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Validation of a Trans-Ancestry Polygenic Risk Score for Type 2 Diabetes in Diverse Populations

Tian Ge, Amit Patki, Vinodh Srinivasasainagendra, Yen-Feng Lin, Marguerite Ryan Irvin, Hemant Tiwari, Nicole Armstrong, Brittney Davis, Emma Perez, Vivian Gainer, Barbara Benoit, Mark O’Connor, Renuka Narayan, Bethany Etheridge, Maria Stamou, Aaron Leong, Miriam Udler, Karmel Choi, Ayme Miles, Krzysztof Kiryluk, Atlas Khan, Chia-Yen Chen, Yen-Chen Anne Feng, Hailiang Huang, James Cimino, Shawn Murphy, Scott Weiss, Christoph Lange, Maggie Ng, Jordan Smoller, Matthew Lebo, James Meigs, Nita Limdi, Elizabeth Karlson,

<h4>ABSTRACT</h4> Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and environmental risk factors that disproportionately afflicts communities of color. Leveraging existing large-scale genome-wide association studies (GWAS), polygenic risk scores (PRS) have shown promise to complement established clinical risk factors and intervention paradigms, and improve early diagnosis ... Read more >>

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100 years of Mycobacterium bovis bacille Calmette-Guérin.

Christoph Lange, Peter Aaby, Marcel A Behr, Peter R Donald, Stefan H E Kaufmann, Mihai G Netea, Anna M Mandalakas,

Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine designed to protect cattle from bovine tuberculosis, was administered for the first time to a newborn baby in Paris in 1921. Over the past century, BCG has saved tens of millions of lives and has been given to more humans than any ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2021, :]

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Emergence of bedaquiline-resistance in a high-burden country of tuberculosis.

Elena Chesov, Dumitru Chesov, Florian P Maurer, Sönke Andres, Christian Utpatel, Ivan Barilar, Ana Donica, Maja Reimann, Stefan Niemann, Christoph Lange, Valeriu Crudu, Jan Heyckendorf, Matthias Merker,

<h4>Rationale</h4>Bedaquiline has been classified as a Group A drug for the treatment of multidrug-resistant tuberculosis (MDR-TB) by the World Health Organization, however globally emerging resistance threatens the effectivity of novel MDR-TB treatment regimens.<h4>Objectives</h4>We analysed pre-existing and emerging bedaquiline resistance in bedaquiline-based MDR-TB therapies, and risk factors associated with treatment failure ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, :]

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Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis.

Wilian Correa-Macedo, Vinicius M Fava, Marianna Orlova, Pauline Cassart, Ron Olivenstein, Joaquín Sanz, Yong Zhong Xu, Anne Dumaine, Renata Hm Sindeaux, Vania Yotova, Alain Pacis, Josée Girouard, Barbara Kalsdorf, Christoph Lange, Jean-Pierre Routy, Luis B Barreiro, Erwin Schurr,

Persons living with HIV (PLWH) are at increased risk of tuberculosis (TB). HIV-associated TB is often the result of recent infection with Mycobacterium tuberculosis (Mtb) followed by rapid progression to disease. Alveolar macrophages (AM) are the first cells of the innate immune system that engage Mtb, but how HIV and ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, :]

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Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model.

Jan Heyckendorf, Sebastian Marwitz, Maja Reimann, Korkut Avsar, Andrew R DiNardo, Gunar Günther, Michael Hoelscher, Elmira Ibraim, Barbara Kalsdorf, Stefan H E Kaufmann, Irina Kontsevaya, Frank van Leth, Anna M Mandalakas, Florian P Maurer, Marius Müller, Dörte Nitschkowski, Ioana D Olaru, Cristina Popa, Andrea Rachow, Thierry Rolling, Jan Rybniker, Helmut J F Salzer, Patricia Sanchez-Carballo, Maren Schuhmann, Dagmar Schaub, Victor Spinu, Isabelle Suárez, Elena Terhalle, Markus Unnewehr, January Weiner, Torsten Goldmann, Christoph Lange,

<h4>Background</h4>The World Health Organization recommends standardised treatment durations for patients with tuberculosis (TB). We identified and validated a host-RNA signature as a biomarker for individualised therapy durations for patients with drug-susceptible (DS)- and multidrug-resistant (MDR)-TB.<h4>Methods</h4>Adult patients with pulmonary TB were prospectively enrolled into five independent cohorts in Germany and Romania. ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 58(3):]

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Evidence-based Definition for Extensively Drug-Resistant Tuberculosis.

Maroussia Roelens, Giovanni Battista Migliori, Liudmila Rozanova, Janne Estill, Jonathon R Campbell, J Peter Cegielski, Simon Tiberi, Domingo Palmero, Greg J Fox, Lorenzo Guglielmetti, Giovanni Sotgiu, James C M Brust, Didi Bang, Christian Lienhardt, Christoph Lange, Dick Menzies, Olivia Keiser, Mario Raviglione,

<b>Rationale:</b> Until 2020, extensively drug-resistant tuberculosis (XDR-TB) was defined as TB with resistance to rifampicin and isoniazid (multidrug-resistant TB [MDR-TB]), any fluoroquinolone (FQ), and any second-line injectable drug (SLID). In 2019, the World Health Organization issued new recommendations for treating patients with drug-resistant TB, substantially limiting the role of SLIDs ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(6):713-722]

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Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.

Brian E Cade, Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen, Sina A Gharib, Daniel J Gottlieb, Xiuqing Guo, Jacqueline M Lane, Jingjing Liang, Xihong Lin, Hao Mei, Sanjay R Patel, Shaun M Purcell, Richa Saxena, Neomi A Shah, Daniel S Evans, Craig L Hanis, David R Hillman, Sutapa Mukherjee, Lyle J Palmer, Katie L Stone, Gregory J Tranah, , Gonçalo R Abecasis, Eric A Boerwinkle, Adolfo Correa, L Adrienne Cupples, Robert C Kaplan, Deborah A Nickerson, Kari E North, Bruce M Psaty, Jerome I Rotter, Stephen S Rich, Russell P Tracy, Ramachandran S Vasan, James G Wilson, Xiaofeng Zhu, Susan Redline, ,

<h4>Background</h4>Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing.<h4>Methods</h4>The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and ... Read more >>

Genome Med (Genome medicine)
[2021, 13(1):136]

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Pathogen-free diagnosis of tuberculosis.

Jan Heyckendorf, Maja Reimann, Sebastian Marwitz, Christoph Lange, ,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2021, 21(8):1066]

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WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.

Julius Brandenburg, Sebastian Marwitz, Simone C Tazoll, Franziska Waldow, Barbara Kalsdorf, Tim Vierbuchen, Thomas Scholzen, Annette Gross, Svenja Goldenbaum, Alexandra Hölscher, Martina Hein, Lara Linnemann, Maja Reimann, Andreas Kispert, Michael Leitges, Jan Rupp, Christoph Lange, Stefan Niemann, Jochen Behrends, Torsten Goldmann, Holger Heine, Ulrich E Schaible, Christoph Hölscher, Dominik Schwudke, Norbert Reiling,

In view of emerging drug-resistant tuberculosis (TB), host-directed adjunct therapies are urgently needed to improve treatment outcomes with currently available anti-TB therapies. One approach is to interfere with the formation of lipid-laden "foamy" macrophages in the host, as they provide a nutrient-rich host cell environment for Mycobacterium tuberculosis (Mtb). Here, ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(16):]

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Seroprevalence of Aspergillus-Specific IgG Antibody among Mozambican Tuberculosis Patients.

Helmut J F Salzer, Isabel Massango, Nilesh Bhatt, Emelva Machonisse, Maja Reimann, Sven Heldt, Christoph Lange, Michael Hoelscher, Celso Khosa, Andrea Rachow,

<h4>Background</h4>Chronic pulmonary aspergillosis (CPA) is a life-threatening sequel in patients with pulmonary tuberculosis (PTB). <i>Aspergillus</i>-specific IgG antibody is a useful diagnostic biomarker supporting CPA diagnosis, especially in countries with limited health recourses.<h4>Methods</h4>We conducted a prospective pilot study to assess the seroprevalence of <i>Aspergillus</i>-specific IgG antibodies among 61 Mozambican tuberculosis patients ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2021, 7(8):]

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New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations

Frauke Degenhardt, David Ellinghaus, Simonas Juzenas, Jon Lerga-Jaso, Mareike Wendorff, Douglas Maya-Miles, Florian Uellendahl-Werth, Hesham ElAbd, Jatin Arora, Onur Özer, Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Lars Wienbrandt, Aaron Blandino Ortiz, Adolfo de Salazar, Adolfo Garrido Chercoles, Adriana Palom, Agustín Ruiz, Alberto Mantovani, Alberto Zanella, Aleksander Rygh Holten, Alena Mayer, Alessandra Bandera, Alessandro Cherubini, Alessandro Protti, Alessio Aghemo, Alessio Gerussi, Alexander Popov, Alfredo Ramirez, Alice Braun, Almut Nebel, Ana Barreira, Ana Lleo, Ana Teles, Anders Benjamin Kildal, Andrea Biondi, Andrea Ganna, Andrea Gori, Andreas Glück, Andreas Lind, Anke Hinney, Anna Carreras Nolla, Anna Ludovica Fracanzani, Annalisa Cavallero, Anne Ma Dyrhol-Riise, Antonella Ruello, Antonio Julià, Antonio Muscatello, Antonio Pesenti, Antonio Voza, Ariadna Rando-Segura, Aurora Solier, Beatriz Cortes, Beatriz Mateos, Beatriz Nafria-Jimenez, Benedikt Schaefer, Björn Jensen, Carla Bellinghausen, Carlo Maj, Carlos Ferrando, Carmen de la Horra, Carmen Quereda, Carsten Skurk, Charlotte Thibeault, Chiara Scollo, Christian Herr, Christoph Spinner, Christoph Lange, Cinzia Hu, Clara Lehmann, Claudio Cappadona, Clinton Azuure, Cristiana Bianco, Cristina Sancho, Dag Arne Lihaug Hoff, Daniela Galimberti, Daniele Prati, David Haschka, David Jiménez, David Pestaña, David Toapanta, Eike Wacker, Elena Azzolini, Elio Scarpini, Elisa Helbig, Eloisa Urrechaga, Elvezia Maria Paraboschi, Emanuele Pontali, Enric Reverter, Enrique Calderón, Enrique Navas, Erik Solligård, Ernesto Contro, Eunate Arana, Federico Garcia, Félix García Sánchez, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Florian Kurth, Francesco Blasi, Francesco Malvestiti, Francisco Medrano, Francisco Mesonero, Francisco Rodriguez-Frias, Frank Hanses, Fredrik Müller, Giacomo Bellani, Giacomo Grasselli, Gianni Pezzoli, Giorgio Costantino, Giovanni Albano, Giuseppe Bellelli, Giuseppe Citerio, Giuseppe Foti, Giuseppe Lamorte, Holger Neb, Ilaria My, Ingo Kurth, Isabel Hernández, Isabell Pink, Itziar de Rojas, Iván Galván-Femenia, Jan Holter, Jan Egil Afset, Jan Heyckendorf, Jan Kristian Damås, Jan Rybniker, Janine Altmüller, Javier Ampuero, Jesus Banales, Joan Ramon Badia, Joaquin Dopazo, Jochen Schneider, Johannes Hov, Jonas Bergan, Jordi Barretina, Jörn Walter, Jose Hernández Quero, Josune Goikoetxea, Juan Delgado, Juan Guerrero, Julia Fazaal, Julia Kraft, Julia Schröder, Kari Risnes, Karina Banasik, Karl Erik Müller, Karoline Gaede, Koldo Garcia-Etxebarria, Kristian Tonby, Lars Heggelund, Laura Izquierdo-Sanchez, Laura Rachele Bettini, Lauro Sumoy, Leif Erik Sander, Lena Lippert, Leonardo Terranova, Lindokuhle Nkambule, Lisa Knopp, Lise Tuset Gustad, Lucia Garbarino, Luigi Santoro, Luis Téllez, Luisa Roade, Mahnoosh Ostadreza, Maider Intxausti, Malte Rühlemann, Manolis Kogevinas, Mar Riveiro-Barciela, Marc Berger, Mari E.K. Niemi, María Gutiérrez-Stampa, Maria Grazia Valsecchi, María Hernandez-Tejero, Maria J.G.T. Vehreschild, Maria Manunta, Mariella D’Angiò, Marina Cazzaniga, Marit Grimsrud, Marit Grimsrud, Markus Cornberg, Markus Nöthen, Marta Marquié, Massimo Castoldi, Mattia Cordioli, Maurizio Cecconi, Mauro D’Amato, Max Augustin, Melissa Tomasi, Mercè Boada, Michael Dreher, Michael Seilmaier, Michael Joannidis, Michael Wittig, Michela Mazzocco, Miguel Rodríguez-Gandía, Natale Imaz Ayo, Natalia Blay, Natalia Chueca, Nicola Montano, Nicole Ludwig, Nikolaus Marx, Nilda Martínez, Oliver Cornely, Oliver Witzke, Orazio Palmieri, Paola Faverio, Paolo Bonfanti, Paolo Tentorio, Pedro Castro, Pedro Rodrigues, Pedro Pablo España, Per Hoffmann, Philip Rosenstiel, Philipp Schommers, Phillip Suwalski, Raúl de Pablo, Ricard Ferrer, Robert Bals, Roberta Gualtierotti, Rocío Gallego-Durán, Rosa Nieto, Rossana Carpani, Rubén Morilla, Salvatore Badalamenti, Sammra Haider, Sandra Ciesek, Sandra May, Sara Bomba,

<h4>ABSTRACT</h4> Due to the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), deepening the host genetic contribution to severe COVID-19 may further improve our understanding about underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, ... Read more >>

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Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain.

Georg Hahn, Chloe M Wu, Sanghun Lee, Sharon M Lutz, Surender Khurana, Lindsey R Baden, Sebastien Haneuse, Dandi Qiao, Julian Hecker, Dawn L DeMeo, Rudolph E Tanzi, Manish C Choudhary, Behzad Etemad, Abbas Mohammadi, Elmira Esmaeilzadeh, Michael H Cho, Jonathan Z Li, Adrienne G Randolph, Nan M Laird, Scott T Weiss, Edwin K Silverman, Katharina Ribbeck, Christoph Lange,

SARS-CoV-2 mortality has been extensively studied in relation to host susceptibility. How sequence variations in the SARS-CoV-2 genome affect pathogenicity is poorly understood. Starting in October 2020, using the methodology of genome-wide association studies (GWAS), we looked at the association between whole-genome sequencing (WGS) data of the virus and COVID-19 ... Read more >>

Genet Epidemiol (Genetic epidemiology)
[2021, 45(7):685-693]

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Genome sequencing unveils a regulatory landscape of platelet reactivity.

Ali R Keramati, Ming-Huei Chen, Benjamin A T Rodriguez, Lisa R Yanek, Arunoday Bhan, Brady J Gaynor, Kathleen Ryan, Jennifer A Brody, Xue Zhong, Qiang Wei, , Kai Kammers, Kanika Kanchan, Kruthika Iyer, Madeline H Kowalski, Achilleas N Pitsillides, L Adrienne Cupples, Bingshan Li, Thorsten M Schlaeger, Alan R Shuldiner, Jeffrey R O'Connell, Ingo Ruczinski, Braxton D Mitchell, Nauder Faraday, Margaret A Taub, Lewis C Becker, Joshua P Lewis, Rasika A Mathias, Andrew D Johnson,

Platelet aggregation at the site of atherosclerotic vascular injury is the underlying pathophysiology of myocardial infarction and stroke. To build upon prior GWAS, here we report on 16 loci identified through a whole genome sequencing (WGS) approach in 3,855 NHLBI Trans-Omics for Precision Medicine (TOPMed) participants deeply phenotyped for platelet ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3626]

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Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: DTNB and DLG2

Dmitry Prokopenko, Sanghun Lee, Julian Hecker, Kristina Mullin, Sarah Morgan, Yuriko Katsumata, Michael Weiner, David Fardo, Nan Laird, Lars Bertram, Winston Hide, Christoph Lange, Rudolph Tanzi, ,

Alzheimer’s disease (AD) is a genetically complex disease for which roughly 30 genes have been identified via genome-wide association studies. We attempted to identify rare variants (minor allele frequency <0.01) associated with AD in a region-based, whole genome sequencing (WGS) association study (GSAS) of two independent AD family datasets (NIMH/NIA; ... Read more >>

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Impact of bedaquiline on treatment outcomes of multidrug-resistant tuberculosis in a high-burden country.

Dumitru Chesov, Jan Heyckendorf, Sofia Alexandru, Ana Donica, Elena Chesov, Maja Reimann, Valeriu Crudu, Victor Botnaru, Christoph Lange,

<h4>Background</h4>Evaluation of novel anti-tuberculosis (TB) drugs for the treatment of multidrug-resistant (MDR)-TB continues to be of high interest on the TB research agenda. We assessed treatment outcomes in patients with pulmonary MDR-TB who received bedaquiline-containing treatment regimens in the Republic of Moldova, a high-burden MDR-TB country.<h4>Method</h4>We systematically analysed the SIMETB ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(6):]

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Variant-specific inflation factors for assessing population stratification at the phenotypic variance level.

Tamar Sofer, Xiuwen Zheng, Cecelia A Laurie, Stephanie M Gogarten, Jennifer A Brody, Matthew P Conomos, Joshua C Bis, Timothy A Thornton, Adam Szpiro, Jeffrey R O'Connell, Ethan M Lange, Yan Gao, L Adrienne Cupples, Bruce M Psaty, , Kenneth M Rice,

In modern Whole Genome Sequencing (WGS) epidemiological studies, participant-level data from multiple studies are often pooled and results are obtained from a single analysis. We consider the impact of differential phenotype variances by study, which we term 'variance stratification'. Unaccounted for, variance stratification can lead to both decreased statistical power, ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3506]

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Perspectives for systems biology in the management of tuberculosis.

Irina Kontsevaya, Christoph Lange, Patricia Comella-Del-Barrio, Cristian Coarfa, Andrew R DiNardo, Stephen H Gillespie, Matthias Hauptmann, Christoph Leschczyk, Anna M Mandalakas, Antal Martinecz, Matthias Merker, Stefan Niemann, Maja Reimann, Olena Rzhepishevska, Ulrich E Schaible, Katrin M Scheu, Erwin Schurr, Pia Abel Zur Wiesch, Jan Heyckendorf,

Standardised management of tuberculosis may soon be replaced by individualised, precision medicine-guided therapies informed with knowledge provided by the field of systems biology. Systems biology is a rapidly expanding field of computational and mathematical analysis and modelling of complex biological systems that can provide insights into mechanisms underlying tuberculosis, identify ... Read more >>

Eur Respir Rev (European respiratory review : an official journal of the European Respiratory Society)
[2021, 30(160):]

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Tuberculosis: The Past, the Present and the Future.

Coenraad F N Koegelenberg, Otto D Schoch, Christoph Lange,

Respiration (Respiration; international review of thoracic diseases)
[2021, 100(7):553-556]

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Case Report: Hemophagocytic Lymphohistiocytosis and Non-Tuberculous Mycobacteriosis Caused by a Novel GATA2 Variant.

Thomas Mika, Deepak Vangala, Matthias Eckhardt, Paul La Rosée, Christoph Lange, Kai Lehmberg, Charlotte Wohlschläger, Saskia Biskup, Ilka Fuchs, Jasmin Mann, Stephan Ehl, Klaus Warnatz, Roland Schroers,

Hemophagocytic lymphohistiocytosis (HLH) is a disorder of uncontrolled immune activation with distinct clinical features including fever, cytopenia, splenomegaly, and sepsis-like symptoms. In a young adolescent patient a novel germline <i>GATA2</i> variant (NM_032638.5 (GATA2): c.177C>G, p.Tyr59Ter) was discovered and had resulted in non-tuberculous mycobacterial (NTM) infection and aggressive HLH. Strikingly, impaired ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:682934]

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Caution against examining the role of reverse causality in Mendelian Randomization.

Sharon M Lutz, Ann Chen Wu, John E Hokanson, Stijn Vansteelandt, Christoph Lange,

Recently, Mendelian Randomization (MR) has gained in popularity as a concept to assess the causal relationship between phenotypes in genetic association studies. An extension of standard MR methodology, the MR Steiger approach, has recently been developed to infer the causal direction between two phenotypes in prospective studies. Through simulation studies, ... Read more >>

Genet Epidemiol (Genetic epidemiology)
[2021, 45(5):445-454]

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The Association Between Lung Hyperinflation and Coronary Artery Disease in Smokers.

Divay Chandra, Aman Gupta, Gregory L Kinney, Carl R Fuhrman, Joseph K Leader, Alejandro A Diaz, Jessica Bon, R Graham Barr, George Washko, Matthew Budoff, John Hokanson, Frank C Sciurba, ,

<h4>Background</h4>Smokers manifest varied phenotypes of pulmonary impairment.<h4>Research question</h4>Which pulmonary phenotypes are associated with coronary artery disease (CAD) in smokers?<h4>Study design and methods</h4>We analyzed data from the University of Pittsburgh COPD Specialized Center for Clinically Oriented Research (SCCOR) cohort (n = 481) and the Genetic Epidemiology of COPD (COPDGene) cohort (n = 2,580). ... Read more >>

Chest (Chest)
[2021, 160(3):858-871]

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Design of multidrug-resistant tuberculosis treatment regimens based on DNA sequencing.

Hans-Peter Grobbel, Matthias Merker, Niklas Köhler, Sönke Andres, Harald Hoffmann, Jan Heyckendorf, Maja Reimann, Ivan Barilar, Viola Dreyer, Doris Hillemann, Barbara Kalsdorf, Thomas A Kohl, Patricia Sanchez-Carballo, Dagmar Schaub, Katharina Todt, Christian Utpatel, Florian P Maurer, Christoph Lange, Stefan Niemann,

<h4>Background</h4>Comprehensive and reliable drug susceptibility testing (DST) is urgently needed to provide adequate treatment regimens for patients with multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB). We investigated if next generation sequencing (NGS) analysis of Mycobacterium tuberculosis complex isolates and genes implicated in drug resistance can guide the design of effective MDR/RR-TB treatment regimens.<h4>Methods</h4>NGS-based genomic ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

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Novel recessive locus for body mass index in childhood asthma.

Sanghun Lee, Jessica Lasky-Su, Sungho Won, Cecelia Laurie, Juan Carlos Celedón, Christoph Lange, Scott Weiss, Julian Hecker,

Most genome-wide association studies of obesity and body mass index (BMI) have so far assumed an additive mode of inheritance in their analysis, although association testing supports a recessive effect for some of the established loci, for example, rs1421085 in <i>FTO</i> In two whole-genome sequencing (WGS) studies of children with ... Read more >>

Thorax (Thorax)
[2021, :]

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Tuberculosis prevention in children: a prospective community-based study in South Africa.

Anna M Mandalakas, Anneke C Hesseling, Alexander Kay, Karen Du Preez, Leonardo Martinez, Lena Ronge, Andrew DiNardo, Christoph Lange, H Lester Kirchner,

Tuberculosis (TB) preventive therapy reduces TB risk in children. However, the effectiveness of TB preventive therapy in children living in high TB burden settings is unclear.In a prospective observational community-based cohort study in Cape Town, South Africa, we assessed the effectiveness of routine TB preventive therapy in children ≤15 years of ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(4):]

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Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.

Silva Kasela, Victor E Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, Srilaxmi Nerella, Kristina L Buschur, Igor Z Barjaktarevic, R Graham Barr, Eugene R Bleecker, Russell P Bowler, Alejandro P Comellas, Christopher B Cooper, David J Couper, Gerard J Criner, Jeffrey L Curtis, MeiLan K Han, Nadia N Hansel, Eric A Hoffman, Robert J Kaner, Jerry A Krishnan, Fernando J Martinez, Merry-Lynn N McDonald, Deborah A Meyers, Robert Paine, Stephen P Peters, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Elliot Israel, Nizar N Jarjour, Bruce D Levy, Xingnan Li, Wendy C Moore, Sally E Wenzel, Joe Zein, , , Charles Langelier, Prescott G Woodruff, Tuuli Lappalainen, Stephanie A Christenson,

<h4>Background</h4>The large airway epithelial barrier provides one of the first lines of defense against respiratory viruses, including SARS-CoV-2 that causes COVID-19. Substantial inter-individual variability in individual disease courses is hypothesized to be partially mediated by the differential regulation of the genes that interact with the SARS-CoV-2 virus or are involved ... Read more >>

Genome Med (Genome medicine)
[2021, 13(1):66]

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