Full Text Journal Articles by
Author Christoph Licht

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Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study.

Carmen Yea, Ari Bitnun, Helen M Branson, Beyza Ciftci-Kavaklioglu, Mubeen F Rafay, Olivier Fortin, Paola Moresoli, Guillaume Sébire, Myriam Srour, Hélène Decaluwe, Louis Marois, Félixe Pelletier, Michelle Barton, Maryam Nabavi Nouri, Jason Brophy, Sunita Venkateswaran, Daniela Pohl, Kathryn Selby, Kevin Jones, Joan Robinson, Aleksandra Mineyko, Christoph Licht, Birgit Ertl-Wagner, E Ann Yeh,

BACKGROUND:Acute flaccid myelitis (AFM) is characterised by rapid onset of limb weakness with spinal cord grey-matter abnormalities on MRI scan. We aimed to assess whether detection of enterovirus in respiratory or other specimens can help predict prognosis in children with AFM. METHODS:In this nationwide, longitudinal study, we evaluated the significance ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):828-836]

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Long-term data on two sisters with C3GN due to an identical, homozygous CFH mutation and autoantibodies.

Agnes Hackl, Florian Erger, Christine Skerka, Andrea Wenzel, Nikolai Tschernoster, Rasmus Ehren, Kathrin Burgmaier, Vera Riehmer, Christoph Licht, Michael Kirschfink, Lutz T Weber, Janine Altmueller, Peter F Zipfel, Sandra Habbig,

C3 glomerulonephritis (C3GN) is a rare but severe form of kidney disease caused by fluid-phase dysregulation of the alternative complement pathway. Causative mutations in complement regulating genes as well as auto-immune forms of C3GN have been described. However, therapy and prognosis in individual patients remain a matter of debate and ... Read more >>

Clin Nephrol (Clinical nephrology)
[2020, 94(4):197-206]

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Plasma C3d levels as a diagnostic marker for complete complement factor I deficiency.

Leslie Naesens, Julie Smet, Simon J Tavernier, Petra Schelstraete, Levi Hoste, Stijn Lambrecht, Helene Verhelst, Jutte van der Werff Ten Bosch, Alina Ferster, Sophie Blumental, Pascale Hilbert, Tessa Kerre, Johan Vande Walle, Christoph Licht, Lubka T Roumenina, Patrick Stordeur, Filomeen Haerynck,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2020, :]

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Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H.

Anne K Mühlig, Lindsay S Keir, Jana C Abt, Hannah S Heidelbach, Rachel Horton, Gavin I Welsh, Catherine Meyer-Schwesinger, Christoph Licht, Richard J Coward, Lars Fester, Moin A Saleem, Jun Oh,

Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases. Complement factors are mainly liver-born and present in circulation. Nevertheless, there is a growing body of evidence for additional sites of ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:1833]

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Primary Human Derived Blood Outgrowth Endothelial Cells: An Appropriate In Vitro Model to Study Shiga Toxin Mediated Damage of Endothelial Cells.

Wouter J C Feitz, Nicole C A J van de Kar, Ian Cheong, Thea J A M van der Velden, Carolina G Ortiz-Sandoval, Dorothea Orth-Höller, Lambert P J W van den Heuvel, Christoph Licht,

Hemolytic uremic syndrome (HUS) is a rare disease primarily characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Endothelial damage is the hallmark of the pathogenesis of HUS with an infection with the Shiga toxin (Stx) producing Escherichia coli (STEC-HUS) as the main underlying cause in childhood. In this study, ... Read more >>

Toxins (Basel) (Toxins)
[2020, 12(8):]

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Impact of steroids and steroid-sparing agents on quality of life in children with nephrotic syndrome.

Shawn Khullar, Tonny Banh, Jovanka Vasilevska-Ristovska, Rahul Chanchlani, Josefina Brooke, Christoph P B Licht, Michele Reddon, Seetha Radhakrishnan, Monica Piekut, Valerie Langlois, Kim Aitken-Menezes, Rachel J Pearl, Diane Hebert, Damien Noone, Rulan S Parekh,

BACKGROUND:Steroids and/or steroid-sparing medications are commonly used for nephrotic syndrome treatment; however, the impact of these medications on health-related quality of life over time is not well described. METHODS:Longitudinal cohort is up to 5 years where children were assessed with baseline and annual Pediatric Quality of Life Inventory questionnaire. A mixed-effects ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Vascular endothelial cells evade complement-mediated membrane injury via Weibel-Palade body mobilization.

Magdalena Riedl Khursigara, Daniel Schlam, Damien G Noone, Valentina Bruno, Carolina G Ortiz-Sandoval, Fred G Pluthero, Walter H A Kahr, Mackenzie L Bowman, Paula James, Sergio Grinstein, Christoph Licht,

BACKGROUND:Defective complement inhibition can lead to the formation of membrane attack complexes (MAC; C5b-9) on the plasma membranes of vascular endothelial cells, resulting in injury that drives the progression of thrombotic microangiopathy (TMA), a key pathology in kidney disease. OBJECTIVE/METHODS:We examined the response of human endothelial cells to complement-mediated damage ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2020, 18(6):1484-1494]

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Hemodialysis Catheters in Infants: A Retrospective Single-Center Cohort Study.

Grace M Y Ma, Luís Marcelo Ventura, Afsaneh Amiribadi, Ralph Gnannt, Rose Nemec, Damien Noone, Christoph Licht, Joao Amaral, Michael Temple, Prakash Muthasami, Dimitri Parra, Racha Chamlati, Bairbre Connolly,

PURPOSE:Evaluate technical aspects and outcomes of insertion/maintenance of hemodialysis (HD) central venous catheter (CVC) during infancy. MATERIALS AND METHODS:Single-center retrospective study of 29 infants who underwent 49 HD-CVC insertions between 2002 and 2016. Demographics, procedural, and post-procedural details, interventional radiology (IR) maintenance procedures, technical modifications, complications, and outcomes were evaluated. ... Read more >>

J Vasc Interv Radiol (Journal of vascular and interventional radiology : JVIR)
[2020, 31(5):778-786]

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Functional Assessment of Fatigue and Other Patient-Reported Outcomes in Patients Enrolled in the Global aHUS Registry.

Larry A Greenbaum, Christoph Licht, Vasileios Nikolaou, Imad Al-Dakkak, Janet Green, Christian Stefan Haas, Elena Román-Ortiz, Hae Il Cheong, Lisa Sartz, Rita Swinford, Ioannis Tomazos, Benjamin Miller, Spero Cataland,

Introduction:Atypical hemolytic uremic syndrome (aHUS) is a progressive and potentially life-threatening disease characterized by complement-mediated thrombotic microangiopathy. Patients with aHUS may experience fatigue, which can negatively impact their lives, but there is a knowledge gap regarding disease burden in these patients. Methods:In this longitudinal study, patients with aHUS from the ... Read more >>

(Kidney international reports)
[2020, 5(8):1161-1171]

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Clinical trial recommendations for potential Alport syndrome therapies.

B André Weinstock, David L Feldman, Alessia Fornoni, Oliver Gross, Clifford E Kashtan, Sharon Lagas, Rachel Lennon, Jeffrey H Miner, Michelle N Rheault, James F Simon, ,

Alport syndrome is experiencing a remarkable increase in preclinical investigations. To proactively address the needs of the Alport syndrome community, as well as offer clarity for future clinical research sponsors, the Alport Syndrome Foundation hosted a workshop to generate consensus recommendations for prospective trials for conventional drugs. Opinions of key ... Read more >>

Kidney Int (Kidney international)
[2020, 97(6):1109-1116]

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Prediction of Short- and Long-Term Outcomes in Childhood Nephrotic Syndrome.

Simon A Carter, Shilan Mistry, Jessica Fitzpatrick, Tonny Banh, Diane Hebert, Valerie Langlois, Rachel J Pearl, Rahul Chanchlani, Christoph P B Licht, Seetha Radhakrishnan, Josefina Brooke, Michele Reddon, Leo Levin, Kimberly Aitken-Menezes, Damien Noone, Rulan S Parekh,

Introduction:It is unknown whether steroid sensitivity and other putative risk factors collected at baseline can predict the disease course of idiopathic nephrotic syndrome in childhood. We determined whether demographic, clinical, and family reported factors at presentation can predict outcomes in idiopathic nephrotic syndrome. Methods:An observational cohort of 631 children aged ... Read more >>

Kidney Int Rep (Kidney international reports)
[2020, 5(4):426-434]

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Clinical Characteristics and Outcome of Canadian Patients Diagnosed With Atypical Hemolytic Uremic Syndrome.

Anne-Laure Lapeyraque, Martin Bitzan, Imad Al-Dakkak, Mira Francis, Shih-Han S Huang, Roger Kaprielian, Loree Larratt, Katerina Pavenski, Christine Ribic, Axel Tosikyan, Christoph Licht, David Philibert,

Background:Atypical hemolytic uremic syndrome (aHUS) is an extremely rare, heterogeneous disease of uncontrolled activation of the alternative complement pathway that is difficult to diagnose. We have evaluated the Canadian patients enrolled in the Global aHUS Registry to provide a Canadian perspective regarding the diagnosis and management of aHUS and the ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2020, 7:2054358119897229]

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Helping nephrologists find answers: hyperinsulinism and tubular dysfunction: Answers.

Laura Betcherman, Mathieu Lemaire, Christoph Licht, David Chitayat, Jennifer Harrington, Damien Noone,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(2):257-260]

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Helping nephrologists find answers: hyperinsulinism and tubular dysfunction: Questions.

Laura Betcherman, Mathieu Lemaire, Christoph Licht, David Chitayat, Jennifer Harrington, Damien Noone,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(2):253-255]

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Comparison between intermittent and continuous leukapheresis protocols for autologous hematopoietic stem cell collections in children.

Salah Ali, Kuang-Yueh Chiang, Ehud Even-Or, Maria Di Mola, Tal Schechter, Muhammad Ali, Elizabeth McDougall, Gordana Svajger, Christoph Licht, Joerg Krueger,

BACKGROUND:Peripheral hematopoietic stem cell (HSC) collections are needed for autologous hematopoietic stem cell transplantation (HSCT). Since 2015, our institution has utilized a secondary chamber mononuclear cell (MNC) protocol on the Spectra Optia apheresis system. Recently, a new continuous mononuclear collection protocol (CMNC) was developed for the same device. As there ... Read more >>

J Clin Apher (Journal of clinical apheresis)
[2019, 34(6):646-655]

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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M Symons, Michael J G Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady, Maria Díaz-González de Ferris,

BACKGROUND:Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS:We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2019, 34(11):2427-2448]

Cited: 1 time

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An upfront immunomodulatory therapy protocol for pediatric opsoclonus-myoclonus syndrome.

Colin Wilbur, Carmen Yea, Christoph Licht, Meredith S Irwin, E Ann Yeh,

BACKGROUND:Treatment of opsoclonus-myoclonus syndrome (OMS) has historically involved corticosteroids and intravenous immunoglobulin (IVIG) for a duration of 6-12 months or longer. This study evaluated whether a brief upfront immunomodulatory therapy protocol with rituximab reduces the duration of OMS therapy without adversely affecting OMS outcomes. PROCEDURE:Retrospective chart review was performed for ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(8):e27776]

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Outcomes in patients with atypical hemolytic uremic syndrome treated with eculizumab in a long-term observational study.

Jan Menne, Yahsou Delmas, Fadi Fakhouri, Christoph Licht, Åsa Lommelé, Enrico E Minetti, François Provôt, Eric Rondeau, Neil S Sheerin, Jimmy Wang, Laurent E Weekers, Larry A Greenbaum,

BACKGROUND:There are limited long-term outcome data in eculizumab-treated patients with atypical hemolytic uremic syndrome (aHUS). We report final results from the largest prospective, observational, multicenter study of patients with aHUS treated with eculizumab. METHODS:Patients with aHUS who participated in any of five parent eculizumab trials and received at least one ... Read more >>

BMC Nephrol (BMC nephrology)
[2019, 20(1):125]

Cited: 5 times

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Association of low birth weight and prematurity with clinical outcomes of childhood nephrotic syndrome: a prospective cohort study.

Natalia Konstantelos, Tonny Banh, Viral Patel, Jovanka Vasilevska-Ristovska, Karlota Borges, Neesha Hussain-Shamsy, Damien Noone, Diane Hebert, Seetha Radhakrishnan, Christoph P B Licht, Valerie Langlois, Rachel J Pearl, Rulan S Parekh,

BACKGROUND:Low birth weight (LBW)/prematurity have been proposed as risk factors for the development of kidney disease in adulthood. Whether there is an association between LBW/prematurity and poor renal outcomes in childhood onset nephrotic syndrome remains unknown. METHODS:Children with nephrotic syndrome diagnosed between 1 and 18 years of age were followed prospectively ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(9):1599-1605]

Cited: 1 time

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Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study.

Rukshana Shroff, Colette Smith, Bruno Ranchin, Aysun K Bayazit, Constantinos J Stefanidis, Varvara Askiti, Karolis Azukaitis, Nur Canpolat, Ayşe Ağbaş, Helen Aitkenhead, Ali Anarat, Bilal Aoun, Daley Aofolaju, Sevcan Azime Bakkaloglu, Devina Bhowruth, Dagmara Borzych-Dużałka, Ipek Kaplan Bulut, Rainer Büscher, John Deanfield, Claire Dempster, Ali Duzova, Sandra Habbig, Wesley Hayes, Shivram Hegde, Saoussen Krid, Christoph Licht, Mieczyslaw Litwin, Mark Mayes, Sevgi Mir, Rose Nemec, Lukasz Obrycki, Fabio Paglialonga, Stefano Picca, Charlotte Samaille, Mohan Shenoy, Manish D Sinha, Brankica Spasojevic, Lynsey Stronach, Enrico Vidal, Karel Vondrák, Alev Yilmaz, Ariane Zaloszyc, Michel Fischbach, Claus Peter Schmitt, Franz Schaefer,

BACKGROUND:Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. METHODS:The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2019, 30(4):678-691]

Cited: 3 times

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Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings : A Midwest Pediatric Nephrology Consortium (MWPNC) study.

Jonathan H Pelletier, Karan R Kumar, Rachel Engen, Adam Bensimhon, Jennifer D Varner, Michelle N Rheault, Tarak Srivastava, Caroline Straatmann, Cynthia Silva, T Keefe Davis, Scott E Wenderfer, Keisha Gibson, David Selewski, John Barcia, Patricia Weng, Christoph Licht, Natasha Jawa, Mahmoud Kallash, John W Foreman, Delbert R Wigfall, Annabelle N Chua, Eileen Chambers, Christoph P Hornik, Eileen D Brewer, Shashi K Nagaraj, Larry A Greenbaum, Rasheed A Gbadegesin,

The original version of this article unfortunately contained a mistake. The subtitle "A Midwest Pediatric Nephrology Consortium (MWPNC) study" was missing. The correct title including subtitle is given above. ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(3):539]

Cited: 1 time

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Prevalence of Asthma and Allergies and Risk of Relapse in Childhood Nephrotic Syndrome: Insight into Nephrotic Syndrome Cohort.

Shivraj Singh Riar, Tonny H M Banh, Karlota Borges, Padmaja Subbarao, Viral Patel, Jovanka Vasilevska-Ristovska, Rahul Chanchlani, Neesha Hussain-Shamsy, Damien Noone, Diane Hebert, Christoph P B Licht, Valerie Langlois, Rachel J Pearl, Rulan S Parekh,

OBJECTIVE:To determine the lifetime prevalence of allergies in childhood nephrotic syndrome, the seasonality of presentation and relapses, and the impact of allergies on subsequent relapses. STUDY DESIGN:In a longitudinal cohort of children with nephrotic syndrome (ages 1-18 years), assessment for allergic diseases was conducted using the validated and modified version of ... Read more >>

J Pediatr (The Journal of pediatrics)
[2019, 208:251-257.e1]

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Eculizumab Use for Kidney Transplantation in Patients With a Diagnosis of Atypical Hemolytic Uremic Syndrome.

Andrew M Siedlecki, Nicole Isbel, Johan Vande Walle, Jennifer James Eggleston, David J Cohen, ,

Introduction:Recurrence of atypical hemolytic uremic syndrome (aHUS) in renal allografts is common, leading to dialysis and graft failure. Pretransplant versus posttransplant initiation of eculizumab treatment in patients with aHUS has not been rigorously investigated. We hypothesized eculizumab pretransplant would reduce dialysis incidence posttransplant. Methods:Of patients enrolled in the Global aHUS ... Read more >>

Kidney Int Rep (Kidney international reports)
[2019, 4(3):434-446]

Cited: 9 times

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Outrageous prices of orphan drugs: a call for collaboration.

Lucio Luzzatto, Hanna I Hyry, Arrigo Schieppati, Enrico Costa, Steven Simoens, Franz Schaefer, Jonathan C P Roos, Giampaolo Merlini, Helena Kääriäinen, Silvio Garattini, Carla E Hollak, Giuseppe Remuzzi, ,

Lancet (Lancet (London, England))
[2018, 392(10149):791-794]

Cited: 17 times

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Fetal Renal Echogenicity Associated with Maternal Focal Segmental Glomerulosclerosis: The Effect of Transplacental Transmission of Permeability Factor suPAR.

Shirley Shuster, Ghada Ankawi, Christoph Licht, Jochen Reiser, Xuexiang Wang, Changli Wei, David Chitayat, Michelle Hladunewich,

We report a case of a pregnant woman with nephrotic syndrome due to biopsy-proven focal segmental glomerulosclerosis (FSGS) whose fetus developed echogenic kidneys and severe oligohydramnios by 27 weeks of gestation. Maternal treatment with prednisone resulted in normalization of the amniotic fluid indices and resolution of fetal renal echogenicity. The ... Read more >>

J Clin Med (Journal of clinical medicine)
[2018, 7(10):]

Cited: 1 time

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