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Plasmacytoid dendritic cells proliferation associated with acute myeloid leukemia: phenotype profile and mutation landscape.

Loria Zalmaï, Pierre-Julien Viailly, Sabeha Biichle, Meyling Cheok, Lou Soret, Fanny Angelot-Delettre, Tony Petrella, Marie-Agnès Collonge-Rame, Estelle Seilles, Sandrine Geffroy, Eric Deconinck, Etienne Daguindau, Sabrina Bouyer, Elodie Dindinaud, Victor Baunin, Magali Le Garff-Tavernier, Damien Roos-Weil, Orianne Wagner-Ballon, Véronique Salaun, Jean Feuillard, Sophie Brun, Bernard Drenou, Caroline Mayeur-Rousse, Patricia Okamba, Véronique Dorvaux, Michel Tichionni, Johann Rose, Marie Thérèse Rubio, Marie Christine Jacob, Victoria Raggueneau, Claude Preudhomme, Philippe Saas, Christophe Ferrand, Olivier Adotevi, Christophe Roumier, Fabrice Jardin, Francine Garnache-Ottou, Florian Renosi,

Neoplasms involving plasmacytoid Dendritic Cells (pDCs) include Blastic pDC Neoplasms (BPDCN) and other pDC proliferations, where pDCs are associated with myeloid malignancies: most frequently Chronic MyeloMonocytic Leukemia (CMML) but also Acute Myeloid Leukemia (AML), hereafter named pDC-AML. We aimed to determine the reactive or neoplastic origin of pDCs in pDC-AML, ... Read more >>

Haematologica (Haematologica)
[2020, Online ahead of print:]

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Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses.

Claire Gorby, Junel Sotolongo Bellón, Stephan Wilmes, Walid Warda, Elizabeth Pohler, Paul K Fyfe, Adeline Cozzani, Christophe Ferrand, Mark R Walter, Suman Mitra, Jacob Piehler, Ignacio Moraga,

Interleukin-10 (IL-10) is a dimeric cytokine with both immunosuppressive and immunostimulatory activities; however, IL-10-based therapies have shown only marginal clinical benefits. Here, we explored whether the stability of the IL-10 receptor complex contributes to the immunomodulatory potency of IL-10. We generated an IL-10 mutant with enhanced affinity for its IL-10Rβ ... Read more >>

Sci Signal (Science signaling)
[2020, 13(649):]

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Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients.

Thomas Crépin, Mathieu Legendre, Clémence Carron, Clément Vachey, Cécile Courivaud, Jean-Michel Rebibou, Christophe Ferrand, Caroline Laheurte, Charline Vauchy, Emilie Gaiffe, Philippe Saas, Didier Ducloux, Jamal Bamoulid,

BACKGROUND:Patients with chronic kidney disease (CKD) are more prone to develop premature age-related diseases. Data on immune senescence are scarce in CKD populations, except in end-stage renal disease and dialysis. We designed a longitudinal prospective study to evaluate immune senescence at different CKD stages and its influence on CKD patient ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2020, 35(4):624-632]

Cited: 4 times

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CD28/4-1BB CD123 CAR T cells in blastic plasmacytoid dendritic cell neoplasm.

Elodie Bôle-Richard, Maxime Fredon, Sabeha Biichlé, François Anna, Jean-Marie Certoux, Florian Renosi, Frédéric Tsé, Chloé Molimard, Séverine Valmary-Degano, Alizée Jenvrin, Walid Warda, Jean-René Pallandre, Francis Bonnefoy, Margaux Poussard, Marina Deschamps, Tony Petrella, Christophe Roumier, Elizabeth Macintyre, Frédéric Féger, Eolia Brissot, Mohamad Mohty, Kiave-Yune HoWangYin, Pierre Langlade-Demoyen, Maria Loustau, Julien Caumartin, Yann Godet, Delphine Binda, Maïder Pagadoy, Eric Deconinck, Etienne Daguindau, Philippe Saas, Christophe Ferrand, Fanny Angelot-Delettre, Olivier Adotévi, Francine Garnache-Ottou,

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is associated with a remarkably poor prognosis and with no treatment consensus. The identification of relevant therapeutic targets is challenging. Here, we investigated the immune functions, antileukemia efficacy and safety of CD28/4-1BB CAR T cells targeting CD123 the interleukin (IL)-3 receptor alpha chain which ... Read more >>

Leukemia (Leukemia)
[2020, :]

Cited: 1 time

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Post-Essential Thrombocythemia Myelofibrosis and Multiple Isodicentric Y Chromosomes: A Unique Case among a Rare Association.

Eric Dahlen, Sinziana I Sarghi, Florian Renosi, Christophe Ferrand, Marie-Agnes Collonge-Rame, Paul Kuentz,

Multiple isodicentric Y chromosomes [idic(Y)] is a rare cytogenetic abnormality, most exclusively described in constitutional karyotypes. Only recently has this entity been reported in hematologic neoplasms such as myeloid disorders, albeit these cases remain very scarce. The possible involvement of increasing copies of potential proto-oncogenes located on the multiple idic(Y) ... Read more >>

Cytogenet. Genome Res. (Cytogenetic and genome research)
[2020, 160(1):18-21]

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How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?

Francine Garnache-Ottou, Chrystelle Vidal, Sabeha Biichlé, Florian Renosi, Eve Poret, Maïder Pagadoy, Maxime Desmarets, Anne Roggy, Estelle Seilles, Lou Soret, Françoise Schillinger, Sandrine Puyraimond, Tony Petrella, Claude Preudhomme, Christophe Roumier, Elisabeth A MacIntyre, Véronique Harrivel, Yohan Desbrosses, Bérengère Gruson, Franck Geneviève, Sylvain Thepot, Yuriy Drebit, Thibaut Leguay, François-Xavier Gros, Nicolas Lechevalier, Pascale Saussoy, Véronique Salaun, Edouard Cornet, Zehaira Benseddik, Richard Veyrat-Masson, Orianne Wagner-Ballon, Célia Salanoubat, Marc Maynadié, Julien Guy, Denis Caillot, Marie-Christine Jacob, Jean-Yves Cahn, Rémy Gressin, Johann Rose, Bruno Quesnel, Estelle Guerin, Franck Trimoreau, Jean Feuillard, Marie-Pierre Gourin, Adriana Plesa, Lucile Baseggio, Isabelle Arnoux, Norbert Vey, Didier Blaise, Romaric Lacroix, Christine Arnoulet, Blandine Benet, Véronique Dorvaux, Caroline Bret, Bernard Drenou, Agathe Debliquis, Véronique Latger-Cannard, Caroline Bonmati, Marie-Christine Bene, Pierre Peterlin, Michel Ticchioni, Pierre-Simon Rohrlich, Anne Arnaud, Stefan Wickenhauser, Valérie Bardet, Sabine Brechignac, Benjamin Papoular, Victoria Raggueneau, Jacques Vargaftig, Rémi Letestu, Daniel Lusina, Thorsten Braun, Vincent Foissaud, Jérôme Tamburini, Hind Bennani, Nicolas Freynet, Catherine Cordonnier, Magali Le Garff-Tavernier, Nathalie Jacques, Karim Maloum, Damien Roos-Weil, Didier Bouscary, Vahid Asnafi, Ludovic Lhermitte, Felipe Suarez, Etienne Lengline, Frédéric Féger, Giorgia Battipaglia, Mohamad Mohty, Sabrina Bouyer, Ouda Ghoual, Elodie Dindinaud, Caroline Basle, Mathieu Puyade, Carinne Lafon, Thierry Fest, Mikael Roussel, Xavier Cahu, Elsa Bera, Sylvie Daliphard, Fabrice Jardin, Lydia Campos, Françoise Solly, Denis Guyotat, Anne-Cécile Galoisy, Alice Eischen, Caroline Mayeur-Rousse, Blandine Guffroy, Christian Recher, Marie Loosveld, Alice Garnier, Vincent Barlogis, Maria Alessandra Rosenthal, Sophie Brun, Nathalie Contentin, Sébastien Maury, Mary Callanan, Christine Lefebvre, Natacha Maillard, Patricia Okamba, Christophe Ferrand, Olivier Adotevi, Philippe Saas, Fanny Angelot-Delettre, Delphine Binda, Eric Deconinck,

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia for which we developed a nationwide network to collect data from new cases diagnosed in France. In a retrospective, observational study of 86 patients (2000-2013), we described clinical and biological data focusing on morphologies and immunophenotype. We found ... Read more >>

Blood Adv (Blood advances)
[2019, 3(24):4238-4251]

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[Requirements for academic production of CAR-T cells in accordance with Good Pharmaceutical Practice (GMP). Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Marina Deschamps, Véronique Decot, Camille Giverne, Marine Pinturaud, Alix Vaissié, Nathalie Parquet, Sylvain Olivero, Mamez Anne-Claire, Jacques-Olivier Bay, Ibrahim Yakoub-Agha, Christophe Ferrand,

The extraordinary and unexpected success of cellular immunotherapy using genetically engineered T-cells to express a chimeric antigen receptor (CAR) targeting CD19, in the treatment of refractory or relapsing B-hematological malignancies, has provided a real therapeutic hope. Indeed, remission rates reach more than 80 % in patients at a stage, without any ... Read more >>

Bull Cancer (Bulletin du cancer)
[2020, 107(1S):S85-S93]

Cited: 0 times

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[IL-1RAP as a candidate for CAR T-cells immunotherapy].

Mathieu Neto Da Rocha, Rim Trad, Walid Warda, Rafik Haderbache, Lucie Bouquet, Clémentine Nicod, Marina Deschamps, Christophe Ferrand,

Med Sci (Paris) (Medecine sciences : M/S)
[2019, 35(6-7):497-500]

Cited: 0 times

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Altered thymic CD4+ T-cell recovery after allogeneic hematopoietic stem cell transplantation is critical for nocardiosis.

Xavier Roussel, Etienne Daguindau, Ana Berceanu, Yohan Desbrosses, Philippe Saas, Christophe Ferrand, Estelle Seilles, Fabienne Pouthier, Eric Deconinck, Fabrice Larosa,

PURPOSE OF THE STUDY:Nocardia affects immunocompromised human host exhibiting an altered cell-mediated immunity. Infectious risk after allogeneic hematopoietic cell transplantation (AHCT) is significantly correlated to the recovery status of donor-derived immune system, especially CD4+ T-cells reconstitution and thymopoiesis. The purpose of this paper is to highlight a lack of cell-mediated ... Read more >>

Curr Res Transl Med (Current research in translational medicine)
[2019, 67(4):135-143]

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CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor-Engineered T Cells.

Walid Warda, Fabrice Larosa, Mathieu Neto Da Rocha, Rim Trad, Eric Deconinck, Ziad Fajloun, Cyril Faure, Denis Caillot, Marius Moldovan, Severine Valmary-Degano, Sabeha Biichle, Etienne Daguindau, Francine Garnache-Ottou, Sebastien Tabruyn, Olivier Adotevi, Marina Deschamps, Christophe Ferrand,

Chronic myeloid leukemia (CML) is a chronic disease resulting in myeloid cell expansion through expression of the BCR-ABL1 fusion transcript. Tyrosine kinase inhibitors (TKI) have significantly increased survival of patients with CML, and deep responders may consider stopping the treatment. However, more than 50% of patients relapse and restart TKI, ... Read more >>

Cancer Res. (Cancer research)
[2019, 79(3):663-675]

Cited: 6 times

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SALL4 oncogene is an immunogenic antigen presented in various HLA-DR contexts.

Marie Kroemer, Laurie Spehner, Patricia Mercier-Letondal, Laura Boullerot, Stefano Kim, Marine Jary, Jeanne Galaine, Emilie Picard, Christophe Ferrand, Thierry Nguyen, Fabrice Larosa, Olivier Adotévi, Yann Godet, Christophe Borg,

Purpose: To investigate the immunoprevalence of SALL4-derived peptides in healthy volunteers and cancer patients. Experimental Design: A multistep approach including prediction algorithms was used to design in silico SALL4-derived peptides theoretically able to bind on common HLA-DR and HLA-A/B molecules. The presence of T-cell responses after a long term T-cell ... Read more >>

(Oncoimmunology)
[2018, 7(4):e1412030]

Cited: 1 time

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Potential added value of a RT-qPCR method of SOX 11 expression, in the context of a multidisciplinary diagnostic assessment of B cell malignancies.

Julien Magne, Alizée Jenvrin, Adrien Chauchet, Olivier Casasnovas, Anne Donzel, Laurence Jego, Bernard Aral, Julien Guy, Nathalie Nadal, Dewi Vernerey, Patrick Callier, Francine Garnache-Ottou, Christophe Ferrand,

Background:Expression of SRY [sex-determining region Y]-box11 (SOX11) is specific to mantle cell lymphoma (MCL) and contributes, in conjunction with immunoglobulin variable heavy chain gene mutation status, to the identification of two forms of this disease. Methods:The aim of this report was firstly, to design an easy and suitable RT-qPCR method ... Read more >>

(Experimental hematology & oncology)
[2018, 7:5]

Cited: 1 time

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[Prerequisite for hematopoietic cellular therapy programs to set up chimeric antigen receptor T-cell therapy (CAR T-cells): Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Ibrahim Yakoub-Agha, Christophe Ferrand, Yves Chalandon, Caroline Ballot, Cristina Castilla Llorente, Marina Deschamps, Jordan Gauthier, Myriam Labalette, Jérôme Larghero, Camille Maheux, Anne-Sophie Moreau, Pauline Varlet, Marie-Odile Pétillon, Marine Pinturaud, Marie Thérèse Rubio, Christian Chabannon,

CAR T-cells are autologous or allogeneic human lymphocytes that are genetically engineered to express a chimeric antigen receptor targeting an antigen expressed on tumor cells such as CD19. CAR T-cells represent a new class of medicinal products, and belong to the broad category of Advanced Therapy Medicinal Products (ATMPs), as ... Read more >>

Bull Cancer (Bulletin du cancer)
[2017, 104(12S):S43-S58]

Cited: 1 time

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[Chimerism analysis after hematopoietic cell transplantation: Guidelines from the Francophone Society of bone marrow transplantation and cellular therapy (SFGM-TC)].

Valérie Dubois, Mehdi Alizadeh, Jean Henri Bourhis, Pascaline Etancelin, Olivier Farchi, Christophe Ferrand, Laure Goursaud, Isabelle Mollet, Virginie Renac, Pauline Varlet, Ibrahim Yakoub-Agha, Jacques-Olivier Bay,

Chimerism analysis is an important step for the patient follow-up after hematopoietic stem cell transplantation. It is used to quantify the donor and the recipient part of a cell population issued from blood or bone marrow sample. In addition to hemogram, this technique is necessary to appreciate the quality of ... Read more >>

Bull Cancer (Bulletin du cancer)
[2017, 104(12S):S59-S64]

Cited: 0 times

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New advances in DPYD genotype and risk of severe toxicity under capecitabine.

Marie-Christine Etienne-Grimaldi, Jean-Christophe Boyer, Christophe Beroud, Litaty Mbatchi, André van Kuilenburg, Christine Bobin-Dubigeon, Fabienne Thomas, Etienne Chatelut, Jean-Louis Merlin, Frédéric Pinguet, Christophe Ferrand, Judith Meijer, Alexandre Evrard, Laurence Llorca, Gilles Romieu, Philippe Follana, Thomas Bachelot, Loic Chaigneau, Xavier Pivot, Véronique Dieras, Rémy Largillier, Mireille Mousseau, Anthony Goncalves, Henri Roché, Jacques Bonneterre, Véronique Servent, Nadine Dohollou, Yann Château, Emmanuel Chamorey, Jean-Pierre Desvignes, David Salgado, Jean-Marc Ferrero, Gérard Milano,

Deficiency in dihydropyrimidine dehydrogenase (DPD) enzyme is the main cause of severe and lethal fluoropyrimidine-related toxicity. Various approaches have been developed for DPD-deficiency screening, including DPYD genotyping and phenotyping. The goal of this prospective observational study was to perform exhaustive exome DPYD sequencing and to examine relationships between DPYD variants ... Read more >>

PLoS One (PloS one)
[2017, 12(5):e0175998]

Cited: 10 times

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Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice.

Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F Baumert, Michele Diana, Patrick Pessaux, Eric Robinet,

The development of multimodal strategies for the treatment of hepatocellular carcinoma requires tractable animal models allowing for advanced in vivo imaging. Here, we characterize an orthotopic hepatocellular carcinoma model based on the injection of luciferase-expressing human hepatoma Huh-7 (Huh-7-Luc) cells in immunodeficient mice. Luciferase allows for an easy repeated monitoring ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:35230]

Cited: 6 times

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Involvement and prognosis value of CD8(+) T cells in giant cell arteritis.

Maxime Samson, Kim Heang Ly, Benjamin Tournier, Nona Janikashvili, Malika Trad, Marion Ciudad, Alexandrine Gautheron, Hervé Devilliers, Valérie Quipourt, François Maurier, Nadine Meaux-Ruault, Nadine Magy-Bertrand, Patrick Manckoundia, Paul Ornetti, Jean-Francis Maillefert, Jean-François Besancenot, Christophe Ferrand, Laura Mesturoux, François Labrousse, Anne-Laure Fauchais, Philippe Saas, Laurent Martin, Sylvain Audia, Bernard Bonnotte,

CD8(+) T cells participate in the pathogenesis of some vasculitides. However, little is known about their role in Giant Cell Arteritis (GCA). This study was conducted to investigate CD8(+) T cell involvement in the pathogenesis of GCA. Analyses were performed at diagnosis and after 3 months of glucocorticoid treatment in ... Read more >>

J. Autoimmun. (Journal of autoimmunity)
[2016, 72:73-83]

Cited: 7 times

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IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner.

Romain Loyon, Emilie Picard, Olivier Mauvais, Lise Queiroz, Virginie Mougey, Jean-René Pallandre, Jeanne Galaine, Patricia Mercier-Letondal, Guillaume Kellerman, Nathalie Chaput, John Wijdenes, Olivier Adotévi, Christophe Ferrand, Pedro Romero, Yann Godet, Christophe Borg,

NK cells are critical for innate immunity-mediated protection. The main roles of NK cells rely on their cytotoxic functions or depend on the tuning of Th1 adaptive immunity by IFN-γ. However, the precise influence of inflammatory cytokines on NK cell and CD4 T lymphocyte interactions was never investigated. In this ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2016, 197(1):85-96]

Cited: 9 times

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Suicide gene-modified killer cells as an allogeneic alternative to autologous cytokine-induced killer cell immunotherapy of hepatocellular carcinoma.

Tao Wu, Céline Leboeuf, Sarah Durand, Bin Su, Marina Deschamps, Xiaowen Zhang, Christophe Ferrand, Patrick Pessaux, Eric Robinet,

Adoptive immunotherapy using autologous cytokine-induced killer (CIK) cells reduces the recurrence rate of hepatocellular carcinoma (HCC) in association with transarterial chemoembolization or radiofrequency. However, a large‑scale development of this immunotherapy remains difficult to consider in an autologous setting, considering the logistical hurdles associated with the production of this cell therapy ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2016, 13(3):2645-2654]

Cited: 1 time

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Immunoprevalence and magnitude of HLA-DP4 versus HLA-DR-restricted spontaneous CD4(+) Th1 responses against telomerase in cancer patients.

Caroline Laheurte, Jeanne Galaine, Laurent Beziaud, Magalie Dosset, Jerome Kerzerho, Claire Jacquemard, Béatrice Gaugler, Christophe Ferrand, Anne Dormoy, François Aubin, Pascale Jacoulet, Virginie Westeel, Christophe Borg, Eric Tartour, Yann Godet, Bernard Maillère, Olivier Adotévi,

Cumulative evidence supports that CD4(+) Th1 cells play a key role in antitumor immunity. We previously reported the presence of spontaneous HLA-DR-restricted CD4(+) Th1 responses against telomerase reverse transcriptase (TERT) in various cancers by using promiscuous HLA-DR epitopes. Here, we described novel highly immunogenic HLA-DP4-binding epitopes from TERT named TERT541-555, ... Read more >>

(Oncoimmunology)
[2016, 5(5):e1137416]

Cited: 6 times

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The alternative CD20 transcript variant is not a surrogate marker for resistance to rituximab in patients with rheumatoid arthritis.

Clémentine Gamonet, Marina Deschamps, Sandrine Marion, Georges Herbein, Gilles Chiocchia, Isabelle Auger, Philippe Saas, Christophe Ferrand, Eric Toussirot,

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2015, 54(9):1744-1745]

Cited: 2 times

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Editorial: Improving the safety of cell therapy products by suicide gene transfer.

Elodie Bole-Richard, Marina Deschamps, Christophe Ferrand, Eric Robinet,

(Frontiers in pharmacology)
[2015, 6:174]

Cited: 1 time

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Erratum to: New CD20 alternative splice variants: molecular identification and differential expression within hematological B cell malignancies.

Clémentine Gamonet, Elodie Bole-Richard, Aurélia Delherme, François Aubin, Eric Toussirot, Francine Garnache-Ottou, Yann Godet, Loïc Ysebaert, Olivier Tournilhac, Caroline Dartigeas, Fabrice Larosa, Eric Deconinck, Philippe Saas, Christophe Borg, Marina Deschamps, Christophe Ferrand,

[This corrects the article DOI: 10.1186/s40164-016-0036-3.]. ... Read more >>

(Experimental hematology & oncology)
[2015, 5:10]

Cited: 0 times

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CD20 alternative splicing isoform generates immunogenic CD4 helper T epitopes.

Charline Vauchy, Clementine Gamonet, Christophe Ferrand, Etienne Daguindau, Jeanne Galaine, Laurent Beziaud, Adrien Chauchet, Carole J Henry Dunand, Marina Deschamps, Pierre Simon Rohrlich, Christophe Borg, Olivier Adotevi, Yann Godet,

Cancer-specific splice variants gain significant interest as they generate neo-antigens that could be targeted by immune cells. CD20, a membrane antigen broadly expressed in mature B cells and in B cell lymphomas, is subject to an alternative splicing named D393-CD20 leading to loss of membrane expression of the spliced isoform. ... Read more >>

Int. J. Cancer (International journal of cancer)
[2015, 137(1):116-126]

Cited: 11 times

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Constitutional and somatic deletions of the Williams-Beuren syndrome critical region in non-Hodgkin lymphoma.

David Guenat, Samuel Quentin, Carmelo Rizzari, Catarina Lundin, Tiziana Coliva, Patrick Edery, Helen Fryssira, Laurent Bermont, Christophe Ferrand, Jean Soulier, Christophe Borg, Pierre-Simon Rohrlich,

Here, we report and investigate the genomic alterations of two novel cases of Non-Hodgkin Lymphoma (NHL) in children with Williams-Beuren syndrome (WBS), a multisystem disorder caused by 7q11.23 hemizygous deletion. Additionally, we report the case of a child with NHL and a somatic 7q11.23 deletion. Although the WBS critical region ... Read more >>

J Hematol Oncol (Journal of hematology & oncology)
[2014, 7:82]

Cited: 4 times

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