Full Text Journal Articles by
Author Christine M Seroogy

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African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.

Charles Washington, Matthew Dapas, Arjun Biddanda, Kevin M Magnaye, Ivy Aneas, Britney A Helling, Brooke Szczesny, Meher Preethi Boorgula, Margaret A Taub, Eimear Kenny, Rasika A Mathias, Kathleen C Barnes, , Gurjit K Khurana Hershey, Carolyn M Kercsmar, Jessica D Gereige, Melanie Makhija, Rebecca S Gruchalla, Michelle A Gill, Andrew H Liu, Deepa Rastogi, William Busse, Peter J Gergen, Cynthia M Visness, Diane R Gold, Tina Hartert, Christine C Johnson, Robert F Lemanske, Fernando D Martinez, Rachel L Miller, Dennis Ownby, Christine M Seroogy, Anne L Wright, Edward M Zoratti, Leonard B Bacharier, Meyer Kattan, George T O'Connor, Robert A Wood, Marcelo A Nobrega, Matthew C Altman, Daniel J Jackson, James E Gern, Christopher G McKennan, Carole Ober,

<h4>Background</h4>Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry.<h4>Methods</h4>We tested for association with haplotypes at the most replicated and significant childhood-onset asthma locus at 17q12-q21 and asthma in European American and African American children. Following this, ... Read more >>

Genome Med (Genome medicine)
[2022, 14(1):112]

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Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy.

Kathryn E McCauley, Elze Rackaityte, Brandon LaMere, Douglas W Fadrosh, Kei E Fujimura, Ariane R Panzer, Din L Lin, Kole V Lynch, Joanna Halkias, Ventura F Mendoza, Trevor D Burt, Casper Bendixsen, Kathrine Barnes, Haejin Kim, Kyra Jones, Dennis R Ownby, Christine C Johnson, Christine M Seroogy, James E Gern, Homer A Boushey, Susan V Lynch, ,

Maternal asthma status, prenatal exposures, and infant gut microbiota perturbation are associated with heightened risk of atopy and asthma risk in childhood, observations hypothetically linked by intergenerational microbial transmission. Using maternal vaginal (n = 184) and paired infant stool (n = 172) samples, we identify four compositionally and functionally distinct Lactobacillus-dominated vaginal ... Read more >>

Cell Rep Med (Cell reports. Medicine)
[2022, 3(8):100713]

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