Full Text Journal Articles by
Author Claudia Jessen Trefzer

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Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis.

Paul Ebensperger, Claudia Jessen-Trefzer,

Artificial metalloenzymes combine the inherent reactivity of transition metal catalysis with the sophisticated reaction control of natural enzymes. By providing new opportunities in bioorthogonal chemistry and biocatalysis, artificial metalloenzymes have the potential to overcome certain limitations in both drug discovery and green chemistry or related research fields. Ongoing advances in ... Read more >>

Biol Chem (Biological chemistry)
[2021, :]

Cited: 0 times

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Pyridinium Modified Anthracenes and Their Endoperoxides Provide a Tunable Scaffold with Activity against Gram-Positive and Gram-Negative Bacteria.

Xuan Wang, Tamara Bittner, Martin Milanov, Laurine Kaul, Stephan Mundinger, Hans-Georg Koch, Claudia Jessen-Trefzer, Henning J Jessen,

Due to the emergence of multidrug resistant bacteria, the development of new antibiotics is required. We introduce here asymmetrically modified positively charged bis(methylpyridinium) anthracenes as a novel tunable scaffold, in which the two positive charges can be placed at a defined distance and angle. Our structure-activity relationship reveals that coupling ... Read more >>

ACS Infect Dis (ACS infectious diseases)
[2021, 7(8):2073-2080]

Cited: 0 times

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The Two-Component Locus MSMEG_0244/0246 Together With MSMEG_0243 Affects Biofilm Assembly in M. smegmatis Correlating With Changes in Phosphatidylinositol Mannosides Acylation.

Miaomaio Li, Henrich Gašparovič, Xing Weng, Si Chen, Jana Korduláková, Claudia Jessen-Trefzer,

Ferric and ferrous iron is an essential transition metal for growth of many bacterial species including mycobacteria. The genomic region <i>msmeg_0234</i> to <i>msmeg_0252</i> from <i>Mycobacterium smegmatis</i> is putatively involved in iron/heme metabolism. We investigate the genes encoding the presumed two component system MSMEG_0244/MSMEG_0246, the neighboring gene <i>msmeg_0243</i> and their involvement ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:570606]

Cited: 1 time

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Understanding the mechanism of action of pyrrolo[3,2-b]quinoxaline-derivatives as kinase inhibitors.

Andrea Unzue, Claudia Jessen-Trefzer, Dimitrios Spiliotopoulos, Eugenio Gaudio, Chiara Tarantelli, Jing Dong, Hongtao Zhao, Johanna Pachmayr, Stefan Zahler, Elena Bernasconi, Giulio Sartori, Luciano Cascione, Francesco Bertoni, Paweł Śledź, Amedeo Caflisch, Cristina Nevado,

The X-ray structure of the catalytic domain of the EphA3 tyrosine kinase in complex with a previously reported type II inhibitor was used to design two novel quinoxaline derivatives, inspired by kinase inhibitors that have reached clinical development. These two new compounds were characterized by an array of cell-based assays ... Read more >>

RSC Med Chem (RSC medicinal chemistry)
[2020, 11(6):665-675]

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Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol.

Miaomiao Li, Christoph Müller, Klemens Fröhlich, Oliver Gorka, Lin Zhang, Olaf Groß, Oliver Schilling, Oliver Einsle, Claudia Jessen-Trefzer,

Nutrient uptake is essential for survival of organisms, and carbohydrates serve as a crucial carbon and energy source for most microorganisms. Given the importance of mycobacteria as human pathogens a detailed knowledge of carbohydrate uptake transporters is highly desirable, but currently available information is severely limited and mainly based on ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2019, 26(6):852-862.e6]

Cited: 3 times

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Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis.

Thomas M Haas, Paul Ebensperger, Verena B Eisenbeis, Christoph Nopper, Tobias Dürr, Nikolaus Jork, Nicole Steck, Claudia Jessen-Trefzer, Henning J Jessen,

A tunable chemoenzymatic strategy provides access to the entire class of magic spot nucleotides and modified analogues. The approach combines chemoselective bisphosphorylations using phosphoramidites with regioselective ribonuclease T2 cyclo-phosphate hydrolysis, leading to flexible and simple gram-scale operations. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2019, 55(37):5339-5342]

Cited: 4 times

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Trehalose Conjugation Enhances Toxicity of Photosensitizers against Mycobacteria.

Amit K Dutta, Eira Choudhary, Xuan Wang, Monika Záhorszka, Martin Forbak, Philipp Lohner, Henning J Jessen, Nisheeth Agarwal, Jana Korduláková, Claudia Jessen-Trefzer,

Trehalose is a natural glucose-derived disaccharide found in the cell wall of mycobacteria. It enters the mycobacterial cell through a highly specific trehalose transporter system. Subsequently, trehalose is equipped with mycolic acid species and is incorporated into the cell wall as trehalose monomycolate or dimycolate. Here, we investigate the phototoxicity ... Read more >>

ACS Cent Sci (ACS central science)
[2019, 5(4):644-650]

Cited: 4 times

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New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant.

Songya Zhang, Jing Zhu, David L Zechel, Claudia Jessen-Trefzer, Richard T Eastman, Thomas Paululat, Andreas Bechthold,

In this study, we report that Streptomyces asterosporus DSM 41452 is a producer of new molecules related to the nonribosomal cyclodepsipeptide WS9326A and the polyketide annimycin. S. asterosporus DSM 41452 is shown to produce six cyclodepsipeptides and peptides, WS9326A to G. Notably, the compounds WS9326F and WS9326G have not been described ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2018, 19(3):272-279]

Cited: 4 times

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Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains - An Unusual Secondary Metabolite with Various Properties.

Anja Greule, Marija Marolt, Denise Deubel, Iris Peintner, Songya Zhang, Claudia Jessen-Trefzer, Christian De Ford, Sabrina Burschel, Shu-Ming Li, Thorsten Friedrich, Irmgard Merfort, Steffen Lüdeke, Philippe Bisel, Michael Müller, Thomas Paululat, Andreas Bechthold,

<i>Streptomyces diastatochromogenes</i> Tü6028 is known to produce the polyketide antibiotic polyketomycin. The deletion of the <i>pokOIV</i> oxygenase gene led to a non-polyketomycin-producing mutant. Instead, novel compounds were produced by the mutant, which have not been detected before in the wild type strain. Four different compounds were identified and named foxicins ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2017, 8:221]

Cited: 1 time

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