Full Text Journal Articles by
Author Claire E Schaar

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Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.

Ziyun Wu, Megan M Senchuk, Dylan J Dues, Benjamin K Johnson, Jason F Cooper, Leira Lew, Emily Machiela, Claire E Schaar, Heather DeJonge, T Keith Blackwell, Jeremy M Van Raamsdonk,

BACKGROUND:The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studies suggesting that mitoUPR activation has complex effects on longevity. RESULTS:Here, we examined the contribution of the mitoUPR to the survival and ... Read more >>

BMC Biol (BMC biology)
[2018, 16(1):147]

Cited: 6 times

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Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.

Megan M Senchuk, Dylan J Dues, Claire E Schaar, Benjamin K Johnson, Zachary B Madaj, Megan J Bowman, Mary E Winn, Jeremy M Van Raamsdonk,

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (clk-1, isp-1 and nuo-6) to identify overlapping genetic pathways that contribute to their longevity. We find that genes regulated by the FOXO transcription ... Read more >>

PLoS Genet (PLoS genetics)
[2018, 14(3):e1007268]

Cited: 14 times

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Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans.

Dylan J Dues, Claire E Schaar, Benjamin K Johnson, Megan J Bowman, Mary E Winn, Megan M Senchuk, Jeremy M Van Raamsdonk,

Mutations affecting components of the mitochondrial electron transport chain have been shown to increase lifespan in multiple species including the worm Caenorhabditis elegans. While it was originally proposed that decreased generation of reactive oxygen species (ROS) resulting from lower rates of electron transport could account for the observed increase in ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2017, 108:362-373]

Cited: 12 times

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Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways.

Dylan J Dues, Emily K Andrews, Claire E Schaar, Alexis L Bergsma, Megan M Senchuk, Jeremy M Van Raamsdonk,

In this work, we examine the relationship between stress resistance and aging. We find that resistance to multiple types of stress peaks during early adulthood and then declines with age. To dissect the underlying mechanisms, we use C. elegans transcriptional reporter strains that measure the activation of different stress responses ... Read more >>

Aging (Albany NY) (Aging)
[2016, 8(4):777-795]

Cited: 32 times

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