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Author Cindy K Miranti

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Erratum: Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex.

Cindy K Miranti, Sara Moore, Yongeun Kim, Venkateshwar Reddy Chappeta, Kui Wu, Biswanath De, Vijay Gokhale, Laurence H Hurley, Elsa M Reyes-Reyes,

[This corrects the article DOI: 10.18632/oncotarget.27589.]. ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(26):2586]

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Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer.

Eric A Nollet, Marina Cardo-Vila, Sourik S Ganguly, Jack D Tran, Veronique V Schulz, Anne Cress, Eva Corey, Cindy K Miranti,

The androgen receptor (AR) is the major driver of prostate cancer growth and survival. However, almost all patients relapse with castration-resistant disease (CRPC) when treated with anti-androgen therapy. In CRPC, AR is often aberrantly activated independent of androgen. Targeting survival pathways downstream of AR could be a viable strategy to ... Read more >>

Oncogene (Oncogene)
[2020, 39(31):5390-5404]

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Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex.

Cindy K Miranti, Sara Moore, Yongeun Kim, Venkateshwar Reddy Chappeta, Kui Wu, Biswanath De, Vijay Gokhale, Laurence H Hurley, Elsa M Reyes-Reyes,

The androgen receptor (AR) is a major driver of prostate cancer development and progression. Men who develop advanced prostate cancer often have long-term cancer control when treated with androgen-deprivation therapies (ADT). Still, their disease inevitably becomes resistant to ADT and progresses to castration-resistant prostate cancer (CRPC). ADT involves potent competitive ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(19):1758-1776]

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Notch3 promotes prostate cancer-induced bone lesion development via MMP-3.

Sourik S Ganguly, Galen Hostetter, Lin Tang, Sander B Frank, Kathylynn Saboda, Rohit Mehra, Lisha Wang, Xiaohong Li, Evan T Keller, Cindy K Miranti,

Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with high-grade disease and metastasis. To address how Notch affects prostate cancer bone lesions, we manipulated Notch expression in mouse tibia xenografts and monitored tumor growth, lesion phenotype, and the ... Read more >>

Oncogene (Oncogene)
[2020, 39(1):204-218]

Cited: 1 time

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Hypoxia-induced PIM kinase and laminin-activated integrin α6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC.

Rachel K Toth, Jack D Tran, Michelle T Muldong, Eric A Nollet, Veronique V Schulz, Corbin C Jensen, Lori A Hazlehurst, Eva Corey, Donald Durden, Christina Jamieson, Cindy K Miranti, Noel A Warfel,

Bone-metastatic castration-resistant prostate cancer (CRPC) is lethal due to inherent resistance to androgen deprivation therapy, chemotherapy, and targeted therapies. Despite the fact that a majority of CRPC patients (approximately 70%) harbor a constitutively active PI3K survival pathway, targeting the PI3K/mTOR pathway has failed to increase overall survival in clinical trials. ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(4):297-312]

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Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell-Cell Biophysical Properties in Prostate Cancer.

Cynthia S Rubenstein, Jaime M C Gard, Mengdie Wang, Julie E McGrath, Nadia Ingabire, James P Hinton, Kendra D Marr, Skyler J Simpson, Raymond B Nagle, Cindy K Miranti, Noel A Warfel, Joe G N Garcia, Hina Arif-Tiwari, Anne E Cress,

Human prostate cancer confined to the gland is indolent (low-risk), but tumors outside the capsule are aggressive (high-risk). Extracapsular extension requires invasion within and through a smooth muscle-structured environment. Because integrins respond to biomechanical cues, we used a gene editing approach to determine if a specific region of laminin-binding α6β1 ... Read more >>

Cancer Res. (Cancer research)
[2019, 79(18):4703-4714]

Cited: 0 times

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Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82.

Alexis Bergsma, Sourik S Ganguly, Mollie E Wiegand, Daniel Dick, Bart O Williams, Cindy K Miranti,

We used a myeloid-specific Cre to conditionally delete CD82 in mouse osteoclasts and their precursors. In contrast to global loss of CD82 (gKO), conditional loss of CD82 (cKO) in osteoclasts does not affect cortical bone, osteoblasts, or adipocytes. CD82 loss results in greater trabecular volume and trabecular number but reduced ... Read more >>

Bone Rep (Bone reports)
[2019, 10:100196]

Cited: 0 times

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Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis.

Alexis Bergsma, Sourik S Ganguly, Daniel Dick, Bart O Williams, Cindy K Miranti,

CD82 is a widely expressed member of the tetraspanin family of transmembrane proteins known to control cell signaling, adhesion, and migration. Tetraspanin CD82 is induced over 9-fold during osteoclast differentiation in vitro; however, its role in bone homeostasis is unknown. A globally deleted CD82 mouse model was used to assess ... Read more >>

Bone (Bone)
[2018, 113:105-113]

Cited: 4 times

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Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC.

Sander B Frank, Penny L Berger, Mats Ljungman, Cindy K Miranti,

Many pathways dysregulated in prostate cancer are also involved in epithelial differentiation. To better understand prostate tumor initiation, we sought to investigate specific genes and mechanisms required for normal basal to luminal cell differentiation. Utilizing human prostate basal epithelial cells and an in vitro differentiation model, we tested the hypothesis ... Read more >>

J. Cell. Sci. (Journal of cell science)
[2017, 130(11):1952-1964]

Cited: 8 times

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Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation.

Penny L Berger, Mary E Winn, Cindy K Miranti,

BACKGROUND:How prostate epithelial cells differentiate and how dysregulation of this process contributes to prostate tumorigenesis remain unclear. We recently identified a Myc target and chromatin reader protein, ING4, as a necessary component of human prostate luminal epithelial cell differentiation, which is often lost in primary prostate tumors. Furthermore, loss of ... Read more >>

Prostate (The Prostate)
[2017, 77(1):49-59]

Cited: 3 times

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Homozygous loss of mouse tetraspanin CD82 enhances integrin αIIbβ3 expression and clot retraction in platelets.

Kristen Uchtmann, Electa R Park, Alexis Bergsma, Justin Segula, Mathew J Edick, Cindy K Miranti,

Integrin αIIbβ3 is critical for platelet-mediated blood clotting. Tetraspanins are well-established regulators of integrins and genetic loss of tetraspanin CD151 or TSSC6 in mice leads to increased bleeding due to inadequate integrin αIIbβ3 outside-in signaling. Conversely, mild but enhanced integrin αIIbβ3 activation and hyperaggregation is observed in CD9 and CD63 ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2015, 339(2):261-269]

Cited: 8 times

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The importance of non-nuclear AR signaling in prostate cancer progression and therapeutic resistance.

Jelani C Zarif, Cindy K Miranti,

The androgen receptor (AR) remains the major oncogenic driver of prostate cancer, as evidenced by the efficacy of androgen deprivation therapy (ADT) in naïve patients, and the continued effectiveness of second generation ADTs in castration resistant disease. However, current ADTs are limited to interfering with AR ligand binding, either through ... Read more >>

Cell. Signal. (Cellular signalling)
[2016, 28(5):348-356]

Cited: 17 times

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Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1.

Lia Tesfay, Veronique V Schulz, Sander B Frank, Laura E Lamb, Cindy K Miranti,

Matrix adhesion via integrins is required for cell survival. Adhesion of epithelial cells to laminin via integrin α3β1 was previously shown to activate at least two independent survival pathways. First, integrin α3β1 is required for autophagy-induced cell survival after growth factor deprivation. Second, integrin α3β1 independently activates two receptor tyrosine ... Read more >>

Mol. Biol. Cell (Molecular biology of the cell)
[2016, 27(15):2493-2504]

Cited: 6 times

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Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase.

Jelani C Zarif, Laura E Lamb, Veronique V Schulz, Eric A Nollet, Cindy K Miranti,

Castration-resistant prostate cancers still depend on nuclear androgen receptor (AR) function despite their lack of dependence on exogenous androgen. Second generation anti-androgen therapies are more efficient at blocking nuclear AR; however resistant tumors still develop. Recent studies indicate Src is highly active in these resistant tumors. By manipulating AR activity ... Read more >>

Oncotarget (Oncotarget)
[2015, 6(9):6862-6876]

Cited: 19 times

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Hepcidin regulation in prostate and its disruption in prostate cancer.

Lia Tesfay, Kathryn A Clausen, Jin Woo Kim, Poornima Hegde, Xiaohong Wang, Lance D Miller, Zhiyong Deng, Nicole Blanchette, Tara Arvedson, Cindy K Miranti, Jodie L Babitt, Herbert Y Lin, Donna M Peehl, Frank M Torti, Suzy V Torti,

Hepcidin is a circulating peptide hormone made by the liver that is a central regulator of systemic iron uptake and recycling. Here, we report that prostate epithelial cells also synthesize hepcidin, and that synthesis and secretion of hepcidin are markedly increased in prostate cancer cells and tissue. Prostatic hepcidin functions ... Read more >>

Cancer Res. (Cancer research)
[2015, 75(11):2254-2263]

Cited: 51 times

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The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis.

Sourik S Ganguly, Xiaohong Li, Cindy K Miranti,

Prostate cancer (PCa) is the second leading cause of cancer death in men worldwide. Most PCa deaths are due to osteoblastic bone metastases. What triggers PCa metastasis to the bone and what causes osteoblastic lesions remain unanswered. A major contributor to PCa metastasis is the host microenvironment. Here, we address ... Read more >>

Front Oncol (Frontiers in Oncology)
[2014, 4:364]

Cited: 22 times

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Transient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis.

Penny L Berger, Sander B Frank, Veronique V Schulz, Eric A Nollet, Mathew J Edick, Brittany Holly, Ting-Tung A Chang, Galen Hostetter, Suwon Kim, Cindy K Miranti,

The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer development are poorly understood. We identified the chromatin remodeling protein, ING4, as a crucial switch downstream of Myc and Pten that is required for human prostate epithelial differentiation. Myc-induced transient expression of ING4 is required for the differentiation ... Read more >>

Cancer Res. (Cancer research)
[2014, 74(12):3357-3368]

Cited: 16 times

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Disruption of prostate epithelial differentiation pathways and prostate cancer development.

Sander B Frank, Cindy K Miranti,

One of the foremost problems in the prostate cancer (PCa) field is the inability to distinguish aggressive from indolent disease, which leads to difficult prognoses and thousands of unnecessary surgeries. This limitation stems from the fact that the mechanisms of tumorigenesis in the prostate are poorly understood. Some genetic alterations ... Read more >>

Front Oncol (Frontiers in Oncology)
[2013, 3:273]

Cited: 20 times

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Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases.

Canan Akfirat, Xiaotun Zhang, Aviva Ventura, Dror Berel, Mary E Colangelo, Cindy K Miranti, Maryla Krajewska, John C Reed, Celestia S Higano, Lawrence D True, Robert L Vessella, Colm Morrissey, Beatrice S Knudsen,

The complexity of survival mechanisms in cancer cells from patients remains poorly understood. To obtain a comprehensive picture of tumour cell survival in lethal prostate cancer metastases, we examined five survival proteins that operate within three survival pathways in a cohort of 185 lethal metastatic prostate metastases obtained from 44 ... Read more >>

J. Pathol. (The Journal of pathology)
[2013, 230(3):291-297]

Cited: 16 times

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The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling.

Laura E Lamb, Jelani C Zarif, Cindy K Miranti,

Recent studies indicate that androgen receptor (AR) signaling is critical for prostate cancer cell survival, even in castration-resistant disease wherein AR continues to function independently of exogenous androgens. Integrin-mediated adhesion to the extracellular matrix is also important for prostate cell survival. AR-positive prostate cancer cells express primarily integrin α6β1 and ... Read more >>

Cancer Res. (Cancer research)
[2011, 71(7):2739-2749]

Cited: 33 times

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E-cadherin-mediated survival of androgen-receptor-expressing secretory prostate epithelial cells derived from a stratified in vitro differentiation model.

Laura E Lamb, Beatrice S Knudsen, Cindy K Miranti,

The androgen receptor (AR) is expressed in differentiated secretory prostate epithelial cells in vivo. However, in the human prostate, it is unclear whether androgens directly promote the survival of secretory cells, or whether secretory cells survive through androgen-dependent signals from the prostate stroma. Biochemical and mechanistic studies have been hampered ... Read more >>

J. Cell. Sci. (Journal of cell science)
[2010, 123(Pt 2):266-276]

Cited: 31 times

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Src, PKCalpha, and PKCdelta are required for alphavbeta3 integrin-mediated metastatic melanoma invasion.

Andrew J Putnam, Veronique V Schulz, Eric M Freiter, Heather M Bill, Cindy K Miranti,

BACKGROUND: Integrins, cell-surface receptors that mediate adhesive interactions between cells and the extracellular matrix (ECM), play an important role in cancer progression. Expression of the vitronectin receptor alphavbeta3 integrin correlates with increased invasive and metastatic capacity of malignant melanomas, yet it remains unclear how expression of this integrin triggers melanoma ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2009, 7:10]

Cited: 21 times

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Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death.

Mathew J Edick, Lia Tesfay, Laura E Lamb, Beatrice S Knudsen, Cindy K Miranti,

In vivo in the prostate gland, basal epithelial cells adhere to laminin 5 (LM5) via alpha3beta1 and alpha6beta4 integrins. When placed in culture primary prostate basal epithelial cells secrete and adhere to their own LM5-rich matrix. Adhesion to LM5 is required for cell survival that is dependent on integrin-mediated, ligand-independent ... Read more >>

Mol. Biol. Cell (Molecular biology of the cell)
[2007, 18(7):2481-2490]

Cited: 45 times

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In vitro efficacy of immuno-chemotherapy with anti-EGFR human Fab-Taxol conjugate on A431 epidermoid carcinoma cells.

Xin Wang, Jin Zhu, Ping Zhao, Yongjun Jiao, Ning Xu, Tessa Grabinski, Chao Liu, Cindy K Miranti, Tao Fu, Brian B Cao,

The aims of this study were to generate a human Fab fragment against EGFR; conjugate it to paclitaxel (Taxol) as an immuno-chemotherapy agent; and investigate its in vitro anti-tumor efficacy on A431 epidermoid carcinoma cells. A431 cells (EGFR-positive), NIH 3T3 cells (EGFR-negative), and purified EGFR were used for subtractive panning ... Read more >>

Cancer Biol. Ther. (Cancer biology & therapy)
[2007, 6(6):980-987]

Cited: 8 times

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The impact of cell adhesion changes on proliferation and survival during prostate cancer development and progression.

Beatrice S Knudsen, Cindy K Miranti,

In the normal prostate epithelium, androgen receptor (AR) negative basal epithelial cells adhere to the substratum, while AR expressing secretory cells lose substratum adhesion. In contrast, prostate cancer cells both express AR and adhere to a tumor basement membrane. In this review, we describe the differential expression of integrins, growth ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2006, 99(2):345-361]

Cited: 28 times

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