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High Plasma Levels of Aβ1-42 Affect Monocytes and Macrophages via Biphasic Effects on Myeloid-Derived Suppressor Cells and Granulocyte-Monocyte Progenitors in Mouse Models of Alzheimer’s Disease

Chunrong Li, Kangding Liu, Jie Zhu, Feiqi Zhu,

<h4>Background: </h4> Microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD). Plasma Aβ 1-42 levels significantly increase 15 years before the onset of dominantly inherited AD. The effects of high plasma levels of Aβ 1-42 on monocytes and macrophages, the hematogenous counterparts of microglia, remain unclear. <h4>Methods: ... Read more >>

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High Plasma Llevels of Aβ1-42 Affect Monocytes and Macrophages via Biphasic Effects on Myeloid-Derived Suppressor Cells and Granulocyte-Monocyte Progenitors in Mouse Models of Alzheimer’s Disease

Chunrong Li, Kangding Liu, Jie Zhu, Feiqi Zhu,

Backgroud : Microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD). Plasma Aβ 1-42 levels significantly increase 15 years before the onset of dominantly inherited AD. The effects of high plasma levels of Aβ 1-42 on monocytes and macrophages, the hematogenous counterparts of microglia, remain unclear. <h4>Methods: ... Read more >>

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Can Control Infections Slow Down the Progression of Alzheimer's Disease? Talking About the Role of Infections in Alzheimer's Disease.

Mingchao Shi, Chunrong Li, Xiaoping Tian, Fengna Chu, Jie Zhu,

Alzheimer's disease as the most common age-related dementia affects more than 40 million people in the world, representing a global public health priority. However, the pathogenesis of Alzheimer's disease (AD) is complex, and it remains unclear. Over the past decades, all efforts made in the treatments of AD, with targeting ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2021, 13:685863]

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Nuclear factor kappa B inhibitor suppresses experimental autoimmune neuritis in mice via declining macrophages polarization to M1 type.

Donghui Shen, Fengna Chu, Yue Lang, Chao Zheng, Chunrong Li, Kangding Liu, Jie Zhu,

Guillain-Barré syndrome (GBS) is an acute inflammatory and immune-mediated demyelinating disease of the peripheral nervous system (PNS). Macrophages play a central role in its animal model, experimental autoimmune neuritis (EAN), which has been well accepted. Additionally, nuclear factor (NF)-κB inhibitors have been used to treat cancers and have shown beneficial ... Read more >>

Clin Exp Immunol (Clinical and experimental immunology)
[2021, 206(1):110-117]

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Cancer cell identification by facile imaging of intracellular reductive substances with fluorescent nanosensor.

Chunrong Li, Yuzhi Xu, Si-Yang Liu, Yanfei Zhang, Wen Yin, Zong Dai, Xiaoyong Zou,

Ascorbic acid (AA) and glutathione (GSH), the most abundant intracellular reductive substances, have been widely used as biomarkers for cancer cells identification. The current methods relying on imaging of AA or GSH alone to identify cancer cells may cause systematic errors, since a mutual conversion relationship exists between AA and ... Read more >>

Talanta (Talanta)
[2021, 234:122650]

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Catechin-grafted arabinoxylan conjugate: Preparation, structural characterization and property investigation.

Qingbin Guo, Xingyue Xiao, Chunrong Li, Ji Kang, Guorong Liu, H Douglas Goff, Changlu Wang,

In this study, a high molecular weight arabinoxylan (AX, Mw: 694 kDa) from wheat bran was alkaline extracted and covalently linked with Catechin (CA) by free radical catalytic reaction. Comparing to AX, arabinoxylan-catechin (AX-CA) conjugates demonstrated an extra UV-vis absorption peak at 274 nm, a new FT-IR absorption band at ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 182:796-805]

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NF-κB inhibitor suppresses experimental autoimmune neuritis in mice via declining macrophages polarization to M1 type

Donghui Shen, Fengna Chu, Yue Lang, Chao Zheng, Chunrong Li, Xiangyu Zheng, Jie Zhu,

Guillain–Barre’ syndrome (GBS) is an acute inflammatory and immune-mediated demyelinating disease of peripheral nervous system (PNS). Macrophages playing a central role in its animal model, experimental autoimmune neuritis (EAN) has been well-accepted. Additionally, NF-κB inhibitors has been used to treat cancers and showed beneficial effects. Here we investigated the therapeutic ... Read more >>

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Long Noncoding RNA Expression Profiles of Periodontal Ligament Stem Cells from the Periodontitis Microenvironment in Response to Static Mechanical Strain.

Jia Liu, Yan Zhao, Qiannan Niu, Ni Qiu, Shuangyun Liu, Chunrong Li, Cuixia Li, Pei Miao, Libo Yan, Qiang Li, Zuolin Jin,

During the period of orthodontic tooth movement, periodontal ligament stem cells (PDLSCs) play an important role in transducing mechanical stimulation and tissue remodeling. However, our previous studies verified that the periodontitis microenvironment causes damage to the biological functions of PDLSCs and abnormal mechanical sensitivity. Long noncoding RNAs (lncRNAs) participate in ... Read more >>

Stem Cells Int (Stem cells international)
[2021, 2021:6655526]

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Parity and the risks of adverse birth outcomes: a retrospective study among Chinese.

Li Lin, Ciyong Lu, Weiqing Chen, Chunrong Li, Vivian Yawei Guo,

<h4>Background</h4>Nulliparity is considered to be a risk factor of preterm birth (PTB), low birth weight (LBW) and small for gestational age (SGA). With the new two-child policy launched in 2016, more Chinese women have delivered their 2nd baby. Yet few studies have assessed the impact of parity on adverse birth ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):257]

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Associations between risk factors for cardiovascular diseases and frailty among community-dwelling older adults in Lanzhou, China.

Yanhong Wang, Hae-Ra Han, Wei Yang, Hongchen Zhang, Jing Zhang, Haihui Ruan, Nan Tang, Jingjing Ren, Xia Sun, Chunrong Li, Lin Han,

<h4>Objectives</h4>To examine the relationship between cardiovascular disease risk factors and frailty in a sample of older Chinese adults.<h4>Methods</h4>A total of 458 community-dwelling older adults (≥65 years) in Lanzhou, Gansu Province of China participated in a cross-sectional survey. Their status was evaluated in terms of frailty phenotype (unintentional weight loss, exhaustion, ... Read more >>

Int J Nurs Sci (International journal of nursing sciences)
[2021, 8(2):168-174]

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Correction to: WeChat-based intervention to support breastfeeding for Chinese mothers: protocol of a randomised controlled trial.

Li Tang, Andy H Lee, Colin W Binns, Lian Duan, Yi Liu, Chunrong Li,

BMC Med Inform Decis Mak (BMC medical informatics and decision making)
[2021, 21(1):46]

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The therapeutic effects of ginkgolides in Guillain-Barré syndrome and experimental autoimmune neuritis.

Chunrong Li, Shan Liu, Qiaolifan Aerqin, Donghui Shen, Xiujuan Wu, Kangding Liu,

<h4>Background</h4>Guillain-Barré syndrome (GBS) is an acquired immune-mediated inflammatory peripheral neuropathy. The immune regulation of ginkgolides have been revealed in recent years. We herein investigate the potential therapeutic effects of ginkgolides both on GBS and its animal model, experimental autoimmune neuritis (EAN).<h4>Methods</h4>EAN in C57BL/6 mice induced by subcutaneous injection with peripheral ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2021, 87:44-49]

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Polysaccharide from Pleurotus nebrodensis: Physicochemical, structural characterization and in vitro fermentation characteristics.

Yingying Gao, Qingbin Guo, Kunlin Zhang, Nifei Wang, Chunrong Li, Zhenjing Li, Ailin Zhang, Changlu Wang,

A high Mw (5012 kDa) polysaccharide (PNPS) from the fruiting body of Pleurotus nebrodensis was isolated using water extraction followed by ethanol precipitation. The structural characteristics and in vitro fermentation behaviors of this polysaccharide was investigated. Chemical composition analysis showed the total sugar content of PNPS was up to 97.20 ± 1.80 wt%. Monosaccharide ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2020, 165(Pt B):1960-1969]

Cited: 3 times

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WeChat-based intervention to support breastfeeding for Chinese mothers: protocol of a randomised controlled trial.

Li Tang, Andy H Lee, Colin W Binns, Lian Duan, Yi Liu, Chunrong Li,

<h4>Background</h4>Exclusive breastfeeding for the first 6 months of life is the optimal way to feed infants. However, recent studies suggest that exclusive breastfeeding rates in China remain low and are well below the recommended target. There has been evidence that a lack of awareness of, or exposure to, breastfeeding information ... Read more >>

BMC Med Inform Decis Mak (BMC medical informatics and decision making)
[2020, 20(1):300]

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The Prevention and Control Experience of Maternal Health Care from Chengu, China During the COVID-19 Epidemic.

Chunrong Li, Li Tang, Yingjuan Luo, Ting Lai, Lingling Gu, Yumei Wang, Liu Yang, Longrong Ran, Rongkang Wen, Yonghong Lin,

Four months after the first case of COVID-19 was diagnosed in Wuhan, the national epidemic has been effectively controlled in China. In Chengdu, the capital city of Sichuan Province, several management measures, which have been proven to be effective, are taken to prevent pregnant women from being infected with COVID-19. ... Read more >>

Risk Manag Healthc Policy (Risk management and healthcare policy)
[2020, 13:2213-2217]

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Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer's Disease.

Feiqi Zhu, Chunrong Li, Fengna Chu, Xiaoping Tian, Jie Zhu,

Alzheimer's disease (AD) is commonly an age-associated dementia with neurodegeneration. The pathogenesis of AD is complex and still remains unclear. The inflammation, amyloid β (Aβ), and neurofibrillary tangles as well misfolded tau protein in the brain may contribute to the occurrence and development of AD. Compared with tau protein, Aβ ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:544235]

Cited: 7 times

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A Rice NBS-ARC Gene Conferring Quantitative Resistance to Bacterial Blight Is Regulated by a Pathogen Effector-Inducible miRNA.

Guanghuai Jiang, Dongfeng Liu, Dedong Yin, Zhuangzhi Zhou, Yue Shi, Chunrong Li, Lihuang Zhu, Wenxue Zhai,

The bacterium Xanthomonas oryzae pv. Oryzae (Xoo) causes blight in rice worldwide, resulting in significant crop loss. However, no gene underlying a quantitative trait locus (QTL) for resistance against Xoo has been cloned yet. Here, we report the map-based cloning of a QTL, in which the NBS8R gene confers quantitative ... Read more >>

Mol Plant (Molecular plant)
[2020, 13(12):1752-1767]

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Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis.

Jie Liu, Chunrong Li, Xiaoyang Zhou, Jian Sun, Meng Zhu, Hongliang Zhang, Lei Cheng, Guobin Li, Tao He, Wenshuai Deng,

<h4>Objective</h4>In recent years, a number of case-control studies have focused on the association between the <i>DJ-1</i> g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the <i>DJ-1</i> g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed.<h4>Methods</h4>Eligible studies concerning ... Read more >>

J Int Med Res (The Journal of international medical research)
[2020, 48(8):300060520947943]

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Association between social support and anxiety among pregnant women in the third trimester during the coronavirus disease 2019 (COVID-19) epidemic in Qingdao, China: The mediating effect of risk perception.

Chongyu Yue, Cuiping Liu, Jing Wang, Meng Zhang, Hongjing Wu, Chunrong Li, Xiuling Yang,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) is a public health emergency of international concern and poses a threat to the mental health of pregnant women.<h4>Aim</h4>The purpose of this study was to investigate the relationship between social support and anxiety, and the mediating effect of risk perception during the COVID-19 epidemic in the ... Read more >>

Int J Soc Psychiatry (The International journal of social psychiatry)
[2021, 67(2):120-127]

Cited: 19 times

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Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures.

Chunrong Li, Kangding Liu, Shan Liu, Qiaolifan Aerqin, Xiujuan Wu,

The inflammatory immune response (IIR) is a physiological or excessive systemic response, induced by inflammatory immune cells according to changes in the internal and external environments. An excessive IIR is the pathological basis for the generation and development of neurological diseases. Ginkgolides are one of the important medicinal ingredients in ... Read more >>

Front Syst Neurosci (Frontiers in systems neuroscience)
[2020, 14:45]

Cited: 3 times

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OsNPR3.3-dependent salicylic acid signaling is involved in recessive gene xa5-mediated immunity to rice bacterial blight.

Guanghuai Jiang, Dedong Yin, Yue Shi, Zhuangzhi Zhou, Chunrong Li, Pengcheng Liu, Yanfeng Jia, Yanyan Wang, Zhenzhen Liu, Minxiang Yu, Xianghong Wu, Wenxue Zhai, Lihuang Zhu,

Salicylic acid (SA) is a key natural component that mediates local and systemic resistance to pathogens in many dicotyledonous species. However, its function is controversial in disease resistance in rice plants. Here, we show that the SA signaling is involved in both pathogen-associated-molecular-patterns triggered immunity (PTI) and effector triggered immunity ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):6313]

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Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats.

Chunrong Li, Xin Li, Xian Wang, Pei Miao, Jia Liu, Cuixia Li, Doudou Li, Weiwei Zhou, Zuolin Jin, Meng Cao,

Osteoporosis is a metabolic disease that results in the progressive loss of bone mass, which, in postmenopausal women, is related to oestrogen deficiency. Periostin (POSTN) plays a key role in the early stages of bone formation. However, whether POSTN participates in oestradiol regulation of osteogenic differentiation of bone marrow stromal ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:9405909]

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Dietary Inflammatory Index and Epithelial Ovarian Cancer in Southern Chinese Women: A Case-Control Study.

Li Tang, Ngoc Minh Pham, Andy H Lee, Nitin Shivappa, James R Hébert, Jian Zhao, Dada Su, Colin W Binns, Chunrong Li,

The association between inflammatory properties of diet and ovarian cancer risk has been investigated in some Western populations. However, little evidence is available from Asian women whose ovarian cancer incidence rates are low and dietary and lifestyle patterns are very different from their Western counterparts. We aimed to examine whether ... Read more >>

Cancer Control (Cancer control : journal of the Moffitt Cancer Center)
[2020, 27(1):1073274820977203]

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Characteristic Dissection of Xanthomonas oryzae pv. oryzae Responsive MicroRNAs in Rice.

Yanfeng Jia, Chunrong Li, Quanlin Li, Pengcheng Liu, Dongfeng Liu, Zhenzhen Liu, Yanyan Wang, Guanghuai Jiang, Wenxue Zhai,

MicroRNAs (miRNAs) are crucial player in plant-pathogen interaction. While the evidence has demonstrated that rice miRNAs mediate immune response to pathogens invasion, the roles of miRNAs on Xanthomonas oryzae pv. oryzae (Xoo) attack remain be in place. Herein, we monitored the responsive changes of rice miRNAs at 0, 8, 24 ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

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TALEN-based editing of TFIIAy5 changes rice response to Xanthomonas oryzae pv. Oryzae.

Jin Han, Zhihui Xia, Pengcheng Liu, Chunrong Li, Yanyan Wang, Lequn Guo, Guanghuai Jiang, Wenxue Zhai,

The xa5 gene encodes a basal transcription factor (TFIIAγ) protein with wide spectrum resistance to bacterial blight caused by Xanthomonas oryzae pv. Oryzae (Xoo) in rice. It was only found in a few rice ecotypes, and the recessive characteristics limited its application in breeding. Here, we employed a TALEN-based technique ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2036]

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