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Differential effects on neuromuscular physiology between Sod1 loss-of-function mutation and paraquat-induced oxidative stress in Drosophila.

Atsushi Ueda, Atulya Iyengar, Chun-Fang Wu,

Oxidative stress is thought to be a major contributor to aging processes. Here, we report differential effects on neurotransmission caused by loss-of-function mutations of <i>Superoxide dismutase 1</i> (<i>Sod1</i>) and by paraquat (PQ) feeding in <i>Drosophila</i>. We demonstrated alterations in <i>Sod1</i> mutants; the larval neuromuscular junction displayed supernumerary discharges and the ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Transcending boundaries: from quantitative genetics to single genes.

Jeffrey S Dason, Ina Anreiter, Chun-Fang Wu,

J Neurogenet (Journal of neurogenetics)
[2021, 35(3):95-98]

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Diet modifies allele-specific phenotypes in Drosophila carrying epilepsy-associated PNPO variants

Wanhao Chi, Atulya SR Iyengar, Wenqin Fu, Wei Liu, Abigayle Berg, Chun-Fang Wu, Xiaoxi Zhuang,

Pyridox(am)ine 5’-phosphate oxidase (PNPO) catalyzes the rate-limiting step in the synthesis of pyridoxal 5’-phosphate (PLP), the active form of vitamin B6 required for the synthesis of neurotransmitters GABA and monoamines. Pathogenic variants in PNPO have been repeatedly identified in patients with neonatal epileptic encephalopathy and early-onset epilepsy. These patients often ... Read more >>

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Fly seizure EEG: field potential activity in the Drosophila brain.

Atulya Iyengar, Chun-Fang Wu,

Hypersynchronous neural activity is a characteristic feature of seizures. Although many <i>Drosophila</i> mutants of epilepsy-related genes display clear behavioral spasms and motor unit hyperexcitability, field potential measurements of aberrant hypersynchronous activity across brain regions during seizures have yet to be described. Here, we report a straightforward method to observe local ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2021, 35(3):295-305]

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Fly seizure EEG: field potential activity in the Drosophila brain

Atulya Iyengar, Chun-Fang Wu,

Hypersynchronous neural activity is a characteristic feature of seizures. Although many Drosophila mutants of epilepsy-related genes display clear behavioral spasms and motor unit hyperexcitability, field potential measurements of aberrant hypersynchronous activity across brain regions during seizures have yet to be described. Here, we report a straightforward method to observe local ... Read more >>

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Differential effects on neuromuscular physiology between Sod loss-of-function mutation and paraquat-induced oxidative stress in Drosophila

Atsushi Ueda, Atulya Iyengar, Chun-Fang Wu,

Oxidative stress is thought to be a major contributor to aging processes. Here, we report differential effects on neurotransmission caused by loss-of-function mutations of Superoxide dismutase ( Sod ) and by paraquat (PQ) feeding in Drosophila . We demonstrated alterations in Sod mutants; the larval neuromuscular junction displayed supernumerary discharges ... Read more >>

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Investigations into modifications of neuromuscular physiology by axonal transport disruptions in Drosophila SOD1 mutants

Tristan O’Harrow, Atsushi Ueda, Xiaomin Xing, Chun-Fang Wu,

Cu/Zn superoxide dismutase (SOD1) is a cytoplasmic antioxidant enzyme, which, when mutant in humans, is linked to familial cases of the motor neurodegenerative disease amyotrophic lateral sclerosis (ALS). The Drosophila SOD1 gene ( Sod ) shares a highly conserved sequence with the human homolog, and this study includes examinations of ... Read more >>

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Nature's gift to neuroscience.

Joy Alcedo, Yishi Jin, Douglas S Portman, Veena Prahlad, David Raizen, Georgia Rapti, X Z Shawn Xu, Yun Zhang, Chun-Fang Wu,

J Neurogenet (Journal of neurogenetics)
[2020, 34(3-4):223-224]

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Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressedDrosophila

Atulya Srisudarshan Ram Iyengar, Hongyu Ruan, Chun-Fang Wu,

We examined several sensory-motor processing circuits in Drosophila across the lifespan and uncovered distinctive age-resilient and age-vulnerable trajectories in their established functional properties. We observed relatively little deterioration toward the end of lifespan in the giant-fiber (GF) and downstream circuit elements responsible for the jump-and-flight escape reflex. In contrast, we ... Read more >>

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Future perspectives of neurogenetics - in honor of Troy D. Zars (1967-2018).

Bertram Gerber, Elizabeth G King, David Schulz, Hiromu Tanimoto, Scott Waddell, Chun-Fang Wu,

J Neurogenet (Journal of neurogenetics)
[2020, 34(1):1]

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Comprehensive transcriptome analysis of faba bean in response to vernalization.

Bei Gao, Xiao-Chun Bian, Feng Yang, Mo-Xian Chen, Debatosh Das, Xiu-Ru Zhu, Yong Jiang, Jianhua Zhang, Yun-Ying Cao, Chun-Fang Wu,

MAIN CONCLUSION:This study unravels the transcriptional response of a highly productive faba bean cultivar under vernalization treatment. Faba bean (Vicia faba L.) is a member of the Leguminosae family and an important food crop worldwide providing valuable nutrients for humans. However, genome-wide studies and comprehensive sequencing resources of faba bean ... Read more >>

Planta (Planta)
[2019, 251(1):22]

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Pyridox (am) ine 5'-phosphate oxidase deficiency induces seizures in Drosophila melanogaster.

Wanhao Chi, Atulya S R Iyengar, Monique Albersen, Marjolein Bosma, Nanda M Verhoeven-Duif, Chun-Fang Wu, Xiaoxi Zhuang,

Pyridox (am) ine 5'-phosphate oxidase (PNPO) is a rate-limiting enzyme in converting dietary vitamin B6 (VB6) to pyridoxal 5'-phosphate (PLP), the biologically active form of VB6 and involved in the synthesis of neurotransmitters including γ-aminobutyric acid (GABA), dopamine, and serotonin. In humans, PNPO mutations have been increasingly identified in neonatal ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2019, 28(18):3126-3136]

Cited: 2 times

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Milk-whey diet substantially suppresses seizure-like phenotypes of paraShu, a Drosophila voltage-gated sodium channel mutant.

Junko Kasuya, Atulya Iyengar, Hung-Lin Chen, Patrick Lansdon, Chun-Fang Wu, Toshihiro Kitamoto,

The <i>Drosophila</i> mutant <i>para<sup>Shu</sup></i> harbors a dominant, gain-of-function allele of the voltage-gated sodium channel gene, <i>paralytic</i> (<i>para</i>). The mutant flies display severe seizure-like phenotypes, including neuronal hyperexcitability, spontaneous spasms, ether-induced leg shaking, and heat-induced convulsions. We unexpectedly found that two distinct food recipes used routinely in the <i>Drosophila</i> research community ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2019, 33(3):164-178]

Cited: 4 times

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Comparative behavioral genetics: the Yamamoto approach.

Hiromu Tanimoto, Chun-Fang Wu,

J Neurogenet (Journal of neurogenetics)
[2019, 33(2):41-43]

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Pyridox(am)ine 5’-phosphate oxidase deficiency induces seizures in Drosophila melanogaster

Wanhao Chi, Atulya Iyengar, Monique Albersen, Marjolein Bosma, Nanda Verhoeven-Duif, Chun-Fang Wu, Xiaoxi Zhuang,

Pyridox(am)ine 5’-phosphate oxidase (PNPO) is a rate-limiting enzyme in converting dietary vitamin B6 (VB6) to pyridoxal 5’-phosphate (PLP), the biologically active form of VB6, and involved in the synthesis of neuro-transmitters including GABA, dopamine, and serotonin. In humans, PNPO mutations have been increasingly identified in neonatal epileptic encephalopathy and more ... Read more >>

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Distinctions among electroconvulsion- and proconvulsant-induced seizure discharges and native motor patterns during flight and grooming: quantitative spike pattern analysis in Drosophila flight muscles.

Jisue Lee, Atulya Iyengar, Chun-Fang Wu,

In <i>Drosophila</i>, high-frequency electrical stimulation across the brain triggers a highly stereotypic repertoire of spasms. These electroconvulsive seizures (ECS) manifest as distinctive spiking discharges across the nervous system and can be stably assessed throughout the seizure repertoire in the large indirect flight muscles dorsal longitudinal muscles (DLMs) to characterize modifications ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2019, 33(2):125-142]

Cited: 2 times

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Distinctions among electroconvulsion- and proconvulsant-induced seizure discharges and native motor patterns during flight and grooming: Quantitative spike pattern analysis in Drosophila flight muscles

Jisue Lee, Atulya Iyengar, Chun-Fang Wu,

In Drosophila , high-frequency electrical stimulation across the brain triggers a highly stereotypic repertoire of spasms known as electroconvulsive seizures (ECS). The distinctive ECS spiking discharges manifest across the nervous system and can be stably assessed throughout the seizure repertoire in the large indirect flight muscles (DLMs). ECS discharges in ... Read more >>

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A reductionist approach to understanding the nervous system: the Harold Atwood legacy.

Jeffrey S Dason, Marla B Sokolowski, Chun-Fang Wu,

J Neurogenet (Journal of neurogenetics)
[2018, 32(3):127-130]

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Inter-relationships among physical dimensions, distal-proximal rank orders, and basal GCaMP fluorescence levels in Ca2+ imaging of functionally distinct synaptic boutons at Drosophila neuromuscular junctions.

Xiaomin Xing, Chun-Fang Wu,

GCaMP imaging is widely employed for investigating neuronal Ca<sup>2+</sup> dynamics. The Drosophila larval neuromuscular junction (NMJ) consists of three distinct types of motor terminals (type Ib, Is and II). We investigated whether variability in synaptic bouton sizes and GCaMP expression levels confound interpretations of GCaMP readouts, in inferring the intrinsic ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2018, 32(3):195-208]

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Unraveling Synaptic GCaMP Signals: Differential Excitability and Clearance Mechanisms Underlying Distinct Ca2+ Dynamics in Tonic and Phasic Excitatory, and Aminergic Modulatory Motor Terminals in Drosophila.

Xiaomin Xing, Chun-Fang Wu,

GCaMP is an optogenetic Ca<sup>2+</sup> sensor widely used for monitoring neuronal activities but the precise physiological implications of GCaMP signals remain to be further delineated among functionally distinct synapses. The <i>Drosophila</i> neuromuscular junction (NMJ), a powerful genetic system for studying synaptic function and plasticity, consists of tonic and phasic glutamatergic ... Read more >>

eNeuro (eNeuro)
[2018, 5(1):]

Cited: 6 times

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Generation and characterization of new alleles of quiver (qvr) that encodes an extracellular modulator of the Shaker potassium channel.

Hongyu Ruan, Atsushi Ueda, Xiaomin Xing, Xuxuan Wan, Benjamin Strub, Spencer Mukai, Kaan Certel, David Green, Kyle Belozerov, Wei-Dong Yao, Wayne Johnson, Jim Jung-Ching Lin, Arthur J Hilliker, Chun-Fang Wu,

Our earlier genetic screen uncovered a paraquat-sensitive leg-shaking mutant quiver<sup>1</sup> (qvr<sup>1</sup>), whose gene product interacts with the Shaker (Sh) K<sup>+</sup> channel. We also mapped the qvr locus to EY04063 and noticed altered day-night activity patterns in these mutants. Such circadian behavioral defects were independently reported by another group, who employed ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2017, 31(4):325-336]

Cited: 1 time

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Zebrafish: from genes and neurons to circuits, behavior and disease.

Anand Chandrasekhar, Su Guo, Ichiro Masai, Teresa Nicolson, Chun-Fang Wu,

J Neurogenet (Journal of neurogenetics)
[2017, 31(3):59-60]

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K+ channel reorganization and homeostatic plasticity during postembryonic development: biophysical and genetic analyses in acutely dissociated Drosophila central neurons.

Taixiang Saur, I-Feng Peng, Peng Jiang, Neng Gong, Wei-Dong Yao, Tian-Le Xu, Chun-Fang Wu,

Intrinsic electric activities of neurons play important roles in establishing and refining neural circuits during development. However, how the underlying ionic currents undergo postembryonic reorganizations remains largely unknown. Using acutely dissociated neurons from larval, pupal, and adult Drosophila brains, we show drastic re-assemblies and compensatory regulations of voltage-gated (I<sub>Kv</sub>) and ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2016, 30(3-4):259-275]

Cited: 1 time

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Photo gallery for the special issue in honor of Barry Ganetzky.

Atsushi Ueda, Tim Patience, Chun-Fang Wu,

J Neurogenet (Journal of neurogenetics)
[2016, 30(3-4):223-236]

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The neurogenetics of Drosophila: the Ganetzky legacy.

Kate M O'Connor-Giles, Bing Zhang, Julie H Simpson, Chun-Fang Wu,

J Neurogenet (Journal of neurogenetics)
[2016, 30(3-4):149-151]

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