Full Text Journal Articles by
Author Claudia Chien

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Optic chiasm measurements may be useful markers of anterior optic pathway degeneration in neuromyelitis optica spectrum disorders.

Valentin Juenger, Graham Cooper, Claudia Chien, Meera Chikermane, Frederike Cosima Oertel, Hanna Zimmermann, Klemens Ruprecht, Sven Jarius, Nadja Siebert, Joseph Kuchling, Athina Papadopoulou, Susanna Asseyer, Judith Bellmann-Strobl, Friedemann Paul, Alexander U Brandt, Michael Scheel,

OBJECTIVES:We aimed to evaluate optic chiasm (OC) measures as potential imaging marker for anterior optic pathway damage assessment in the context of neuromyelitis optica spectrum disorders (NMOSD). MATERIALS AND METHOD:This cross-sectional study included 39 patients exclusively with aquaporin 4-IgG seropositive NMOSD of which 25 patients had a history of optic ... Read more >>

Eur Radiol (European radiology)
[2020, :]

Cited: 0 times

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Fingolimod after a first unilateral episode of acute optic neuritis (MOVING) - preliminary results from a randomized, rater-blind, active-controlled, phase 2 trial.

Christian Albert, Janine Mikolajczak, Anja Liekfeld, Sophie K Piper, Michael Scheel, Hanna G Zimmermann, Claus Nowak, Jan Dörr, Judith Bellmann-Strobl, Claudia Chien, Alexander U Brandt, Friedemann Paul, Olaf Hoffmann,

BACKGROUND:Neuroprotection and promotion of remyelination represent important therapeutic gaps in multiple sclerosis (MS). Acute optic neuritis (ON) is a frequent MS manifestation. Based on the presence and properties of sphingosine-1-phosphate receptors (S1PR) on astrocytes and oligodendrocytes, we hypothesized that remyelination can be enhanced by treatment with fingolimod, a S1PR modulator ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):75]

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Attack-related damage of thalamic nuclei in neuromyelitis optica spectrum disorders.

Athina Papadopoulou, Frederike Cosima Oertel, Laura Gaetano, Joseph Kuchling, Hanna Zimmermann, Claudia Chien, Nadja Siebert, Susanna Asseyer, Judith Bellmann-Strobl, Klemens Ruprecht, M Mallar Chakravarty, Michael Scheel, Stefano Magon, Jens Wuerfel, Friedemann Paul, Alexander Ulrich Brandt,

OBJECTIVES:In neuromyelitis optica spectrum disorders (NMOSD) thalamic damage is controversial, but thalamic nuclei were never studied separately. We aimed at assessing volume loss of thalamic nuclei in NMOSD. We hypothesised that only specific nuclei are damaged, by attacks affecting structures from which they receive afferences: the lateral geniculate nucleus (LGN), ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2019, 90(10):1156-1164]

Cited: 1 time

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Standardization of T1w/T2w Ratio Improves Detection of Tissue Damage in Multiple Sclerosis.

Graham Cooper, Carsten Finke, Claudia Chien, Alexander U Brandt, Susanna Asseyer, Klemens Ruprecht, Judith Bellmann-Strobl, Friedemann Paul, Michael Scheel,

Normal appearing white matter (NAWM) damage develops early in multiple sclerosis (MS) and continues in the absence of new lesions. The ratio of T1w and T2w (T1w/T2w ratio), a measure of white matter integrity, has previously shown reduced intensity values in MS NAWM. We evaluate the validity of a standardized ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:334]

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Spinal cord lesions and atrophy in NMOSD with AQP4-IgG and MOG-IgG associated autoimmunity.

Claudia Chien, Michael Scheel, Tanja Schmitz-Hübsch, Nadja Borisow, Klemens Ruprecht, Judith Bellmann-Strobl, Friedemann Paul, Alexander U Brandt,

BACKGROUND:Spinal cord (SC) affection is a hallmark symptom of neuromyelitis optica spectrum disorders (NMOSD). Patients with aquaporin-4 (AQP4-IgG+) or myelin oligodendrocyte glycoprotein (MOG-IgG+) antibody seropositivity show this overlapping clinical phenotype. OBJECTIVE:Quantitative comparison of SC lesions and atrophy in AQP4-IgG+ and MOG-IgG+ NMOSD. METHODS:AQP4-IgG+ (n = 38), MOG-IgG+ (n = 15) NMOSD patients and healthy ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, 25(14):1926-1936]

Cited: 3 times

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Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders.

Olga Ciccarelli, Jeffrey A Cohen, Stephen C Reingold, Brian G Weinshenker, ,

Spinal cord involvement is an important cause of disability in patients with multiple sclerosis or neuromyelitis optica spectrum disorders (NMOSDs). Multiple sclerosis and NMOSDs can be distinguished from other disorders that cause myelopathy by results from laboratory and radiological investigations. However, limitations in the sensitivity and specificity of spinal cord ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2019, 18(2):185-197]

Cited: 4 times

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The impact of thermal cycling on Staphylococcus aureus biofilm growth on stainless steel and titanium orthopaedic plates.

Margarete K Akens, Claudia Chien, Ryan N Katchky, Hans J Kreder, Joel Finkelstein, Cari M Whyne,

BACKGROUND:Orthopaedic implant infections are difficult to eradicate because bacteria adhering to implant surfaces inhibit the ability of the immune system and antibiotics to combat these infections. Thermal cycling is a temperature modulation process that improves performance and longevity of materials through molecular structural reorientation, thereby increasing surface uniformity. Thermal cycling ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2018, 19(1):260]

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Pain in AQP4-IgG-positive and MOG-IgG-positive neuromyelitis optica spectrum disorders.

Susanna Asseyer, Felix Schmidt, Claudia Chien, Michael Scheel, Klemens Ruprecht, Judith Bellmann-Strobl, Alexander U Brandt, Friedemann Paul,

Pain is a frequent symptom in aquaporin-4-immunoglobulin-G-positive neuromyelitis optica spectrum disorders (AQP4-IgG-pos. NMOSD). Data on pain in myelin-oligodendrocyte-glycoprotein-immunoglobulin-G autoimmunity with a clinical NMOSD phenotype (MOG-IgG-pos. NMOSD) are scarce.The objective of this paper is to investigate pain in MOG-IgG-pos. NMOSD, AQP4-IgG-pos. NMOSD and NMOSD without AQP4/MOG-IgG detection (AQP4/MOG-IgG-neg. NMOSD).Forty-nine MOG-IgG-pos. (n = 14), ... Read more >>

Mult Scler J Exp Transl Clin (Multiple sclerosis journal - experimental, translational and clinical)
[2018, 4(3):2055217318796684]

Cited: 2 times

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Microstructural visual system changes in AQP4-antibody-seropositive NMOSD.

Frederike C Oertel, Joseph Kuchling, Hanna Zimmermann, Claudia Chien, Felix Schmidt, Benjamin Knier, Judith Bellmann-Strobl, Thomas Korn, Michael Scheel, Alexander Klistorner, Klemens Ruprecht, Friedemann Paul, Alexander U Brandt,

OBJECTIVE:To trace microstructural changes in patients with aquaporin-4 antibody (AQP4-ab)-seropositive neuromyelitis optica spectrum disorders (NMOSDs) by investigating the afferent visual system in patients without clinically overt visual symptoms or visual pathway lesions. METHODS:Of 51 screened patients with NMOSD from a longitudinal observational cohort study, we compared 6 AQP4-ab-seropositive NMOSD patients ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2017, 4(3):e334]

Cited: 27 times

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Gadopentetate but not gadobutrol accumulates in the dentate nucleus of multiple sclerosis patients.

Ludwig Schlemm, Claudia Chien, Judith Bellmann-Strobl, Jan Dörr, Jens Wuerfel, Alexander U Brandt, Friedemann Paul, Michael Scheel,

Previous studies have postulated an association between dentate nucleus T1 hyperintensity and multiple sclerosis (MS)-related progressive neurodegeneration. Therefore, MS patients have been excluded from most studies investigating brain deposition of gadolinium-based contrast agents (GBCAs).To study the hypothesis that dentate nucleus T1 hyperintensity in MS patients is associated with GBCA administration.In ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2017, 23(7):963-972]

Cited: 27 times

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Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis.

Stuart K Bisland, Claudia Chien, Brian C Wilson, Shane Burch,

Osteomyelitis can lead to severe morbidity and even death resulting from an acute or chronic inflammation of the bone and contiguous structures due to fungal or bacterial infection. Incidence approximates 1 in 1000 neonates and 1 in 5000 children in the United States annually and increases up to 0.36% and ... Read more >>

Photochem. Photobiol. Sci. (Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology)
[2006, 5(1):31-38]

Cited: 43 times

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