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Christopher Lai, Jean-Louis Teboul, Xavier Monnet,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1185-e1186]

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In vitro susceptibility of ceftolozane/tazobactam against typhoidal, non-typhoidal and extended spectrum β-lactamase-producing Salmonella.

Jade L L Teng, Elaine Chan, Asher C H Dai, Gillian Ng, Tsz Tuen Li, Christopher Lai, Alan K L Wu, Susanna K P Lau, Patrick C Y Woo,

Both typhoidal and non-typhoidal salmonellae are included in the top 15 drug-resistant threats described by the Center for Disease Control and Prevention of the United States. There is an urgent need to look for alternative antibiotics for the treatment of Salmonella infections. We examined the in vitro susceptibilities of ceftolozane/tazobactam ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2021, :AAC0122421]

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Be Prepared: Preoperative Coronal Malalignment Often Leads to More Extensive Surgery Than Sagittal Malalignment During Adult Spinal Deformity Surgery.

Scott L Zuckerman, Christopher S Lai, Yong Shen, Mena G Kerolus, Alex S Ha, Ian A Buchanan, Nathan J Lee, Eric Leung, Meghan Cerpa, Ronald A Lehman, Lawrence G Lenke,

<h4>Objective</h4>To evaluate the effect of coronal alignment on: (1) surgical invasiveness and operative complexity and (2) postoperative complications.<h4>Methods</h4>A retrospective, cohort study of adult spinal deformity patients was conducted. Alignment groups were: (1) neutral alignment (NA): coronal vertical axis (CVA) ≤ 3 cm and sagittal vertical axis (SVA) ≤ 5 cm; ... Read more >>

Neurospine (Neurospine)
[2021, 18(3):570-579]

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Christopher Lai, Jean-Louis Teboul, Xavier Monnet,

Crit Care Med (Critical care medicine)
[2021, 49(10):e1046-e1047]

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Longitudinal Genomic Characterization of Carbapenemase-producing Enterobacteriaceae (CPE) Reveals Changing Pattern of CPE Isolated in Hong Kong Hospitals.

Chendi Zhu, Carmen Li, Christopher K C Lai, Rita Ng, Ka Yee Chau, Kam Tak Wong, Norman W S Lo, Nilakshi Barua, Ying Yang, Veranja Liyanapathirana, Mamie Hui, Raymond W Lai, Kitty S C Fung, Dominic N Tsang, Margaret Ip,

An active, territory-wide, CPE surveillance program implemented from 2011 showed increasing levels of carbapenemase-producing Enterobacteriaceae (CPE) isolates from patients in Hong Kong hospitals. The molecular epidemiology of 567 CPE from patients of three of seven public hospital clusters in Hong Kong are described. During a 7-year period, the incidence of ... Read more >>

Int J Antimicrob Agents (International journal of antimicrobial agents)
[2021, :106430]

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Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.

Gregory G Schwartz, Michael Szarek, Vera A Bittner, Rafael Diaz, Shaun G Goodman, J Wouter Jukema, Ulf Landmesser, Patricio López-Jaramillo, Garen Manvelian, Robert Pordy, Michel Scemama, Peter R Sinnaeve, Harvey D White, Ph Gabriel Steg, ,

<h4>Background</h4>Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk.<h4>Objectives</h4>In a post hoc analysis ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2021, 78(5):421-433]

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Norepinephrine potentiates the efficacy of volume expansion on mean systemic pressure in septic shock.

Imane Adda, Christopher Lai, Jean-Louis Teboul, Laurent Guerin, Francesco Gavelli, Xavier Monnet,

<h4>Background</h4>Through venous contraction, norepinephrine (NE) increases stressed blood volume and mean systemic pressure (Pms) and exerts a "fluid-like" effect. When both fluid and NE are administered, Pms may not only result from the sum of the effects of both drugs. Indeed, norepinephrine may enhance the effects of volume expansion: because fluid ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):302]

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Multimodal Patient-Specific Registration for Breast Imaging Using Biomechanical Modeling with Reference to AI Evaluation of Breast Tumor Change.

Cheng Xue, Fuk-Hay Tang, Christopher W K Lai, Lars J Grimm, Joseph Y Lo,

<h4>Background</h4>The strategy to combat the problem associated with large deformations in the breast due to the difference in the medical imaging of patient posture plays a vital role in multimodal medical image registration with artificial intelligence (AI) initiatives. How to build a breast biomechanical model simulating the large-scale deformation of ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(8):]

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Comparison of self-collected mouth gargle with deep-throat saliva samples for the diagnosis of COVID-19: Mouth gargle for diagnosis of COVID-19.

Christopher Kc Lai, Grace Cy Lui, Zigui Chen, Yuk-Yam Cheung, Kwok Chu Cheng, Agnes Sy Leung, Rita Wy Ng, Jo Lk Cheung, Apple Cm Yeung, Wendy Cs Ho, Kate C Chan, David Sc Hui, Dominic Nc Tsang, Paul Ks Chan,

J Infect (The Journal of infection)
[2021, 83(4):496-522]

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Knee joint loadings are related to tibial torsional alignments in people with radiographic medial knee osteoarthritis.

Chen Huang, Ping Keung Chan, Kwong Yuen Chiu, Chun Hoi Yan, Desmond Shun Shing Yeung, Christopher Wai Keung Lai, Siu Ngor Fu,

Torsional malalignment was detected in subjects with medial knee osteoarthritis (KOA) but few studies have reported the effect of torsional deformity on knee joint loads during walking. Therefore, this study examined the relationships between lower limb torsional alignments and knee joint loads during gait in people with symptomatic medial KOA ... Read more >>

PLoS One (PloS one)
[2021, 16(7):e0255008]

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Myeloid phenotypes in severe COVID-19 predict secondary infection and mortality: a pilot study.

Clémence Marais, Caroline Claude, Nada Semaan, Ramy Charbel, Simon Barreault, Brendan Travert, Jean-Eudes Piloquet, Zoé Demailly, Luc Morin, Zied Merchaoui, Jean-Louis Teboul, Philippe Durand, Jordi Miatello, Pierre Tissières, ,

<h4>Background</h4>De-regulated host response to severe coronavirus disease 2019 (COVID-19), directly referring to the concept of sepsis-associated immunological dysregulation, seems to be a strong signature of severe COVID-19. Myeloid cells phenotyping is well recognized to diagnose critical illness-induced immunodepression in sepsis and has not been well characterized in COVID-19. The aim ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):111]

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L5 Vertebral Column Resection for Correction of Severe Lumbar Hyperlordosis and Pelvic Anteversion in an Adolescent With Prior Myelomeningocele Repair and Lumbar Fusion: Case Report.

Christopher S Lai, Meghan Cerpa, Scott L Zuckerman, Richard Menger, Lawrence G Lenke,

<h4>Background and importance</h4>Lumbar hyperlordosis in ambulatory children is an uncommon but potentially problematic spinal deformity, and the operative management has not been comprehensively described.<h4>Clinical presentation</h4>We report the case of a 14-yr-old girl presenting with severe progressive lumbar hyperlordosis (-122°) and sagittal imbalance (-6 cm). She had multiple prior surgeries, including myelomeningocele ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2021, 21(2):E129-E135]

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Spatial Distribution and Quantification of Mammographic Breast Density, and Its Correlation with BI-RADS Using an Image Segmentation Method.

Yi Ling Eileen Goh, Zhen Yu Lee, Christopher Lai,

(1) Background: Mammographic breast density (MBD) and older age are classical breast cancer risk factors. Normally, MBDs are not evenly distributed in the breast, with different women having different spatial distribution and clustering patterns. The presence of MBDs makes tumors and other lesions challenging to be identified in mammograms. The ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(6):]

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COVID-19 ARDS is characterized by higher extravascular lung water than non-COVID-19 ARDS: the PiCCOVID study.

Rui Shi, Christopher Lai, Jean-Louis Teboul, Martin Dres, Francesca Moretto, Nello De Vita, Tài Pham, Vincent Bonny, Julien Mayaux, Rosanna Vaschetto, Alexandra Beurton, Xavier Monnet,

<h4>Background</h4>In acute respiratory distress syndrome (ARDS), extravascular lung water index (EVLWi) and pulmonary vascular permeability index (PVPI) measured by transpulmonary thermodilution reflect the degree of lung injury. Whether EVLWi and PVPI are different between non-COVID-19 ARDS and the ARDS due to COVID-19 has never been reported. We aimed at comparing ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):186]

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The odontoid-CSVL distance in a global population of asymptomatic volunteers: normative values and implications for spinal coronal alignment.

Scott L Zuckerman, Zeeshan M Sardar, Christopher S Lai, Gerard F Marciano, Mena G Kerolus, Ian A Buchanan, Alex S Ha, Meghan Cerpa, Michael P Kelly, Stéphane Bourret, Kazuhiro Hasegawa, Hee-Kit Wong, Gabriel Liu, Hwee Weng Dennis Hey, Hend Riahi, Jean-Charles Le Huec, Lawrence G Lenke,

<h4>Purpose</h4>In a population of asymptomatic volunteers across 5 countries, we sought to: (a) establish normative values of the Odontoid-Central Sacral Vertical Line (OD-CSVL) across patient factors, and (b) assess correlations of OD-CSVL with other radiographic parameters.<h4>Methods</h4>A prospective, cross-sectional study of asymptomatic adult volunteers, ages 18-80 years, were enrolled across 5 countries ... Read more >>

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2021, :]

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Do Adult Spinal Deformity Patients Undergoing Surgery Continue to Improve From 1-Year to 2-Years Postoperative?

Scott L Zuckerman, Christopher S Lai, Yong Shen, Meghan Cerpa, Nathan J Lee, Mena G Kerolus, Alex S Ha, Ian A Buchanan, Clinton J Devin, Ronald A Lehman, Lawrence G Lenke,

<h4>Objective</h4>Evaluate clinical improvement as measured by patient-reported outcomes (PROs) during the 1 to 2-year interval.<h4>Study design</h4>Retrospective Cohort.<h4>Methods</h4>A single-institution registry of ASD patients undergoing surgery was queried for patients with ≥6 level fusions. Demographics and radiographic variables were collected. PROs collected were the ODI and SRS-22r scores at: preoperative, 1-year and ... Read more >>

Global Spine J (Global spine journal)
[2021, :21925682211019352]

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Challenges and optimization strategies in medical imaging service delivery during COVID-19.

Yi Xiang Tay, Suchart Kothan, Sundaran Kada, Sihui Cai, Christopher Wai Keung Lai,

In coronavirus disease 2019 (COVID-19), medical imaging plays an essential role in the diagnosis, management and disease progression surveillance. Chest radiography and computed tomography are commonly used imaging techniques globally during this pandemic. As the pandemic continues to unfold, many healthcare systems worldwide struggle to balance the heavy strain due ... Read more >>

World J Radiol (World journal of radiology)
[2021, 13(5):102-121]

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Effects of Prone Positioning on Venous Return in Patients With Acute Respiratory Distress Syndrome.

Christopher Lai, Imane Adda, Jean-Louis Teboul, Romain Persichini, Francesco Gavelli, Laurent Guérin, Xavier Monnet,

<h4>Objectives</h4>To examine the effects of prone positioning on venous return and its determinants such as mean systemic pressure and venous return resistance in patients with acute respiratory distress syndrome.<h4>Design</h4>Prospective monocentric study.<h4>Settings</h4>A 25-bed medical ICU.<h4>Patients</h4>About 22 patients with mild-to-severe acute respiratory distress syndrome in whom prone positioning was decided.<h4>Interventions</h4>We obtained cardiac ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(5):781-789]

Cited: 1 time

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Coronal Alignment in Adult Spinal Deformity Surgery: Definitions, Measurements, Treatment Algorithms, and Impact on Clinical Outcomes.

Scott L Zuckerman, Meghan Cerpa, Christopher S Lai, Lawrence G Lenke,

The major focus of realignment in adult spinal deformity (ASD) surgery has been on the sagittal plane, and less emphasis has been given to the coronal plane. In light of this overlooked area within ASD surgery, we aimed to refocus the narrative on coronal alignment in ASD surgery. The objectives ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2021, :]

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A Chemical Probe Based on the PreQ1 Metabolite Enables Transcriptome-wide Mapping of Binding Sites

Sumirtha Balaratnam, Curran Rhodes, Desta Bume, Colleen Connelly, Christopher Lai, James Kelley, Kamyar Yazdani, Phil Homan, Danny Incarnato, Tomoyuki Numata, Jay Schneekloth,

The role of metabolite-responsive riboswitches in regulating gene expression in bacteria is well known and makes them useful systems for the study of RNA-small molecule interactions. Here, we study the PreQ1 riboswitch system, assessing sixteen diverse PreQ1-derived probes for their ability to selectively modify the riboswitch aptamer covalently. For the ... Read more >>

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A global analysis of replacement of genetic variants of SARS-CoV-2 in association with containment capacity and changes in disease severity.

Zigui Chen, Ka Chun Chong, Martin C S Wong, Siaw S Boon, Junjie Huang, Maggie H Wang, Rita W Y Ng, Christopher K C Lai, Paul K S Chan,

<h4>Objectives</h4>To examine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant replacement in association with containment capacity and changes in case fatality at country level.<h4>Methods</h4>Altogether, 69 571 full SARS-CoV-2 genomes collected globally within the first 6 months of the pandemic were examined. The correlation between variant replacement and containment capacity was examined by ... Read more >>

Clin Microbiol Infect (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2021, :]

Cited: 1 time

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A territory-wide study on the factors associated with recurrent asthma exacerbations requiring hospitalization in Hong Kong.

Ka Pang Chan, Fanny Wai San Ko, Kwun Cheung Ling, Pik Shan Cheung, Lee Veronica Chan, Yu Hong Chan, Yi Tat Lo, Chun Kong Ng, Macy Mei-Sze Lui, Kwok Sang Wilson Yee, Cee Zhung Steven Tseng, Pak Yiu Tse, Mo Lin Maureen Wong, Kah Lin Choo, Wai Kei Lam, Chun Man Wong, Sheng Sheng Ho, Chung Tat Lun, Christopher Kei Wai Lai,

<h4>Background</h4>The real-world relationships between the demographic and clinical characteristics of asthma patients, their prehospitalization management and the frequency of hospitalization due to asthma exacerbation is poorly established.<h4>Objective</h4>To determine the risk factors of recurrent asthma exacerbations requiring hospitalizations and evaluate the standard of baseline asthma care.<h4>Methods</h4>A territory-wide, multicentre retrospective study in ... Read more >>

Immun Inflamm Dis (Immunity, inflammation and disease)
[2021, 9(2):569-581]

Cited: 1 time

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Acceptance of the COVID-19 vaccine based on the health belief model: A population-based survey in Hong Kong.

Martin C S Wong, Eliza L Y Wong, Junjie Huang, Annie W L Cheung, Kevin Law, Marc K C Chong, Rita W Y Ng, Christopher K C Lai, Siaw S Boon, Joseph T F Lau, Zigui Chen, Paul K S Chan,

<h4>Background</h4>Vaccines for COVID-19 are anticipated to be available by 2021. Vaccine uptake rate is a crucial determinant for herd immunity. We examined factors associated with acceptance of vaccine based on (1). constructs of the Health Belief Model (HBM), (2). trust in the healthcare system, new vaccine platforms and manufacturers, and ... Read more >>

Vaccine (Vaccine)
[2021, 39(7):1148-1156]

Cited: 25 times

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The strategy to develop newly joined radiographers in a COVID-19 world: a curated orientation programme.

Yi Xiang Tay, Yu-Min Wei, Lian Ping Aw, Christopher Lai,

J Med Imaging Radiat Sci (Journal of medical imaging and radiation sciences)
[2020, :]

Cited: 2 times

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Laboratory testing for the diagnosis of COVID-19.

Christopher K C Lai, Wilson Lam,

Rapid and accurate laboratory diagnosis of active COVID-19 infection is one of the cornerstones of pandemic control. With the myriad of tests available in the market, the use of correct specimen type and laboratory-testing technique in the right clinical scenario could be challenging for non-specialists. In this mini-review, we will ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 538:226-230]

Cited: 7 times

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