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Author Chunhua Zhou

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The optical properties of Cs4PbBr6-CsPbBr3 perovskite composites.

Zhixing Gan, Fei Zheng, Wenxin Mao, Chunhua Zhou, Weijian Chen, Udo Bach, Patrick Tapping, Tak W Kee, Jeffrey A Davis, Baohua Jia, Xiaoming Wen,

Although the optoelectronic applications of metal halide perovskites have been intensively investigated in recent years, the fundamental carrier dynamics of zero-dimensional (0D) Cs4PbBr6 perovskites has been relatively underexplored; in particular, the nature of the green fluorescence is highly debated. Nevertheless, the unique photophysical properties are of immense interest for a ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(31):14676-14683]

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MiR-185-3p mimic promotes the chemosensitivity of CRC cells via AQP5.

Chunhua Zhou, Wencheng Kong, Tongfa Ju, Qi Xie, Lulu Zhai,

BACKGROUND:Studies showed that microRNAs (miRNAs) are important regulators in drug resistance. The current study investigated the role of miR-185-3p and its predicted target gene AQP5 in 5-FU-insensitive colorectal cancer (CRC) cells. METHODS:Quantitative real-time polymerase chain reaction (qRT-PCR) and Spearman's correlation analysis were conducted to determine the correlation of expression levels ... Read more >>

Cancer Biol. Ther. (Cancer biology & therapy)
[2020, :1-9]

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Metformin Enhances Antidepressant/Antipsychotic Combination Therapy of Schizophrenia With Comorbid Depression in a Murine Model.

Chunhua Zhou, Dezhi Kong, Rong Xue, Min Chen, Gongying Li, Yong Xu, Sha Liu, Hongjun Tian, Chuanjun Zhuo,

Comorbid depressive disorders confound the diagnosis and therapy of schizophrenia. Using a murine model incorporating both MK801 and chronic unpredictable mild stress exposures, we successfully replicated both psychosis and depression. Ex vivo patch clamp recordings and in vivo calcium imaging demonstrated impaired neural activity in the prefrontal cortex (PFC). We ... Read more >>

Front Neurosci (Frontiers in Neuroscience)
[2020, 14:517]

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Bifidobacterium longum alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation.

Chunhua Zhou, Xue Fang, Jiajia Xu, Jun Gao, Ling Zhang, Jiulong Zhao, Yuting Meng, Wei Zhou, Xu Han, Yu Bai, Zhaoshen Li, Duowu Zou,

Although the oral administration of Bifidobacterium longum (B. longum) relieves the signs of irritable bowel syndrome (IBS) in clinical settings, the mechanisms underlying its effects are unclear. In this study, we evaluated the precise effects of B. longum on IBS via regulation of Paneth cell function. We confirmed the beneficial ... Read more >>

Gut Microbes (Gut microbes)
[2020, :1-17]

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Transient effects of multi-infusion ketamine augmentation on treatment-resistant depressive symptoms in patients with treatment-resistant bipolar depression - An open-label three-week pilot study.

Chuanjun Zhuo, Feng Ji, Hongjun Tian, Lina Wang, Feng Jia, Deguo Jiang, Ce Chen, Chunhua Zhou, Xiaodong Lin, Jingjing Zhu,

INTRODUCTION:While the psychiatric benefits of ketamine have been verified through clinical trials, there is limited information about ketamine augmentation in patients with treatment-resistant bipolar depression (TRBPD). Hence, in the present study, we investigate the therapeutic efficacy and functional brain alterations associated with multi-infusion ketamine augmentation in patients with TRBPD. METHODS:The ... Read more >>

Brain Behav (Brain and behavior)
[2020, :e01674]

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Efficient Energy Funnelling by Engineering Bandgap of Perovskite: Förster Resonance Energy Transfer or Charge Transfer?

Zhixing Gan, Weijian Chen, Chunhua Zhou, Liyan Yu, Lifeng Dong, Baohua Jia, Xiaoming Wen,

Energy funnelling enables directional carrier transfer along cascaded energy level, which can be employed to significantly improve energy transfer efficiency and photoelectronic performances. However, the exact mechanism is still under intensive debate on whether Förster resonance energy transfer (FRET) or charge transfer (CT) is playing the dominant role, hindering broad ... Read more >>

J Phys Chem Lett (The journal of physical chemistry letters)
[2020, :]

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Revealing the Role of Methylammonium Chloride for Improving the Performance of 2D Perovskite Solar Cells.

Fei Zheng, Chuantian Zuo, Mengsi Niu, Chunhua Zhou, Siobhan J Bradley, Christopher R Hall, Weilong Xu, Xiaoming Wen, Xiaotao Hao, Mei Gao, Trevor A Smith, Kenneth P Ghiggino,

Layered perovskite films, composed of two-dimensional (2D) Ruddlesden-Popper perovskites (RPPs), show improved stability compared to their conventional three-dimensional (3D) counterparts in perovskite solar cells (PSCs). However, 2D PSCs exhibit a lower power conversion efficiency (PCE), which has been attributed to compositional inhomogeneity and nonuniform alignment of the 2D perovskite phases. ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(23):25980-25990]

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Determining In-Plane Carrier Diffusion in Two-Dimensional Perovskite Using Local Time-Resolved Photoluminescence.

Chunhua Zhou, Weijian Chen, Shuang Yang, Qingdong Ou, Zhixing Gan, Qiaoliang Bao, Baohua Jia, Xiaoming Wen,

The diffusion length of photogenerated carriers is a crucial parameter in semiconductors for optoelectronic applications. However, it is a challenging task to determine the diffusion length in layered nanoplatelets due to their anisotropic diffusion of photogenerated carriers and nanometer-thin thickness. Here, we demonstrate a novel method to determine the in-plane ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(23):26384-26390]

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Analysis of vaginal delivery outcomes among pregnant women in Wuhan, China during the COVID-19 pandemic.

Jing Liao, Xiaoyan He, Qing Gong, Lingyun Yang, Chunhua Zhou, Jiafu Li,

OBJECTIVE:To study vaginal delivery outcomes and neonatal prognosis and summarize the management of vaginal delivery during the COVID-19 pandemic. METHODS:A retrospective analysis of medical records and comparison of vaginal delivery outcomes between 10 pregnant women with clinical diagnosis of COVID-19 and 53 pregnant women without COVID-19 admitted to Zhongnan Hospital ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, 150(1):53-57]

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Depressive symptoms combined with auditory hallucinations are accompanied with severe gray matter brain impairments in patients with first-episode untreated schizophrenia - A pilot study in China.

Chuanjun Zhuo, Xuexin Xu, Xiaodong Lin, Min Chen, Feng Ji, Deguo Jiang, Yong Xu, Lina Wang, Yancheng Li, Hongjun Tian, Wenqiang Wang, Chunhua Zhou,

BACKGROUND:Depressive symptoms and auditory hallucinations (AHs) are often accompanied by gray matter volume (GMV) alterations in schizophrenia. However, little is known about the effects of concurrent depressive symptoms and AHs on the GMV of patients with schizophrenia. AIM:To investigate the pathological features of gray brain matter in patients with first-episode ... Read more >>

Neurosci. Lett. (Neuroscience letters)
[2020, 730:135033]

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Antipsychotic agents deteriorate brain and retinal function in schizophrenia patients with combined auditory and visual hallucinations: A pilot study and secondary follow-up study.

Chuanjun Zhuo, Bo Xiao, Ce Chen, Deguo Jiang, Gongying Li, Xiaoyan Ma, Ranli Li, Lina Wang, Yong Xu, Chunhua Zhou, Xiaodong Lin,

INTRODUCTION:Schizophrenia patients often experience auditory hallucinations (AHs) and visual hallucinations (VHs). However, the degree and type of brain and retinal alterations associated with combined AHs and VHs in schizophrenia patients remain unknown. There is an urgent need for a study that investigates the trajectory of brain and retinal alterations in ... Read more >>

Brain Behav (Brain and behavior)
[2020, 10(6):e01611]

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A typical antipsychotic treatment induced gradually expanding white matter alterations in healthy individuals with persistent auditory verbal hallucinations-an artificially controlled pilot study.

Xiaodong Lin, Gongying Li, Feng Ji, Langlang Cheng, Guangdong Chen, Wei Zhang, Zhonghua Su, Zhenqing Zhang, Wenqiang Wang, Chunhua Zhou, Yong Xu, Chuanjun Zhuo,

Objective: The aim of this study was to explore the effects of atypical antipsychotics (AaPs) on brain white matter (WM) tracts in healthy individuals with auditory verbal hallucinations (Hi-AVHs).Methods: We analyzed neuroimaging, AVH symptoms, and cognitive assessment data obtained from 39 Hi-AVHs who reported being distressed by persistent AVHs and ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-8]

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BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling.

Shengyong Yu, Chunhua Zhou, Shangtao Cao, Jiangping He, Baomei Cai, Kaixin Wu, Yue Qin, Xingnan Huang, Lizhan Xiao, Jing Ye, Shuyang Xu, Wenxiu Xie, Junqi Kuang, Shilong Chu, Jing Guo, He Liu, Wei Pang, Lin Guo, Mengying Zeng, Xiaoshan Wang, Rongping Luo, Chen Li, Guoqing Zhao, Bo Wang, Linlin Wu, Jiekai Chen, Jing Liu, Duanqing Pei,

BMP4 regulates a plethora of developmental processes, including the dorsal-ventral axis and neural patterning. Here, we report that BMP4 reconfigures the nuclear architecture during the primed-to-naive transition (PNT). We first established a BMP4-driven PNT and show that BMP4 orchestrates the chromatin accessibility dynamics during PNT. Among the loci opened early ... Read more >>

Nat. Cell Biol. (Nature cell biology)
[2020, 22(6):651-662]

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A unified model of shared brain structural alterations in patients with different mental disorders who experience own-thought auditory verbal hallucinations-A pilot study.

Chuanjun Zhuo, Chunxiang Wang, Xueqin Song, Xuexin Xu, Gongying Li, Xiaodong Lin, Yong Xu, Hongjun Tian, Deguo Jiang, Wenqiang Wang, Chunhua Zhou,

OBJECTIVE:To explore shared brain structural alterations in patients diagnosed with mental disorders who experience own-thought auditory verbal hallucinations (OTAVHs). METHODS:A cohort of 143 first-diagnosis, nonmedicated patients with OTAVHs was enrolled: 25 with schizophrenia (FUSCH-OTAVH), 20 with major depression disorder (FUMDD-OTAVH), 28 with bipolar disorder (FUBD-OTAVH), 22 patients with posttraumatic stress ... Read more >>

Brain Behav (Brain and behavior)
[2020, 10(6):e01614]

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Abberant inverted U-shaped brain pattern and trait-related retinal impairment in schizophrenia patients with combined auditory and visual hallucinations: a pilot study.

Chuanjun Zhuo, Bo Xiao, Ce Chen, Deguo Jiang, Gongying Li, Xiaoyan Ma, Ranli Li, Lina Wang, Yong Xu, Chunhua Zhou, Xiaodong Lin,

Schizophrenic patients often experience auditory hallucinations (AHs) and visual hallucinations (VHs). However, brain and retinal alterations associated with combined AHs and VHs in schizophrenic patients are unknown. This study aimed o investigate brain and retinal alterations in first episode un-treated schizophrenic patients with combined AHs and VHs (FUSCHAV). FUSCHAV patients ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2020, :]

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Predicting COVID-19 malignant progression with AI techniques

Xiang Bai, Cong Fang, Yu Zhou, Song Bai, Zaiyi Liu, Qianlan Chen, Yongchao Xu, Tian Xia, Shi Gong, Xudong Xie, Dejia Song, Ronghui Du, Chunhua Zhou, Chengyang Chen, Dianer Nie, Dandan Tu, Changzheng Zhang, Xiaowu Liu, Lixin Qin, Weiwei Chen,

Background: The coronavirus disease 2019 (COVID-19) has become a worldwide pandemic since mid-December 2019, which greatly challenge public medical systems. With limited medical resources, it is a natural strategy, while adopted, to access the severity of patients then determine the treatment priority. However, our work observes the fact that the ... Read more >>

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Unified and disease specific alterations to brain structure in patients across six categories of mental disorders who experience own-thought auditory verbal hallucinations: A pilot study.

Chuanjun Zhuo, Xiaodong Lin, Chunxiang Wang, Xueqin Song, Xuexin Xu, Gongying Li, Yong Xu, Hongjun Tian, Yonghui Zhang, Wenqiang Wang, Chunhua Zhou,

OBJECTIVE:To explore the unified and disease specific structural features of the brain in patients spanning six mental disorders who experience own-thought auditory verbal hallucinations (OTAVH). METHODS:A pilot study was conducted on 25 patients with schizophrenia (FUSCH-OTAVH), 20 patients with major depression disorder (FUMDD-OTAVH), 28 patients with bipolar disorder (FUBD-OTAVH), 22 ... Read more >>

Brain Res. Bull. (Brain research bulletin)
[2020, 160:33-39]

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Efficacy and Safety of Apatinib Plus Vinorelbine in Patients With Wild-Type Advanced Non-Small Cell Lung Cancer After Second-Line Treatment Failure: A Nonrandomized Clinical Trial.

Xiangyu Zhang, Yi Xiong, Qing Xia, Fang Wu, Lingli Liu, Yuling Zhou, Liang Zeng, Chunhua Zhou, Chen Xia, Wenjuan Jiang, Dehua Liao, Lili Xiao, Li Liu, Haiyan Yang, Rui Guan, Kunyan Li, Jing Wang, Guang Lei, Yongchang Zhang, Nong Yang,

Importance:There is currently no standard treatment strategy for patients with advanced non-small cell lung cancer (NSCLC) without driver gene variation after failure of 2 or more lines of chemotherapy. Objective:To assess the efficacy and safety of apatinib combined with oral vinorelbine. Design, Setting, and Participants:This phase 2 prospective nonrandomized clinical ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e201226]

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Study on the population evolution of Ascaris lumbricoides and Ascaris suum based on whole genome resequencing.

Chunhua Zhou, Jinping Chen, Hongyan Niu, Shan Ouyang, Xiaoping Wu,

Ascaris lumbricoides and Ascaris suum are parasitic nematodes that mainly parasitize the small intestines of people and pigs, respectively. Ascariasis seriously endangers human health and causes huge economic losses in the pig industry. A. lumbricoides and A. suum have similar morphologies and genetic structures, and occasionally these organisms cross-infect the ... Read more >>

Vet. Parasitol. (Veterinary parasitology)
[2020, 279:109062]

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Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model.

Chunhua Zhou, Dezhi Kong, Xiaodong Zhu, Wei Wu, Rong Xue, Gongying Li, Yong Xu, Sha Liu, Hongjun Tian, Chuanjun Zhuo,

Schizophrenia is frequently accompanied by depressive symptoms, but the pathological mechanisms remain to be elucidated. In this study, we used chronic unpredicted mild stress plus MK801 injection to generate a mouse model of schizophrenia with depression, in which in vivo 2-photon calcium imaging and electrophysiological recordings were performed in conjunction ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:115]

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Detection of Nonreciprocal/Reciprocal ALK Translocation as Poor Predictive Marker in Patients With First-Line Crizotinib-Treated ALK-Rearranged NSCLC.

Yongchang Zhang, Liang Zeng, Chunhua Zhou, Yizhi Li, Lin Wu, Chen Xia, Wenjuan Jiang, Yijuan Hu, Dehua Liao, Lili Xiao, Li Liu, Haiyan Yang, Yi Xiong, Rui Guan, Analyn Lizaso, Aaron S Mansfield, Nong Yang,

INTRODUCTION:During nonreciprocal/reciprocal translocation process, 5'-anaplastic lymphoma kinase (ALK) sometimes gets retained in the genome and is detectable by next-generation sequencing; however, no study has investigated its clinical significance. Our study aimed to assess the impact of harboring 5'-ALK on the efficacy of crizotinib. METHODS:A total of 150 patients with next-generation ... Read more >>

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2020, 15(6):1027-1036]

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Color image segmentation using adaptive hierarchical-histogram thresholding.

Min Li, Lei Wang, Shaobo Deng, Chunhua Zhou,

Histogram-based thresholding is one of the widely applied techniques for conducting color image segmentation. The key to such techniques is the selection of a set of thresholds that can discriminate objects and background pixels. Many thresholding techniques have been proposed that use the shape information of histograms and identify the ... Read more >>

PLoS ONE (PloS one)
[2020, 15(1):e0226345]

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Depression and cardiovascular disease: Shared molecular mechanisms and clinical implications.

Mingjing Shao, Xiaodong Lin, Deguo Jiang, Hongjun Tian, Yong Xu, Lina Wang, Feng Ji, Chunhua Zhou, Xueqing Song, Chuanjun Zhuo,

Depression is a highly prevalent risk factor for both the onset of cardiovascular disease (CVD) and the mortality of CVD patients, and people suffering from CVD are more likely to develop depression than healthy individuals. The aim of this review is to summarize recent findings regarding the underlying relationship between ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 285:112802]

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Differences in functional connectivity density among subtypes of schizophrenic auditory hallucination.

Chuanjun Zhuo, Gongying Li, Feng Ji, Ce Chen, Deguo Jiang, Xiaodong Lin, Yong Xu, Hongjun Tian, Lina Wang, Chunhua Zhou, Xiao Lin,

This study aimed to investigate alterations in brain function among different subtypes of auditory hallucinations (AH) in drug-naïve first episode schizophrenia patients. We recruited 20 patients with drug-naïve first episode schizophrenia who had constant commanding and commenting auditory verbal hallucinations (CCCAVH), 15 drug-naïve first episode schizophrenia patients who had nonverbal ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2020, :]

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Applying the new intensive blood pressure categories to a nondialysis chronic kidney disease population: the Prevalence, Awareness and Treatment Rates in Chronic Kidney Disease Patients with Hypertension in China survey.

Ying Zheng, Li Tang, Weiguang Zhang, Delong Zhao, Dong Zhang, Li Zhang, Guangyan Cai, Xiangmei Chen, ,

BACKGROUND:The 2017 high blood pressure (BP) clinical practice guideline reported by the American College of Cardiology/American Heart Association put forward new categories of BP. This study aimed to assess the applicability of the new guideline in a nondialysis chronic kidney disease (CKD) population. METHODS:This is a nationwide, multicenter, cross-sectional study ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2020, 35(1):155-161]

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