Full Text Journal Articles by
Author Christoph Brochhausen

Advertisement

Find full text journal articles






Stanniocalcin 1 is overexpressed in multipotent mesenchymal stromal cells from acute myeloid leukemia patients.

Roland Christian Schelker, Andrea Kratzer, Gunnar Müller, Christoph Brochhausen, Christina Hart, Thomas Stempfl, Daniel Heudobler, Christoph Moehle, Wolfgang Herr, Sabine Iberl, Jochen Grassinger,

<b>Objectives:</b> Multipotent mesenchymal stromal cells (MSC) play a pivotal role in the bone marrow (BM) niche. Stanniocalcin 1 (STC1) secreted by MSC has been demonstrated to promote the survival of neoplastic cells and was suggested a marker for minimal residual disease of acute myeloid leukemia (AML). Therefore, we evaluated the ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):565-576]

Cited: 0 times

View full text PDF listing >>



Betulinic Acid Protects from Ischemia-Reperfusion Injury in the Mouse Retina.

Aytan Musayeva, Johanna C Unkrig, Mayagozel B Zhutdieva, Caroline Manicam, Yue Ruan, Panagiotis Laspas, Panagiotis Chronopoulos, Marie L Göbel, Norbert Pfeiffer, Christoph Brochhausen, Andreas Daiber, Matthias Oelze, Huige Li, Ning Xia, Adrian Gericke,

Ischemia/reperfusion (I/R) events are involved in the pathophysiology of numerous ocular diseases. The purpose of this study was to test the hypothesis that betulinic acid protects from I/R injury in the mouse retina. Ocular ischemia was induced in mice by increasing intraocular pressure (IOP) to 110 mm Hg for 45 ... Read more >>

Cells (Cells)
[2021, 10(9):]

Cited: 0 times

View full text PDF listing >>



Advertisement

Intracellular S. aureus in Osteoblasts in a Clinical Sample from a Patient with Chronic Osteomyelitis-A Case Report.

Nike Walter, Daniel Mendelsohn, Christoph Brochhausen, Markus Rupp, Volker Alt,

The pathophysiological role of intracellular bacteria in osteomyelitis is still a matter of debate. Here, we demonstrate for the first time the presence of <i>Staphylococcus aureus</i> internalized into osteoblasts in human tissue samples of a case with a chronic osteomyelitis using ultrastructural transmission electron microscope analysis. ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2021, 10(8):]

Cited: 0 times

View full text PDF listing >>



[Treatment of bone and periprosthetic infections with bacteriophages : A systematic review].

Nike Walter, Li Deng, Christoph Brochhausen, Volker Alt, Markus Rupp,

<h4>Background</h4>The treatment of bone and prosthesis infections remains difficult despite modern treatment concepts. Further tools for the improvement of treatment outcome are desirable. Preclinical studies provide promising evidence of the efficacy of bacteriophages for the treatment of bone and joint infections.<h4>Objectives</h4>The present work provides a systematic review of the clinical application ... Read more >>

Orthopade (Der Orthopade)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Short-term radiological results after spheroid-based autologous chondrocyte implantation in the knee are independent of defect localisation.

David Grevenstein, Darius Schafigh, Stavros Oikonomidis, Peer Eysel, Christoph Brochhausen, Christian Karl Spies, Johannes Oppermann,

<h4>Background</h4>Lesions of articular cartilage represent a crucial risk factor for the early development of osteoarthritis. Autologous chondrocyte implantation (ACI) is a well-established procedure in therapy of those lesions in the knee. The aim of the presented study is to detect differences in short-term radiological outcome depending on defect localization (femoral ... Read more >>

Technol Health Care (Technology and health care : official journal of the European Society for Engineering and Medicine)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Semiautomated quantification of the fibrous tissue response to complex three-dimensional filamentous scaffolds using digital image analysis.

Friedrich Barsch, Andreas Mamilos, Maximilian Babel, Willi L Wagner, Hinrich B Winther, Volker H Schmitt, Helmut Hierlemann, Andreas Teufel, Christoph Brochhausen,

Fibrosis represents a relevant response to the implantation of biomaterials, which occurs not only at the tissue-material interface (fibrotic encapsulation) but also within the void fraction of complex three-dimensional (3D) biomaterial constructions (fibrotic ingrowth). Usual evaluation of the biocompatibility mostly depicts fibrosis at the interface of the biomaterial using semiquantitative ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Suspicious breast lesions incidentally detected on chest computer tomography with histopathological correlation.

Martina Georgieva, Janine Rennert, Christoph Brochhausen, Christian Stroszczynski, Ernst-Michael Jung,

<h4>Objective</h4>To evaluate incidental breast lesions on chest computed tomography with histopathological correlation. It is important for general radiologist to characterize a breast lesion as benign, indetermined, or sufficiently suspicious to warrant further work-up.<h4>Methods</h4>A total of 35.000 chest CT examinations were performed between January 2016 and December 2020. 27 patients (mean ... Read more >>

Breast J (The breast journal)
[2021, 27(9):715-722]

Cited: 0 times

View full text PDF listing >>



Biobanking of Specimens from COVID-19 Patients: An Economic Perspective from a Clinical Biobank.

Tanja Niedermair, Meet Bhatt, Stefan Wallner, Maximilian Babel, Ralph Burkhardt, Christoph Brochhausen,

Biopreserv Biobank (Biopreservation and biobanking)
[2021, :]

Cited: 0 times

View full text PDF listing >>



RASSF1A independence and early Galectin-1 upregulation in PIK3CA induced hepatocarcinogenesis: new therapeutic venues

Alexander Scheiter, Katja Evert, Lucas Reibenspies, Antonio Cigliano, Katharina Annweiler, Karolina Müller, Laura-Maria-Giovanna Pöhmerer, Timo Itzel, Silvia Materna-Reichelt, Andrea Coluccio, Kamran Honarnejad, Andreas Teufel, Christoph Brochhausen, Frank Dombrowski, Xin Chen, Matthias Evert, Diego Calvisi, Kirsten Utpatel,

Aberrant activation of the PI3K/AKT/mTOR and Ras/Mitogen-Activated Protein Kinase pathways is a hepatocarcinogenesis hallmark. In a subset of hepatocellular carcinomas (HCC), PI3K/AKT/mTOR signaling dysregulation depends on PIK3CA mutations, while RAS/MAPK activation is partly attributed to promoter methylation of the tumor suppressor RASSF1A . To evaluate a possible co-carcinogenic effect of ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties

Julian Triebelhorn, Kerstin Kuffner, Iseline Cardon, Katrin Meindl, Tanja Rothhammer-Hampl, Markus Riemenschneider, Konstantin Drexler, Mark Berneburg, Caroline Nothdurfter, Andre Manook, Christoph Brochhausen, Thomas Baghai, Rainer Rupprecht, Vladimir Milenkovic, Christian Wetzel,

BACKGROUND: The molecular pathomechanisms of major depressive disorder (MDD) are still not completely understood. Here, we follow the hypothesis, that mitochondrial dysfunction which is inevitably associated with bioenergetic misbalance is a risk factor that contributes to the susceptibility of an individual to develop MDD. MDD can be regarded as disease ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors.

Kirsten Ackermann, Susanne Wallner, Christoph Brochhausen, Stephan Schreml,

The acid-sensing ion channels ASIC1 and ASIC2, as well as the transient receptor potential vanilloid channels TRPV1 and TRPV4, are proton-gated cation channels that can be activated by low extracellular pH (pH<sub>e</sub>), which is a hallmark of the tumor microenvironment in solid tumors. However, the role of these channels in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(11):]

Cited: 0 times

View full text PDF listing >>



Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.

Kerstin Renner, Tobias Schwittay, Sophia Chaabane, Johanna Gottschling, Christine Müller, Charlotte Tiefenböck, Jan-Niklas Salewski, Frederike Winter, Simone Buchtler, Saidou Balam, Maximilian V Malfertheiner, Matthias Lubnow, Dirk Lunz, Bernhard Graf, Florian Hitzenbichler, Frank Hanses, Hendrik Poeck, Marina Kreutz, Evelyn Orsó, Ralph Burkhardt, Tanja Niedermair, Christoph Brochhausen, André Gessner, Bernd Salzberger, Matthias Mack,

Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3006]

Cited: 1 time

View full text PDF listing >>



Novel pathomechanism for spontaneous bacterial peritonitis: disruption of cell junctions by cellular and bacterial proteases.

Marika Haderer, Philip Neubert, Eva Rinner, Annika Scholtis, Lucile Broncy, Heidi Gschwendtner, Arne Kandulski, Vlad Pavel, Alexander Mehrl, Christoph Brochhausen, Sophie Schlosser, Karsten Gülow, Claudia Kunst, Martina Müller,

<h4>Objective</h4>Spontaneous bacterial peritonitis (SBP) is a life-threatening complication of liver cirrhosis with a 1-year mortality of 66%. Bacterial translocation (BT) from the intestine to the mesenteric lymph nodes is crucial for the pathogenesis of SBP.<h4>Design</h4>Since BT presupposes a leaky intestinal epithelium, the integrity of mucus and epithelial cell junctions (E-cadherin ... Read more >>

Gut (Gut)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Correction to: In vivo comparison of braided (Accero) and laser-cut intracranial stents (Acclino, Credo): evaluation of vessel responses at subacute and mid-term follow-up in a rabbit model.

Ruben Mühl-Benninghaus, Toshiki Tomori, Stefanie Krajewski, Philipp Dietrich, Andreas Simgen, Umut Yilmaz, Christoph Brochhausen, Mara Kießling, Wolfgang Reith, Giorgio Cattaneo,

J Mater Sci Mater Med (Journal of materials science. Materials in medicine)
[2021, 32(4):45]

Cited: 0 times

View full text PDF listing >>



Corrigendum to "Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells" [Biomaterials 236 (2020) 119,802].

Heyong Yin, Franziska Strunz, Zexing Yan, Jiaju Lu, Christoph Brochhausen, Stefanie Kiderlen, Hauke Clausen-Schaumann, Xiumei Wang, Manuela E Gomes, Volker Alt, Denitsa Docheva,

Biomaterials (Biomaterials)
[2021, 269:120617]

Cited: 0 times

View full text PDF listing >>



Recurrent necrotizing cellulitis, multi-organ autoimmune disease and humoral immunodeficiency due to a novel NFKB1 frameshift mutation.

Astrid Bergbreiter, Teresa Jaeger, Antje Karle, Diane Bitzinger, Tobias Ettl, Gerrit Spanier, Herbert Jägle, Reiner Neu, Yorick Söder, Matthias Evert, Torsten E Reichert, Mark Berneburg, Christoph Brochhausen, Julia Schreml, Manfred Fliegauf, Ulrich Salzer, Andreas Redel, Stephan Schreml,

<h4>Background</h4>Mutations in NFKB1(nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) are associated with a variety of clinical symptoms, including lymphadenopathy, splenomegaly, hepatomegaly, autoimmune haemolytic anaemia, arthralgia, recurrent respiratory tract infections and post-operative necrotizing cellulitis.<h4>Case presentation</h4>We describe a case of a 47-year-old man, who presented with deep necrotizing ... Read more >>

Eur J Med Genet (European journal of medical genetics)
[2021, 64(3):104144]

Cited: 1 time

View full text PDF listing >>



In vivo comparison of braided (Accero) and laser-cut intracranial stents (Acclino, Credo): evaluation of vessel responses at subacute and mid-term follow-up in a rabbit model.

Ruben Mühl-Benninghaus, Toshiki Tomori, Stefanie Krajewski, Philipp Dietrich, Andreas Simgen, Umut Yilmaz, Christoph Brochhausen, Mara Kießling, Wolfgang Reith, Giorgio Cattaneo,

This study aimed to investigate in vivo two stent technologies, with particular emphasis on thrombogenicity and inflammatory vessel remodeling processes. The micro-stents tested in this study were developed for intracranial aneurysm treatment. In our study twelve, New Zealand white rabbits were divided into two groups: 18 laser-cut stents (LCS) and ... Read more >>

J Mater Sci Mater Med (Journal of materials science. Materials in medicine)
[2020, 31(12):131]

Cited: 0 times

View full text PDF listing >>



Improved detection of sentinel lymph node metastases allows reliable intraoperative identification of patients with extended axillary lymph node involvement in early breast cancer.

Cristina L Cotarelo, Annemarie Zschöck-Manus, Marcus Schmidt, Arno Schad, Christoph Brochhausen, Charles James Kirkpatrick, Sonja Thaler,

<h4>Background</h4>An improved procedure that allows accurate detection of negative sentinel lymph node (SLN) and of SLN macrometastases during surgery would be highly desirable in order to protect patients from further surgery and to avoid unnecessary costs. We evaluated the accuracy of an intraoperative procedure that combines touch imprint cytology (TIC) ... Read more >>

Clin Exp Metastasis (Clinical & experimental metastasis)
[2021, 38(1):61-72]

Cited: 0 times

View full text PDF listing >>



Distinguished properties of cells isolated from the dentin-pulp interface.

Marialucia Gallorini, Stephanie Krifka, Matthias Widbiller, Agnes Schröder, Christoph Brochhausen, Amelia Cataldi, Karl-Anton Hiller, Wolfgang Buchalla, Helmut Schweikl,

<h4>Background</h4>Dental odontoblasts produce dentin mineralized matrix, trigger immune responses and act as sensory cells. The understanding of the mechanisms of these functions has been particularly restricted due to the lack of odontoblasts being cultivable in vitro. Because of the lack of specific markers to identify cells of the odontoblastic lineage, ... Read more >>

Ann Anat (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2021, 234:151628]

Cited: 2 times

View full text PDF listing >>



Metabolic stress and disease-stage specific basigin expression of peripheral blood immune cell subsets in COVID-19 patients

Peter Siska, Katrin Singer, Jana Klitzke, Nathalie Kauer, Sonja-Maria Decking, Christina Bruss, Carina Matos, Kristina Kolodova, Alice Peuker, Gabriele Schönhammer, Johanna Raithel, Dirk Lunz, Bernhard Graf, Florian Geismann, Matthias Lubnow, Matthias Mack, Peter Hau, Christopher Bohr, Ralph Burkhardt, Andre Gessner, Bernd Salzberger, Frank Hanses, Florian Hitzenbichler, Daniel Heudobler, Florian Lüke, Tobias Pukrop, Wolfgang Herr, Daniel Wolff, Hendrik Poeck, Christoph Brochhausen, Petra Hoffmann, Michael Rehli, Marina Kreutz, Kathrin Renner,

<h4>Summary</h4> Coronavirus disease 2019 (COVID-19) is driven by dysregulated immune responses yet the role of immunometabolism in COVID-19 pathogenesis remains unclear. By investigating 47 patients with confirmed SARS-CoV-2 infection and 16 uninfected controls, we found an immunometabolic dysregulation specific for patients with progressed disease that was reversible in the recovery ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Insights Into Mechanisms of Antimicrobial Photodynamic Action Toward Biofilms Using Phenalen-1-One Derivatives as Photosensitizers.

Denise Muehler, Christina M Rupp, Sercan Keceli, Christoph Brochhausen, Heiko Siegmund, Tim Maisch, Karl-Anton Hiller, Wolfgang Buchalla, Fabian Cieplik,

<h4>Introduction</h4>In view of increasing resistance against antibiotics and antiseptics, antimicrobial photodynamic therapy (aPDT) may be a promising approach for use in dentistry. The aim of this study was to investigate the mechanism of action of aPDT with the phenalene-1-one derivatives SAPYR and SA-PN-05 as photosensitizers by evaluating bacterial ability to ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:589364]

Cited: 1 time

View full text PDF listing >>



The first quantitative histomorphological analyses of bone vitality and inflammation in surgical specimens of patients with medication-related osteonecrosis of the jaw.

Andreas Mamilos, Steffen Spörl, Gerrit Spanier, Tobias Ettl, Christoph Brochhausen, Christoph Klingelhöffer,

<h4>Background</h4>The purpose of the study was to categorize the vitality and inflammation of resected bone of patients with medication-related osteonecrosis of the jaw (MRONJ) and to correlate the grade of inflammation with the surgical success.<h4>Methods</h4>This prospective study includes 44 patients with stage III MRONJ. Necrotic bone was resected in a ... Read more >>

J Oral Pathol Med (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology)
[2021, 50(1):76-84]

Cited: 0 times

View full text PDF listing >>



T cell anergy in COVID-19 reflects virus persistence and poor outcomes

Kerstin Renner, Christine Müller, Charlotte Tiefenböck, Jan-Niklas Salewski, Frederike Winter, Simone Buchtler, Maximilian Malfertheiner, Matthias Lubnow, Dirk Lunz, Bernhard Graf, Florian Hitzenbichler, Frank Hanses, Hendrik Poeck, Marina Kreutz, Evelyn Orso, Ralph Burkhardt, Tanja Niedermair, Christoph Brochhausen, Andre Gessner, Bernd Salzberger, Matthias Mack,

Coronavirus disease 2019 (COVID-19) can lead to severe pneumonia and hyperinflammation. So far, insufficient or excessive T cell responses were described in patients. We applied novel approaches to analyze T cell reactivity and showed that T anergy is already present in non-ventilated COVID-19 patients, very pronounced in ventilated patients, strongly ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.

Wybke Klatt, Susanne Wallner, Christoph Brochhausen, Judith A Stolwijk, Stephan Schreml,

The proton-sensing GPCRs (pH-GPCRs) GPR4 (GPR19), TDAG8 (GPR65, T-cell death associated gene 8), OGR1 (GPR68, ovarian cancer GPCR1), and G2A (GPR132, G2 accumulation protein) are involved in sensing and transducing changes in extracellular pH (pH<sub>e</sub>). Extracellular acidification is a central hallmark of solid cancer. pH-GPCR function has been associated with ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):15327]

Cited: 3 times

View full text PDF listing >>



Comparison of histological and computed tomographic measurements of pig lung bronchi.

Volker H Schmitt, Christine Schmitt, David Hollemann, Andreas Mamilos, Willi Wagner, Oliver Weinheimer, Christoph Brochhausen,

<h4>Aim</h4>Light microscopy is used as template in the evaluation and further development of medical imaging methods. Tissue shrinkage caused by histological processing is known to influence lung tissue dimensions. In diagnosis of COPD, computed tomography (CT) is widely used for automated airway measurement. The aim of this study was to ... Read more >>

ERJ Open Res (ERJ open research)
[2020, 6(4):]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

1.0326 s