Full Text Journal Articles by
Author Christophe Perrin

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Access to paediatric formulations for the treatment of childhood tuberculosis.

Madlen Nash, Christophe Perrin, James A Seddon, Jennifer Furin, Janika Hauser, Ben Marais, Ian Kitai, Jeffrey Starke, Lindsay McKenna,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(12):855-857]

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Proliferating Onychomatricoma. Clinical, Dermoscopical, and Pathologic Features of Onychomatricoma New Variant Resembling Onycholemmal/Squamous Cell Carcinoma.

Christophe Perrin, Damien Ambrosetti, Brigitte Balme, Luc Thomas,

Proliferating onychomatricoma is a new challenging variant of onychomatricoma that can clinically and histologically mimic squamous cell carcinoma/onycholemmal carcinoma. This is a retrospective case series study of the clinicopathologic and dermoscopic features of 6 patients with a pathologic diagnosis of proliferating onychomatricoma, which was conducted in the dermatology and dermatopathology ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2020, 42(11):827-834]

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Histological Evaluation of the Relationships Between Distal Interphalangeal Psoriatic Arthritis and Nail Psoriasis: Correlations With Anatomical Studies of the Normal Nail Unit and the Main Radiological Data Concerning Distal Interphalangeal Psoriatic Arthritis.

Christophe Perrin,

To determine whether distal interphalangeal joint psoriatic arthritis (DIP PsA) and nail psoriasis are anatomically linked, we studied 2 fingers taken from a cadaver presenting a typical cutaneous and nail psoriasis in the setting of a dactylitis limited to the fourth toe. This comprehensive study of the inflammatory pattern of ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2020, :]

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Acquired (True) Leukonychia Punctate and Striata: Pathogenesis in the Light of Onychocytic Matricoma and Onychomatricoma.

Christophe Perrin,

Am J Dermatopathol (The American Journal of dermatopathology)
[2020, :]

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S-100 Protein Positivity in Onychomatricoma, a Potential Diagnostic Pitfall?

Christophe Perrin,

Am J Dermatopathol (The American Journal of dermatopathology)
[2020, 42(8):622-623]

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COVID-19 pneumonia: relationship between inflammation assessed by whole-body FDG PET/CT and short-term clinical outcome.

Matthieu Dietz, Gilles Chironi, Yann-Erick Claessens, Ryan Lukas Farhad, Isabelle Rouquette, Benjamin Serrano, Valérie Nataf, Florent Hugonnet, Benoît Paulmier, Frédéric Berthier, Olivia Keita-Perse, Francesco Giammarile, Christophe Perrin, Marc Faraggi, ,

PURPOSE:[18F]-2-Fluoro-2-deoxy-D-glucose PET/CT (FDG PET/CT) is a sensitive and quantitative technic for detecting inflammatory process. Glucose uptake is correlated with an increased anaerobic glycolysis seen in activated inflammatory cells such as monocytes, lymphocytes, and granulocytes. The aim of the study was to assess the inflammatory status at the presumed peak of the ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2020, :]

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Europe should lead in coordinated procurement of quality-assured medicines for programmes in low-income and middle-income countries.

Christophe Perrin, Sandrine Cloez, Catherine Dujardin, Raffaella Ravinetto,

BMJ Glob Health (BMJ global health)
[2020, 5(7):]

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Real-world Evaluation of Oral Vinorelbine in the Treatment of Metastatic Breast Cancer: An ESME-MBC Study.

Pierre Heudel, Suzette Delaloge, Damien Parent, Nicolas Madranges, Christelle Levy, Florence Dalenc, Etienne Brain, Lionel Uwer, Veronique D'Hondt, Paule Augereau, Audrey Mailliez, Christophe Perrin, Jean-Sebastien Frenel, Marie-Paule Sablin, Marie-Ange Mouret-Reynier, Thomas Vermeulin, Jean-Christophe Eymard, Thierry Petit, Jean-Marc Ferrero, Silvia Ilie, Anthony Goncalves, GaËlle Chenuc, Mathieu Robain, GaËtane Simon, David Perol,

BACKGROUND/AIM:Vinorelbine is indicated for use in the treatment of MBC as a single agent or in combination but there is little real world data on this molecule and even less on its oral form. We exploited the Unicancer Epidemiology Strategy Medical-Economics (ESME) metastatic breast cancer (MBC) database to investigate current ... Read more >>

Anticancer Res (Anticancer research)
[2020, 40(7):3905-3913]

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Accuracy of routine biomarkers and blood leucocytes count to assist diagnosis of COVID-19-associated pneumonia in adult patients visiting the emergency department

Cécile Maincent, Frédéric Berthier, Ryan Lukas Farhad, Cristel Fissore-Magdelein, Claire Claire Dittlot, Nathalie Beau, Jérémy Lépine, Marjorie Lorillou, Matthieu Dietz, Mathieu Liberatore, Atul Pathak, Marc Marc Faraggi, Sylvie Chaillou-Orpitz, Olivia Keita-Perse, Gilles Chironi, Christophe Perrin, Yann-Erick Claessens,

Abstract Background To investigate whether routine biomarkers and blood leucocytes count could assist diagnosis of COVID-19-associated pneumonia in adult patients visiting the emergency department (ED). Methods This monocentre retrospective study enrolled 254 patients with nasopharyngeal RT-PCR for SARS-COV-2, routine biomarkers (D-dimers, fibrinogen, C-reactive protein, procalcitonin, NTpro-BNP, cTnT-hs) and blood cell ... Read more >>

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Impact of age at diagnosis of metastatic breast cancer on overall survival in the real-life ESME metastatic breast cancer cohort.

Sophie Frank, Matthieu Carton, Coraline Dubot, Mario Campone, Barbara Pistilli, Florence Dalenc, Audrey Mailliez, Christelle Levy, Véronique D'Hondt, Marc Debled, Thomas Vermeulin, Bruno Coudert, Christophe Perrin, Anthony Gonçalves, Lionel Uwer, Jean-Marc Ferrero, Jean-Christophe Eymard, Thierry Petit, Marie-Ange Mouret-Reynier, Anne Patsouris, Tahar Guesmia, Thomas Bachelot, Mathieu Robain, Paul Cottu,

BACKGROUND:Young age is a poor prognostic factor in early stage breast cancer (BC) but its value is less established in metastatic BC (MBC). We evaluated the impact of age at MBC diagnosis on overall survival (OS) across three age groups (<40, 40 to 60 and > 60 years(y)). METHODS:ESME MBC database is ... Read more >>

Breast (Breast (Edinburgh, Scotland))
[2020, 52:50-57]

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AVAPS-AE versus ST mode: A randomized controlled trial in patients with obesity hypoventilation syndrome.

Maxime Patout, Frédéric Gagnadoux, Claudio Rabec, Wojciech Trzepizur, Marjolaine Georges, Christophe Perrin, Renaud Tamisier, Jean-Louis Pépin, Claudia Llontop, Valerie Attali, Frederic Goutorbe, Sandrine Pontier-Marchandise, Pierre Cervantes, Vanessa Bironneau, Adriana Portmann, Jacqueline Delrieu, Antoine Cuvelier, Jean-François Muir,

BACKGROUND AND OBJECTIVE:Average volume-assured pressure support-automated expiratory positive airway pressure (AVAPS-AE) combines an automated positive expiratory pressure to maintain upper airway patency to an automated pressure support with a targeted tidal volume. The aim of this study was to compare the effects of 2-month AVAPS-AE ventilation versus pressure support (ST) ... Read more >>

Respirology (Respirology (Carlton, Vic.))
[2020, :]

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Onychomatricoma Micropapilliferum, a New Variant of Onychomatricoma: Clinical, Dermoscopical, and Histological Correlations (Report of 4 Cases).

Christophe Perrin,

This is a report of a previously undescribed type of onychomatricoma (OM) with an unusual clinical presentation as a thickened free edge of the nail plate without discernible cavities and distinguished histologically from the ordinary OM by 3 features: (1) the lack of cavitation at the proximal border of the ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2020, 42(2):103-110]

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Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer.

Shanu Modi, Cristina Saura, Toshinari Yamashita, Yeon Hee Park, Sung-Bae Kim, Kenji Tamura, Fabrice Andre, Hiroji Iwata, Yoshinori Ito, Junji Tsurutani, Joohyuk Sohn, Neelima Denduluri, Christophe Perrin, Kenjiro Aogi, Eriko Tokunaga, Seock-Ah Im, Keun Seok Lee, Sara A Hurvitz, Javier Cortes, Caleb Lee, Shuquan Chen, Lin Zhang, Javad Shahidi, Antoine Yver, Ian Krop, ,

BACKGROUND:Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate composed of an anti-HER2 (human epidermal growth factor receptor 2) antibody, a cleavable tetrapeptide-based linker, and a cytotoxic topoisomerase I inhibitor. In a phase 1 dose-finding study, a majority of the patients with advanced HER2-positive breast cancer had a response to trastuzumab deruxtecan ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 382(7):610-621]

Cited: 28 times

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Implanted Phrenic Stimulation Impairs Local Diaphragm Myofiber Reinnervation in Amyotrophic Lateral Sclerosis.

Raquel Guimarães-Costa, Marie-Cécile Niérat, Isabelle Rivals, Capucine Morélot-Panzini, Norma Beatriz Romero, Fabrice Menegaux, François Salachas, Jésus Gonzalez-Bermejo, Thomas Similowski, Gaëlle Bruneteau, ,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(9):1183-1187]

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Cellular Angiofibroma: Case Report of a Unique Subungual Presentation.

Christophe Perrin, Giuseppe E Cannata, Florence Pedeutour, Bérengère Dadone-Montaudié, Damien Ambrosetti,

Acta Derm Venereol (Acta dermato-venereologica)
[2019, 99(10):915-916]

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Predictive factors associated with involved margins in breast cancer treated with neoadjuvant chemotherapy followed by breast-conserving therapy.

Elise Davoine, Ludivine Dion, Krystel Nyangoh Timoh, Eugenie Beraud, Patrick Tas, Aude Tavenard, Bruno Laviolle, Christophe Perrin, Fabrice Foucher, Jean Levêque, Vincent Lavoué,

INTRODUCTION:This study sought to identify predictive factors of involved surgical margins in breast-conserving surgery (BCS) after neoadjuvant chemotherapy (NAC) to help guide the surgical procedure. MATERIALS AND METHODS:Retrospective study of patients who had BCS after NAC between January 2008 and December 2013. OUTCOME MEASURE:tumor-involved margin, defined by tumor cells on ... Read more >>

J Gynecol Obstet Hum Reprod (Journal of gynecology obstetrics and human reproduction)
[2019, 48(7):467-472]

Cited: 1 time

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Nail Anatomy, Nail Psoriasis, and Nail Extensor Enthesitis Theory: What Is the Link?

Christophe Perrin,

The concept of the nail unit as a musculoskeletal appendage has become popular in the dermatological and rheumatological literature. However, an exact knowledge of the characteristics of mesenchyme surrounding the nail such as the composition of the collagen and elastic fibers and their arrangement is fundamental before one can propose ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2019, 41(6):399-409]

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Results of API-AI based regimen in osteosarcoma adult patients included in the French OS2006/Sarcome-09 study.

Sophie Piperno-Neumann, Isabelle Ray-Coquard, Bob-Valéry Occean, Valérie Laurence, Didier Cupissol, Christophe Perrin, Nicolas Penel, Emmanuelle Bompas, Maria Rios, Axel Le Cesne, Antoine Italiano, Philippe Anract, Gonzague de Pinieux, Olivier Collard, François Bertucci, Florence Duffaud, Marie-Cécile Le Deley, Jessy Delaye, Laurence Brugieres, Jean-Yves Blay,

In the OS2006 study, patients younger than 18 years were treated with a methotrexate-based regimen (MTX), patients older than 25 years with a doxorubicin-cisplatin-ifosfamide-based regimen (API-AI), whereas patients aged 18-25 years received either API-AI or MTX. We herein report the prespecified subgroup analysis of the outcome of 106 patients treated with API-AI. Preoperative ... Read more >>

Int J Cancer (International journal of cancer)
[2020, 146(2):413-423]

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Therapeutic innovations in breast cancer.

Fanny Le Du, Christophe Perrin, Angélique Brunot, Laurence Crouzet, Thibault De La Motte Rouge, Claudia Lefeuvre-Plesse, Véronique Dieras,

Managing endocrine resistance and resistance to endocrine therapy for ER+ HER2- breast cancer with the CDK 4/6 inhibitors in the metastatic setting. New antibodies drug conjugates for HER2+ and TNBC. Targeting DNA damage and synthetic lethality strategies with PARP inhibitors for breast cancer patients harboring BRCA mutation. Immunotherapies in 1st ... Read more >>

Presse Med (Presse medicale (Paris, France : 1983))
[2019, 48(10):1131-1137]

Cited: 2 times

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Preliminary safety and efficacy of first-line pertuzumab combined with trastuzumab and taxane therapy for HER2-positive locally recurrent or metastatic breast cancer (PERUSE).

T Bachelot, E Ciruelos, A Schneeweiss, F Puglisi, T Peretz-Yablonski, I Bondarenko, S Paluch-Shimon, A Wardley, J-L Merot, Y du Toit, V Easton, N Lindegger, D Miles, ,

BACKGROUND:Pertuzumab combined with trastuzumab and docetaxel is the standard first-line therapy for HER2-positive metastatic breast cancer, based on results from the phase III CLEOPATRA trial. PERUSE was designed to assess the safety and efficacy of investigator-selected taxane with pertuzumab and trastuzumab in this setting. PATIENTS AND METHODS:In the ongoing multicentre ... Read more >>

Ann. Oncol. (Annals of oncology : official journal of the European Society for Medical Oncology)
[2019, 30(5):766-773]

Cited: 6 times

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Framework for patient-ventilator asynchrony during long-term non-invasive ventilation.

Jesus Gonzalez-Bermejo, Jean-Paul Janssens, Claudio Rabec, Christophe Perrin, Frédéric Lofaso, Bruno Langevin, Annalisa Carlucci, Manel Lujan, ,

Episodes of patient-ventilator asynchrony (PVA) occur during acute and chronic non-invasive positive pressure ventilation (NIV). In long-term NIV, description and quantification of PVA is not standardised, thus limiting assessment of its clinical impact. The present report provides a framework for a systematic analysis of polygraphic recordings of patients under NIV ... Read more >>

Thorax (Thorax)
[2019, 74(7):715-717]

Cited: 2 times

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Countries are out of step with international recommendations for tuberculosis testing, treatment, and care: Findings from a 29-country survey of policy adoption and implementation

Karishma Saran, Tiziana Masini, Isaac Chikwanha, Gregory Paton, Rosalind Scourse, Patricia Kahn, Suvanand Sahu, Christophe Perrin, Lucica Ditiu, Sharonann Lynch,

ABSTRACT Background Tuberculosis (TB) poses a global health crisis requiring robust international and country-level action. Adopting and implementing TB policies from the World Health Organization (WHO) is essential to meeting global targets for reducing TB burden. However, many high TB burden countries lag in implementing WHO recommendations. Assessing the progress ... Read more >>

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Essential Medicines at the National Level: The Global Asthma Network's Essential Asthma Medicines Survey 2014.

Karen Bissell, Philippa Ellwood, Eamon Ellwood, Chen-Yuan Chiang, Guy B Marks, Asma El Sony, Innes Asher, Nils Billo, Christophe Perrin, ,

Patients with asthma need uninterrupted supplies of affordable, quality-assured essential medicines. However, access in many low- and middle-income countries (LMICs) is limited. The World Health Organization (WHO) Non-Communicable Disease (NCD) Global Action Plan 2013⁻2020 sets an 80% target for essential NCD medicines' availability. Poor access is partly due to medicines ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(4):]

Cited: 1 time

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Human diaphragm atrophy in amyotrophic lateral sclerosis is not predicted by routine respiratory measures.

Raquel Guimarães-Costa, Thomas Similowski, Isabelle Rivals, Capucine Morélot-Panzini, Marie-Cécile Nierat, Mai Thao Bui, David Akbar, Christian Straus, Norma Beatriz Romero, Patrick Pierre Michel, Fabrice Menegaux, François Salachas, Jésus Gonzalez-Bermejo, Gaëlle Bruneteau, , ,

Amyotrophic lateral sclerosis (ALS) patients show progressive respiratory muscle weakness leading to death from respiratory failure. However, there are no data on diaphragm histological changes in ALS patients and how they correlate with routine respiratory measurements.We collected 39 diaphragm biopsies concomitantly with laparoscopic insertion of intradiaphragmatic electrodes during a randomised ... Read more >>

Eur Respir J (The European respiratory journal)
[2019, 53(2):]

Cited: 2 times

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Melanocytes Pattern in the Normal Nail, With Special Reference to Nail Bed Melanocytes.

Christophe Perrin, Jean-F Michiels, Julien Boyer, Damien Ambrosetti,

Previous studies of the density of melanocytes in the normal nail bed have had conflicting results. This is unfortunate because knowing the normal values might help the difficult distinction between a benign subungual melanotic macule and an early melanoma in situ. Five specimens of normal nail unit were analyzed. On ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2018, 40(3):180-184]

Cited: 1 time

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