Full Text Journal Articles by
Author Cinzia Auriti

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Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far.

Domenico Umberto De Rose, Fiammetta Piersigilli, Maria Paola Ronchetti, Alessandra Santisi, Iliana Bersani, Andrea Dotta, Olivier Danhaive, Cinzia Auriti, ,

Recently, an outbreak of viral pneumonitis in Wuhan, Hubei, China successively spread as a global pandemia, led to the identification of a novel betacoronavirus species, the 2019 novel coronavirus, successively designated 2019-nCoV then SARS-CoV-2). The SARS-CoV-2 causes a clinical syndrome designated coronavirus disease 2019 (COVID19) with a spectrum of manifestations ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):56]

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Use of Disinfectant Wipes to Sanitize Milk's Containers of Human Milk Bank During COVID-19 Pandemic.

Domenico Umberto De Rose, Maria Paola Reposi, Patrizia Amadio, Cinzia Auriti, Immacolata Dall'Oglio, Tiziana Corsetti, Andrea Dotta, Guglielmo Salvatori,

J Hum Lact (Journal of human lactation : official journal of International Lactation Consultant Association)
[2020, :890334420924639]

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Juvenile idiopathic arthritis in infants with Harlequin Ichthyosis: two cases report and literature review.

Cinzia Auriti, Roberta Rotunno, Andrea Diociaiuti, Silvia Magni Manzoni, Andrea Uva, Iliana Bersani, Alessandra Santisi, Andrea Dotta, May El Hachem,

BACKGROUND:Harlequin Ichthyosis is the most severe variant of congenital autosomal recessive ichthyosis, associated with severe morbidity and potentially lethal in early life. At birth, patients present thick and plaque-like scales all over the body, with consequent cutaneous and extra-cutaneous complications, such as poor thermoregulation, recurrent infections, pain, electrolytes imbalance and ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):44]

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An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, microRNA, and metabolomic profiling.

Fiammetta Piersigilli, Mansoor Syed, TuKiet T Lam, Andrea Dotta, Michela Massoud, Pamela Vernocchi, Andrea Quagliariello, Lorenza Putignani, Cinzia Auriti, Guglielmo Salvatori, Pietro Bagolan, Vineet Bhandari,

INTRODUCTION:The omic approach can help identify a signature that can be potentially used as biomarkers in babies with congenital diaphragmatic hernia (CDH). OBJECTIVES:To find a specific microRNA (miR) and metabolic fingerprint of the tracheal aspirates (TA) of CDH patients. We conducted a genetic analysis from blood samples. METHODS:TA samples collected ... Read more >>

J Perinatol (Journal of Perinatology)
[2020, 40(6):952-961]

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Early predictors of perinatal brain damage: the role of neurobiomarkers.

Iliana Bersani, Francesca Pluchinotta, Andrea Dotta, Immacolata Savarese, Francesca Campi, Cinzia Auriti, Natalia Chuklantseva, Fiammetta Piersigilli, Francesca Gazzolo, Alessandro Varrica, Angela Satriano, Diego Gazzolo,

The early detection of perinatal brain damage in preterm and term newborns (i.e. intraventricular hemorrhage, periventricular leukomalacia and perinatal asphyxia) still constitute an unsolved issue. To date, despite technological improvement in standard perinatal monitoring procedures, decreasing the incidence of perinatal mortality, the perinatal morbidity pattern has a flat trend. Against ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(4):471-486]

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul T Heath, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

BACKGROUND:The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, recruited in single centres or countries, evaluated antibiotics not in clinical use anymore ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229380]

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Antifungal Drugs for Invasive Candida Infections (ICI) in Neonates: Future Perspectives.

Iliana Bersani, Fiammetta Piersigilli, Bianca Maria Goffredo, Alessandra Santisi, Sara Cairoli, Maria Paola Ronchetti, Cinzia Auriti,

Fungal infections may complicate the neonatal clinical course, and the spectrum of therapies for their treatment in the perinatal period is limited. Polyenes, Azoles and Echinocandins represent the three classes of antifungal drugs commonly used in the neonatal period. The present review provides an overview about the most recent therapeutic ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:375]

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Familial aggregation of "apple peel" intestinal atresia and cardiac left-sided obstructive lesions: A possible causal relationship with NOTCH1 gene mutations.

M Cristina Digilio, Monia Magliozzi, Alessandra Di Pede, Laura Valfrè, Maria Lisa Dentici, Cinzia Auriti, Bruno Marino, Antonio Novelli, Bruno Dallapiccola,

"Apple peel" intestinal atresia is a rare form of small bowel atresia, in which the duodenum or proximal jejunum ends in a blind pouch and the distal small bowel wraps around its vascular supply, in a spiral resembling an apple peel. The etiology of "apple peel" intestinal atresia is presently ... Read more >>

Am. J. Med. Genet. A (American journal of medical genetics. Part A)
[2019, 179(8):1570-1574]

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A new MRI severity score to predict long-term adverse neurologic outcomes in children with congenital Cytomegalovirus infection.

Giulia Lucignani, Maria Camilla Rossi Espagnet, Antonio Napolitano, Lorenzo Figà Talamanca, Francesca Ippolita Calò Carducci, Cinzia Auriti, Daniela Longo,

Background: Congenital cytomegalovirus (CMV) infection is one of the main causes of deafness in childhood. It frequently causes serious long-term neurological sequelae. In children who are asymptomatic at birth, tests to accurately predict these sequelae are still unavailable. Aims: We describe different brain MRI patterns of congenital CMV infection correlated ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, :1-8]

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Neonatal acute liver failure due to enteroviruses: a 14 years single NICU experience.

Iliana Bersani, Cinzia Auriti, Fiammetta Piersigilli, Andrea Dotta, Francesca Diomedi-Camassei, Alessandra Di Pede, Gabriele Buttinelli, Olivier Danhaive,

BACKGROUND:Neonatal acute liver failure (ALF) is a severe condition with a mortality rate up to 70%. Human enterovirus (HEV) infections are associated with serious diseases in newborns, including myocarditis, meningoencephalitis and, more rarely, ALF with a fulminant course. METHODS:Cases of neonatal-onset ALF were identified using the institutional clinical database. The ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, :1-5]

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Intrahepatic Administration of Liposomal Amphotericin B (Ambisome) for the Management of a Liver Abscess from Candida albicans in a Preterm Infant.

Cinzia Auriti, Maria Paola Ronchetti, Iliana Bersani, Fabrizio Gennari, Fiammetta Piersigilli,

Hepatic fungal abscesses are rare in the neonatal period and often constitute a severe complication of the catheterization of the umbilical vessels. Such life-threatening lesions are observed more frequently in preterm than in other newborn infants and the optimal treatment remains uncertain. We present the case of a preterm neonate, ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2018, 62(12):]

Cited: 1 time

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): a randomised controlled trial

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul Heath Frcpch, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

Abstract Background The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, were single centre or country, insufficiently powered, evaluated antibiotics not in ... Read more >>

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Validation of Heel Stick Microsampling To Optimize Micafungin Doses in Neonates and Young Infants.

Cinzia Auriti, Bianca Maria Goffredo, Maria Paola Ronchetti, Fiammetta Piersigilli, Sara Cairoli, Iliana Bersani, Andrea Dotta, Manjunath P Pai,

Major gaps exist in our knowledge of antimicrobial pharmacokinetics in critically ill neonates and infants that require validated microsampling and bioanalysis methods to support therapeutic drug monitoring. We compared serially collected intravenous (i.v.) and heel stick capillary (HSC)-sampled plasma concentrations of micafungin (8 mg/kg) in eight infants born preterm with ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2018, 62(10):]

Cited: 1 time

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Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies.

Eva Germovsek, Irja Lutsar, Karin Kipper, Mats O Karlsson, Tim Planche, Corine Chazallon, Laurence Meyer, Ursula M T Trafojer, Tuuli Metsvaht, Isabelle Fournier, Mike Sharland, Paul Heath, Joseph F Standing, ,

Background:Sepsis and bacterial meningitis are major causes of mortality and morbidity in neonates and infants. Meropenem, a broad-spectrum antibiotic, is not licensed for use in neonates and infants below 3 months of age and sufficient information on its plasma and CSF disposition and dosing in neonates and infants is lacking. Objectives:To ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2018, 73(7):1908-1916]

Cited: 1 time

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Propofol and fentanyl sedation for laser treatment of retinopathy of prematurity to avoid intubation.

Fiammetta Piersigilli, Alessandra Di Pede, Gino Catena, Simona Lozzi, Cinzia Auriti, Iliana Bersani, Irma Capolupo, Anna Lipreri, Vincenzo Di Ciommo, Andrea Dotta, Stefania Sgrò,

BACKGROUND:Despite the optimization of neonatal assistance, severe retinopathy of prematurity (ROP, stage III-IV) remains a common condition among preterm infants. Laser photocoagulation usually requires general anesthesia and intubation, but extubation can be difficult and these infants often affected by chronic lung disease. We retrospectively evaluated the clinical charts of 13 ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, 32(3):517-521]

Cited: 1 time

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Bacterial sepsis in neonates: Single centre study in a Neonatal intensive care unit in Bosnia and Herzegovina.

Izeta Softić, Husref Tahirović, Vincenzo Di Ciommo, Cinzia Auriti,

The aim of the study was to evaluate the incidence, mortality, risk factors, aetiology and the susceptibility to antibiotics of the bacteria responsible for sepsis.A single centre, prospective, observational study, involving 200 neonates admitted over 12 months to the NICU of the University Children's Hospital, Tuzla, Bosnia and Herzegovina.The crude ... Read more >>

Acta Med Acad (Acta medica academica)
[2017, 46(1):7-15]

Cited: 1 time

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Mannose-Binding Lectin: Biologic Characteristics and Role in the Susceptibility to Infections and Ischemia-Reperfusion Related Injury in Critically Ill Neonates.

Cinzia Auriti, Giusi Prencipe, Maria Moriondo, Iliana Bersani, Chiara Bertaina, Vito Mondì, Rita Inglese,

The mannose-binding lectin (MBL) is a member of the collectin family, belonging to the innate immunity system. Genetic, biologic, and clinical properties of MBL have been widely investigated throughout the last decades, although some interesting aspects of its potential clinical relevance are still poorly understood. Low circulating concentrations of MBL ... Read more >>

J Immunol Res (Journal of immunology research)
[2017, 2017:7045630]

Cited: 5 times

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High-Dose Micafungin for Preterm Neonates and Infants with Invasive and Central Nervous System Candidiasis.

Cinzia Auriti, Marco Falcone, Maria Paola Ronchetti, Bianca Maria Goffredo, Sara Cairoli, Rosamaria Crisafulli, Fiammetta Piersigilli, Tiziana Corsetti, Andrea Dotta, Manjunath P Pai,

High doses of micafungin are advocated in neonates with systemic candidiasis, but limited pharmacokinetic (PK) and safety data are available to support their use. Eighteen preterm neonates and infants with systemic candidiasis, three of whom had meningitis, were treated for at least 14 days with 8 to 15 mg/kg of ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2016, 60(12):7333-7339]

Cited: 7 times

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Decreased CDKN1C Expression in Congenital Alveolar Rhabdomyosarcoma Associated with Beckwith-Wiedemann Syndrome.

Fiammetta Piersigilli, Cinzia Auriti, Vito Mondì, Paola Francalanci, Guglielmo Salvatori, Olivier Danhaive,

The Beckwith-Wiedemann syndrome (BWS) is a genetic disorder characterized by somatic overgrowth and predisposition to embryonal tumors, such as Wilm's tumor, hepatoblastoma, neuroblastoma and rhabdomyosarcoma (RMS). BWS is associated with various genetic alterations: a variety of molecular lesions are described on the chromosome 11p15, affecting gene expression for IGF2, H19, ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2016, 83(12-13):1476-1478]

Cited: 0 times

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Shunt lock therapy with micafungin to treat shunt-associated Candida albicans meningitis in an infant.

Cinzia Auriti, Fiammetta Piersigilli, Maria Paola Ronchetti, Francesca Campi, Paolina Giuseppina Amante, Marco Falcone, Bianca Maria Goffredo,

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2016, 71(7):2060-2061]

Cited: 3 times

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The Skin as an Early Expression of Malignancies in the Neonatal Age: A Review of the Literature and a Case Series.

Vito Mondì, Fiammetta Piersigilli, Guglielmo Salvatori, Cinzia Auriti,

Skin lesions are a frequent finding in childhood, from infancy throughout adolescence. They can arise from many conditions, including infections and inflammation. Most neonatal rashes are benign and self-limiting and require no treatment. Other conditions may be an expression of malignancy or may be a marker for other abnormalities, such ... Read more >>

Biomed Res Int (BioMed research international)
[2015, 2015:809406]

Cited: 1 time

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Use of early biomarkers in neonatal brain damage and sepsis: state of the art and future perspectives.

Iliana Bersani, Cinzia Auriti, Maria Paola Ronchetti, Giusi Prencipe, Diego Gazzolo, Andrea Dotta,

The identification of early noninvasive biochemical markers of disease is a crucial issue of the current scientific research, particularly during the first period of life, since it could provide useful and precocious diagnostic information when clinical and radiological signs are still silent. The ideal biomarker should be practical and sensitive ... Read more >>

Biomed Res Int (BioMed research international)
[2015, 2015:253520]

Cited: 4 times

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Kabuki syndrome: clinical and molecular diagnosis in the first year of life.

Maria Lisa Dentici, Alessandra Di Pede, Francesca Romana Lepri, Maria Gnazzo, Mary Haywood Lombardi, Cinzia Auriti, Stefano Petrocchi, Elisa Pisaneschi, Emanuele Bellacchio, Rossella Capolino, Annabella Braguglia, Adriano Angioni, Andrea Dotta, Maria Cristina Digilio, Bruno Dallapiccola,

OBJECTIVE:To review the clinical and molecular genetic characteristics of 16 patients presenting a suspected diagnosis of Kabuki syndrome (KS) in the first year of life, to evaluate the clinical handles leading to a prompt diagnosis of KS in newborns. Clinical diagnosis of KS can be challenging during the first year ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2015, 100(2):158-164]

Cited: 30 times

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MBL2 gene polymorphisms increase the risk of adverse neurological outcome in preterm infants: a preliminary prospective study.

Cinzia Auriti, Giusi Prencipe, Barbara Caravale, Maria Franca Coletti, Maria Paola Ronchetti, Fiammetta Piersigilli, Chiara Azzari, Vincenzo M Di Ciommo,

As described in animal models, the lectin-complement pathway is central to the propagation of ischemia-reperfusion injuries in many tissues, including the brain. Similarly, it might affect the genesis of brain damage in preterm infants. MBL2 gene single-nucleotide polymorphisms (SNPs), regulating mannose-binding lectin (MBL) serum levels, could predict the risk of ... Read more >>

Pediatr. Res. (Pediatric research)
[2014, 76(5):464-469]

Cited: 3 times

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Antifungal lock therapy with combined 70% ethanol and micafungin in a critically ill infant.

Fiammetta Piersigilli, Cinzia Auriti, Iliana Bersani, Bianca Goffredo, Giuseppe Bianco, Imma Savarese, Andrea Dotta,

So-called lock therapy, consisting of high concentrations of antimicrobials instilled into the lumen of the catheter, has been suggested avoid central venous catheter removal during fungal infection. We report a baby who developed catheter-related candidemia. Systemic antifungal treatment did not resolve the candidemia. Lock therapy with 0.3 mL of ethanol ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2014, 33(4):419-420]

Cited: 9 times

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