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. Central obesity, a key BE/EAC risk ... Read more >>

Carcinogenesis (Carcinogenesis)
[2021, 42(3):369-377]

Cited: 1 time

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Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo.

Ben Woods, Rúben D M Silva, Claudia Schmidt, Darren Wragg, Marco Cavaco, Vera Neves, Vera F C Ferreira, Lurdes Gano, Tânia S Morais, Filipa Mendes, João D G Correia, Angela Casini,

The biomedical application of discrete supramolecular metal-based structures, specifically self-assembled metallacages, is still an emergent field of study. Capitalizing on the knowledge gained in recent years on the development of 3-dimensional (3D) metallacages as novel drug delivery systems and <i>theranostic</i> agents, we explore here the possibility to target [Pd<sub>2</sub>L<sub>4</sub>]<sup>4+</sup> cages ... Read more >>

Bioconjug Chem (Bioconjugate chemistry)
[2021, 32(7):1399-1408]

Cited: 1 time

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Control of response interference: caudate nucleus contributes to selective inhibition.

Claudia C Schmidt, David C Timpert, Isabel Arend, Simone Vossel, Gereon R Fink, Avishai Henik, Peter H Weiss,

While the role of cortical regions in cognitive control processes is well accepted, the contribution of subcortical structures (e.g., the striatum), especially to the control of response interference, remains controversial. Therefore, the present study aimed to investigate the cortical and particularly subcortical neural mechanisms of response interference control (including selective ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20977]

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[Child abuse-reduction in the estimated number of unreported cases by restructuring a clinical child protection program].

Claudia Maria Schmidt, Saskia Klein, Philippe Stock, Konrad Reinshagen, Ingo Königs,

<h4>Background</h4>Identification of child abuse is a daily challenge in medical work. The estimated number of unreported cases of child abuse and neglect is high.<h4>Objectives</h4>The aim of this study was to investigate the effectiveness of the redesigned clinical child protection program of a major German pediatric hospital and to improve programs in other ... Read more >>

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz)
[2020, 63(10):1241-1249]

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Off and On Again: De- and Reubiquitination during Membrane Protein Degradation.

Claudia C Schmidt, Alexander Stein,

In this issue of Molecular Cell, Hu et al. (2020) show that the cytosolic E3 ligase RNF126 reubiquitinates membrane proteins after their extraction from the membrane of the endoplasmic reticulum to target them for proteasomal degradation. ... Read more >>

Mol Cell (Molecular cell)
[2020, 79(2):203-204]

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A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT-116 Colorectal Carcinoma Cells.

Jing-Jing Zhang, Mohamed A Abu El Maaty, Henrik Hoffmeister, Claudia Schmidt, Julienne K Muenzner, Rainer Schobert, Stefan Wölfl, Ingo Ott,

A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3-(1,3-dimethylxanthine-7-yl)prop-1-yn-1-yl)gold(I) 1 displayed mutiple biological activites including selective proliferation inhibitory, anti-metastatic, and anti-angiogenic effects. The complex also induced effects related to aneuploidy in HCT-116 colon carcinoma cells, which might be mainly ascribed to the dysfunction of mitochondrial bioenergetics and downregulation of glycolysis. Induction of ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2020, 59(38):16795-16800]

Cited: 2 times

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Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation.

Claudia C Schmidt, Vedran Vasic, Alexander Stein,

In endoplasmic reticulum-associated protein degradation (ERAD), membrane proteins are ubiquitinated, extracted from the membrane, and degraded by the proteasome. The cytosolic ATPase Cdc48 drives extraction by pulling on polyubiquitinated substrates. How hydrophobic transmembrane (TM) segments are moved from the phospholipid bilayer into cytosol, often together with hydrophilic and folded ER ... Read more >>

Elife (eLife)
[2020, 9:]

Cited: 5 times

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Multiaction Pt(IV) Carbamate Complexes Can Codeliver Pt(II) Drugs and Amine Containing Bioactive Molecules.

Tomer Babu, Amrita Sarkar, Subhendu Karmakar, Claudia Schmidt, Dan Gibson,

Multiaction Pt(IV) prodrugs can overcome resistance associated with the FDA approved Pt(II) drugs like cisplatin. Intracellular reduction of the octahedral Pt(IV) derivatives of cisplatin releases cisplatin and the two axial ligands. When the released axial ligands act synergistically with cisplatin to kill the cancer cells, we have multiaction prodrugs. Most ... Read more >>

Inorg Chem (Inorganic chemistry)
[2020, 59(7):5182-5193]

Cited: 3 times

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Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins.

Vedran Vasic, Niels Denkert, Claudia C Schmidt, Dietmar Riedel, Alexander Stein, Michael Meinecke,

During endoplasmic-reticulum-associated protein degradation (ERAD), misfolded proteins are polyubiquitinated, extracted from the ER membrane and degraded by the proteasome<sup>1-4</sup>. In a process called retrotranslocation, misfolded luminal proteins first need to traverse the ER membrane before ubiquitination can occur in the cytosol. It was suggested that the membrane-embedded ubiquitin ligase Hrd1 ... Read more >>

Nat Cell Biol (Nature cell biology)
[2020, 22(3):274-281]

Cited: 9 times

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The Ubiquitin-Specific Protease Usp7, a Novel Merkel Cell Polyomavirus Large T-Antigen Interaction Partner, Modulates Viral DNA Replication.

Manja Czech-Sioli, Svenja Siebels, Sonja Radau, René P Zahedi, Claudia Schmidt, Thomas Dobner, Adam Grundhoff, Nicole Fischer,

Merkel cell polyomavirus (MCPyV) is the major cause for Merkel cell carcinoma (MCC), a rare but highly aggressive skin cancer predominantly found in elderly and immunosuppressed patients. The early viral gene products large T-antigen (LT) and small T-antigen (sT) are important for efficient viral DNA replication, and both contribute to ... Read more >>

J Virol (Journal of virology)
[2020, 94(5):]

Cited: 5 times

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A gold(i) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs.

Claudia Schmidt, Lucia Albrecht, Shantheya Balasupramaniam, Rainer Misgeld, Bianka Karge, Mark Brönstrup, Aram Prokop, Knut Baumann, Stephan Reichl, Ingo Ott,

Gold complexes with N-heterocyclic carbene (NHC) ligands have been attracting major attention in medicinal inorganic chemistry based on their favorable antiproliferative effects and the structural versatility of the coordinated NHC ligands. Here we present a novel complex of the type (NHC)2Au+, which represents a substantially improved and selective TrxR inhibitor ... Read more >>

Metallomics (Metallomics : integrated biometal science)
[2019, 11(3):533-545]

Cited: 7 times

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Straightforward Immobilization of Phosphonic Acids and Phosphoric Acid Esters on Mesoporous Silica and Their Application in an Asymmetric Aldol Reaction.

Christian Weinberger, Tatjana Heckel, Patrick Schnippering, Markus Schmitz, Anpeng Guo, Waldemar Keil, Heinrich C Marsmann, Claudia Schmidt, Michael Tiemann, René Wilhelm,

The combined benefits of moisture-stable phosphonic acids and mesoporous silica materials (SBA-15 and MCM-41) as large-surface-area solid supports offer new opportunities for several applications, such as catalysis or drug delivery. We present a comprehensive study of a straightforward synthesis method via direct immobilization of several phosphonic acids and phosphoric acid ... Read more >>

Nanomaterials (Basel) (Nanomaterials (Basel, Switzerland))
[2019, 9(2):]

Cited: 1 time

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No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study.

Jing Dong, Puya Gharahkhani, Wong-Ho Chow, Marilie D Gammon, Geoffrey Liu, Carlos Caldas, Anna H Wu, Weimin Ye, Lynn Onstad, Lesley A Anderson, Leslie Bernstein, Paul D Pharoah, Harvey A Risch, Douglas A Corley, Rebecca C Fitzgerald, , Prasad G Iyer, Brian J Reid, Jesper Lagergren, Nicholas J Shaheen, Thomas L Vaughan, Stuart MacGregor, Sharon Love, Claire Palles, Ian Tomlinson, Ines Gockel, Andrea May, Christian Gerges, Mario Anders, Anne C Böhmer, Jessica Becker, Nicole Kreuser, Rene Thieme, Tania Noder, Marino Venerito, Lothar Veits, Thomas Schmidt, Claudia Schmidt, Jakob R Izbicki, Arnulf H Hölscher, Hauke Lang, Dietmar Lorenz, Brigitte Schumacher, Rupert Mayershofer, Yogesh Vashist, Katja Ott, Michael Vieth, Josef Weismüller, Markus M Nöthen, Susanne Moebus, Michael Knapp, Wilbert H M Peters, Horst Neuhaus, Thomas Rösch, Christian Ell, Janusz Jankowski, Johannes Schumacher, Rachel E Neale, David C Whiteman, Aaron P Thrift,

<h4>Background & aims</h4>Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE).<h4>Methods</h4>We conducted a ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2019, 17(11):2227-2235.e1]

Cited: 5 times

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Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies.

Morwen R M Williams, Benoît Bertrand, David L Hughes, Zoë A E Waller, Claudia Schmidt, Ingo Ott, Maria O'Connell, Mark Searcey, Manfred Bochmann,

A series of cationic mixed cyclometallated (C^N)Au(iii) dithiocarbamate complexes has been synthesized in good yields [HC^N = 2-(p-t-butylphenyl)pyridine]. The crystal structure of [(C^N)AuS2CNEt2]PF6 (3) has been determined. The cytotoxic properties of the new complexes have been evaluated in vitro against a panel of human cancer cell lines and healthy cells ... Read more >>

Metallomics (Metallomics : integrated biometal science)
[2018, 10(11):1655-1666]

Cited: 6 times

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Preserved but Less Efficient Control of Response Interference After Unilateral Lesions of the Striatum.

Claudia C Schmidt, David C Timpert, Isabel Arend, Simone Vossel, Anna Dovern, Jochen Saliger, Hans Karbe, Gereon R Fink, Avishai Henik, Peter H Weiss,

Previous research on the neural basis of cognitive control processes has mainly focused on cortical areas, while the role of subcortical structures in cognitive control is less clear. Models of basal ganglia function as well as clinical studies in neurodegenerative diseases suggest that the striatum (putamen and caudate nucleus) modulates ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2018, 12:414]

Cited: 1 time

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The Twofold Role of 12-Hydroxyoctadecanoic Acid (12-HOA) in a Ternary Water-Surfactant-12-HOA System: Gelator and Co-Surfactant.

Katja Steck, Claudia Schmidt, Cosima Stubenrauch,

Gelled lyotropic liquid crystals can be formed by adding a gelator to a mixture of surfactant and solvent. If the gel network and the liquid-crystalline phase coexist without influencing each other, the self-assembly is called orthogonal. In this study, the influence of the organogelator 12-hydroxyoctadecanoic acid (12-HOA) on the lamellar ... Read more >>

Gels (Gels (Basel, Switzerland))
[2018, 4(3):]

Cited: 2 times

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Multilamellar Vesicle Formation Probed by Rheo-NMR and Rheo-SALS under Large Amplitude Oscillatory Shear.

Stefan Kuczera, Luigi Gentile, Timothy I Brox, Ulf Olsson, Claudia Schmidt, Petrik Galvosas,

The formation of multilamellar vesicles (MLVs) in the lyotropic lamellar phase of the system triethylene glycol mono n-decyl ether (C<sub>10</sub>E<sub>3</sub>)/water is investigated under large amplitude oscillatory shear (LAOS) using spatially resolved rheo-NMR spectroscopy and a combination of rheo-small angle light scattering (rheo-SALS) and conventional rheology. Recent advances in rheo-NMR hardware ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2018, 34(28):8314-8325]

Cited: 0 times

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Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors.

Jan Hormann, Jaroslav Malina, Oliver Lemke, Max J Hülsey, Stefanie Wedepohl, Jan Potthoff, Claudia Schmidt, Ingo Ott, Bettina G Keller, Viktor Brabec, Nora Kulak,

Many drugs that are applied in anticancer therapy such as the anthracycline doxorubicin contain DNA-intercalating 9,10-anthraquinone (AQ) moieties. When Cu(II) cyclen complexes were functionalized with up to three (2-anthraquinonyl)methyl substituents, they efficiently inhibited DNA and RNA synthesis resulting in high cytotoxicity (selective for cancer cells) accompanied by DNA condensation/aggregation phenomena. ... Read more >>

Inorg Chem (Inorganic chemistry)
[2018, 57(9):5004-5012]

Cited: 1 time

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[Undetected Cases of Non-Accidental Burns in Children - Preventive Strategies].

Michaela Klinke, Claudia Maria Schmidt, Laura Tegtmeyer, Konrad Reinshagen, Michael Boettcher, Ingo Koenigs,

BACKGROUND:Thermal injuries are a frequent cause of accidents within the pediatric population that may result in long periods of hospitalization as well as severe physical and mental impairment and lifelong consequences. Especially in infants, burns caused by scalding are the most common cause of injury. Beside accidental injuries, intential burns ... Read more >>

Klin Padiatr (Klinische Padiatrie)
[2018, 230(2):61-67]

Cited: 1 time

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Synthesis, structure and cytotoxicity of cyclic (alkyl)(amino) carbene and acyclic carbene complexes of group 11 metals.

Benoît Bertrand, Alexander S Romanov, Mark Brooks, Josh Davis, Claudia Schmidt, Ingo Ott, Maria O'Connell, Manfred Bochmann,

A series of complexes of cyclic (alkyl)(amino)carbene (CAAC) complexes of copper, silver and gold have been investigated for their antiproliferative properties. A second series of acyclic carbene (ACC) complexes of gold(i) were prepared by nucleophilic attack on isocyanide complexes by amines and amino esters, to give (ACC)AuCl, [(ACC)Au(PTA)]+ (PTA = ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2017, 46(45):15875-15887]

Cited: 3 times

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