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Author Chun Liang

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Does continuous positive airway pressure therapy benefit patients with coronary artery disease and obstructive sleep apnea? A systematic review and meta-analysis.

Yasha Chen, Yihong Chen, Feng Wen, Zhiqing He, Wenhao Niu, Changzhen Ren, Na Li, Qinqin Wang, Yusheng Ren, Chun Liang,

The prevalent co-morbidity of coronary artery disease (CAD) and obstructive sleep apnea (OSA) has attracted great interest. However, effects of continuous positive airway pressure (CPAP) in patients with OSA and CAD for cardiovascular outcomes and deaths are still controversial. Usage of CPAP among patients with CAD and OSA could decrease ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, :]

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Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin.

Zhong Han, Jianmin Guo, Feibiao Meng, Haifeng Liao, Yinghua Deng, Yuankeng Huang, Xialing Lei, Chun Liang, Richou Han, Wei Yang,

<h4>Introduction</h4>Forsythin is the main ingredient of <i>Forsythia suspensa</i> and is widely used in treatment of fever, viral cold, gonorrhea, and ulcers clinically. This study aimed to evaluate the potential genetic toxicity of forsythin and its safety for human use.<h4>Methods</h4>Based on the Good Laboratory Practice regulations and test guidelines, the genetic ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2021, 2021:6610793]

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Transcriptome Profiling of Embryonic Retinal Pigment Epithelium Reprogramming.

Jared A Tangeman, Agustín Luz-Madrigal, Sutharzan Sreeskandarajan, Erika Grajales-Esquivel, Lin Liu, Chun Liang, Panagiotis A Tsonis, Katia Del Rio-Tsonis,

The plasticity of human retinal pigment epithelium (RPE) has been observed during proliferative vitreoretinopathy, a defective repair process during which injured RPE gives rise to fibrosis. In contrast, following injury, the RPE of the embryonic chicken can be reprogrammed to regenerate neural retina in a fibroblast growth factor 2 (FGF2)-dependent ... Read more >>

Genes (Basel) (Genes)
[2021, 12(6):]

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The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-κB signaling pathway inhibition.

Muhammad Jahangir Hossen, Aftab Amin, Xiu-Qiong Fu, Ji-Yao Chou, Jia-Ying Wu, Xiao-Qi Wang, Ying-Jie Chen, Ying Wu, Junkui Li, Cheng-Le Yin, Chun Liang, Gui-Xin Chou, Zhi-Ling Yu,

<h4>Ethnopharmacological relevance</h4>The dried rhizome of Atractylodes lancea (Thumb.) DC. (Compositae) has been prescribed in folk medicine for the management of various inflammatory conditions such as rheumatic diseases, gastritis and hepatitis. However, the molecular mechanisms underlying the beneficial properties of this herb remain elusive.<h4>Aim of the study</h4>In this study, we investigated ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2021, 277:114183]

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Nur77 Attenuates Inflammasome Activation by Inhibiting Caspase-1 Expression in Pulmonary Vascular Endothelial Cells.

Ru Ding, Xiaobo Sun, Bing Yi, Wennan Liu, Kyosuke Kazama, Xinyun Xu, Deepak Deshpande, Chun Liang, Jianxin Sun,

Inflammasomes are intracellular multiprotein complexes that help trigger and maintain the inflammatory response as part of the innate immune system. Recently, it has been increasingly recognized that aberrant inflammasome activation is critically involved endothelial dysfunction in a variety of human diseases, such as atherosclerosis, acute lung injury (ALI), and type ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2021, :]

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Corrigendum to "Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities" [Bioorg. Med. Chem. Lett. 20(23) (2010) 7110-7115].

Chun Liang, Yan Ding, Huu Tung Nguyen, Jeong-Ah Kim, Hye-Jin Boo, Hee-Kyoung Kang, Mahn Cuong Nguyen, Young Ho Kim,

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2021, 41:128014]

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Sodium-Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK-mTOR Signaling Pathway-Mediated Autophagy.

Changzhen Ren, Kaiqiang Sun, Yanda Zhang, Yangxi Hu, Bowen Hu, Jian Zhao, Zhiqing He, Ru Ding, Weizhong Wang, Chun Liang,

<b>Background:</b> Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been shown to decrease the adverse cardiac events and risks of cardiovascular mortality among patients with or without diabetes, which has made these drugs promising treatment options for patients with chronic heart failure. Cardiac dysfunction is a common and severe side effect induced by ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:664181]

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Transcriptome profiling of embryonic retinal pigment epithelium reprogramming

Jared Tangeman, Agustín Luz-Madrigal, Sutharzan Sreeskandarajan, Erika Grajales- Esquivel, Lin Liu, Chun Liang, Panagiotis Tsonis, Katia Del Rio-Tsonis,

The plasticity of human retinal pigment epithelium (RPE) has been observed during proliferative vitreoretinopathy, a defective repair process during which injured RPE gives rise to fibrosis. In contrast, following injury, the RPE of the embryonic chicken can be reprogrammed to regenerate neural retina in an FGF2-dependent manner. To characterize the ... Read more >>

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Dysfunction of the Auditory Brainstem as a Neurophysiology Subtype of Autism Spectrum Disorder.

Jierong Chen, Zhen Wei, Chun Liang, Binguang Liu, Jimin Guo, Xuejun Kong, Minshi Huang, Ziwen Peng, Guobin Wan,

Autism spectrum disorder (ASD) is very heterogeneous, particularly in language. Studies have suggested that language impairment is linked to auditory-brainstem dysfunction in ASD. However, not all ASD children have these deficits, which suggests potential subtypes of ASD. We classified ASD children into two subtypes according to their speech-evoked auditory brainstem ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2021, 15:637079]

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Exposure Load: Using biomonitoring data to quantify multi-chemical exposure burden in a population.

Jeff B Willey, Tyler Pollock, Errol M Thomson, Chun Lei Liang, Aubrey Maquiling, Mike Walker, Annie St-Amand,

People are often concurrently exposed to numerous chemicals. Here we sought to leverage existing large biomonitoring datasets to improve our understanding of multi-chemical exposures in a population. Using nationally-representative data from the 2012-2015 Canadian Health Measures Survey (CHMS), we developed Exposure Load, a metric that counts the number of chemicals ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2021, 234:113704]

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Metabolomics reveal dynamic changes in eicosanoid profile in patients with ST-elevation myocardial infarction after percutaneous coronary intervention.

Liuyang Zhang, Zhi Dai, Ruifeng Guo, Xiao Wang, Wei Gong, Juanhui Duan, Zhiqing He, Ru Ding, Xu Zhang, Shaoping Nie, Chun Liang,

Eicosanoids play important roles in the cardiovascular system. The metabolic disorders involving some eicosanoids in the pathophysiologic process include myocardial infarction and myocardial ischaemia-reperfusion injury. Percutaneous coronary intervention (PCI) is often the first-choice strategy for acute ST-segment elevation myocardial infarction (STEMI) according to current guidelines. This study aimed to investigate ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2021, 48(4):463-470]

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Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6.

Wen-Hao Niu, Feng Wu, Wen-Yue Cao, Zong-Gui Wu, Yu-Chieh Chao, Chun Liang,

<h4>Objective</h4>´Three formulas and three medicines,' namely, Jinhua Qinggan Granule, Lianhua Qingwen Capsule, Xuebijing Injection, Qingfei Paidu Decoction, HuaShi BaiDu Formula, and XuanFei BaiDu Granule, were proven to be effective for coronavirus disease 2019 (COVID-19) treatment. The present study aimed to identify the active chemical constituents of this traditional Chinese medicine ... Read more >>

Biosci Rep (Bioscience reports)
[2021, 41(1):]

Cited: 6 times

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Anti-Gastric Cancer Effect of Purified Omphalia Lapidescens Protein via Regulating the JAK/STAT3 Signaling Pathway

Wenjun Xu, Zhongxia Lu, Man Hei Cheung, Yuqin Xu, Meiai Lin, Chun Liang, Jianshu Lou, Yitao Chen,

<h4>Background: </h4> Gastric cancer is the leading cause of cancer-related death worldwide. The aim of present study was to investigate the anti-tumor effect of purified Omphalia lapidescens protein (pPeOp) in gastric cancer. <h4>Methods: </h4> Microarray analysis was performed to find out differentially expressed genes in pPeOp-treated MC-4 gastric cancer cells. ... Read more >>

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Efferent control of hearing sensitivity and protection via inner ear supporting cells

Hong-Bo Zhao, Li-Man Liu, Ling Mei, Ning Yu, Jin Chen, Yan Zhu, Chun Liang,

It is critical for hearing that the descending cochlear efferent system provide negative feedback to hair cells to regulate hearing sensitivity and provide protection from noise. The medial olivocochlear (MOC) efferent nerves project to outer hair cells (OHCs) and inhibit OHC electromotility, which is an active cochlear amplification and can ... Read more >>

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Role of Lipid-Lowering Therapy in Low-Density Lipoprotein Cholesterol Goal Attainment: Focus on Patients With Acute Coronary Syndrome.

Qinqin Wang, Chun Liang,

Dyslipidemia is a major risk factor for cardiovascular (CV) disease, which is the leading cause of death globally. Acute coronary syndrome (ACS) is a common cause of death, accounting for nearly half of the global burden of CV mortality. Epidemiologic studies have identified low-density lipoprotein cholesterol (LDL-C) as an independent ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2020, 76(6):658-670]

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Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair.

Chaoshan Han, Jin Zhou, Chun Liang, Bin Liu, Xiangbin Pan, Yu Zhang, Yanli Wang, Bing Yan, Wenping Xie, Feng Liu, Xi-Yong Yu, Yangxin Li,

Stem cell-derived exosomes have been recognized as a potential therapy for cardiovascular disease. However, the low retention rate of exosomes after transplantation in vivo remains a major challenge in clinical applications. The aim of this study is to investigate whether human umbilical cord mesenchymal stem cell derived exosomes (UMSC-Exo) encapsulated ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(7):2920-2933]

Cited: 28 times

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A two-herb formula inhibits STAT3 signaling and exerts anti-melanoma effects in cell and animal models.

Jun-Kui Li, Ji-Yao Chou, Cheng-Le Yin, Xiu-Qiong Fu, Ying Wu, Ying-Jie Chen, Jing-Xuan Bai, Jia-Ying Wu, Chun Liang, Zhi-Ling Yu,

<h4>Ethnopharmacological relevance</h4>Malignant melanoma is a fatal cancer. Signal transducer and activator of transcription 3 (STAT3) has been proposed as a therapeutic target of melanoma. An herbal formula Huai-Hua-San (HHS) comprising Sophorae Flos (SF) and Gardeniae Fructus (GF) is traditionally used for treating cancers including melanoma, but the pharmacological basis is ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2021, 268:113671]

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Evidence for a protective role of placental growth factor in cardiovascular disease.

Yihong Chen, Anna Hultgårdh Nilsson, Isabel Goncalves, Andreas Edsfeldt, Gunnar Engström, Olle Melander, Marju Orho-Melander, Uwe Rauch, Christoffer Tengryd, Shreenidhi M Venuraju, Avijit Lahiri, Chun Liang, Jan Nilsson,

Placental growth factor (PlGF) is a mitogen for endothelial cells, but it can also act as a proinflammatory cytokine. Because it promotes early stages of plaque formation in experimental models of atherosclerosis and was implicated in epidemiological associations with risk of cardiovascular disease (CVD), PlGF has been attributed a pro-atherogenic ... Read more >>

Sci Transl Med (Science translational medicine)
[2020, 12(572):]

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Pre-treatment with compound Danshen dripping pills prevents lipid infusion-induced microvascular dysfunction in mice.

Yanda Zhang, Jian Zhao, Ru Ding, Wenhao Niu, Zhiqing He, Chun Liang,

<h4>Context</h4>Recent studies have shown compound Danshen dripping pills (CDDP) could improve microcirculation in ischemic/reperfusion injury and other microvascular disorders. The mechanism for CDDP's role in microcirculation is not clear.<h4>Objective</h4>To explore the protective effects of CDDP on microvascular dysfunction.<h4>Materials and methods</h4>C57BL/6 male mice (6-8 weeks) were randomized into control, model and CDDP ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):701-706]

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Analysis of CACTA transposase genes unveils the mechanism of intron loss and distinct small RNA silencing pathways underlying divergent evolution of Brassica genomes.

Beibei Liu, Aiko Iwata-Otsubo, Diya Yang, Robert L Baker, Chun Liang, Scott A Jackson, Shengyi Liu, Jianxin Ma, Meixia Zhao,

In comparison with retrotransposons, DNA transposons make up a smaller proportion of most plant genomes. However, these elements are often proximal to genes to affect gene expression depending on the activity of the transposons, which is largely reflected by the activity of the transposase genes. Here, we show that three ... Read more >>

Plant J (The Plant journal : for cell and molecular biology)
[2021, 105(1):34-48]

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Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID-19.

Wenhao Niu, Feng Wu, Haiming Cui, Wenyue Cao, YuChieh Chao, Zonggui Wu, Min Fan, Chun Liang,

"Three formulas and three medicines," which include Jinhua Qinggan granule, Lianhua Qingwen capsule/granule, Xuebijing injection, Qingfei Paidu decoction, HuaShiBaiDu formula, and XuanFeiBaiDu granule, have been proven to be effective in curbing coronavirus disease 2019 (COVID-19), according to the State Administration of Traditional Chinese Medicine. The aims of this study were ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2020, 2020:7493281]

Cited: 5 times

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FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly.

Huadong Jiang, Shanshan Liu, Man-Hei Cheung, Aftab Amin, Chun Liang,

Primary cilia are microtubule-based, antenna-like organelles, which are formed in G<sub>0</sub> phase and resorbed as cells re-enter the cell cycle. It has been reported that primary cilia can influence the timing of cell cycle progression. However, the molecular links between ciliogenesis and cell cycle progression are not well understood. The ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:590449]

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CLIC4 abrogation promotes epithelial-mesenchymal transition in gastric cancer.

Baolong Wang, Jiqing Zheng, Qiongyuan Chen, Chaofan Wu, Yangxin Li, Xi-Yong Yu, Bin Liu, Chun Liang, Song-Bai Liu, Hui Ding, Shuochen Wang, Ting Xue, David Song, Zhangni Lei, Hesham M Amin, Yao-Hua Song, Jin Zhou,

Chloride intracellular channel protein 4 (CLIC4) has been implicated in different types of cancers, but the role of CLIC4 in the development of gastric cancer (GC) remains unknown. We analyzed the expression of CLIC4 in 102 pairs of gastric adenocarcinomas by western blot and real-time PCR. Our data revealed that ... Read more >>

Carcinogenesis (Carcinogenesis)
[2020, 41(6):841-849]

Cited: 1 time

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Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway.

Bing Yan, Yu Zhang, Chun Liang, Bin Liu, Fengzhi Ding, Yanli Wang, Bao Zhu, Ranzun Zhao, Xi-Yong Yu, Yangxin Li,

<b>Rational:</b> Ischemic injury of the skeletal muscle remains a serious clinical problem and currently there is no effective therapy. The aim of the present study is to determine whether human umbilical cord mesenchymal stem cells- derived exosomes (UMSC-Exo) could repair ischemic injury by releasing circular RNA. <b>Methods and Results:</b> To ... Read more >>

Theranostics (Theranostics)
[2020, 10(15):6728-6742]

Cited: 9 times

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The Effect of Side of Implantation on the Cortical Processing of Frequency Changes in Adult Cochlear Implant Users.

Chun Liang, Lisa H Wenstrup, Ravi N Samy, Jing Xiang, Fawen Zhang,

Cochlear implants (CI) are widely used in children and adults to restore hearing function. However, CI outcomes are vary widely. The affected factors have not been well understood. It is well known that the right and left hemispheres play different roles in auditory perception in adult normal hearing listeners. It ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:368]

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