Full Text Journal Articles by
Author Christopher D Incarvito

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Cytotoxicity of a Ti(IV) compound is independent of serum proteins.

Arthur D Tinoco, Horatio R Thomas, Christopher D Incarvito, Alan Saghatelian, Ann M Valentine,

Titanium(IV) compounds are excellent anticancer drug candidates, but they have yet to find success in clinical applications. A major limitation in developing further compounds has been a general lack of understanding of the mechanism governing their bioactivity. To determine factors necessary for bioactivity, we tested the cytotoxicity of different ligand ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2012, 109(13):5016-5021]

Cited: 19 times

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Mechanism of the rhodium(III)-catalyzed arylation of imines via C-H bond functionalization: inhibition by substrate.

Michael E Tauchert, Christopher D Incarvito, Arnold L Rheingold, Robert G Bergman, Jonathan A Ellman,

Rh(III)-catalyzed arylation of imines provides a new method for C-C bond formation while simultaneously introducing an α-branched amine as a functional group. This detailed mechanistic study provides insights for the rational future development of this new reaction. Relevant intermediate Rh(III) complexes have been isolated and characterized, and their reactivities in ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2012, 134(3):1482-1485]

Cited: 58 times

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Distinguishing homogeneous from heterogeneous catalysis in electrode-driven water oxidation with molecular iridium complexes.

Nathan D Schley, James D Blakemore, Navaneetha K Subbaiyan, Christopher D Incarvito, Francis D'Souza, Robert H Crabtree, Gary W Brudvig,

Molecular water-oxidation catalysts can deactivate by side reactions or decompose to secondary materials over time due to the harsh, oxidizing conditions required to drive oxygen evolution. Distinguishing electrode surface-bound heterogeneous catalysts (such as iridium oxide) from homogeneous molecular catalysts is often difficult. Using an electrochemical quartz crystal nanobalance (EQCN), we ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2011, 133(27):10473-10481]

Cited: 67 times

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Iodination of anilines and phenols with 18-crown-6 supported ICl2-.

Hannah W Mbatia, Olbelina A Ulloa, Daniel P Kennedy, Christopher D Incarvito, Shawn C Burdette,

A highly crystalline iodinating reagent, {[K·18-C-6]ICl(2)}(n), was synthesized in high yield (93%). The trihalide is supported by an 18-crown-6 macrocycle and forms a coordination polymer in the solid state. This reagent iodinates anilines and phenols efficiently under mild conditions. Controlled mono-iodination with anilines was easily achieved while poly-iodination was observed ... Read more >>

Org. Biomol. Chem. (Organic & biomolecular chemistry)
[2011, 9(8):2987-2991]

Cited: 0 times

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Palladium(I)-bridging allyl dimers for the catalytic functionalization of CO2.

Damian P Hruszkewycz, Jianguo Wu, Nilay Hazari, Christopher D Incarvito,

In general, the chemistry of both η(1)-allyl and η(3)-allyl Pd complexes is extremely well understood; η(1)-allyls are nucleophilic and react with electrophiles, whereas η(3)-allyls are electrophilic and react with nucleophiles. In contrast, relatively little is known about the chemistry of metal complexes with bridging allyl ligands. In this work, we ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2011, 133(10):3280-3283]

Cited: 30 times

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Isostructural Pd(II) and Pt(II) pyrophosphato complexes: polymorphism and unusual bond character in d8-d8 systems.

Nadia Marino, Christopher H Fazen, James D Blakemore, Christopher D Incarvito, Nilay Hazari, Robert P Doyle,

Isostructural, "clamshell"-like, neutral dimeric pyrophosphato complexes of general formula {[M(bipy)](2)(μ-P(2)O(7))} [M = Pd(II) (1) or Pt(II) (2)] were synthesized and studied through single-crystal X-ray diffraction, IR, (31)P NMR spectroscopy, and MALDI-TOF mass spectrometry. Compound 1 was synthesized through the reaction of palladium(II) acetate, 2,2'-bipyridine (bipy), and sodium pyrophosphate (Na(4)P(2)O(7)) in ... Read more >>

Inorg Chem (Inorganic chemistry)
[2011, 50(6):2507-2520]

Cited: 12 times

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Exploring the reactions of CO2 with PCP supported nickel complexes.

Timothy J Schmeier, Nilay Hazari, Christopher D Incarvito, Jevgenij A Raskatov,

The reactions of PCP supported Ni hydride, methyl and allyl species with CO(2) to generate Ni carboxylates are described. Computational studies suggest that all three reactions follow different pathways. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2011, 47(6):1824-1826]

Cited: 19 times

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The Reaction of Carbon Dioxide with Palladium Allyl Bonds.

Jianguo Wu, Jennifer C Green, Nilay Hazari, Damian P Hruszkewycz, Christopher D Incarvito, Timothy J Schmeier,

A family of palladium allyl complexes of the type bis(2-methylallyl)Pd(L) (L = PMe(3) (1), PEt(3) (2), PPh(3) (3) or NHC (4); NHC = 1,3-Bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene) have been prepared through the reaction of bis(2-methylallyl)Pd with the appropriate free ligand. Compounds 1-4 contain one η(1) and one η(3)-2-methylallyl ligand and 3 was characterized ... Read more >>

Organometallics (Organometallics)
[2010, 29(23):6369-6376]

Cited: 15 times

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Half-sandwich iridium complexes for homogeneous water-oxidation catalysis.

James D Blakemore, Nathan D Schley, David Balcells, Jonathan F Hull, Gerard W Olack, Christopher D Incarvito, Odile Eisenstein, Gary W Brudvig, Robert H Crabtree,

Iridium half-sandwich complexes of the types Cp*Ir(N-C)X, [Cp*Ir(N-N)X]X, and [CpIr(N-N)X]X are catalyst precursors for the homogeneous oxidation of water to dioxygen. Kinetic studies with cerium(IV) ammonium nitrate as primary oxidant show that oxygen evolution is rapid and continues over many hours. In addition, [Cp*Ir(H(2)O)(3)]SO(4) and [(Cp*Ir)(2)(μ-OH)(3)]OH can show even higher ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2010, 132(45):16017-16029]

Cited: 132 times

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FerriCast: a macrocyclic photocage for Fe3+.

Daniel P Kennedy, Christopher D Incarvito, Shawn C Burdette,

The non-siderophoric Fe(3+) photocage FerriCast (4,5-dimethoxy-2-nitrophenyl)-[4-(1-oxa-4,10-dithia-7-aza-cyclododec-7-yl)phenyl] methanol (2) has been prepared in high yield using an optimized two-step reaction sequence that utilizes a trimethylsilyl trifluoromethanesulfonate (TMSOTf) assisted electrophilic aromatic substitution as the key synthetic step. Spectrophotometric assessment of Fe(3+) binding to FerriCast revealed a binding stoichiometry and metal ion affinity ... Read more >>

Inorg Chem (Inorganic chemistry)
[2010, 49(3):916-923]

Cited: 12 times

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Electronic structure and proton transfer in ground-state hexafluoroacetylacetone.

Chandrima Chatterjee, Christopher D Incarvito, Lori A Burns, Patrick H Vaccaro,

The ground electronic state (X(1)A(1)) of hexafluoroacetylacetone (HFAA) has been subjected to synergistic experimental and theoretical investigations designed to resolve controversies surrounding the nature of intramolecular hydrogen bonding for the enol tautomer. Cryogenic (93K) X-ray diffraction studies were conducted on single HFAA crystals grown in situ by means of the ... Read more >>

J Phys Chem A (The journal of physical chemistry. A)
[2010, 114(24):6630-6640]

Cited: 2 times

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Titanium(IV) complexes with N,N'-dialkyl-2,3-dihydroxyterephthalamides and 1-hydroxy-2(1H)-pyridinone as siderophore and tunichrome analogues.

Ritika Uppal, Hayley P Israel, Christopher D Incarvito, Ann M Valentine,

The aqueous chemistry of Ti(IV) with biological ligands siderophores and tunichromes is modeled by using N,N'-dialkyl-2,3-dihydroxyterephthalamides (alTAMs), analogues of catecholamide-containing biomolecules, and 1-hydroxy-2(1H)-pyridinone (1,2-HOPO), an analogue of hydroxamate-containing biomolecules. Both types of ligands stabilize Ti(IV) with respect to hydrolytic precipitation, and afford tractable complexes. Complexes with the methyl derivative of ... Read more >>

Inorg Chem (Inorganic chemistry)
[2009, 48(22):10769-10779]

Cited: 5 times

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Photoinduced release of Zn2+ with ZinCleav-1: a nitrobenzyl-based caged complex.

H M Dhammika Bandara, Daniel P Kennedy, Elif Akin, Christopher D Incarvito, Shawn C Burdette,

Caged complexes are metal ion chelators that release analytes when exposed to light of a specific wavelength. The synthesis and properties of ZinCleav-1, a cage for Zn(2+) that fragments upon photolysis, is reported. The general uncaging strategy involves integrating a nitrobenzyl group on the backbone of the ligand so that ... Read more >>

Inorg Chem (Inorganic chemistry)
[2009, 48(17):8445-8455]

Cited: 16 times

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Highly active and robust Cp* iridium complexes for catalytic water oxidation.

Jonathan F Hull, David Balcells, James D Blakemore, Christopher D Incarvito, Odile Eisenstein, Gary W Brudvig, Robert H Crabtree,

A series of Cp*Ir catalysts are the most active known by over an order of magnitude for water oxidation with Ce(IV). DFT calculations support a Cp*Ir=O complex as an active species. ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2009, 131(25):8730-8731]

Cited: 154 times

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Manganese catalysts with molecular recognition functionality for selective alkene epoxidation.

Jonathan F Hull, Effiette L O Sauer, Christopher D Incarvito, J W Faller, Gary W Brudvig, Robert H Crabtree,

Selective epoxidation of alkenes is possible with a new manganese porphyrin catalyst, C(PMR), that uses hydrogen bonding between the carboxylic acid on the substrate molecule and a Kemp's triacid unit. For two out of three olefin substrates employed, molecular recognition prevents the unselective oxidation of C-H bonds, and directs oxidation ... Read more >>

Inorg Chem (Inorganic chemistry)
[2009, 48(2):488-495]

Cited: 7 times

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Hydrolytic metal with a hydrophobic periphery: titanium(IV) complexes of naphthalene-2,3-diolate and interactions with serum albumin.

Arthur D Tinoco, Emily V Eames, Christopher D Incarvito, Ann M Valentine,

Serum albumin, the most abundant protein in human plasma (700 microM), binds diverse ligands at multiple sites. While studies have shown that serum albumin binds hard metals in chelate form, few have explored the trafficking of these metals by this protein. Recent work demonstrated that serum albumin may play a ... Read more >>

Inorg Chem (Inorganic chemistry)
[2008, 47(18):8380-8390]

Cited: 14 times

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Copper complexes of anionic nitrogen ligands in the amidation and imidation of aryl halides.

Jesse W Tye, Zhiqiang Weng, Adam M Johns, Christopher D Incarvito, John F Hartwig,

Copper(I) imidate and amidate complexes of chelating N,N-donor ligands, which are proposed intermediates in copper-catalyzed amidations of aryl halides, have been synthesized and characterized by X-ray diffraction and detailed solution-phase methods. In some cases, the complexes adopt neutral, three-coordinate trigonal planar structures in the solid state, but in other cases ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2008, 130(30):9971-9983]

Cited: 76 times

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Controlling curvature in a family of oligoamide alpha-helix mimetics.

Ishu Saraogi, Christopher D Incarvito, Andrew D Hamilton,

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2008, 47(50):9691-9694]

Cited: 14 times

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Directly observed transmetalation from boron to rhodium. beta-aryl elimination from Rh(I) arylboronates and diarylborinates.

Pinjing Zhao, Christopher D Incarvito, John F Hartwig,

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2007, 129(7):1876-1877]

Cited: 36 times

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Copper(I) complex O(2)-reactivity with a N(3)S thioether ligand: a copper-dioxygen adduct including sulfur ligation, ligand oxygenation, and comparisons with all nitrogen ligand analogues.

Dong-Heon Lee, Lanying Q Hatcher, Michael A Vance, Ritimukta Sarangi, Ashley E Milligan, Amy A Narducci Sarjeant, Christopher D Incarvito, Arnold L Rheingold, Keith O Hodgson, Britt Hedman, Edward I Solomon, Kenneth D Karlin,

In order to contribute to an understanding of the effects of thioether sulfur ligation in copper-O(2) reactivity, the tetradentate ligands L(N3S) (2-ethylthio-N,N-bis(pyridin-2-yl)methylethanamine) and L(N3S')(2-ethylthio-N,N-bis(pyridin-2-yl)ethylethanamine) have been synthesized. Corresponding copper(I) complexes, [CuI(L(N3S))]ClO(4) (1-ClO(4)), [CuI(L(N3S))]B(C(6)F(5))(4) (1-B(C(6)F(5))(4)), and [CuI(L(N3S'))]ClO(4) (2), were generated, and their redox properties, CO binding, and O(2)-reactivity were compared to ... Read more >>

Inorg Chem (Inorganic chemistry)
[2007, 46(15):6056-6068]

Cited: 19 times

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Preparation and structure of a solid-state hypervalent-iodine polymer containing iodine and oxygen atoms in fused 12-atom hexagonal rings.

Helen W Richter, Gerald F Koser, Christopher D Incarvito, Arnold L Rheingold,

The treatment of dilute aqueous solutions of [hydroxy(tosyloxy)iodo]benzene with aqueous Mg(ClO4)2 produced thin elongated-hexagonal plates exhibiting a supramolecular structure in which tetra-mu-oxopentaiodanyl dication repeat units are joined to each other by significantly ionic bonds and each unit is associated with two perchlorate ions. The linearly extended cationic structure is formed ... Read more >>

Inorg Chem (Inorganic chemistry)
[2007, 46(14):5555-5561]

Cited: 1 time

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Reductive elimination of ether from T-shaped, monomeric arylpalladium alkoxides.

James P Stambuli, Zhiqiang Weng, Christopher D Incarvito, John F Hartwig,

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2007, 46(40):7674-7677]

Cited: 14 times

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Palladium-catalyzed asymmetric phosphination. Scope, mechanism, and origin of enantioselectivity.

Natalia F Blank, Jillian R Moncarz, Tim J Brunker, Corina Scriban, Brian J Anderson, Omar Amir, David S Glueck, Lev N Zakharov, James A Golen, Christopher D Incarvito, Arnold L Rheingold,

Asymmetric cross-coupling of aryl iodides (ArI) with secondary arylphosphines (PHMe(Ar'), Ar' = (2,4,6)-R3C6H2; R = i-Pr (Is), Me (Mes), Ph (Phes)) in the presence of the base NaOSiMe3 and a chiral Pd catalyst precursor, such as Pd((R,R)-Me-Duphos)(trans-stilbene), gave the tertiary phosphines PMe(Ar')(Ar) in enantioenriched form. Sterically demanding secondary phosphine substituents ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2007, 129(21):6847-6858]

Cited: 20 times

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Calorimetric, spectroscopic, and model studies provide insight into the transport of Ti(IV) by human serum transferrin.

Arthur D Tinoco, Christopher D Incarvito, Ann M Valentine,

Evidence suggests that transferrin can bind Ti(IV) in an unhydrolyzed form (without bound hydroxide or oxide) or in a hydrolyzed form. Ti(IV) coordination by N,N'-di(o-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED) at different pH values models the two forms of Ti(IV)-loaded transferrin spectrally and structurally. 13C NMR and stopped-flow kinetic experiments reveal that when ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2007, 129(11):3444-3454]

Cited: 20 times

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Molecular recognition in the selective oxygenation of saturated C-H bonds by a dimanganese catalyst.

Siddhartha Das, Christopher D Incarvito, Robert H Crabtree, Gary W Brudvig,

Although enzymes often incorporate molecular recognition elements to orient substrates selectively, such strategies are rarely achieved by synthetic catalysts. We combined molecular recognition through hydrogen bonding with C-H activation to obtain high-turnover catalytic regioselective functionalization of sp3 C-H bonds remote from the -COOH recognition group. The catalyst contains a Mn(mu-O)2Mn ... Read more >>

Science (Science (New York, N.Y.))
[2006, 312(5782):1941-1943]

Cited: 143 times

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