Full Text Journal Articles by
Author Claudia F Lucchinetti

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Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis.

Jordan M Wilkins, Oleksandr Gakh, Parijat Kabiraj, Christina B McCarthy, W Oliver Tobin, Charles L Howe, Claudia F Lucchinetti,

Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease and the most common cause of non-traumatic disability in young adults. Despite progress in the treatment of the active relapsing disease, therapeutic options targeting irreversible progressive decline remain limited. Studies using skin fibroblasts derived from patients with neurodegenerative disorders ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(14):15134-15156]

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Steroid-sparing maintenance immunotherapy for MOG-IgG associated disorder.

John J Chen, Eoin P Flanagan, M Tariq Bhatti, Jiraporn Jitprapaikulsan, Divyanshu Dubey, Alfonso Sebastian S Lopez Chiriboga, James P Fryer, Brian G Weinshenker, Andrew McKeon, Jan-Mendelt Tillema, Vanda A Lennon, Claudia F Lucchinetti, Amy Kunchok, Collin M McClelland, Michael S Lee, Jeffrey L Bennett, Victoria S Pelak, Gregory Van Stavern, Ore-Ofe O Adesina, Eric R Eggenberger, Marie D Acierno, Dean M Wingerchuk, Byron L Lam, Heather Moss, Shannon Beres, Aubrey L Gilbert, Veeral Shah, Grayson Armstrong, Gena Heidary, Dean M Cestari, Hadas Stiebel-Kalish, Sean J Pittock,

OBJECTIVE:Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) associated disorder (MOGAD) often manifests with recurrent CNS demyelinating attacks. The optimal treatment for reducing relapses is unknown. To help determine the efficacy of long-term immunotherapy in preventing relapse in patients with MOGAD, we conducted a multicenter retrospective study to determine the rate of relapses ... Read more >>

Neurology (Neurology)
[2020, 95(2):e111-e120]

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Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology.

R Ross Reichard, Kianoush B Kashani, Nicholas A Boire, Eleni Constantopoulos, Yong Guo, Claudia F Lucchinetti,

We report the neuropathological findings of a patient who died from complications of COVID-19. The decedent was initially hospitalized for surgical management of underlying coronary artery disease. He developed post-operative complications and was evaluated with chest imaging studies. The chest computed tomography (CT) imaging results were indicative of COVID-19 and ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2020, 140(1):1-6]

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The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody.

Romana Höftberger, Yong Guo, Eoin P Flanagan, A Sebastian Lopez-Chiriboga, Verena Endmayr, Sonja Hochmeister, Damir Joldic, Sean J Pittock, Jan Mendelt Tillema, Mark Gorman, Hans Lassmann, Claudia F Lucchinetti,

We sought to define the pathological features of myelin oligodendrocyte glycoprotein (MOG) antibody associated disorders (MOGAD) in an archival autopsy/biopsy cohort. We histopathologically analyzed 2 autopsies and 22 brain biopsies from patients with CNS inflammatory demyelinating diseases seropositive for MOG-antibody by live-cell-based-assay with full length MOG in its conformational form. MOGAD autopsies ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2020, 139(5):875-892]

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Pathological findings in central nervous system demyelination associated with infliximab.

Alicja Kalinowska-Lyszczarz, Mahboobeh Fereidan-Esfahani, Yong Guo, Claudia F Lucchinetti, W Oliver Tobin,

BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) inhibitors, such as infliximab, are commonly used to treat rheumatoid arthritis (RA) and other immune-mediated disorders. OBJECTIVE:To determine whether infliximab-associated central nervous system (CNS) demyelination can be differentiated from multiple sclerosis (MS). METHODS:We present a case of pathologically proven CNS demyelination in a patient treated ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2020, 26(9):1124-1129]

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Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain.

Gregory N Ruegsegger, Patrick M Vanderboom, Surendra Dasari, Katherine A Klaus, Parijat Kabiraj, Christina B McCarthy, Claudia F Lucchinetti, K Sreekumaran Nair,

Insulin resistance associates with increased risk for cognitive decline and dementia; however, the underpinning mechanisms for this increased risk remain to be fully defined. As insulin resistance impairs mitochondrial oxidative metabolism and increases ROS in skeletal muscle, we considered whether similar events occur in the brain, which - like muscle ... Read more >>

JCI Insight (JCI insight)
[2019, 4(18):]

Cited: 1 time

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Phosphodiesterase 10A IgG: A novel biomarker of paraneoplastic neurologic autoimmunity.

Anastasia Zekeridou, Thomas Kryzer, Yong Guo, Anhar Hassan, Vanda Lennon, Claudia F Lucchinetti, Sean Pittock, Andrew McKeon,

OBJECTIVE:To describe a novel antibody biomarker of neurologic paraneoplastic autoimmunity specific for phosphodiesterase 10A (PDE10A), a striatum-enriched phosphodiesterase, and to characterize the clinical phenotype of patients with PDE10A immunoglobulin G (IgG). METHODS:We describe 7 patients with autoantibodies specific for PDE10A identified in the Mayo Clinic Neuroimmunology Laboratory. Patient specimens (sera, ... Read more >>

Neurology (Neurology)
[2019, 93(8):e815-e822]

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Using germline variants to estimate glioma and subtype risks.

Jeanette E Eckel-Passow, Paul A Decker, Matt L Kosel, Thomas M Kollmeyer, Annette M Molinaro, Terri Rice, Alissa A Caron, Kristen L Drucker, Corinne E Praska, Melike Pekmezci, Helen M Hansen, Lucie S McCoy, Paige M Bracci, Bradley J Erickson, Claudia F Lucchinetti, Joseph L Wiemels, John K Wiencke, Melissa L Bondy, Beatrice Melin, Terry C Burns, Caterina Giannini, Daniel H Lachance, Margaret R Wrensch, Robert B Jenkins,

BACKGROUND:Twenty-five single nucleotide polymorphisms (SNPs) are associated with adult diffuse glioma risk. We hypothesized that the inclusion of these 25 SNPs with age at diagnosis and sex could estimate risk of glioma as well as identify glioma subtypes. METHODS:Case-control design and multinomial logistic regression were used to develop models to ... Read more >>

Neuro-oncology (Neuro-oncology)
[2019, 21(4):451-461]

Cited: 1 time

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Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody.

Divyanshu Dubey, Sean J Pittock, Karl N Krecke, Padraig P Morris, Elia Sechi, Nicholas L Zalewski, Brian G Weinshenker, Eslam Shosha, Claudia F Lucchinetti, James P Fryer, A Sebastian Lopez-Chiriboga, John C Chen, Jiraporn Jitprapaikulsan, Andrew McKeon, Avi Gadoth, B Mark Keegan, Jan-Mendelt Tillema, Elie Naddaf, Marc C Patterson, Kevin Messacar, Kenneth L Tyler, Eoin P Flanagan,

Importance:Recognizing the characteristics of myelin oligodendrocyte glycoprotein autoantibody (MOG-IgG) myelitis is essential for early accurate diagnosis and treatment. Objective:To evaluate the clinical, radiologic, and prognostic features of MOG-IgG myelitis and compare with myelitis with aquaporin-4-IgG (AQP4-IgG) and multiple sclerosis (MS). Design, Setting, and Participants:We retrospectively identified 199 MOG-IgG-positive Mayo Clinic ... Read more >>

JAMA Neurol (JAMA neurology)
[2019, 76(3):301-309]

Cited: 11 times

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Paraneoplastic neuronal intermediate filament autoimmunity.

Eati Basal, Nicholas Zalewski, Thomas J Kryzer, Shannon R Hinson, Yong Guo, Divyanshu Dubey, Eduardo E Benarroch, Claudia F Lucchinetti, Sean J Pittock, Vanda A Lennon, Andrew McKeon,

OBJECTIVE:To describe paraneoplastic neuronal intermediate filament (NIF) autoimmunity. METHODS:Archived patient and control serum and CSF specimens were evaluated by tissue-based indirect immunofluorescence assay (IFA). Autoantigens were identified by Western blot and mass spectrometry. NIF specificity was confirmed by dual tissue section staining and 5 recombinant NIF-specific HEK293 cell-based assays (CBAs, ... Read more >>

Neurology (Neurology)
[2018, 91(18):e1677-e1689]

Cited: 2 times

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Myelin Oligodendrocyte Glycoprotein Antibody-Positive Optic Neuritis: Clinical Characteristics, Radiologic Clues, and Outcome.

John J Chen, Eoin P Flanagan, Jiraporn Jitprapaikulsan, Alfonso Sebastian S López-Chiriboga, James P Fryer, Jacqueline A Leavitt, Brian G Weinshenker, Andrew McKeon, Jan-Mendelt Tillema, Vanda A Lennon, W Oliver Tobin, B Mark Keegan, Claudia F Lucchinetti, Orhun H Kantarci, Collin M McClelland, Michael S Lee, Jeffrey L Bennett, Victoria S Pelak, Yanjun Chen, Gregory VanStavern, Ore-Ofe O Adesina, Eric R Eggenberger, Marie D Acierno, Dean M Wingerchuk, Paul W Brazis, Jessica Sagen, Sean J Pittock,

PURPOSE:To characterize the clinical phenotype of myelin oligodendrocyte glycoprotein antibody (MOG-IgG) optic neuritis. DESIGN:Observational case series. METHODS:Setting: Multicenter. Patient/Study Population: Subjects meeting inclusion criteria: (1) history of optic neuritis; (2) seropositivity (MOG-IgG binding index > 2.5); 87 MOG-IgG-seropositive patients with optic neuritis were included (Mayo Clinic, 76; other medical centers, ... Read more >>

Am. J. Ophthalmol. (American journal of ophthalmology)
[2018, 195:8-15]

Cited: 12 times

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Population-based study of "no evident disease activity" in MS.

Natalie E Parks, Sean J Pittock, Jay Mandrekar, Orhun H Kantarci, Claudia F Lucchinetti, Brian G Weinshenker, B Mark Keegan, W Oliver Tobin, Jan-Mendelt Tillema, Michel Toledano, Eoin P Flanagan,

Objective:To determine the persistence of no evident disease activity (NEDA) in a population-based relapsing-remitting MS (RRMS) cohort. Methods:All incident cases of RRMS in Olmsted County between 2000 and 2011 were identified using a medical records linkage system. Persistence of NEDA after RRMS diagnosis was determined by retrospective chart review. MRI ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2018, 5(6):e495]

Cited: 1 time

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Neuromyelitis Optica and Herpes Simplex Virus 2: A Viral Trigger for Aquaporin-4 Autoimmunity?

I Vanessa Marin Collazo, Charles L Howe, Claudia F Lucchinetti, W Oliver Tobin,

The clinical and radiographic spectrum of Neuromyelitis optica spectrum disorder has broadened following the description of the aquaporin-4 antibody. The initial triggering event and reason for disease quiescence between relapses is unclear. We present a case of myeloradiculitis associated with aquaporin-4 antibody and concomitant herpes simplex virus 2 infection. ... Read more >>

Neurologist (The neurologist)
[2018, 23(3):92-93]

Cited: 1 time

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Differences in the Reponses to Apheresis Therapy of Patients With 3 Histopathologically Classified Immunopathological Patterns of Multiple Sclerosis.

Lidia Stork, David Ellenberger, Tim Beißbarth, Tim Friede, Claudia F Lucchinetti, Wolfgang Brück, Imke Metz,

Importance:Plasma exchange and immunoadsorption are second-line apheresis therapies for patients experiencing multiple sclerosis relapses. Early active multiple sclerosis lesions can be classified into different histopathological patterns of demyelination. Pattern 1 and 2 lesions show T-cell- and macrophage-associated demyelination, and pattern 2 is selectively associated with immunoglobulin and complement deposits, suggesting ... Read more >>

JAMA Neurol (JAMA neurology)
[2018, 75(4):428-435]

Cited: 6 times

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Multiple Sclerosis.

Daniel S Reich, Claudia F Lucchinetti, Peter A Calabresi,

N. Engl. J. Med. (The New England journal of medicine)
[2018, 378(2):169-180]

Cited: 159 times

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NEDA treatment target? No evident disease activity as an actionable outcome in practice.

Natalie E Parks, Eoin P Flanagan, Claudia F Lucchinetti, Dean M Wingerchuk,

"No evident disease activity" (NEDA) is a proposed measure of disease activity-free status in multiple sclerosis (MS) that is typically defined as absence of relapses, disability progression, and MRI activity over a defined time period. NEDA is increasingly reported in randomized controlled trials of MS disease modifying therapies where it ... Read more >>

J. Neurol. Sci. (Journal of the Neurological Sciences)
[2017, 383:31-34]

Cited: 7 times

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Purkinje cell cytoplasmic antibody type I (anti-Yo): predictive of gastrointestinal adenocarcinomas in men.

Jenny Linnoila, Yong Guo, Avi Gadoth, Aditya Raghunathan, Becky Parks, Andrew McKeon, Claudia F Lucchinetti, Vanda A Lennon, Sean J Pittock,

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2018, 89(10):1116-1117]

Cited: 0 times

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Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).

W Oliver Tobin, Yong Guo, Karl N Krecke, Joseph E Parisi, Claudia F Lucchinetti, Sean J Pittock, Jay Mandrekar, Divyanshu Dubey, Jan Debruyne, B Mark Keegan,

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a central nervous system inflammatory syndrome predominantly affecting the brainstem, cerebellum, and spinal cord. Following its initial description, the salient features of CLIPPERS have been confirmed and expanded upon, but the lack of formalized diagnostic criteria has led ... Read more >>

Brain (Brain : a journal of neurology)
[2017, 140(9):2415-2425]

Cited: 24 times

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Clinical Reasoning: A 50-year-old woman with SLE and a tumefactive lesion.

Jee-Hye Choi, Asya Izraelit Wallach, Dominique Rosales, Stefan E Margiewicz, H Michael Belmont, Claudia F Lucchinetti, Mia T Minen,

Neurology (Neurology)
[2017, 89(12):e140-e145]

Cited: 0 times

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Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions.

Bogdan F Popescu, Josa M Frischer, Samuel M Webb, Mylyne Tham, Reginald C Adiele, Christopher A Robinson, Patrick D Fitz-Gibbon, Stephen D Weigand, Imke Metz, Susan Nehzati, Graham N George, Ingrid J Pickering, Wolfgang Brück, Simon Hametner, Hans Lassmann, Joseph E Parisi, Guo Yong, Claudia F Lucchinetti,

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) in which oligodendrocytes, the CNS cells that stain most robustly for iron and myelin are the targets of injury. Metals are essential for normal CNS functioning, and metal imbalances have been linked to demyelination and ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2017, 134(1):45-64]

Cited: 18 times

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Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica.

Yong Guo, Stephen D Weigand, Bogdan F Popescu, Vanda A Lennon, Joseph E Parisi, Sean J Pittock, Natalie E Parks, Stacey L Clardy, Charles L Howe, Claudia F Lucchinetti,

Pathogenic autoantibodies associated with neuromyelitis optica (NMO) induce disease by targeting aquaporin-4 (AQP4) water channels enriched on astrocytic endfeet at blood-brain interfaces. AQP4 is also expressed at cerebrospinal fluid (CSF)-brain interfaces, such as the pial glia limitans and the ependyma and at the choroid plexus blood-CSF barrier. However, little is ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2017, 133(4):597-612]

Cited: 5 times

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Ring-enhancing spinal cord lesions in neuromyelitis optica spectrum disorders.

Nicholas L Zalewski, Padraig P Morris, Brian G Weinshenker, Claudia F Lucchinetti, Yong Guo, Sean J Pittock, Karl N Krecke, Timothy J Kaufmann, Dean M Wingerchuk, Neeraj Kumar, Eoin P Flanagan,

OBJECTIVE:We assessed the frequency and characteristics of ring-enhancing spinal cord lesions in neuromyelitis optica spectrum disorder (NMOSD) myelitis and myelitis of other cause. METHODS:We reviewed spinal cord MRIs for ring-enhancing lesions from 284 aquaporin-4 (AQP4)-IgG seropositive patients at Mayo Clinic from 1996 to 2014. Inclusion criteria were as follows: (1) ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2017, 88(3):218-225]

Cited: 11 times

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Clinical-radiological-pathological spectrum of central nervous system-idiopathic inflammatory demyelinating disease in the elderly.

W Oliver Tobin, Chiara Costanzi, Yong Guo, Joseph E Parisi, Stephen D Weigand, Claudia F Lucchinetti,

The spectrum of central nervous system-idiopathic inflammatory demyelinating disease (CNS-IIDD) in the elderly is uncertain.To describe the clinical, radiological, and pathological features of a cohort of 30 pathologically proven CNS-IIDD patients ⩾65 years.Elderly multiple sclerosis (MS)/clinically isolated syndrome (CIS) patients were compared to a cohort of 125 patients with pathologically proven ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2017, 23(9):1204-1213]

Cited: 2 times

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In vivo detection of connectivity between cortical and white matter lesions in early MS.

Jan-Mendelt Tillema, Stephen D Weigand, Jay Mandrekar, Yunhong Shu, Claudia F Lucchinetti, Istvan Pirko, John D Port,

The relationship between cortical lesions (CLs) and white matter lesions (WMLs) in multiple sclerosis (MS) is poorly understood. Pathological studies support a topographical association between CLs and underlying subcortical WMLs and suggest CLs may play a role in both disease initiation and progression. We hypothesized that cortical MS lesions are ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2017, 23(7):973-981]

Cited: 1 time

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Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome.

Daniela Pohl, Gulay Alper, Keith Van Haren, Andrew J Kornberg, Claudia F Lucchinetti, Silvia Tenembaum, Anita L Belman,

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating CNS disorder with predilection to early childhood. ADEM is generally considered a monophasic disease. However, recurrent ADEM has been described and defined as multiphasic disseminated encephalomyelitis. ADEM often occurs postinfectiously, although a causal relationship has never been established. ADEM and multiple sclerosis ... Read more >>

Neurology (Neurology)
[2016, 87(9 Suppl 2):S38-45]

Cited: 29 times

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