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Author Christina Wenneberg

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Effectiveness of cognitive remediation in the ultra-high risk state for psychosis.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

(World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, 19(3):401-402]

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Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis: Results of the FOCUS randomised clinical trial.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

BACKGROUND:Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibility and efficacy of CR for this population. ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, :]

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No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis-A Randomized Clinical Trial.

Tina D Kristensen, Bjørn H Ebdrup, Carsten Hjorthøj, René C W Mandl, Jayachandra M Raghava, Jens Richardt M Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y Glenthøj, Merete Nordentoft,

Background:Individuals at ultra-high risk for psychosis (UHR) present with subtle alterations in cerebral white matter (WM), which appear to be associated with clinical and functional outcome. The effect of cognitive remediation on WM organization in UHR individuals has not been investigated previously. Methods:In a randomized, clinical trial, UHR individuals aged ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:873]

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T46. THE EFFECT OF COMPREHENSIVE COGNITIVE REMEDIATION IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS: A SINGLE-BLIND, RANDOMISED, CLINICAL TRIAL (FOCUS).

Louise Birkedal Glenthoej, Mariegaard Lise, Birgitte Fagerlund, Jens Richardt Jepsen, Tina Dam Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David Roberts, Carsten Hjorthøj, Merete Nordentoft,

AbstractBackgroundIndividuals at ultra-high risk (UHR) for psychosis display significant cognitive deficits that constitute a barrier to functional recovery. Applying cognitive remediation (CR) before the onset of manifest psychosis may improve cognition and the clinical and functional prognosis of UHR individuals.MethodsThis randomised, clinical trial randomly assigned 146 UHR individuals aged 18–40 ... Read more >>

(Schizophrenia bulletin)
[2020, 46(Suppl 1):S249-S249]

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T18. EFFECTS OF COGNITIVE REMEDIATION ON WHITE MATTER IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS – A RANDOMIZED, CONTROLLED CLINICAL TRIAL.

Tina Kristensen, Bjørn H Ebdrup, Carsten Hjorthøj, Rene C W Mandl, Jayachandra Mitta Raghava, Jens Richardt Møllegaard Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y Glenthøj, Merete Nordentoft,

AbstractBackgroundIndividuals at ultra-high risk for psychosis (UHR) present with subtle white matter alterations, which have been associated with clinical and functional outcome. The effect of cognitive remediation on white matter (WM) in UHR-individuals has not been investigated.MethodsIn a randomized, clinical intervention-trial (FOCUS), UHR-individuals aged 18–40 years were assigned to treatment ... Read more >>

(Schizophrenia bulletin)
[2020, 46(Suppl 1):S237-S238]

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M233. EXPERIENTIAL NEGATIVE SYMPTOMS ARE MORE PREDICTIVE OF REAL-LIFE FUNCTIONAL OUTCOME THAN EXPRESSIVE NEGATIVE SYMPTOMS IN CLINICAL HIGH-RISK STATES.

Louise Birkedal Glenthoej, Tina Dam Kristensen, Christina Wenneberg, Carsten Hjorthøj, Merete Nordentoft,

AbstractBackgroundNegative symptoms are key features of schizophrenia spectrum disorders that are linked to psychosis development and functional impairments. This study investigated the predictive power of negative symptoms domains on multiple aspects of real-life functional outcome in individuals at Ultra High-Risk (UHR) for psychosis.MethodsA total of 146 UHR individuals were enrolled ... Read more >>

(Schizophrenia bulletin)
[2020, 46(Suppl 1):S225-S225]

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Experiential negative symptoms are more predictive of real-life functional outcome than expressive negative symptoms in clinical high-risk states.

Louise Birkedal Glenthøj, Tina Dam Kristensen, Christina Wenneberg, Carsten Hjorthøj, Merete Nordentoft,

BACKGROUND:Negative symptoms are key features of psychosis-spectrum disorders linked to psychosis development and functional impairments. This study investigated the predictive strength of negative symptoms domains on multiple aspects of real-life functional outcome in individuals at clinical high-risk (CHR) for psychosis. METHODS:A total of 146 UHR individuals were enrolled in a ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, 218:151-156]

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Predictors of remission from the ultra-high risk state for psychosis.

Louise B Glenthøj, Tina D Kristensen, Christina Wenneberg, Carsten Hjorthøj, Merete Nordentoft,

AIM:A significant proportion of individuals at Ultra-High Risk (UHR) for psychosis do not transition to manifest psychosis. Many non-transitioning UHR individuals do, however, display poor long-term outcomes such as persistence of attenuated psychotic symptoms. Evidence is scarce on which variables may predict a better clinical and functional prognosis such as ... Read more >>

Early Interv Psychiatry (Early intervention in psychiatry)
[2020, :]

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No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis—A Randomized Clinical Trial

Tina D. Kristensen, Bjørn H. Ebdrup, Carsten Hjorthøj, René C. W. Mandl, Jayachandra M. Raghava, Jens Richardt M. Jepsen, Birgitte Fagerlund, Louise B. Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y. Glenthøj, Merete Nordentoft,

Background Individuals at ultra-high risk for psychosis (UHR) present with subtle alterations in cerebral white matter (WM), which appear to be associated with clinical and functional outcome. The effect of cognitive remediation on WM organization in UHR individuals has not been investigated previously. Methods In a randomized, clinical trial, UHR ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:]

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Cerebral Glutamate and Gamma-Aminobutyric Acid Levels in Individuals at Ultra-high Risk for Psychosis and the Association With Clinical Symptoms and Cognition.

Christina Wenneberg, Merete Nordentoft, Egill Rostrup, Louise Birkedal Glenthøj, Kirsten Borup Bojesen, Birgitte Fagerlund, Carsten Hjorthøj, Kristine Krakauer, Tina Dam Kristensen, Camilla Schwartz, Richard A E Edden, Brian Villumsen Broberg, Birte Yding Glenthøj,

BACKGROUND:Studies examining glutamate or gamma-aminobutyric acid (GABA) in ultra-high risk for psychosis (UHR) and the association with pathophysiology and cognition have shown conflicting results. We aimed to determine whether perturbed glutamate and GABA levels in the anterior cingulate cortex and glutamate levels in the left thalamus were present in UHR ... Read more >>

Biol Psychiatry Cogn Neurosci Neuroimaging (Biological psychiatry. Cognitive neuroscience and neuroimaging)
[2020, 5(6):569-579]

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Supplementary data for a focused review and meta-analysis of 1H-MRS studies on cerebral glutamate and GABA levels in high-risk of psychosis states.

Christina Wenneberg, Birte Yding Glenthøj, Carsten Hjorthøj, Frederik Johan Buchardt Zingenberg, Louise Birkedal Glenthøj, Egill Rostrup, Brian Villumsen Broberg, Merete Nordentoft,

Data (attached) for a focused review and meta-analysis of cerebral levels of glutamate, Glx, and GABA levels assessed with 1H-MRS in high-risk of psychosis states was collected and stored at covidence.org and extracted to The Cochrane Collaboration Review Manager software package (RevMan Version 5.3) for meta-analytical purposes. Meta-analyses were performed with ... Read more >>

Data Brief (Data in brief)
[2020, 28:104920]

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Cerebral glutamate and GABA levels in high-risk of psychosis states: A focused review and meta-analysis of 1H-MRS studies.

Christina Wenneberg, Birte Yding Glenthøj, Carsten Hjorthøj, Frederik Johan Buchardt Zingenberg, Louise Birkedal Glenthøj, Egill Rostrup, Brian Villumsen Broberg, Merete Nordentoft,

Disturbances in the brain glutamate and GABA (γ-aminobutyric acid) homeostasis may be markers of transition to psychosis in individuals at high-risk (HR). Knowledge of GABA and glutamate levels in HR stages could give an insight into changes in the neurochemistry underlying psychosis. Studies on glutamate in HR have provided conflicting ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, 215:38-48]

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Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis.

Tina D Kristensen, René C W Mandl, Jayachandra M Raghava, Kasper Jessen, Jens Richardt M Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Merete Nordentoft, Birte Y Glenthøj, Bjørn H Ebdrup,

In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional white matter and cognitive functions in individuals at ultra-high risk for psychosis. One hundred and sixteen individuals at ultra-high risk for psychosis and 49 matched healthy controls ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2019, 40(18):5185-5201]

Cited: 2 times

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T97. PATTERNS OF COGNITIVE FUNCTION ARE UNIQUELY ASSOCIATED WITH WHITE MATTER-MICROSTRUCTURE IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS.

Tina Kristensen, Rene C W Mand, Jaychandra Raghava, Kasper Jessen, Jens Richardt M Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Merete Nordentoft, Birte Y Glenthøj, Bjørn H Ebdrup,

AbstractBackgroundIndividuals at ultra-high-risk for psychosis (UHR) are characterized by decline in cognitive functions. As cognition are suggested to be structural dependent on cerebral white matter organization, we here examine, if patterns of cognitive functions are associated with alterations in white matter for UHR compared to healthy controls (HC).Methods116 UHR and ... Read more >>

(Schizophrenia bulletin)
[2019, 45(Suppl 2):S241-S242]

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Emotion recognition latency, but not accuracy, relates to real life functioning in individuals at ultra-high risk for psychosis.

Louise Birkedal Glenthøj, Nikolai Albert, Birgitte Fagerlund, Tina Dam Kristensen, Christina Wenneberg, Carsten Hjorthøj, Merete Nordentoft, Jens Richardt Møllegaard Jepsen,

BACKGROUND:Emotion recognition deficits are essential features of psychotic disorders and the ultra-high risk state of psychosis (UHR), that are known to relate to functional outcome. The potential associations between aspects of emotion recognition deficits and functioning are, however, understudied in UHR individuals. METHOD:Emotion recognition accuracy and latency were assessed in ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2019, 210:197-202]

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Examining speed of processing of facial emotion recognition in individuals at ultra-high risk for psychosis: Associations with symptoms and cognition.

Louise Birkedal Glenthøj, Birgitte Fagerlund, Nikolaj Bak, Carsten Hjorthøj, Maja Gregersen, Tina Dam Kristensen, Christina Wenneberg, Kristine Krakauer, Joseph Ventura, Jens Richardt Møllegaard Jepsen, Merete Nordentoft,

Schizophr. Res. (Schizophrenia research)
[2018, 195:562-563]

Cited: 1 time

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T16. GLUTAMATERGIC CHANGES IN UHR.

Christina Wenneberg, Brian Broberg, Egill Rostrup, Louise Birkedal Glenthøj, Birte Glenthoj, Merete Nordentoft, Tina Dam Kristensen,

AbstractBackgroundThe search for biomarkers may prove significant for short-term identification of UHR individuals (remission/non-remission). On a long-term basis, biomarkers might give the opportunity to delay or prevent psychotic episodes. Disturbances of the neurotransmitters glutamate and GABA have long been suspected to be involved in the pathophysiology of psychosis. These disorders ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2018, 44(Suppl 1):S119-S119]

Cited: 0 times

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SA81. Glutamatergic and GABAergic Disturbances in Individuals at Ultra-High Risk of Psychosis: Implications for Clinical and Functional Outcome.

Christina Wenneberg, Birte Y. Glenthøj, Brian V. Broberg, Louise B. Glenthøj, Tina D. Kristensen, Kristine Krakauer, Egill Rostrup, Merete Nordentoft,

Abstract CAARMS criteria identifies individuals at ultra-high risk (UHR) of psychosis of which approximately 30% develop psychosis within 2 years. These criteria require loss of function and a genetic predisposition or attenuated psychotic symptoms. Recent studies indicate that fewer UHR individuals have transition to psychosis, hence stratification of UHR individuals ... Read more >>

(Schizophrenia bulletin)
[2017, 43(Suppl 1):S142-S142]

Cited: 0 times

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Social cognition in patients at ultra-high risk for psychosis: What is the relation to social skills and functioning?

Louise B Glenthøj, Birgitte Fagerlund, Carsten Hjorthøj, Jens R M Jepsen, Nikolaj Bak, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, David L Roberts, Merete Nordentoft,

OBJECTIVE:Patients at ultra-high risk (UHR) for psychosis show significant impairments in functioning. It is essential to determine which factors influence functioning, as it may have implications for intervention strategies. This study examined whether social cognitive abilities and clinical symptoms are associated with functioning and social skills. METHODS:The study included 65 ... Read more >>

(Schizophrenia research. Cognition)
[2016, 5:21-27]

Cited: 7 times

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EFFECTIVENESS OF DIALECTICAL BEHAVIOR THERAPY VERSUS COLLABORATIVE ASSESSMENT AND MANAGEMENT OF SUICIDALITY TREATMENT FOR REDUCTION OF SELF-HARM IN ADULTS WITH BORDERLINE PERSONALITY TRAITS AND DISORDER-A RANDOMIZED OBSERVER-BLINDED CLINICAL TRIAL.

Kate Andreasson, Jesper Krogh, Christina Wenneberg, Helle K L Jessen, Kristine Krakauer, Christian Gluud, Rasmus R Thomsen, Lasse Randers, Merete Nordentoft,

Many psychological treatments have shown effect on reducing self-harm in adults with borderline personality disorder. There is a need of brief psychotherapeutical treatment alternative for suicide prevention in specialized outpatient clinics.The DiaS trial was designed as a pragmatic single-center, two-armed, parallel-group observer-blinded, randomized clinical superiority trial. The participants had at ... Read more >>

Depress Anxiety (Depression and anxiety)
[2016, 33(6):520-530]

Cited: 15 times

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The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial.

Louise B Glenthøj, Birgitte Fagerlund, Lasse Randers, Carsten R Hjorthøj, Christina Wenneberg, Kristine Krakauer, Astrid Vosgerau, Christian Gluud, Alice Medalia, David L Roberts, Merete Nordentoft,

Cognitive deficits are a distinct feature among people at ultra-high risk (UHR) for psychosis and pose a barrier to functional recovery. Insufficient evidence exists on how to ameliorate these cognitive deficits in patients at UHR for psychosis and hence improve daily living and quality of life. The aim of the ... Read more >>

Trials (Trials)
[2015, 16:25]

Cited: 11 times

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