Full Text Journal Articles by
Author Christopher G Sobey

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Ischemic Stroke and Infection: A brief update on mechanisms and potential therapies.

Drishti P Ghelani, Hyun Ah Kim, Shenpeng R Zhang, Grant R Drummond, Christopher G Sobey, T Michael De Silva,

Ischemic stroke triggers a multifaceted inflammatory response in the brain that contributes to secondary brain injury and infarct expansion. In parallel with brain inflammation, ischemic stroke also leads to post-stroke immunosuppression. Stroke-induced leukopenia then predisposes patients to opportunistic infections potentially leading to pneumonia or unrinary tract infections and a worsened ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, :114768]

Cited: 0 times

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IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice.

Jordyn M Thomas, Yeong H Ling, Brooke Huuskes, Maria Jelinic, Prerna Sharma, Narbada Saini, Dorota M Ferens, Henry Diep, Shalini M Krishnan, Barbara K Kemp-Harper, Paul M O'Connor, Eicke Latz, Thiruma V Arumugam, Tomasz J Guzik, Michael J Hickey, Ashley Mansell, Christopher G Sobey, Antony Vinh, Grant R Drummond,

IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood pressure and end-organ damage is unknown. We examined the role of IL-18 in the development of renal inflammation and injury in a mouse model of low-renin hypertension. Hypertension was induced in male C57BL6/J (WT) and IL-18<sup>-/-</sup> mice ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2021, :HYPERTENSIONAHA12016437]

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Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP).

Christopher H George, Stephen P H Alexander, Giuseppe Cirino, Paul A Insel, Angelo A Izzo, Yong Ji, David A Kendall, Reynold A Panettieri, Hemal H Patel, Christopher G Sobey, S Clare Stanford, Barbara Stefanska, Gary Stephens, Mauro Teixeira, Amrita Ahluwalia,

Br J Pharmacol (British journal of pharmacology)
[2021, 178(18):3605-3610]

Cited: 0 times

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Estrogen: reducing the pressure by arginine vasopressin.

Quynh Nhu Dinh, Grant R Drummond, Christopher G Sobey,

Cardiovasc Res (Cardiovascular research)
[2021, 117(10):2143-2144]

Cited: 0 times

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Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging.

Sang-Ha Baik, Sharmelee Selvaraji, David Y Fann, Luting Poh, Dong-Gyu Jo, Deron R Herr, Shenpeng R Zhang, Hyun Ah Kim, Michael De Silva, Mitchell K P Lai, Christopher Li-Hsian Chen, Grant R Drummond, Kah-Leong Lim, Christopher G Sobey, Thiruma V Arumugam,

Vascular dementia (VaD) is a progressive cognitive impairment of vascular etiology. VaD is characterized by cerebral hypoperfusion, increased blood-brain barrier permeability and white matter lesions. An increased burden of VaD is expected in rapidly aging populations. The hippocampus is particularly susceptible to hypoperfusion, and the resulting memory impairment may play ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(11):14651-14674]

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G protein-coupled estrogen receptor 1: a novel target to treat cardiovascular disease in a sex-specific manner?

Quynh Nhu Dinh, Antony Vinh, Thiruma V Arumugam, Grant R Drummond, Christopher G Sobey,

As an agonist of the classical nuclear receptors, estrogen receptor-α and -β (NR3A1/2), estrogen has been assumed to inhibit the development of cardiovascular disease in premenopausal women. Indeed, reduced levels of estrogen after menopause are believed to contribute to accelerated morbidity and mortality rates in women. However, estrogen replacement therapy ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2021, 178(19):3849-3863]

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Adjustment for body mass index changes inverse associations of HDL-cholesterol with blood pressure and hypertension to positive associations.

Guang Yang, Tingting Qian, Hui Sun, Qun Xu, Xujuan Hou, Wenqi Hu, Guang Zhang, Grant R Drummond, Christopher G Sobey, Paul K Witting, Kate M Denton, Fadi J Charchar, Jonathan Golledge, Yutang Wang,

The associations between high-density lipoprotein cholesterol (HDL-C) and blood pressure (BP) or hypertension are inconsistent in previous studies. This study aimed to assess these associations in a large cohort of Chinese adults and across different age groups. This cross-sectional association study included 22,081 Chinese adults. Associations of HDL-C with BP ... Read more >>

J Hum Hypertens (Journal of human hypertension)
[2021, :]

Cited: 0 times

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Aldosterone-induced hypertension is sex-dependent, mediated by T cells and sensitive to GPER activation.

Quynh Nhu Dinh, Antony Vinh, Hyun Ah Kim, Narbada Saini, Brad R S Broughton, Sophocles Chrissobolis, Henry Diep, Courtney P Judkins, Grant R Drummond, Christopher G Sobey,

<h4>Aims</h4>The G protein-coupled estrogen receptor 1 (GPER) may modulate some effects of aldosterone. In addition, G-1 (a GPER agonist) can lower blood pressure (BP) and promote T cell-mediated anti-inflammatory responses. This study aimed to test the effects of G-1 and G-15 (a GPER antagonist) on aldosterone-induced hypertension in mice and ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2021, 117(3):960-970]

Cited: 1 time

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Reduced renal function may explain the higher prevalence of hyperuricemia in older people.

Yutang Wang, Wanlin Zhang, Tingting Qian, Hui Sun, Qun Xu, Xujuan Hou, Wenqi Hu, Guang Zhang, Grant R Drummond, Christopher G Sobey, Fadi J Charchar, Jonathan Golledge, Guang Yang,

This study aimed to investigate the contribution of renal dysfunction to enhanced hyperuricemia prevalence in older people. A cohort of 13,288 Chinese people aged between 40 and 95 years were recruited from January to May 2019. Serum uric acid concentration and estimated glomerular filtration rate [eGFR] were measured. The associations between ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):1302]

Cited: 1 time

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Targeting the Immune System for Ischemic Stroke.

Shenpeng R Zhang, Thanh G Phan, Christopher G Sobey,

Stroke is responsible for almost 6 million deaths and more than 10% of all mortalities each year, and two-thirds of stroke survivors remain disabled. With treatments for ischemic stroke still limited to clot lysis and/or mechanical removal, new therapeutic targets are desperately needed. In this review, we provide an overview ... Read more >>

Trends Pharmacol Sci (Trends in pharmacological sciences)
[2021, 42(2):96-105]

Cited: 1 time

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Hyperuricemia is independently associated with hypertension in men under 60 years in a general Chinese population.

Tingting Qian, Hui Sun, Qun Xu, Xujuan Hou, Wenqi Hu, Guang Zhang, Grant R Drummond, Christopher G Sobey, Fadi J Charchar, Jonathan Golledge, Yutang Wang, Guang Yang,

Hyperuricemia has been associated with hypertension, however, whether this association exists across all decades of adult life is unknown. This study aimed to assess the association between hyperuricemia and hypertension in relation to age. This retrospective cross-sectional study included a total of 22,556 adult Chinese people who attended Health Physical ... Read more >>

J Hum Hypertens (Journal of human hypertension)
[2020, :]

Cited: 2 times

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AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia.

Luting Poh, David Y Fann, Peiyan Wong, Hong Meng Lim, Sok Lin Foo, Sung-Wook Kang, Vismitha Rajeev, Sharmelee Selvaraji, Vinaya Rajagopal Iyer, Nageiswari Parathy, Mohammad Badruzzaman Khan, David C Hess, Dong-Gyu Jo, Grant R Drummond, Christopher G Sobey, Mitchell K P Lai, Christopher Li-Hsian Chen, Lina H K Lim, Thiruma V Arumugam,

Chronic cerebral hypoperfusion is associated with vascular dementia (VaD). Cerebral hypoperfusion may initiate complex molecular and cellular inflammatory pathways that contribute to long-term cognitive impairment and memory loss. Here we used a bilateral common carotid artery stenosis (BCAS) mouse model of VaD to investigate its effect on the innate immune ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, :]

Cited: 5 times

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Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model.

Louise Pham, David K Wright, William T O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M Casillas-Espinosa, Anup D Shah, Ralf B Schittenhelm, Christopher G Sobey, Rhys D Brady, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald,

A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological conditions, however there is still much unknown about the underlying mechanisms. To provide new insights, this study used a clinically relevant model of repeated mTBI in rats to characterize the acute and chronic neuropathological ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2021, 148:105151]

Cited: 3 times

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ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020.

Elliott Lilley, S Clare Stanford, David E Kendall, Stephen P H Alexander, Giuseppe Cirino, James R Docherty, Christopher H George, Paul A Insel, Angelo A Izzo, Yong Ji, Reynold A Panettieri, Christopher G Sobey, Barbara Stefanska, Gary Stephens, Mauro Teixeira, Amrita Ahluwalia,

Br J Pharmacol (British journal of pharmacology)
[2020, 177(16):3611-3616]

Cited: 35 times

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Vitamin D Deficiency and the Risk of Cerebrovascular Disease.

Hyun Ah Kim, Andrea Perrelli, Alberto Ragni, Francesca Retta, T Michael De Silva, Christopher G Sobey, Saverio Francesco Retta,

Vitamin D deficiency has been clearly linked to major chronic diseases associated with oxidative stress, inflammation, and aging, including cardiovascular and neurodegenerative diseases, diabetes, and cancer. In particular, the cardiovascular system appears to be highly sensitive to vitamin D deficiency, as this may result in endothelial dysfunction and vascular defects ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2020, 9(4):]

Cited: 2 times

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A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research.

Angelo A Izzo, Mauro Teixeira, Steve P H Alexander, Giuseppe Cirino, James R Docherty, Christopher H George, Paul A Insel, Yong Ji, David A Kendall, Reynold A Panattieri, Christopher G Sobey, S Clare Stanford, Barbara Stefanska, Gary Stephens, Amrita Ahluwalia,

Br J Pharmacol (British journal of pharmacology)
[2020, 177(10):2169-2178]

Cited: 3 times

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The Vascular Consequences of Metabolic Syndrome: Rodent Models, Endothelial Dysfunction, and Current Therapies.

Vivian Tran, T Michael De Silva, Christopher G Sobey, Kyungjoon Lim, Grant R Drummond, Antony Vinh, Maria Jelinic,

Metabolic syndrome is characterized by visceral obesity, dyslipidemia, hyperglycemia and hypertension, and affects over one billion people. Independently, the components of metabolic syndrome each have the potential to affect the endothelium to cause vascular dysfunction and disrupt vascular homeostasis. Rodent models of metabolic syndrome have significantly advanced our understanding of ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:148]

Cited: 2 times

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The need to incorporate aged animals into the preclinical modeling of neurological conditions.

Mujun Sun, Stuart J McDonald, Rhys D Brady, Lyndsey Collins-Praino, Glenn R Yamakawa, Mastura Monif, Terence J O'Brien, Geoffrey C Cloud, Christopher G Sobey, Richelle Mychasiuk, David J Loane, Sandy R Shultz,

Neurological conditions such as traumatic brain injury, stroke, Parkinson's disease, epilepsy, multiple sclerosis, and Alzheimer's disease are serious clinical problems that affect millions of people worldwide. The majority of clinical trials for these common conditions have failed, and there is a critical need to understand why treatments in preclinical animal ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2020, 109:114-128]

Cited: 5 times

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Epigenetic Regulation by Dietary Restriction: Part II.

Gavin Yong-Quan Ng, David Yang-Wei Fann, Dong-Gyu Jo, Christopher G Sobey, Thiruma V Arumugam,

In the first part of our review, we extensively discuss the different variants of dietary restriction (DR) regimens, as well as its corresponding mechanism(s) and subsequent effects. We also provide a detailed analysis of the different epigenetic mechanisms based on current knowledge. We postulate that DR may represent an environmental ... Read more >>

Cond Med (Conditioning medicine)
[2019, 2(6):300-310]

Cited: 2 times

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Dietary Restriction and Epigenetics: Part I.

Gavin Yong-Quan Ng, David Yang-Wei Fann, Dong-Gyu Jo, Christopher G Sobey, Thiruma V Arumugam,

Biological aging occurs concomitantly with chronological aging and is commonly burdened by the development of age-related conditions, such as neurodegenerative, cardiovascular, and a myriad of metabolic diseases. With a current global shift in disease epidemiology associated with aging and the resultant social, economic, and healthcare burdens faced by many countries, ... Read more >>

Cond Med (Conditioning medicine)
[2019, 2(6):284-299]

Cited: 5 times

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The BJP expects authors to share data.

Christopher H George, Stephen P H Alexander, Giuseppe Cirino, James R Docherty, Daniel Hoyer, Paul A Insel, Angelo A Izzo, Yong Ji, Reynold A Panettieri, Christopher G Sobey, S Clare Stanford, Barbara Stefanska, Gary Stephens, Mauro Teixeira, Amrita Ahluwalia,

Br J Pharmacol (British journal of pharmacology)
[2019, 176(24):4595-4598]

Cited: 1 time

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Stroke Severity, and Not Cerebral Infarct Location, Increases the Risk of Infection.

Raymond Shim, Shu Wen Wen, Brooke J Wanrooy, Michelle Rank, Tharani Thirugnanachandran, Luke Ho, Tara Sepehrizadeh, Michael de Veer, Velandai K Srikanth, Henry Ma, Thanh G Phan, Christopher G Sobey, Connie H Y Wong,

Infection is a leading cause of death in patients with stroke; however, the impact of cerebral infarct size or location on infectious outcome is unclear. To examine the effect of infarct size on post-stroke infection, we utilised the intraluminal middle-cerebral artery occlusion (MCAO) mouse model of ischemic stroke and adjusted ... Read more >>

Transl Stroke Res (Translational stroke research)
[2020, 11(3):387-401]

Cited: 4 times

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Sex: A change in our guidelines to authors to ensure that this is no longer an ignored experimental variable.

James R Docherty, S Clare Stanford, Reynold A Panattieri, Steve P H Alexander, Giuseppe Cirino, Christopher H George, Daniel Hoyer, Angelo A Izzo, Yong Ji, Elliot Lilley, Christopher G Sobey, Phil Stanley, Barbara Stefanska, Gary Stephens, Mauro Teixeira, Amrita Ahluwalia,

Br J Pharmacol (British journal of pharmacology)
[2019, 176(21):4081-4086]

Cited: 11 times

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Immune mechanisms of hypertension.

Grant R Drummond, Antony Vinh, Tomasz J Guzik, Christopher G Sobey,

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke. Traditionally, hypertension has been regarded as a disorder of two systems that are involved in the regulation of salt-water balance and cardiovascular function: the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system (SNS). However, ... Read more >>

Nat Rev Immunol (Nature reviews. Immunology)
[2019, 19(8):517-532]

Cited: 51 times

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microRNA-367-3p regulation of GPRC5A is suppressed in ischemic stroke.

Fatiha Tabet, Seyoung Lee, Wanying Zhu, Michael G Levin, Cynthia L Toth, Luisa F Cuesta Torres, Antony Vinh, Hyun Ah Kim, Hannah X Chu, Megan A Evans, Meaghan E Kuzmich, Grant R Drummond, Alan T Remaley, Kerry-Anne Rye, Christopher G Sobey, Kasey C Vickers,

Ischemic stroke is a major cause of mortality and long-term disability with limited treatment options, and a greater understanding of the gene regulatory mechanisms underlying ischemic stroke-associated neuroinflammation is required for new therapies. To study ischemic stroke <i>in vivo</i>, mice were subjected to sustained ischemia by intraluminal filament-induced middle cerebral artery ... Read more >>

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2020, 40(6):1300-1315]

Cited: 2 times

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