Full Text Journal Articles by
Author Chun Wong

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Aerobic exercise in older people with subclinical sporadic cerebral small vessel disease: A randomized clinical trial.

Adrian Wong, Bonnie Yin Ka Lam, Margaret Kit Yi Mak, Linda Chiu Wa Lam, Lisa Wing Chi Au, Brian Ka Fung Yiu, Chun Wong, Hor Yee Tong, Sin Ki Yeung, Winnie Chiu Wing Chu, Lin Shi, Thomas Wai Hong Leung, Yannie Oi Yan Soo, Alexander Yuk Lun Lau, Bonaventure Yiu Ming Ip, Timothy Chi Yui Kwok, Ho Ko, Vincent Chung Tong Mok,

<h4>Introduction</h4>The benefit and risk of aerobic exercise among older people harboring advanced cerebral small vessel disease (CSVD) upon cognition, mood, and motor functions are unknown.<h4>Methods</h4>This rater-blind randomized trial examined effects of a 24-week aerobic exercise training (60 min/session, twice/week) upon clinical (cognition, mood, motor functions) and hemodynamic (pulse pressure [PP], ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2021, 7(1):e12224]

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A review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer.

Huihai Yang, Grace Gar Lee Yue, Ping Chung Leung, Chun Kwok Wong, Clara Bik San Lau,

Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. Obesity has been proven to be closely related to colorectal carcinogenesis. This review summarized the potential underlying mechanisms linking obesity to CRC in different aspects, including energy metabolism, inflammation, activities of adipokines and hormones. Furthermore, the potential therapeutic ... Read more >>

Pharmacol Res (Pharmacological research)
[2022, 175:106031]

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Misdiagnosis of aortic dissection: A systematic review of the literature.

Saul Lovatt, Chun Wai Wong, Konstantin Schwarz, Josip A Borovac, Ted Lo, Mark Gunning, Thanh Phan, Ashish Patwala, Diane Barker, Christian D Mallen, Chun Shing Kwok,

<h4>Background</h4>Aortic dissection is a rare but potentially catastrophic condition. Misdiagnosis of aortic dissection is not uncommon as symptoms can overlap with other diagnoses.<h4>Objective</h4>We conducted a systematic review to better understand the factors contributing to incorrect diagnosis of this condition.<h4>Methods</h4>We searched MEDLINE and EMBASE for studies that evaluated the misdiagnosis of ... Read more >>

Am J Emerg Med (The American journal of emergency medicine)
[2021, 53:16-22]

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Longitudinal Cytokine Profile in Patients With Mild to Critical COVID-19.

Lowell Ling, Zigui Chen, Grace Lui, Chun Kwok Wong, Wai Tat Wong, Rita W Y Ng, Eugene Y K Tso, Kitty S C Fung, Veronica Chan, Apple C M Yeung, David S C Hui, Paul K S Chan,

The cytokine release syndrome has been proposed as the driver of inflammation in coronavirus disease 2019 (COVID-19). However, studies on longitudinal cytokine profiles in patients across the whole severity spectrum of COVID-19 are lacking. In this prospective observational study on adult COVID-19 patients admitted to two Hong Kong public hospitals, ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:763292]

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Altered Cytokine and BDNF Levels in Individuals with Autism Spectrum Disorders

Yvonne M.Y. Han, Suk Yu Yau, Melody M.Y. Chan, Chun Kwok Wong, Agnes Chan,

Previous studies have shown that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASDs). The present study examined whether immunological abnormalities are associated with cognitive deficits and problem behaviors in children with ASD and whether children with ASD show different immunological biomarkers and brain-derived neurotrophic factor BDNF ... Read more >>

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Internet of Things (IoT)-Enhanced Applied Behavior Analysis (ABA) for Special Education Needs.

Chun Man Victor Wong, Rosanna Yuen-Yan Chan, Yen Na Yum, Kangzhong Wang,

Applied behavior analysis (ABA) has become a popular behavioral therapy in the special education needs (SEN) community. ABA is used to manage SEN students' behaviors by solving problems in socially important settings, and puts emphasis on having precise measurements on physical and observable events. In this work, we present how ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2021, 21(19):]

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Smoking cessation after acute coronary syndrome: A systematic review and meta-analysis.

Saul Lovatt, Chun Wai Wong, Eric Holroyd, Rob Butler, Thanh Phan, Ashish Patwala, Yoon K Loke, Christian D Mallen, Chun Shing Kwok,

<h4>Background</h4>Smoking cessation is an effective secondary prevention measure after acute coronary syndrome (ACS). We conducted a systematic review with the aim to better understand which patients have a greater propensity to quit smoking and the risk factors for continued smoking after ACS.<h4>Methods</h4>We searched MEDLINE and EMBASE for studies that evaluated ... Read more >>

Int J Clin Pract (International journal of clinical practice)
[2021, 75(12):e14894]

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Disentangling Ferroelectric Wall Dynamics and Identification of Pinning Mechanisms via Deep Learning.

Yongtao Liu, Roger Proksch, Chun Yin Wong, Maxim Ziatdinov, Sergei V Kalinin,

Field-induced domain-wall dynamics in ferroelectric materials underpins multiple applications ranging from actuators to information technology devices and necessitates a quantitative description of the associated mechanisms including giant electromechanical couplings, controlled nonlinearities, or low coercive voltages. While the advances in dynamic piezoresponse force microscopy measurements over the last two decades have ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2021, 33(43):e2103680]

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Hypericin and Pheophorbide a Mediated Photodynamic Therapy Fighting MRSA Wound Infections: A Translational Study from In Vitro to In Vivo.

Ben Chung Lap Chan, Priyanga Dharmaratne, Baiyan Wang, Kit Man Lau, Ching Ching Lee, David Wing Shing Cheung, Judy Yuet Wa Chan, Grace Gar Lee Yue, Clara Bik San Lau, Chun Kwok Wong, Kwok Pui Fung, Margaret Ip,

High prevalence rates of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and lack of effective antibacterial treatments urge discovery of alternative therapeutic modalities. The advent of antibacterial photodynamic therapy (aPDT) is a promising alternative, composing rapid, nonselective cell destruction without generating resistance. We used a panel of clinically relevant MRSA to evaluate hypericin ... Read more >>

Pharmaceutics (Pharmaceutics)
[2021, 13(9):]

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Extracellular and Intracellular Angiotensin II Regulate the Automaticity of Developing Cardiomyocytes via Different Signaling Pathways.

Zenghua Qi, Tao Wang, Xiangmao Chen, Chun Kit Wong, Qianqian Ding, Heinrich Sauer, Zhi-Feng Chen, Cheng Long, Xiaoqiang Yao, Zongwei Cai, Suk Ying Tsang,

Angiotensin II (Ang II) plays an important role in regulating various physiological processes. However, little is known about the existence of intracellular Ang II (iAng II), whether iAng II would regulate the automaticity of early differentiating cardiomyocytes, and the underlying mechanism involved. Here, iAng II was detected by immunocytochemistry and ... Read more >>

Front Mol Biosci (Frontiers in molecular biosciences)
[2021, 8:699827]

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Self-Reported Symptom Study of COVID-19 Chemosensory Dysfunction in Malaysia

Shen-Han Lee, Zhi Xiang Yeoh, Ida Sadja'ah Sachlin, Norzi Gazali, Shahrul Aiman Soelar, Lee Lee Low, Sharifah Baizura Syed Alwi, Tengku Mohamed Izam Tengku Kamalden, Jothi Shanmuganathan, Masliza Zaid, Chun Yiing Wong, Hock Hin Chua, Suhaimi Yusuf, Dzawani Muhamad, Philip Rajan Devesahayam, Hong Bee Ker, Zulkiflee Salahuddin, Mahiran Mustafa, Halimuddin Sawali, Heng Gee Lee, Sobani Din, Nor Arisah Misnan, Amran Mohamad, Mohd Noor Ismail, Chenthilnathan Periasamy, Ting Soo Chow, Elang Kumaran Krishnan, Chee Loon Leong, Linda Pei Fang Lim, Nor Zaila Zaidan, Zambri Ibrahim, Suhaila Abd Wahab, Siti Sabzah Mohd Hashim, ,

Alterations in the three chemosensory modalities – smell, taste, and chemesthesis – have been implicated in Coronavirus Disease 2019 (COVID-19), yet emerging data suggest a wide geographic and ethnic variation in the prevalence of these symptoms. Studies on chemosensory disorders in COVID-19 have predominantly focused on Caucasian populations whereas Asians ... Read more >>

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Evaluation of a child food reward task and its association with maternal feeding practices.

Jia Ying Toh, Phaik Ling Quah, Chun Hong Wong, Wen Lun Yuan, Izzuddin M Aris, Keri McCrickerd, Keith M Godfrey, Yap-Seng Chong, Lynette P Shek, Kok Hian Tan, Fabian Yap, Michael J Meaney, Ciarán G Forde, Yung Seng Lee, Birit F P Broekman, Mary F F Chong,

Food reward is defined as the momentary value of a food to the individual at the time of ingestion and is characterised by two psychological processes-"liking" and "wanting". We aimed to validate an age-appropriate food reward task to quantify implicit wanting of children from the GUSTO cohort (n = 430). ... Read more >>

PLoS One (PloS one)
[2021, 16(7):e0254773]

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A recessive S174X mutation in Optineurin causes amyotrophic lateral sclerosis through a loss of function via allele-specific nonsense-mediated decay.

Marc Gotkine, Martina de Majo, Chun Hao Wong, Simon D Topp, Rachel Michaelson-Cohen, Silvina Epsztejn-Litman, Rachel Eiges, Yossef Lerner Y, Moein Kanaan, Hagar Mor Shaked, Nada Alahmady, Caroline Vance, Stephen J Newhouse, Gerome Breen, Agnes L Nishimura, Christopher E Shaw, Bradley N Smith,

Loss of function (LoF) mutations in Optineurin can cause recessive amyotrophic lateral sclerosis (ALS) with some heterozygous LoF mutations associated with dominant ALS. The molecular mechanisms underlying the variable inheritance pattern associated with OPTN mutations have remained elusive. We identified that affected members of a consanguineous Middle Eastern ALS kindred ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2021, 106:351.e1-351.e6]

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Border Restriction as a Public Health Measure to Limit Outbreak of Coronavirus Disease 2019

Wang Chun Kwok, Chun Ka Wong, Ting Fung Ma, Ka Wai Ho, Wai Tong Louis Fan, King Pui Florence Chan, Shung Kay Samuel Chan, Chi Chun Terence Tam, Pak Leung Ho,

<h4>Background: </h4> Coronavirus Disease 2019 (COVID-19) led to pandemic that affected almost all countries in the world. Many countries have implemented border restriction as a public health measure to limit local outbreak. However, there is inadequate scientific data to support such a practice, especially in the presence of an established ... Read more >>

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Misdiagnosis of Heart Failure: A Systematic Review of the Literature.

Chun Wai Wong, Jacopo Tafuro, Ziyad Azam, Duwarakan Satchithananda, Simon Duckett, Diane Barker, Ashish Patwala, Fozia Z Ahmed, Christian Mallen, Chun Shing Kwok,

<h4>Background</h4>Heart failure (HF) is a chronic disease associated with a significant burden to patients, families, and health services. The diagnosis of HF can be easily missed owing to similar symptoms with other conditions especially respiratory diseases.<h4>Methods and results</h4>We conducted a systematic review to determine the rates of HF and cardiomyopathy ... Read more >>

J Card Fail (Journal of cardiac failure)
[2021, 27(9):925-933]

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The role of the Tei index in assessing for cardiotoxicity from anthracycline chemotherapy: a systematic review.

Sadie Bennett, Arzu Cubukcu, Chun Wai Wong, Timothy Griffith, Cheryl Oxley, Diane Barker, Simon Duckett, Duwarakan Satchithananda, Ashish Patwala, Grant Heatlie, Chun Shing Kwok,

<h4>Background</h4>Anthracycline agents are known to be effective in treating tumors and hematological malignancies. Although these agents improve survival, their use is associated with cardiotoxic effects, which most commonly manifests as left ventricular systolic dysfunction (LVSD). As such, guidelines recommend the periodic assessment of left ventricular ejection fraction (LVEF). However, as ... Read more >>

Echo Res Pract (Echo research and practice)
[2021, 8(1):R1-R11]

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β-Cyclodextrin-containing chitosan-oligonucleotide nanoparticles improve insulin bioactivity, gut cellular permeation and glucose consumption.

Chun Yuen Jerry Wong, Hani Al-Salami, Crispin R Dass,

<h4>Objectives</h4>The main objective of the present study was to develop a nanoparticulate drug delivery system that can protect insulin against harsh conditions in the gastrointestinal (GI) tract. The effects of the following employed techniques, including lyophilisation, cross-linking and nanoencapsulation, on the physicochemical properties of the formulation were investigated.<h4>Methods</h4>We herein developed ... Read more >>

J Pharm Pharmacol (The Journal of pharmacy and pharmacology)
[2021, 73(6):726-739]

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Evaluation of the performance of traditional machine learning algorithms, convolutional neural network and AutoML Vision in ultrasound breast lesions classification: a comparative study.

Ka Wing Wan, Chun Hoi Wong, Ho Fung Ip, Dejian Fan, Pak Leung Yuen, Hoi Ying Fong, Michael Ying,

<h4>Background</h4>In recent years, there was an increasing popularity in applying artificial intelligence in the medical field from computer-aided diagnosis (CAD) to patient prognosis prediction. Given the fact that not all healthcare professionals have the required expertise to develop a CAD system, the aim of this study was to investigate the ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2021, 11(4):1381-1393]

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A territory-wide study on the factors associated with recurrent asthma exacerbations requiring hospitalization in Hong Kong.

Ka Pang Chan, Fanny Wai San Ko, Kwun Cheung Ling, Pik Shan Cheung, Lee Veronica Chan, Yu Hong Chan, Yi Tat Lo, Chun Kong Ng, Macy Mei-Sze Lui, Kwok Sang Wilson Yee, Cee Zhung Steven Tseng, Pak Yiu Tse, Mo Lin Maureen Wong, Kah Lin Choo, Wai Kei Lam, Chun Man Wong, Sheng Sheng Ho, Chung Tat Lun, Christopher Kei Wai Lai,

<h4>Background</h4>The real-world relationships between the demographic and clinical characteristics of asthma patients, their prehospitalization management and the frequency of hospitalization due to asthma exacerbation is poorly established.<h4>Objective</h4>To determine the risk factors of recurrent asthma exacerbations requiring hospitalizations and evaluate the standard of baseline asthma care.<h4>Methods</h4>A territory-wide, multicentre retrospective study in ... Read more >>

Immun Inflamm Dis (Immunity, inflammation and disease)
[2021, 9(2):569-581]

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Fabrication techniques for the preparation of orally administered insulin nanoparticles.

Chun Y Wong, Hani Al-Salami, Crispin R Dass,

The development of orally administered protein drugs is challenging due to their intrinsic unfavourable features, including large molecular size and poor chemical stability, both of which limit gastrointestinal (GI) absorption efficiency. Nanoparticles can overcome the GI barriers effectively and improve the oral bioavailability of proteins in the GI tract. They ... Read more >>

J Drug Target (Journal of drug targeting)
[2021, 29(4):365-386]

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Location of death among patients presenting with cardiovascular disease to the emergency department in the United states.

Chun Shing Kwok, Chun Wai Wong, Roshini Ravindran, Erin D Michos, Safi U Khan, Islam Abudayyeh, Mohamed Mohamed, Purvi Parwani, Ritu Thamman, Islam Y Elgendy, Harriette G C Van Spall, Mamas A Mamas,

<h4>Background</h4>In-hospital deaths are an important outcome and little is known about deaths in the emergency department (ED). Among patients who died of cardiovascular diseases (CVD), we assessed causes of death, temporal trends and the relative distribution of deaths in the ED versus hospital.<h4>Methods</h4>Using the United States Nationwide Emergency Department Sample, ... Read more >>

Int J Clin Pract (International journal of clinical practice)
[2021, 75(4):e13798]

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Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA.

Chun Shing Kwok, Chun Wai Wong, Evangelos Kontopantelis, Ana Barac, Sherry-Ann Brown, Poonam Velagapudi, Anthony A Hilliard, Aditya S Bharadwaj, M Chadi Alraies, Mohamed Mohamed, Deepak L Bhatt, Mamas A Mamas,

<h4>Aims</h4>The post-discharge outcomes of patients with cancer who undergo PCI are not well understood. This study evaluates the rates of readmissions within 90 days for acute myocardial infarction (AMI) and bleeding among patients with cancer who undergo percutaneous coronary intervention (PCI).<h4>Methods and results</h4>Patients treated with PCI in the years from 2010 ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(10):1019-1034]

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Immunological Roles of NLR in Allergic Diseases and Its Underlying Mechanisms.

Miranda Sin-Man Tsang, Tianheng Hou, Ben Chung-Lap Chan, Chun Kwok Wong,

Our understanding on the immunological roles of pathogen recognition in innate immunity has vastly increased over the past 20 years. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLR) are cytosolic pattern recognition receptors (PRR) that are responsible for sensing microbial motifs and endogenous damage signals in mammalian cytosol for immune surveillance and ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(4):]

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Pediatric osteomyelitis due to rare tropical multi-drug resistance (MDR) organisms: a treatment quandary.

Chan Jing Er, Wong Kin Chun, Lim Ming Chiang, Mohd Naim Bin Mohd Nasir,

Osteomyelits due to concurrent multi-drug resistance organisms is difficult to treat for any surgeon and infectious disease physician. An eleven-year-old boy presenting with an open fracture of the left radius and ulna after a fall in a stagnant wet field. Despite prophylactic antibiotics and surgical intervention, the open wound was ... Read more >>

Rev Inst Med Trop Sao Paulo (Revista do Instituto de Medicina Tropical de Sao Paulo)
[2021, 63:e7]

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Deep learning model for prediction of extended-spectrum beta-lactamase (ESBL) production in community-onset Enterobacteriaceae bacteraemia from a high ESBL prevalence multi-centre cohort.

Alfred Lok Hang Lee, Curtis Chun Kit To, Angus Lang Sun Lee, Ronald Cheong Kin Chan, Janus Siu Him Wong, Chun Wai Wong, Viola Chi Ying Chow, Raymond Wai Man Lai,

Adequate empirical antimicrobial coverage is instrumental in clinical management of community-onset Enterobacteriaceae bacteraemia in areas with high ESBL prevalence, while balancing the risk of carbapenem overuse and emergence of carbapenem-resistant organisms. It is unknown whether machine learning offers additional advantages to conventional statistical methods in prediction of ESBL production. To ... Read more >>

Eur J Clin Microbiol Infect Dis (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2021, 40(5):1049-1061]

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