Full Text Journal Articles by
Author Christopher J Potter

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Rapid degeneration of Drosophila olfactory neurons in Orco mutant maxillary palps.

Darya Task, Christopher J Potter,

<i>Drosophila melanogaster</i> vinegar flies have two olfactory organs: the antenna and maxillary palp. Olfactory neurons in these tissues respond to odorants via odorant receptors. Insect odorant receptors are heterotetramers of two proteins: an odorant binding OrX subunit and an Odorant Receptor Co-Receptor (Orco). Mutation of <i>Orco</i> disrupts odorant receptor formation, ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 0 times

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The number of neurons in Drosophila and mosquito brains.

Joshua I Raji, Christopher J Potter,

Various insect species serve as valuable model systems for investigating the cellular and molecular mechanisms by which a brain controls sophisticated behaviors. In particular, the nervous system of Drosophila melanogaster has been extensively studied, yet experiments aimed at determining the number of neurons in the Drosophila brain are surprisingly lacking. ... Read more >>

PLoS One (PloS one)
[2021, 16(5):e0250381]

Cited: 1 time

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The irritant receptor TRPA1 mediates the mosquito repellent effect of catnip.

Nadia Melo, Matthew Capek, Oscar M Arenas, Ali Afify, Ayse Yilmaz, Christopher J Potter, Peter J Laminette, Alessia Para, Marco Gallio, Marcus C Stensmyr,

Catnip (Nepeta cataria) is a common garden herb well known for its euphoric and hallucinogenic effects on domestic cats,<sup>1-3</sup> for its medicinal properties,<sup>4</sup><sup>,</sup><sup>5</sup> as well as for its powerful repellent action on insects.<sup>6</sup><sup>,</sup><sup>7</sup> Catnip extracts have been proposed as a natural alternative to synthetic insect repellents, such as N,N-diethyl-3-methylbenzamide (DEET),<sup>8</sup><sup>,</sup><sup>9</sup> ... Read more >>

Curr Biol (Current biology : CB)
[2021, 31(9):1988-1994.e5]

Cited: 2 times

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Olfaction in Anopheles mosquitoes.

Joanna K Konopka, Darya Task, Ali Afify, Joshua Raji, Katelynn Deibel, Sarah Maguire, Randy Lawrence, Christopher J Potter,

As vectors of disease, mosquitoes are a global threat to human health. The Anopheles mosquito is the deadliest mosquito species as the insect vector of the malaria-causing parasite, which kills hundreds of thousands every year. These mosquitoes are reliant on their sense of smell (olfaction) to guide most of their ... Read more >>

Chem Senses (Chemical senses)
[2021, 46:]

Cited: 1 time

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Insect repellents mediate species-specific olfactory behaviours in mosquitoes.

Ali Afify, Christopher J Potter,

<h4>Background</h4>The species-specific mode of action for DEET and many other mosquito repellents is often unclear. Confusion may arise for many reasons. First, the response of a single mosquito species is often used to represent all mosquito species. Second, behavioural studies usually test the effect of repellents on mosquito attraction towards ... Read more >>

Malar J (Malaria journal)
[2020, 19(1):127]

Cited: 4 times

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Commonly Used Insect Repellents Hide Human Odors from Anopheles Mosquitoes.

Ali Afify, Joshua F Betz, Olena Riabinina, Chloé Lahondère, Christopher J Potter,

The mode of action for most mosquito repellents is unknown. This is primarily due to the difficulty in monitoring how the mosquito olfactory system responds to repellent odors. Here, we used the Q-system of binary expression to enable activity-dependent Ca<sup>2+</sup> imaging in olfactory neurons of the African malaria mosquito Anopheles ... Read more >>

Curr Biol (Current biology : CB)
[2019, 29(21):3669-3680.e5]

Cited: 13 times

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Diet Drugs Trick Mosquitoes into Feeling Full.

Sarah E Maguire, Christopher J Potter,

After a bloodmeal, Aedesaegypti mosquitoes lose interest in bloodfeeding. Duvall et al. (Cell 2019;176:687-701) determined that the neuropeptide Y (NPY)-like receptor 7 (NPYLR7) controls mosquito satiety and also identified six NPYLR7 drug targets that suppress biting. This work highlights an innovative approach in vector control linking insect behavior to drug ... Read more >>

Trends Pharmacol Sci (Trends in pharmacological sciences)
[2019, 40(7):449-451]

Cited: 0 times

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Olfaction: Mosquitoes Love Your Acid Odors.

Christopher J Potter,

Mosquitoes use their sense of smell to find humans. A new study shows that the ionotropic receptor 8a (IR8a) plays a primary and non-redundant role in human host-seeking behaviors. ... Read more >>

Curr Biol (Current biology : CB)
[2019, 29(8):R282-R284]

Cited: 0 times

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Shining a Light on Olfactory Circuits.

Christopher J Potter,

How is odor information organized in the brain? In this issue of Neuron, Jeanne et al. (2018) pair optogenetics with electrophysiology to map functional connections between two olfactory brain regions. They suggest that lateral horn neurons encode "odor scenes" to represent biologically relevant odor environments. ... Read more >>

Neuron (Neuron)
[2018, 98(6):1061-1063]

Cited: 0 times

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Olfactory Neurons and Brain Centers Directing Oviposition Decisions in Drosophila.

Sonia G Chin, Sarah E Maguire, Paavo Huoviala, Gregory S X E Jefferis, Christopher J Potter,

The sense of smell influences many behaviors, yet how odors are represented in the brain remains unclear. A major challenge to studying olfaction is the lack of methods allowing activation of specific types of olfactory neurons in an ethologically relevant setting. To address this, we developed a genetic method in ... Read more >>

Cell Rep (Cell reports)
[2018, 24(6):1667-1678]

Cited: 8 times

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A Genetic Toolkit for Dissecting Dopamine Circuit Function in Drosophila.

Tingting Xie, Margaret C W Ho, Qili Liu, Wakako Horiuchi, Chun-Chieh Lin, Darya Task, Haojiang Luan, Benjamin H White, Christopher J Potter, Mark N Wu,

The neuromodulator dopamine (DA) plays a key role in motor control, motivated behaviors, and higher-order cognitive processes. Dissecting how these DA neural networks tune the activity of local neural circuits to regulate behavior requires tools for manipulating small groups of DA neurons. To address this need, we assembled a genetic ... Read more >>

Cell Rep (Cell reports)
[2018, 23(2):652-665]

Cited: 18 times

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Organization of olfactory centres in the malaria mosquito Anopheles gambiae.

Olena Riabinina, Darya Task, Elizabeth Marr, Chun-Chieh Lin, Robert Alford, David A O'Brochta, Christopher J Potter,

Mosquitoes are vectors for multiple infectious human diseases and use a variety of sensory cues (olfactory, temperature, humidity and visual) to locate a human host. A comprehensive understanding of the circuitry underlying sensory signalling in the mosquito brain is lacking. Here we used the Q-system of binary gene expression to ... Read more >>

Nat Commun (Nature communications)
[2016, 7:13010]

Cited: 37 times

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Editing Transgenic DNA Components by Inducible Gene Replacement in Drosophila melanogaster.

Chun-Chieh Lin, Christopher J Potter,

Gene conversions occur when genomic double-strand DNA breaks (DSBs) trigger unidirectional transfer of genetic material from a homologous template sequence. Exogenous or mutated sequence can be introduced through this homology-directed repair (HDR). We leveraged gene conversion to develop a method for genomic editing of existing transgenic insertions in Drosophila melanogaster ... Read more >>

Genetics (Genetics)
[2016, 203(4):1613-1628]

Cited: 30 times

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Olfactory Behaviors Assayed by Computer Tracking Of Drosophila in a Four-quadrant Olfactometer.

Chun-Chieh Lin, Olena Riabinina, Christopher J Potter,

A key challenge in neurobiology is to understand how neural circuits function to guide appropriate animal behaviors. Drosophila melanogaster is an excellent model system for such investigations due to its complex behaviors, powerful genetic techniques, and compact nervous system. Laboratory behavioral assays have long been used with Drosophila to simulate ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2016, (114):]

Cited: 0 times

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The Q-System: A Versatile Expression System for Drosophila.

Olena Riabinina, Christopher J Potter,

Binary expression systems are flexible and versatile genetic tools in Drosophila. The Q-system is a recently developed repressible binary expression system that offers new possibilities for transgene expression and genetic manipulations. In this review chapter, we focus on current state-of-the-art Q-system tools and reagents. We also discuss in vivo applications ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2016, 1478:53-78]

Cited: 11 times

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Re-Classification of Drosophila melanogaster Trichoid and Intermediate Sensilla Using Fluorescence-Guided Single Sensillum Recording.

Chun-Chieh Lin, Christopher J Potter,

Drosophila olfactory receptor neurons are found within specialized sensory hairs on antenna and maxillary palps. The linking of odorant-induced responses to olfactory neuron activities is often accomplished via Single Sensillum Recordings (SSR), in which an electrode inserted into a single sensory hair records the neuronal activities of all the neurons ... Read more >>

PLoS One (PloS one)
[2015, 10(10):e0139675]

Cited: 13 times

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Food odors trigger Drosophila males to deposit a pheromone that guides aggregation and female oviposition decisions.

Chun-Chieh Lin, Katharine A Prokop-Prigge, George Preti, Christopher J Potter,

Animals use olfactory cues for navigating complex environments. Food odors in particular provide crucial information regarding potential foraging sites. Many behaviors occur at food sites, yet how food odors regulate such behaviors at these sites is unclear. Using Drosophila melanogaster as an animal model, we found that males deposit the ... Read more >>

Elife (eLife)
[2015, 4:]

Cited: 30 times

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Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes.

Fengqiu Diao, Holly Ironfield, Haojiang Luan, Feici Diao, William C Shropshire, John Ewer, Elizabeth Marr, Christopher J Potter, Matthias Landgraf, Benjamin H White,

Genetically encoded effectors are important tools for probing cellular function in living animals, but improved methods for directing their expression to specific cell types are required. Here, we introduce a simple, versatile method for achieving cell-type-specific expression of transgenes that leverages the untapped potential of "coding introns" (i.e., introns between coding ... Read more >>

Cell Rep (Cell reports)
[2015, 10(8):1410-1421]

Cited: 123 times

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A transcriptional reporter of intracellular Ca(2+) in Drosophila.

Xiaojing J Gao, Olena Riabinina, Jiefu Li, Christopher J Potter, Thomas R Clandinin, Liqun Luo,

Intracellular Ca(2+) is a widely used neuronal activity indicator. Here we describe a transcriptional reporter of intracellular Ca(2+) (TRIC) in Drosophila that uses a binary expression system to report Ca(2+)-dependent interactions between calmodulin and its target peptide. We found that in vitro assays predicted in vivo properties of TRIC and ... Read more >>

Nat Neurosci (Nature neuroscience)
[2015, 18(6):917-925]

Cited: 38 times

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Improved and expanded Q-system reagents for genetic manipulations.

Olena Riabinina, David Luginbuhl, Elizabeth Marr, Sha Liu, Mark N Wu, Liqun Luo, Christopher J Potter,

The Q system is a repressible binary expression system for transgenic manipulations in living organisms. Through protein engineering and in vivo functional tests, we report here variants of the Q-system transcriptional activator, including QF2, for driving strong and ubiquitous expression in all Drosophila tissues. Our QF2, Gal4QF and LexAQF chimeric ... Read more >>

Nat Methods (Nature methods)
[2015, 12(3):219-22, 5 p following 222]

Cited: 50 times

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Stop the biting: targeting a mosquito's sense of smell.

Christopher J Potter,

Mosquitoes are a great threat to human health. Fortunately, they have a weakness: they utilize their sense of smell to target a human host. Recent studies examine the effectiveness of protecting humans from attack by ablating or odorant targeting mosquito olfactory receptors. The results are both promising and alarming. ... Read more >>

Cell (Cell)
[2014, 156(5):878-881]

Cited: 22 times

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Farnesol-detecting olfactory neurons in Drosophila.

David S Ronderos, Chun-Chieh Lin, Christopher J Potter, Dean P Smith,

We set out to deorphanize a subset of putative Drosophila odorant receptors expressed in trichoid sensilla using a transgenic in vivo misexpression approach. We identified farnesol as a potent and specific activator for the orphan odorant receptor Or83c. Farnesol is an intermediate in juvenile hormone biosynthesis, but is also produced ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2014, 34(11):3959-3968]

Cited: 41 times

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GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons.

Liang Liang, Yulong Li, Christopher J Potter, Ofer Yizhar, Karl Deisseroth, Richard W Tsien, Liqun Luo,

We characterize an inhibitory circuit motif in the Drosophila olfactory system, parallel inhibition, which differs from feedforward or feedback inhibition. Excitatory and GABAergic inhibitory projection neurons (ePNs and iPNs) each receive input from antennal lobe glomeruli and send parallel output to the lateral horn, a higher center implicated in regulating ... Read more >>

Neuron (Neuron)
[2013, 79(5):917-931]

Cited: 60 times

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Specific kinematics and motor-related neurons for aversive chemotaxis in Drosophila.

Xiaojing J Gao, Christopher J Potter, Daryl M Gohl, Marion Silies, Alexander Y Katsov, Thomas R Clandinin, Liqun Luo,

<h4>Background</h4>Chemotaxis, the ability to direct movements according to chemical cues in the environment, is important for the survival of most organisms. The vinegar fly, Drosophila melanogaster, displays robust olfactory aversion and attraction, but how these behaviors are executed via changes in locomotion remains poorly understood. In particular, it is not ... Read more >>

Curr Biol (Current biology : CB)
[2013, 23(13):1163-1172]

Cited: 12 times

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Adoption of the Q transcriptional regulatory system for zebrafish transgenesis.

Abhignya Subedi, Michelle Macurak, Stephen T Gee, Estela Monge, Mary G Goll, Christopher J Potter, Michael J Parsons, Marnie E Halpern,

The Gal4-UAS regulatory system of yeast is widely used to modulate gene expression in Drosophila; however, there are limitations to its usefulness in transgenic zebrafish, owing to progressive methylation and silencing of the CpG-rich multicopy upstream activation sequence. Although a modified, less repetitive UAS construct may overcome this problem, it ... Read more >>

Methods (Methods (San Diego, Calif.))
[2014, 66(3):433-440]

Cited: 21 times

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