Full Text Journal Articles by
Author Christopher Harris

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Postnatal dexamethasone exposure and lung function in adolescents born very prematurely.

Christopher Harris, Alessandra Bisquera, Sanja Zivanovic, Alan Lunt, Sandy Calvert, Neil Marlow, Janet L Peacock, Anne Greenough,

We previously demonstrated corticosteroid administration on the neonatal intensive care unit was associated with reduced lung function at 11 to 14 years of age in children born very prematurely. The objective of this observational study was to assess if lung function remained impaired at 16 to 19 years of age ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237080]

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Outcomes of the Neonatal Trial of High-Frequency Oscillation at 16 to 19 Years.

Christopher Harris, Alessandra Bisquera, Alan Lunt, Janet L Peacock, Anne Greenough,

N. Engl. J. Med. (The New England journal of medicine)
[2020, 383(7):689-691]

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Lung function and exercise capacity in prematurely born young people.

Christopher Harris, Alan Lunt, Alessandra Bisquera, Janet Peacock, Anne Greenough,

OBJECTIVES:To determine if lung function abnormalities in young people born very prematurely routinely exposed to antenatal corticosteroids and postnatal surfactant were associated with reduced exercise capacity. WORKING HYPOTHESIS:In the current era, lung function abnormalities would not be associated with exercise intolerance STUDY DESIGN: Follow-up of young people from the United ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, :]

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Primary dermal melanoma: clinical behaviour, prognosis and treatment.

Christopher G Harris, Serigne Lo, Tasnia Ahmed, Richard A Scolyer, Peter M Ferguson, Rooshdiya Z Karim, Tai Khoa Lam, Kenneth K Lee, Kerwin F Shannon, Andrew J Spillane, Jonathan R Stretch, John F Thompson, Robyn Pm Saw,

PURPOSE:Primary dermal melanoma (PDM) is a subtype of cutaneous melanoma, confined to the dermis, which poses a challenging clinical dilemma. It may represent a true primary melanoma or a dermal cutaneous metastasis. This study aimed to delineate the histopathological characteristics and prognosis of PDM in a large patient cohort to ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2020, :]

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Age-Associated DNA Methylation Patterns Are Shared Between the Hippocampus and Peripheral Blood Cells.

Christopher J Harris, Brett A Davis, Jonathan A Zweig, Kimberly A Nevonen, Joseph F Quinn, Lucia Carbone, Nora E Gray,

As the population ages, interest in identifying biomarkers of healthy aging and developing antiaging interventions has increased. DNA methylation has emerged as a potentially powerful molecular marker of aging. Methylation changes at specific sites in the human genome that have been identified in peripheral blood have been used as robust ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:111]

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Adjuvant chemotherapy in upper tract urothelial carcinoma (the POUT trial): a phase 3, open-label, randomised controlled trial.

Alison Birtle, Mark Johnson, John Chester, Robert Jones, David Dolling, Richard T Bryan, Christopher Harris, Andrew Winterbottom, Anthony Blacker, James W F Catto, Prabir Chakraborti, Jenny L Donovan, Paul Anthony Elliott, Ann French, Satinder Jagdev, Benjamin Jenkins, Francis Xavier Keeley, Roger Kockelbergh, Thomas Powles, John Wagstaff, Caroline Wilson, Rachel Todd, Rebecca Lewis, Emma Hall,

BACKGROUND:Urothelial carcinomas of the upper urinary tract (UTUCs) are rare, with poorer stage-for-stage prognosis than urothelial carcinomas of the urinary bladder. No international consensus exists on the benefit of adjuvant chemotherapy for patients with UTUCs after nephroureterectomy with curative intent. The POUT (Peri-Operative chemotherapy versus sUrveillance in upper Tract urothelial ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10232):1268-1277]

Cited: 3 times

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Neurorobotics Workshop for High School Students Promotes Competence and Confidence in Computational Neuroscience.

Christopher A Harris, Lucia Guerri, Stanislav Mircic, Zachary Reining, Marcio Amorim, Ðorđe Jović, William Wallace, Jennifer DeBoer, Gregory J Gage,

Understanding the brain is a fascinating challenge, captivating the scientific community and the public alike. The lack of effective treatment for most brain disorders makes the training of the next generation of neuroscientists, engineers and physicians a key concern. Over the past decade there has been a growing effort to ... Read more >>

Front Neurorobot (Frontiers in neurorobotics)
[2020, 14:6]

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Which Early Withdrawal Penalty Attracts the Most Deposits to a Commitment Savings Account?

John Beshears, James J Choi, Christopher Harris, David Laibson, Brigitte C Madrian, Jung Sakong,

Previous research has shown that some people voluntarily use commitment contracts that restrict their own choice sets. We study how people divide money between two accounts: a liquid account that permits unrestricted withdrawals and a commitment account that is randomly assigned in a between-subject design to have either a 10% ... Read more >>

J Public Econ (Journal of public economics)
[2020, 183:]

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Lung function and respiratory outcomes in teenage boys and girls born very prematurely.

Christopher Harris, Sanja Zivanovic, Alan Lunt, Sandy Calvert, Alessandra Bisquera, Neil Marlow, Janet L Peacock, Anne Greenough,

OBJECTIVES:Male sex in prematurely born infants has been associated with worse respiratory outcomes in early childhood. WORKING HYPOTHESIS:Respiratory outcomes at 11 to 14 years of age in children born very prematurely and routinely exposed to antenatal corticosteroids and postnatal surfactant would differ according to sex. STUDY DESIGN:Analysis of follow-up data. ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(3):682-689]

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The Impact of Antiplatelet Use on the Risk of Intracerebral Hemorrhage in Patients with Alzheimer's Disease: A Nationwide Cohort Study.

Christopher J Harris, Nora E Gray, Maya Caruso, Marguex Hunter, Martina Ralle, Joseph F Quinn,

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2020, 74(3):1011]

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Minimum Information and Quality Standards for Conducting, Reporting, and Organizing In Vitro Research.

Christoph H Emmerich, Christopher M Harris,

Insufficient description of experimental practices can contribute to difficulties in reproducing research findings. In response to this, "minimum information" guidelines have been developed for different disciplines. These standards help ensure that the complete experiment is described, including both experimental protocols and data processing methods, allowing a critical evaluation of the ... Read more >>

Handb Exp Pharmacol (Handbook of experimental pharmacology)
[2020, 257:177-196]

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An automated segmentation approach to calibrating infantile nystagmus waveforms.

Matt J Dunn, Christopher M Harris, Fergal A Ennis, Tom H Margrain, J Margaret Woodhouse, Lee McIlreavy, Jonathan T Erichsen,

Infantile nystagmus (IN) describes a regular, repetitive movement of the eyes. A characteristic feature of each cycle of the IN eye movement waveform is a period in which the eyes are moving at minimal velocity. This so-called "foveation" period has long been considered the basis for the best vision in ... Read more >>

Behav Res Methods (Behavior research methods)
[2019, 51(5):2074-2084]

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Short Neurorobotics Workshop for High School Students Promotes Competence and Confidence in Computational Neuroscience

Christopher Harris, Stanislav Mircic, Zachary Reining, Marcio Amorim, Đorđe Jović, Lucia Guerri, William Wallace, Gregory Gage,

ABSTRACT Understanding the brain is a fascinating challenge, captivating the scientific community and the public alike. The lack of effective treatment for most brain disorders makes the training of the next generation of neuroscientists, engineers and physicians a key concern. Over the past decade there has been a growing effort ... Read more >>

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An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation.

Christopher Harris, Stephen D Thorpe, Sara Rushwan, Wei Wang, Clare L Thompson, Janet L Peacock, Martin M Knight, Bibek Gooptu, Anne Greenough,

Children randomised in the neonatal period to high frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) in the United Kingdom Oscillation study (UKOS) had superior lung function at 11 to 14 years of age. During HFOV, much smaller tidal volumes, but a higher mean airway distending pressure is delivered, hence, ... Read more >>

J Biomech (Journal of biomechanics)
[2019, 88:186-189]

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US pediatric pulmonology workforce.

Christopher Harris, Julie Katkin, Mary Cataletto, Henry Dorkin, Laura Laskosz, Holly Ruch-Ross,

AIM:Children with respiratory conditions benefit from care provided by pediatric pulmonologists. As these physicians are a small portion of the overall pediatric workforce, it is necessary to understand the practices and career plans of these specialists. METHODS:An internet survey was developed by the American Academy of Pediatrics Division of Workforce ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2019, 54(4):444-450]

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Small for gestational age and extremely low birth weight infant outcomes.

Elinor Charles, Katie A Hunt, Christopher Harris, Ann Hickey, Anne Greenough,

Background Small for gestational age (SGA) infants are less likely to develop respiratory distress syndrome (RDS), but more likely to develop bronchopulmonary dysplasia (BPD) and have a higher mortality. Our aim was to focus on outcomes of those with a birth weight less than or equal to 750 g. Methods ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2019, 47(2):247-251]

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Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design.

Adrian D Hobson, Russell A Judge, Ana L Aguirre, Brian S Brown, Yifang Cui, Ping Ding, Eric Dominguez, Enrico DiGiammarino, David A Egan, Gail M Freiberg, Sujatha M Gopalakrishnan, Christopher M Harris, Marie P Honore, Karen L Kage, Nicolas J Kapecki, Christopher Ling, Junli Ma, Helmut Mack, Mulugeta Mamo, Stefan Maurus, Bradford McRae, Nigel S Moore, Bernhard K Mueller, Reinhold Mueller, Marian T Namovic, Kaushal Patel, Steve D Pratt, C Brent Putman, Kara L Queeney, Kathy K Sarris, Lisa M Schaffter, Vincent Stoll, Anil Vasudevan, Lei Wang, Lu Wang, William Wirthl, Kimberly Yach,

A HTS campaign identified compound 1, an excellent hit-like molecule to initiate medicinal chemistry efforts to optimize a dual ROCK1 and ROCK2 inhibitor. Substitution (2-Cl, 2-NH2, 2-F, 3-F) of the pyridine hinge binding motif or replacement with pyrimidine afforded compounds with a clean CYP inhibition profile. Cocrystal structures of an ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2018, 61(24):11074-11100]

Cited: 2 times

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Methemoglobinemia during the Use of Glyceryl Trinitrate Patches in Neonates: Two Case Reports.

Alison Mintoft, Emma Williams, Christopher Harris, Nigel Kennea, Anne Greenough,

Methemoglobinemia can result in severe hypoxia. It has been frequently reported during the use of inhaled nitric oxide, but can occur where nitrate containing medications are used. Glyceryl trinitrate (GTN) patches have been used in the treatment of digital and limb ischemia in prematurely born infants. Little is known about ... Read more >>

AJP Rep (AJP reports)
[2018, 8(4):e227-e229]

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Replacing hospital-based epilepsy clinics with rural epilepsy clinics and education in Uganda: impact on attendance.

Christopher Harris, Bwambale George, Unity Harris, Mary Munyagwa, Anne Greenough,

Background: A high proportion of the Ugandan population with epilepsy receive no treatment. Aim: To determine whether introduction of an agreed multidisciplinary guideline and establishment of a local clinic outside the hospital and four rural satellite clinics improved attendance and follow-up by children with epilepsy in Western Uganda. Methods: A ... Read more >>

Paediatr Int Child Health (Paediatrics and international child health)
[2019, 39(2):128-131]

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Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer.

Craig M Bielski, Mark T A Donoghue, Mayur Gadiya, Aphrothiti J Hanrahan, Helen H Won, Matthew T Chang, Philip Jonsson, Alexander V Penson, Alexander Gorelick, Christopher Harris, Alison M Schram, Aijazuddin Syed, Ahmet Zehir, Paul B Chapman, David M Hyman, David B Solit, Kevin Shannon, Sarat Chandarlapaty, Michael F Berger, Barry S Taylor,

Driver mutations in oncogenes encode proteins with gain-of-function properties that enhance fitness. Heterozygous mutations are thus viewed as sufficient for tumorigenesis. We describe widespread oncogenic mutant allele imbalance in 13,448 prospectively characterized cancers. Imbalance was selected for through modest dosage increases of gain-of-fitness mutations. Negative selection targeted haplo-essential effectors of ... Read more >>

Cancer Cell (Cancer cell)
[2018, 34(5):852-862.e4]

Cited: 9 times

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UK neonatal resuscitation survey.

Elinor Charles, Katie Hunt, Vadivelam Murthy, Christopher Harris, Anne Greenough,

BACKGROUND:Previous surveys have demonstrated that neonatal resuscitation practices on the delivery suite vary between UK units, particularly according to the hospital's neonatal unit's level. Our aim was to determine if recent changes to the Resuscitation Council guidelines had influenced clinical practice. METHODS:Surveys of resuscitation practices at UK delivery units carried ... Read more >>

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2019, 104(3):F324-F325]

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Baseline corticosterone does not reflect iridescent plumage traits in female tree swallows.

Keneth Sarpong, Christine L Madliger, Christopher M Harris, Oliver P Love, Stéphanie M Doucet, Pierre-Paul Bitton,

The production of high quality secondary sexual traits can be constrained by trade-offs in the allocation of energy and nutrients with other metabolic activities, and is mediated by physiological processes. In birds, the factors influencing male plumage quality have been well studied; however, factors affecting female plumage quality are poorly ... Read more >>

Gen. Comp. Endocrinol. (General and comparative endocrinology)
[2019, 270:123-130]

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Baseline corticosterone does not reflect iridescent plumage traits in female tree swallows

Keneth Sarpong, Christine Madliger, Christopher Harris, Oliver Love, Stéphanie Doucet, Pierre-Paul Bitton,

Abstract The production of high quality secondary sexual traits can be constrained by trade-offs in the allocation of energy and nutrients with other metabolic activities, and is mediated by physiological processes. In birds, the factors influencing male plumage quality have been well studied; however, factors affecting female plumage quality are ... Read more >>

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Infection control and treatment guidelines and neonatal mortality in a rural hospital in Uganda.

Christopher Harris, Harsita Patel, Olivia Corn, Unity Harris, Mary Munyagwa, Anne Greenough,

Background: The neonatal mortality rate in Uganda has been 24-27/1000 live births for the last 14 years. Aim: To determine the impact on neonatal mortality of the introduction of infection prevention and treatment guidelines in a resource-poor setting. Methods: A prospective study was undertaken in Kagando Hospital, a rural hospital in ... Read more >>

Paediatr Int Child Health (Paediatrics and international child health)
[2019, 39(2):124-127]

Cited: 0 times

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Ensuring Comprehensive Care and Support for Transgender and Gender-Diverse Children and Adolescents.

Jason Rafferty, , , ,

As a traditionally underserved population that faces numerous health disparities, youth who identify as transgender and gender diverse (TGD) and their families are increasingly presenting to pediatric providers for education, care, and referrals. The need for more formal training, standardized treatment, and research on safety and medical outcomes often leaves ... Read more >>

Pediatrics (Pediatrics)
[2018, 142(4):]

Cited: 10 times

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