Full Text Journal Articles by
Author Christina Jamieson

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Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer.

Stephen T Ryan, Jing Zhang, Danielle N Burner, Michael Liss, Emily Pittman, Michelle Muldong, Ahmed Shabaik, Jason Woo, Nicole Basler, Jonathan Cunha, Shabnam Shalapour, Monica V Estrada, Michael Karin, Karen Messer, Stephen Howell, Christopher J Kane, Christina A M Jamieson,

BACKGROUND:Immunotherapeutic regulation of the tumor microenvironment in prostate cancer patients is not understood. Most antibody immunotherapies have not succeeded in prostate cancer. We showed previously that high-risk PCa patients have a higher density of tumor infiltrating B-cells in prostatectomy specimens. In mouse models, anti-CD20 antibody ablation of B-cells delayed PCa ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):214]

Cited: 0 times

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The Impact of Whole Genome Data on Therapeutic Decision-Making in Metastatic Prostate Cancer: A Retrospective Analysis.

Megan Crumbaker, Eva K F Chan, Tingting Gong, Niall Corcoran, Weerachai Jaratlerdsiri, Ruth J Lyons, Anne-Maree Haynes, Anna A Kulidjian, Anton M F Kalsbeek, Desiree C Petersen, Phillip D Stricker, Christina A M Jamieson, Peter I Croucher, Christopher M Hovens, Anthony M Joshua, Vanessa M Hayes,

BACKGROUND:While critical insights have been gained from evaluating the genomic landscape of metastatic prostate cancer, utilizing this information to inform personalized treatment is in its infancy. We performed a retrospective pilot study to assess the current impact of precision medicine for locally advanced and metastatic prostate adenocarcinoma and evaluate how ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(5):]

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Establishment and Analysis of Three-Dimensional (3D) Organoids Derived from Patient Prostate Cancer Bone Metastasis Specimens and their Xenografts.

Sanghee Lee, Danielle N Burner, Theresa R Mendoza, Michelle T Muldong, Catalina Arreola, Christina N Wu, Nicholas A Cacalano, Anna A Kulidjian, Christopher J Kane, Christina A M Jamieson,

Three-dimensional (3D) culture of organoids from tumor specimens of human patients and patient-derived xenograft (PDX) models of prostate cancer, referred to as patient-derived organoids (PDO), are an invaluable resource for studying the mechanism of tumorigenesis and metastasis of prostate cancer. Their main advantage is that they maintain the distinctive genomic ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2020, (156):]

Cited: 1 time

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Hypoxia-induced PIM kinase and laminin-activated integrin α6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC.

Rachel K Toth, Jack D Tran, Michelle T Muldong, Eric A Nollet, Veronique V Schulz, Corbin C Jensen, Lori A Hazlehurst, Eva Corey, Donald Durden, Christina Jamieson, Cindy K Miranti, Noel A Warfel,

Bone-metastatic castration-resistant prostate cancer (CRPC) is lethal due to inherent resistance to androgen deprivation therapy, chemotherapy, and targeted therapies. Despite the fact that a majority of CRPC patients (approximately 70%) harbor a constitutively active PI3K survival pathway, targeting the PI3K/mTOR pathway has failed to increase overall survival in clinical trials. ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(4):297-312]

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Hypoxia-Induced PIM Kinase and Laminin-Activated Integrin α6 Mediate Resistance to PI3K Inhibitors in Bone-Metastatic CRPC

Rachel Toth, Jack Tran, Michelle Muldong, Eric Nollet, Veronique Schulz, Corbin Jensen, Lori Hazelhurst, Eva Corey, Donald Durden, Christina Jamieson, Cindy Miranti, Noel Warfel,

ABSTRACT Bone-metastatic castration-resistant prostate cancer (CRPC) is lethal due to inherent resistance to androgen deprivation therapy, chemotherapy, and targeted therapies. Despite the fact that a majority of CRPC patients (approximately 70%) harbor a constitutively active PI3K survival pathway, targeting the PI3K/mTOR pathway has failed to increase overall survival in clinical ... Read more >>

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Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy.

Varadha Balaji Venkadakrishnan, Adam D DePriest, Sangeeta Kumari, Dhirodatta Senapati, Salma Ben-Salem, Yixue Su, Giridhar Mudduluru, Qiang Hu, Eduardo Cortes, Elena Pop, James L Mohler, Gissou Azabdaftari, Kristopher Attwood, Rajal B Shah, Christina Jamieson, Scott M Dehm, Cristina Magi-Galluzzi, Eric Klein, Nima Sharifi, Song Liu, Hannelore V Heemers,

Sustained reliance on androgen receptor (AR) after failure of AR-targeting androgen deprivation therapy (ADT) prevents effective treatment of castration-recurrent (CR) prostate cancer (CaP). Interfering with the molecular machinery by which AR drives CaP progression may be an alternative therapeutic strategy but its feasibility remains to be tested. Here, we explore ... Read more >>

Oncogene (Oncogene)
[2019, 38(23):4496-4511]

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A Randomized, Double-blind, Phase II Trial of PSA-TRICOM (PROSTVAC) in Patients with Localized Prostate Cancer: The Immunotherapy to Prevent Progression on Active Surveillance Study.

J Kellogg Parsons, Peter A Pinto, Christian P Pavlovich, Edward Uchio, Hyung L Kim, Mikel N Nguyen, James L Gulley, Christina Jamieson, Paul Hsu, Margarita Wojtowicz, Howard Parnes, Jeffrey Schlom, William L Dahut, Ravi A Madan, Renee N Donahue, H-H Sherry Chow,

The Immunotherapy to Prevent Progression on Active Surveillance Study is the first trial of immunotherapy for localized prostate cancer. We randomized active surveillance patients to PSA-TRICOM (PROSTVAC) or placebo for 5mo. Final results will be available in 2019. ... Read more >>

Eur Urol Focus (European urology focus)
[2018, 4(5):636-638]

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WNT5A induces castration-resistant prostate cancer via CCL2 and tumour-infiltrating macrophages.

Geun Taek Lee, Seok Joo Kwon, Jongmyung Kim, Young Suk Kwon, Nara Lee, Jeong Hee Hong, Christina Jamieson, Wun-Jae Kim, Isaac Yi Kim,

BACKGROUND:Although the standard treatment for the patients with recurrent and metastatic prostate cancer (CaP) is androgen deprivation therapy, castration-resistant prostate cancer (CRPC) eventually emerges. Our previous report indicated that bone morphogenetic protein 6 (BMP6) induced CRPC via tumour-infiltrating macrophages. In a separate line of study, we have observed that the ... Read more >>

Br. J. Cancer (British journal of cancer)
[2018, 118(5):670-678]

Cited: 9 times

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Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer.

Takeshi Hirata, Seung Chol Park, Michelle T Muldong, Christina N Wu, Tomonori Yamaguchi, Amy Strasner, Omer Raheem, Hiromi Kumon, Robert L Sah, Nicholas A Cacalano, Catriona H M Jamieson, Christopher J Kane, Koichi Masuda, Anna A Kulidjian, Christina A M Jamieson,

Bone metastasis occurs in up to 90% of men with advanced prostate cancer and leads to fractures, severe pain and therapy-resistance. Bone metastases induce a spectrum of types of bone lesions which can respond differently to therapy even within individual prostate cancer patients. Thus, the special environment of the bone ... Read more >>

Asian J Urol (Asian journal of urology)
[2016, 3(4):229-239]

Cited: 1 time

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Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.

Shabnam Shalapour, Joan Font-Burgada, Giuseppe Di Caro, Zhenyu Zhong, Elsa Sanchez-Lopez, Debanjan Dhar, Gerald Willimsky, Massimo Ammirante, Amy Strasner, Donna E Hansel, Christina Jamieson, Christopher J Kane, Tobias Klatte, Peter Birner, Lukas Kenner, Michael Karin,

Cancer-associated genetic alterations induce expression of tumour antigens that can activate CD8(+) cytotoxic T cells (CTLs), but the microenvironment of established tumours promotes immune tolerance through poorly understood mechanisms. Recently developed therapeutics that overcome tolerogenic mechanisms activate tumour-directed CTLs and are effective in some human cancers. Immune mechanisms also affect ... Read more >>

Nature (Nature)
[2015, 521(7550):94-98]

Cited: 141 times

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PCSD1, a new patient-derived model of bone metastatic prostate cancer, is castrate-resistant in the bone-niche.

Elana Godebu, Michelle Muldong, Amy Strasner, Christina N Wu, Seung Chol Park, Jason R Woo, Wenxue Ma, Michael A Liss, Takeshi Hirata, Omer Raheem, Nicholas A Cacalano, Anna A Kulidjian, Christina A M Jamieson,

Prostate cancer bone metastasis occurs in 50-90% of men with advanced disease for which there is no cure. Bone metastasis leads to debilitating fractures and severe bone pain. It is associated with therapy resistance and rapid decline. Androgen deprivation therapy (ADT) is standard of care for advanced prostate cancer, however, ... Read more >>

J Transl Med (Journal of translational medicine)
[2014, 12:275]

Cited: 14 times

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Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts.

Massimo Ammirante, Shabnam Shalapour, Youngjin Kang, Christina A M Jamieson, Michael Karin,

Prostate cancer (PC) is a slowly progressing malignancy that often responds to androgen ablation or chemotherapy by becoming more aggressive, acquiring a neuroendocrine phenotype, and undergoing metastatic spread. We found that B lymphocytes recruited into regressing androgen-deprived tumors by C-X-C motif chemokine 13 (CXCL13), a chemokine whose expression correlates with ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(41):14776-14781]

Cited: 60 times

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Tumor infiltrating B-cells are increased in prostate cancer tissue.

Jason R Woo, Michael A Liss, Michelle T Muldong, Kerrin Palazzi, Amy Strasner, Massimo Ammirante, Nissi Varki, Ahmed Shabaik, Stephen Howell, Christopher J Kane, Michael Karin, Christina A M Jamieson,

The presence of increased B-cell tumor infiltrating lymphocytes (TILs) was seen in mouse prostate cancer (PCa) but has not been fully documented in human PCa. We, therefore, investigated the density of infiltrating B cells within human PCa utilizing a quantitative computational method.Archived radical prostatectomy specimens from 53 patients with known ... Read more >>

J Transl Med (Journal of translational medicine)
[2014, 12:30]

Cited: 57 times

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A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions.

Omer Raheem, Anna A Kulidjian, Christina Wu, Young B Jeong, Tomonori Yamaguchi, Kristen M Smith, Daniel Goff, Heather Leu, Sheldon R Morris, Nicholas A Cacalano, Koichi Masuda, Catriona H M Jamieson, Christopher J Kane, Christina A M Jamieson,

Prostate cancer metastasizes to bone in the majority of patients with advanced disease leading to painfully debilitating fractures, spinal compression and rapid decline. In addition, prostate cancer bone metastases often become resistant to standard therapies including androgen deprivation, radiation and chemotherapy. There are currently few models to elucidate mechanisms of ... Read more >>

J Transl Med (Journal of translational medicine)
[2011, 9:185]

Cited: 20 times

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Dexamethasone induces dysferlin in myoblasts and enhances their myogenic differentiation.

Joseph J Belanto, Silvia V Diaz-Perez, Clara E Magyar, Michele M Maxwell, Yasemin Yilmaz, Kasey Topp, Guney Boso, Catriona H Jamieson, Nicholas A Cacalano, Christina A M Jamieson,

Glucocorticoids are beneficial in many muscular dystrophies but they are ineffective in treating dysferlinopathy, a rare muscular dystrophy caused by loss of dysferlin. We sought to understand the molecular basis for this disparity by studying the effects of a glucocorticoid on differentiation of the myoblast cell line, C2C12, and dysferlin-deficient ... Read more >>

Neuromuscul. Disord. (Neuromuscular disorders : NMD)
[2010, 20(2):111-121]

Cited: 27 times

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Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency.

Li Peng, Ting-Ting Wu, Jason H Tchieu, Jun Feng, Helen J Brown, Jiaying Feng, Xudong Li, Jing Qi, Hongyu Deng, Igor Vivanco, Ingo K Mellinghoff, Christina Jamieson, Ren Sun,

Cellular signalling pathways are critical in regulating the balance between latency and lytic replication of herpesviruses. Here, we investigated the effect of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway on replication of two gamma-2 herpesviruses, murine gammaherpesvirus-68 (MHV-68) and human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus (HHV-8/KSHV). We found that de novo infection of MHV-68 ... Read more >>

J. Gen. Virol. (The Journal of general virology)
[2010, 91(Pt 2):463-469]

Cited: 24 times

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SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage.

John C Sitko, Brian Yeh, Moonhong Kim, Hong Zhou, Giichi Takaesu, Akihiko Yoshimura, William H McBride, Anahid Jewett, Christina A M Jamieson, Nicholas A Cacalano,

Genotoxic agents such as ionizing radiation trigger cell cycle arrest at the G1/S and G2/M checkpoints, allowing cells to repair damaged DNA before entry into mitosis. DNA damage-induced G1 arrest involves p53-dependent expression of p21 (Cip1/Waf-1), which inhibits cyclin-dependent kinases and blocks S phase entry. While much of the core ... Read more >>

Cell. Signal. (Cellular signalling)
[2008, 20(12):2221-2230]

Cited: 22 times

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Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme.

Hong Zhou, Rika Miki, Mervi Eeva, Francesca M Fike, David Seligson, Lu Yang, Akihiko Yoshimura, Michael A Teitell, Christina A M Jamieson, Nicholas A Cacalano,

The expression of suppressors of cytokine signaling 1 (SOCS1) and SOCS3 genes is dysregulated in several solid tumors, causing aberrant activation of cell growth and survival signaling pathways. In this study, we analyzed SOCS1 and SOCS3 gene expression in glioblastoma multiforme (GBM) and studied the role of each protein in ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2007, 13(8):2344-2353]

Cited: 51 times

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Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling.

C A Jamieson, K R Yamamoto,

Activation of the glucocorticoid receptor (GR) triggers apoptosis in T cells. However, activation of the T cell antigen receptor (TCR) blocks glucocorticoid-induced apoptosis, implying functional crosstalk between these two distinct signaling systems. By reconstructing or selectively blocking TCR-stimulated signaling pathways, we show here that TCR activation of the mitogen-activated protein ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2000, 97(13):7319-7324]

Cited: 48 times

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Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response.

Bland, Jamieson, Akana, Bornstein, Eisenhofer, Dallman, Ingraham,

Adrenal steroids are essential for homeostasis and survival during severe physiological stress. Analysis of a patient heterozygous for the steroidogenic factor-1 (SF-1) gene suggested that reduced expression of this nuclear receptor leads to adrenal failure. We therefore examined SF-1 heterozygous (+/-) mice as a potential model for delineating mechanisms underlying ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2000, 97(26):14488-14493]

Cited: 80 times

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