Full Text Journal Articles by
Author Christine Ferrara Cook

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ERp29 as a regulator of Insulin biosynthesis.

Jeffrey Viviano, Margaret Brecker, Christine Ferrara-Cook, Laurence Suaud, Ronald C Rubenstein,

The environment within the Endoplasmic Reticulum (ER) influences Insulin biogenesis. In particular, ER stress may contribute to the development of Type 2 Diabetes (T2D) and Cystic Fibrosis Related Diabetes (CFRD), where evidence of impaired Insulin processing, including elevated secreted Proinsulin/Insulin ratios, are observed. Our group has established the role of ... Read more >>

PLoS ONE (PloS one)
[2020, 15(5):e0233502]

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Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents.

Christine Ferrara-Cook, Susan Michelle Geyer, Carmella Evans-Molina, Ingrid M Libman, Dorothy J Becker, Stephen E Gitelman, Maria Jose Redondo, ,

OBJECTIVE:Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI also accelerates the progression of islet autoimmunity before T1D diagnosis. RESEARCH DESIGN AND METHODS:We studied 706 single autoantibody-positive pediatric TrialNet participants (ages 1.6-18.6 years at baseline). Cumulative ... Read more >>

Diabetes Care (Diabetes care)
[2020, 43(3):580-587]

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