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Author Christoph Licht

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Hemodialysis Catheters in Infants: A Retrospective Single-Center Cohort Study.

Grace M Y Ma, Luís Marcelo Ventura, Afsaneh Amiribadi, Ralph Gnannt, Rose Nemec, Damien Noone, Christoph Licht, Joao Amaral, Michael Temple, Prakash Muthasami, Dimitri Parra, Racha Chamlati, Bairbre Connolly,

PURPOSE:Evaluate technical aspects and outcomes of insertion/maintenance of hemodialysis (HD) central venous catheter (CVC) during infancy. MATERIALS AND METHODS:Single-center retrospective study of 29 infants who underwent 49 HD-CVC insertions between 2002 and 2016. Demographics, procedural, and post-procedural details, interventional radiology (IR) maintenance procedures, technical modifications, complications, and outcomes were evaluated. ... Read more >>

J Vasc Interv Radiol (Journal of vascular and interventional radiology : JVIR)
[2020, 31(5):778-786]

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Clinical trial recommendations for potential Alport syndrome therapies.

B André Weinstock, David L Feldman, Alessia Fornoni, Oliver Gross, Clifford E Kashtan, Sharon Lagas, Rachel Lennon, Jeffrey H Miner, Michelle N Rheault, James F Simon, ,

Alport syndrome is experiencing a remarkable increase in preclinical investigations. To proactively address the needs of the Alport syndrome community, as well as offer clarity for future clinical research sponsors, the Alport Syndrome Foundation hosted a workshop to generate consensus recommendations for prospective trials for conventional drugs. Opinions of key ... Read more >>

Kidney Int. (Kidney international)
[2020, 97(6):1109-1116]

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Vascular endothelial cells evade complement-mediated membrane injury via Weibel-Palade body mobilization.

Magdalena Riedl Khursigara, Daniel Schlam, Damien G Noone, Valentina Bruno, Carolina G Ortiz Sandoval, Fred G Pluthero, Walter H A Kahr, Mackenzie L Bowman, Paula James, Sergio Grinstein, Christoph Licht,

BACKGROUND:Defective complement inhibition can lead to the formation of membrane attack complexes (MAC; C5b-9) on the plasma membranes of vascular endothelial cells, resulting in injury that drives the progression of thrombotic microangiopathy (TMA), a key pathology in kidney disease. OBJECTIVE/METHODS:We examined the response of human endothelial cells to complement-mediated damage ... Read more >>

J. Thromb. Haemost. (Journal of thrombosis and haemostasis : JTH)
[2020, :]

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Clinical Characteristics and Outcome of Canadian Patients Diagnosed With Atypical Hemolytic Uremic Syndrome.

Anne-Laure Lapeyraque, Martin Bitzan, Imad Al-Dakkak, Mira Francis, Shih-Han S Huang, Roger Kaprielian, Loree Larratt, Katerina Pavenski, Christine Ribic, Axel Tosikyan, Christoph Licht, David Philibert,

Background:Atypical hemolytic uremic syndrome (aHUS) is an extremely rare, heterogeneous disease of uncontrolled activation of the alternative complement pathway that is difficult to diagnose. We have evaluated the Canadian patients enrolled in the Global aHUS Registry to provide a Canadian perspective regarding the diagnosis and management of aHUS and the ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2020, 7:2054358119897229]

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Prediction of Short- and Long-Term Outcomes in Childhood Nephrotic Syndrome.

Simon A Carter, Shilan Mistry, Jessica Fitzpatrick, Tonny Banh, Diane Hebert, Valerie Langlois, Rachel J Pearl, Rahul Chanchlani, Christoph P B Licht, Seetha Radhakrishnan, Josefina Brooke, Michele Reddon, Leo Levin, Kimberly Aitken-Menezes, Damien Noone, Rulan S Parekh,

Introduction:It is unknown whether steroid sensitivity and other putative risk factors collected at baseline can predict the disease course of idiopathic nephrotic syndrome in childhood. We determined whether demographic, clinical, and family reported factors at presentation can predict outcomes in idiopathic nephrotic syndrome. Methods:An observational cohort of 631 children aged ... Read more >>

Kidney Int Rep (Kidney International Reports)
[2020, 5(4):426-434]

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Helping nephrologists find answers: hyperinsulinism and tubular dysfunction: Answers.

Laura Betcherman, Mathieu Lemaire, Christoph Licht, David Chitayat, Jennifer Harrington, Damien Noone,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(2):257-260]

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Helping nephrologists find answers: hyperinsulinism and tubular dysfunction: Questions.

Laura Betcherman, Mathieu Lemaire, Christoph Licht, David Chitayat, Jennifer Harrington, Damien Noone,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(2):253-255]

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Comparison between intermittent and continuous leukapheresis protocols for autologous hematopoietic stem cell collections in children.

Salah Ali, Kuang-Yueh Chiang, Ehud Even-Or, Maria Di Mola, Tal Schechter, Muhammad Ali, Elizabeth McDougall, Gordana Svajger, Christoph Licht, Joerg Krueger,

BACKGROUND:Peripheral hematopoietic stem cell (HSC) collections are needed for autologous hematopoietic stem cell transplantation (HSCT). Since 2015, our institution has utilized a secondary chamber mononuclear cell (MNC) protocol on the Spectra Optia apheresis system. Recently, a new continuous mononuclear collection protocol (CMNC) was developed for the same device. As there ... Read more >>

J Clin Apher (Journal of clinical apheresis)
[2019, 34(6):646-655]

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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M Symons, Michael J G Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady, Maria Díaz-González de Ferris,

BACKGROUND:Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS:We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(11):2427-2448]

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An upfront immunomodulatory therapy protocol for pediatric opsoclonus-myoclonus syndrome.

Colin Wilbur, Carmen Yea, Christoph Licht, Meredith S Irwin, E Ann Yeh,

BACKGROUND:Treatment of opsoclonus-myoclonus syndrome (OMS) has historically involved corticosteroids and intravenous immunoglobulin (IVIG) for a duration of 6-12 months or longer. This study evaluated whether a brief upfront immunomodulatory therapy protocol with rituximab reduces the duration of OMS therapy without adversely affecting OMS outcomes. PROCEDURE:Retrospective chart review was performed for ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(8):e27776]

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Outcomes in patients with atypical hemolytic uremic syndrome treated with eculizumab in a long-term observational study.

Jan Menne, Yahsou Delmas, Fadi Fakhouri, Christoph Licht, Åsa Lommelé, Enrico E Minetti, François Provôt, Eric Rondeau, Neil S Sheerin, Jimmy Wang, Laurent E Weekers, Larry A Greenbaum,

BACKGROUND:There are limited long-term outcome data in eculizumab-treated patients with atypical hemolytic uremic syndrome (aHUS). We report final results from the largest prospective, observational, multicenter study of patients with aHUS treated with eculizumab. METHODS:Patients with aHUS who participated in any of five parent eculizumab trials and received at least one ... Read more >>

BMC Nephrol (BMC nephrology)
[2019, 20(1):125]

Cited: 1 time

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Association of low birth weight and prematurity with clinical outcomes of childhood nephrotic syndrome: a prospective cohort study.

Natalia Konstantelos, Tonny Banh, Viral Patel, Jovanka Vasilevska-Ristovska, Karlota Borges, Neesha Hussain-Shamsy, Damien Noone, Diane Hebert, Seetha Radhakrishnan, Christoph P B Licht, Valerie Langlois, Rachel J Pearl, Rulan S Parekh,

BACKGROUND:Low birth weight (LBW)/prematurity have been proposed as risk factors for the development of kidney disease in adulthood. Whether there is an association between LBW/prematurity and poor renal outcomes in childhood onset nephrotic syndrome remains unknown. METHODS:Children with nephrotic syndrome diagnosed between 1 and 18 years of age were followed prospectively ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(9):1599-1605]

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Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study.

Rukshana Shroff, Colette Smith, Bruno Ranchin, Aysun K Bayazit, Constantinos J Stefanidis, Varvara Askiti, Karolis Azukaitis, Nur Canpolat, Ayşe Ağbaş, Helen Aitkenhead, Ali Anarat, Bilal Aoun, Daley Aofolaju, Sevcan Azime Bakkaloglu, Devina Bhowruth, Dagmara Borzych-Dużałka, Ipek Kaplan Bulut, Rainer Büscher, John Deanfield, Claire Dempster, Ali Duzova, Sandra Habbig, Wesley Hayes, Shivram Hegde, Saoussen Krid, Christoph Licht, Mieczyslaw Litwin, Mark Mayes, Sevgi Mir, Rose Nemec, Lukasz Obrycki, Fabio Paglialonga, Stefano Picca, Charlotte Samaille, Mohan Shenoy, Manish D Sinha, Brankica Spasojevic, Lynsey Stronach, Enrico Vidal, Karel Vondrák, Alev Yilmaz, Ariane Zaloszyc, Michel Fischbach, Claus Peter Schmitt, Franz Schaefer,

BACKGROUND:Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. METHODS:The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2019, 30(4):678-691]

Cited: 1 time

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Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings : A Midwest Pediatric Nephrology Consortium (MWPNC) study.

Jonathan H Pelletier, Karan R Kumar, Rachel Engen, Adam Bensimhon, Jennifer D Varner, Michelle N Rheault, Tarak Srivastava, Caroline Straatmann, Cynthia Silva, T Keefe Davis, Scott E Wenderfer, Keisha Gibson, David Selewski, John Barcia, Patricia Weng, Christoph Licht, Natasha Jawa, Mahmoud Kallash, John W Foreman, Delbert R Wigfall, Annabelle N Chua, Eileen Chambers, Christoph P Hornik, Eileen D Brewer, Shashi K Nagaraj, Larry A Greenbaum, Rasheed A Gbadegesin,

The original version of this article unfortunately contained a mistake. The subtitle "A Midwest Pediatric Nephrology Consortium (MWPNC) study" was missing. The correct title including subtitle is given above. ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(3):539]

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Prevalence of Asthma and Allergies and Risk of Relapse in Childhood Nephrotic Syndrome: Insight into Nephrotic Syndrome Cohort.

Shivraj Singh Riar, Tonny H M Banh, Karlota Borges, Padmaja Subbarao, Viral Patel, Jovanka Vasilevska-Ristovska, Rahul Chanchlani, Neesha Hussain-Shamsy, Damien Noone, Diane Hebert, Christoph P B Licht, Valerie Langlois, Rachel J Pearl, Rulan S Parekh,

OBJECTIVE:To determine the lifetime prevalence of allergies in childhood nephrotic syndrome, the seasonality of presentation and relapses, and the impact of allergies on subsequent relapses. STUDY DESIGN:In a longitudinal cohort of children with nephrotic syndrome (ages 1-18 years), assessment for allergic diseases was conducted using the validated and modified version of ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2019, 208:251-257.e1]

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Eculizumab Use for Kidney Transplantation in Patients With a Diagnosis of Atypical Hemolytic Uremic Syndrome.

Andrew M Siedlecki, Nicole Isbel, Johan Vande Walle, Jennifer James Eggleston, David J Cohen, ,

Introduction:Recurrence of atypical hemolytic uremic syndrome (aHUS) in renal allografts is common, leading to dialysis and graft failure. Pretransplant versus posttransplant initiation of eculizumab treatment in patients with aHUS has not been rigorously investigated. We hypothesized eculizumab pretransplant would reduce dialysis incidence posttransplant. Methods:Of patients enrolled in the Global aHUS ... Read more >>

Kidney Int Rep (Kidney international reports)
[2019, 4(3):434-446]

Cited: 6 times

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Fetal Renal Echogenicity Associated with Maternal Focal Segmental Glomerulosclerosis: The Effect of Transplacental Transmission of Permeability Factor suPAR.

Shirley Shuster, Ghada Ankawi, Christoph Licht, Jochen Reiser, Xuexiang Wang, Changli Wei, David Chitayat, Michelle Hladunewich,

We report a case of a pregnant woman with nephrotic syndrome due to biopsy-proven focal segmental glomerulosclerosis (FSGS) whose fetus developed echogenic kidneys and severe oligohydramnios by 27 weeks of gestation. Maternal treatment with prednisone resulted in normalization of the amniotic fluid indices and resolution of fetal renal echogenicity. The ... Read more >>

J Clin Med (Journal of clinical medicine)
[2018, 7(10):]

Cited: 1 time

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Outrageous prices of orphan drugs: a call for collaboration.

Lucio Luzzatto, Hanna I Hyry, Arrigo Schieppati, Enrico Costa, Steven Simoens, Franz Schaefer, Jonathan C P Roos, Giampaolo Merlini, Helena Kääriäinen, Silvio Garattini, Carla E Hollak, Giuseppe Remuzzi, ,

Lancet (Lancet (London, England))
[2018, 392(10149):791-794]

Cited: 7 times

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Effect of haemodiafiltration vs conventional haemodialysis on growth and cardiovascular outcomes in children - the HDF, heart and height (3H) study.

Rukshana Shroff, Aysun Bayazit, Constantinos J Stefanidis, Varvara Askiti, Karolis Azukaitis, Nur Canpolat, Ayse Agbas, Ali Anarat, Bilal Aoun, Sevcan Bakkaloglu, Devina Bhowruth, Dagmara Borzych-Dużałka, Ipek Kaplan Bulut, Rainer Büscher, Claire Dempster, Ali Duzova, Sandra Habbig, Wesley Hayes, Shivram Hegde, Saoussen Krid, Christoph Licht, Mieczyslaw Litwin, Mark Mayes, Sevgi Mir, Rose Nemec, Lukasz Obrycki, Fabio Paglialonga, Stefano Picca, Bruno Ranchin, Charlotte Samaille, Mohan Shenoy, Manish Sinha, Colette Smith, Brankica Spasojevic, Enrico Vidal, Karel Vondrák, Alev Yilmaz, Ariane Zaloszyc, Michel Fischbach, Franz Schaefer, Claus Peter Schmitt,

BACKGROUND:Cardiovascular disease is prevalent in children on dialysis and accounts for almost 30% of all deaths. Randomised trials in adults suggest that haemodiafiltration (HDF) with high convection volumes is associated with reduced cardiovascular mortality compared to high-flux haemodialysis (HD); however paediatric data are scarce. We designed the haemodiafiltration, heart and ... Read more >>

BMC Nephrol (BMC nephrology)
[2018, 19(1):199]

Cited: 3 times

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Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings.

Jonathan H Pelletier, Karan R Kumar, Rachel Engen, Adam Bensimhon, Jennifer D Varner, Michelle N Rheault, Tarak Srivastava, Caroline Straatmann, Cynthia Silva, T Keefe Davis, Scott E Wenderfer, Keisha Gibson, David Selewski, John Barcia, Patricia Weng, Christoph Licht, Natasha Jawa, Mahmoud Kallash, John W Foreman, Delbert R Wigfall, Annabelle N Chua, Eileen Chambers, Christoph P Hornik, Eileen D Brewer, Shashi K Nagaraj, Larry A Greenbaum, Rasheed A Gbadegesin,

BACKGROUND AND OBJECTIVES:Steroid-resistant nephrotic syndrome (SRNS) due to focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) is a leading cause of end-stage kidney disease in children. Recurrence of primary disease following transplantation is a major cause of allograft loss. The clinical determinants of disease recurrence are not completely known. ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2018, 33(10):1773-1780]

Cited: 5 times

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Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome.

Franz Schaefer, Gianluigi Ardissino, Gema Ariceta, Fadi Fakhouri, Marie Scully, Nicole Isbel, Åsa Lommelé, Varant Kupelian, Christoph Gasteyger, Larry A Greenbaum, Sally Johnson, Masayo Ogawa, Christoph Licht, Johan Vande Walle, Véronique Frémeaux-Bacchi, ,

Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, life-threatening disease. The Global aHUS Registry collects real-world data on the natural history of the disease. Here we characterize end-stage renal disease (ESRD)-free survival, the rate of thrombotic microangiopathy, organ involvement and the genetic background of 851 patients in the registry, ... Read more >>

Kidney Int. (Kidney international)
[2018, 94(2):408-418]

Cited: 10 times

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Eculizumab prevents thrombotic microangiopathy in patients with atypical haemolytic uraemic syndrome in a long-term observational study.

Jan Menne, Yahsou Delmas, Fadi Fakhouri, John F Kincaid, Christoph Licht, Enrico E Minetti, Chris Mix, François Provôt, Eric Rondeau, Neil S Sheerin, Jimmy Wang, Laurent E Weekers, Larry A Greenbaum,

Background:Eculizumab, a terminal complement inhibitor, is approved for atypical haemolytic uraemic syndrome (aHUS) to inhibit complement-mediated thrombotic microangiopathy (TMA). Methods:In five parent studies, eculizumab effectively prevented TMA and improved renal and haematologic outcomes in patients with aHUS; therefore, these patients could enrol in this long-term, prospective, observational and multicentre study. ... Read more >>

Clin Kidney J (Clinical Kidney Journal)
[2019, 12(2):196-205]

Cited: 1 time

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Relative antibacterial functions of complement and NETs: NETs trap and complement effectively kills bacteria.

Louiza Azzouz, Ahmed Cherry, Magdalena Riedl, Meraj Khan, Fred G Pluthero, Walter H A Kahr, Nades Palaniyar, Christoph Licht,

Neutrophil extracellular traps (NETs) are web-like DNA structures released by activated neutrophils. These structures are decorated with antimicrobial proteins, and considered to trap and kill bacteria extracellularly. However, the exact functions of NETs remain elusive, and contradictory observations have been made with NETs functioning as an antimicrobial or a pathogentrapping ... Read more >>

Mol. Immunol. (Molecular immunology)
[2018, 97:71-81]

Cited: 3 times

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Is there a case for eculizumab for pediatric renal transplantation?

Guido Filler, Christoph Licht, Shih-Han Susan Huang,

Pediatr Transplant (Pediatric transplantation)
[2018, 22(2):]

Cited: 0 times

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Renal thrombotic microangiopathy and pulmonary arterial hypertension in a patient with late-onset cobalamin C deficiency.

Taylor E Petropoulos, Maria Erika Ramirez, John Granton, Christoph Licht, Rohan John, Yasbanoo Moayedi, Chantal F Morel, Rory F McQuillan,

Cobalamin C (cblC) deficiency is the most commonly inherited inborn error of vitamin B12 metabolism. It is characterized by multisystem involvement with severe neurological, hematological, renal and cardiopulmonary manifestations. Disease is most commonly diagnosed early in the first decade of life. We report a case of a 20-year-old woman who ... Read more >>

Clin Kidney J (Clinical Kidney Journal)
[2018, 11(3):310-314]

Cited: 1 time

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