Full Text Journal Articles by
Author Christiane Mougin

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Treatment algorithm and prognostic factors for patients with stage I-III carcinoma of the anal canal: a 20-year multicenter study.

Diane Bruyere, Franck Monnien, Prudence Colpart, Patrick Roncarati, Lucine Vuitton, Elodie Hendrick, Alexis Lepinoy, Alexandra Luquain, Charlotte Pilard, Thomas Lerho, Chloé Molimard, Philippe Maingon, Laurent Arnould, Marie-Christine Bone-Lepinoy, Laurence Dusserre, Laurent Martin, Celia Reynders, Marie Ancion, Didier Peiffert, Agnès Leroux, Pascale Hubert, Jean-Baptiste Delhorme, Jean-Pierre Ghnassia, Anne-Sophie Woronoff, Philippe Delvenne, Jean-Luc Prétet, Jean-François Bosset, Olivier Peulen, Christiane Mougin, Séverine Valmary-Degano, Michael Herfs,

Despite a growing incidence in developed countries and a recent improved understanding of its pathogenesis, anal cancer management has not evolved over the past decades and drug combination used as first-line regimen still largely depends on clinician preferences. Aiming at paving the way for precision medicine, a large cohort of ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, :]

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DNA demethylation agent 5azadC downregulates HPV16 E6 expression in cervical cancer cell lines independently of TBX2 expression.

Jerome Perrard, Adrien Morel, Koceila Meznad, Philippe Paget-Bailly, Veronique Dalstein, David Guenat, Celine Mourareau, Christine Clavel, Sylvie Fauconnet, Aurelie Baguet, Christiane Mougin, Jean-Luc Pretet,

HPV16 is the most carcinogenic human papillomavirus and causes >50% of cervical cancers, the majority of anal cancers and 30% of oropharyngeal squamous cell carcinomas. HPV carcinogenesis relies on the continuous expression of the two main viral oncoproteins E6 and E7 that target >150 cellular proteins. Among them, epigenetic modifiers, ... Read more >>

Oncol Lett (Oncology letters)
[2020, 19(1):1074-1081]

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[Cervical cancer: Current situation and management in Morocco].

Essaada Belglaiaa, Christiane Mougin,

With more than 3300 new cases and almost 2500 deaths each year, cervical cancer (CC) ranks second among female cancers in Moroccan women. The majority of cases occurs in women aged 50 and over. In absence of a national cancer registry, data published in Morocco are limited to the number ... Read more >>

Bull Cancer (Bulletin du cancer)
[2019, 106(11):1008-1022]

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Comparative RNA sequencing reveals that HPV16 E6 abrogates the effect of E6*I on ROS metabolism.

Philippe Paget-Bailly, Koceila Meznad, Diane Bruyère, Jérôme Perrard, Michael Herfs, Alain C Jung, Christiane Mougin, Jean-Luc Prétet, Aurélie Baguet,

High-risk Human Papillomavirus infections are responsible for anogenital and oropharyngeal cancers. Alternative splicing is an important mechanism controlling HPV16 gene expression. Modulation in the splice pattern leads to polycistronic HPV16 early transcripts encoding a full length E6 oncoprotein or truncated E6 proteins, commonly named E6*. Spliced E6*I transcripts are the ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):5938]

Cited: 1 time

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Awareness of cervical cancer among women attending an HIV treatment centre: a cross-sectional study from Morocco.

Essaada Belglaiaa, Tiatou Souho, Latifa Badaoui, Michel Segondy, Jean-Luc Prétet, David Guenat, Christiane Mougin,

OBJECTIVE:To explore awareness about cervical cancer among Moroccan women attending an HIV treatment centre in Laâyoune city, Morocco. DESIGN:A cross-sectional study was conducted from April to June 2017 using a knowledge test regarding cervical cancer, its risk factors and its prevention. SETTING:HIV treatment centre at the Hospital of Moulay Hassan ... Read more >>

BMJ Open (BMJ open)
[2018, 8(8):e020343]

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Development and interlaboratory agreement of real-time PCR for HPV16 quantification in liquid-based cervical samples.

David Guenat, Véronique Dalstein, Frédéric Mauny, Maëlle Saunier, Jenny Briolat, Christine Clavel, Didier Riethmuller, Christiane Mougin, Jean-Luc Prétet,

High risk HPV infection is the necessary cause for the development of precancerous and cancerous lesions of the cervix. Among HPV, HPV16 represents the most carcinogenic type. Since the determination of HPV16 DNA load could be clinically useful, we assessed quantitative real-time PCR targeting E6HPV16 and albumin genes on two ... Read more >>

Papillomavirus Res (Papillomavirus research (Amsterdam, Netherlands))
[2018, 6:27-32]

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A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

Michael Herfs, Patrick Roncarati, Benjamin Koopmansch, Olivier Peulen, Diane Bruyere, Alizee Lebeau, Elodie Hendrick, Pascale Hubert, Aurelie Poncin, William Penny, Nathalie Piazzon, Franck Monnien, David Guenat, Christiane Mougin, Jean-Luc Prétet, Lucine Vuitton, Karin Segers, Frederic Lambert, Vincent Bours, Laurence de Leval, Severine Valmary-Degano, Charles M Quick, Christopher P Crum, Philippe Delvenne,

BACKGROUND:Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has yet to be developed. The present article aimed at addressing this information gap by in-depth characterising ... Read more >>

Br. J. Cancer (British journal of cancer)
[2018, 118(10):1302-1312]

Cited: 3 times

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High Prevalence of Anal Canal High-Risk Human Papillomavirus Infection in Patients With Crohn's Disease.

Lucine Vuitton, Elise Jacquin, Anne-Laure Parmentier, Elise Crochet, Francine Fein, Anne-Claire Dupont-Gossart, Laurianne Plastaras, Charles-Henri Bretagne, Frédéric Mauny, Stéphane Koch, Jean-Luc Prétet, Christiane Mougin, Séverine Valmary-Degano,

BACKGROUND & AIMS:The increasing incidence of anal canal carcinomas requires better knowledge on anal human papillomavirus (HPV) infection. We aimed to assess anal canal HPV infection prevalence and risk factors among patients seen at a gastroenterology department in France. METHODS:We analyzed anal tissue samples collected from 469 consecutive patients (median ... Read more >>

Clin. Gastroenterol. Hepatol. (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2018, 16(11):1768-1776.e5]

Cited: 2 times

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Cell death and restoration of TRAIL-sensitivity by ciglitazone in resistant cervical cancer cells.

Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Christiane Mougin, Jean Rommelaere, Isabelle Lascombe,

Known activators of the Peroxisome Proliferator-Activated Receptor γ (PPARγ), thiazolidinediones (TZD) induce apoptosis in a variety of cancer cells through dependent and/or independent mechanisms of the receptor. We tested a panel of TZD (Rosiglitazone, Pioglitazone, Ciglitazone) to shed light on their potential therapeutic effects on three cervical cancer cell lines ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(64):107744-107762]

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5azadC treatment upregulates miR-375 level and represses HPV16 E6 expression.

Adrien Morel, Aurélie Baguet, Jérôme Perrard, Caroline Demeret, Elise Jacquin, David Guenat, Christiane Mougin, Jean-Luc Prétet,

High-risk human papillomaviruses are the etiological agents of cervical cancer and HPV16 is the most oncogenic genotype. Immortalization and transformation of infected cells requires the overexpression of the two viral oncoproteins E6 and E7 following HPV DNA integration into the host cell genome. Integration often leads to the loss of ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(28):46163-46176]

Cited: 5 times

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Somatic mutational spectrum analysis in a prospective series of 104 gastrointestinal stromal tumors.

David Guenat, Olivier Deroo, Sandrine Magnin, Loïc Chaigneau, Franck Monnien, Christophe Borg, Christiane Mougin, Jean-François Emile, Jean-Luc Prétet,

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors distinguished by driver mutations in proto-oncogenes KIT or PDGFRA in 85-90% of cases. These mutations have been linked to the response to imatinib, a multikinase inhibitor, and have independent prognostic impact. Here, we describe the prospective study of the molecular characteristics of 104 GISTs ... Read more >>

Oncol. Rep. (Oncology reports)
[2017, 37(3):1671-1681]

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Human papillomaviruses in colorectal cancers: A case-control study in western patients.

Lucine Vuitton, Carine Jaillet, Elise Jacquin, Franck Monnien, Marine Heberle, Maria I Mihai, Catherine Lassabe, Johnny Raffoul, Marc Puyraveau, Zaher Lakkis, Najib Lamfichekh, Alain Picard, Jean-Luc Prétet, Christiane Mougin, Séverine Valmary-Degano,

Colorectal cancer (CRC) is one of the most common cancers. As in other cancer locations, the involvement of human papillomaviruses (HPV) has been suggested but remains highly debated with wide differences among reported prevalence of HPV infection in CRCs.To determine the actual prevalence of high risk HPV16 and 18 in ... Read more >>

Dig Liver Dis (Digestive and Liver Disease)
[2017, 49(4):446-450]

Cited: 2 times

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Validation of Novaprep(®) HQ+ liquid-based cytology medium for high-risk human papillomavirus detection by hc2.

David Guenat, Sophie Launay, Didier Riethmuller, Christiane Mougin, Jean-Luc Prétet,

Preanalytical conditions determine the reliability and validity of bioassays. Therefore, the analytic performances of biological tests need to be determined when preanalytical steps differ from those recommended by the manufacturer. The objective of the study was to assess the analytic performance of the hc2 test for the detection of high-risk ... Read more >>

Infect. Agents Cancer (Infectious agents and cancer)
[2016, 11:41]

Cited: 1 time

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Risk of second primary cancer after a first potentially-human papillomavirus-related cancer: A population-based study.

Florent Neumann, Jérémie Jégu, Christiane Mougin, Jean-Luc Prétet, Anne-Valérie Guizard, Bénédicte Lapôtre-Ledoux, Simona Bara, Véronique Bouvier, Marc Colonna, Xavier Troussard, Brigitte Trétarre, Pascale Grosclaude, Michel Velten, Anne-Sophie Woronoff,

Human papillomaviruses (HPV) are involved in the development of anogenital and head and neck cancers. The purpose of this study was to assess the risk of developing a second primary cancer (SPC) after a first potentially-HPV-related cancer, and to analyze the sites where SPCs most frequently occurred in these patients. ... Read more >>

Prev Med (Preventive medicine)
[2016, 90:52-58]

Cited: 12 times

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Efferocytosis of apoptotic human papillomavirus-positive cervical cancer cells by human primary fibroblasts.

François Hermetet, Elise Jacquin, Sophie Launay, Emilie Gaiffe, Mélanie Couturier, Fabienne Hirchaud, Patrick Sandoz, Jean-Luc Prétet, Christiane Mougin,

Efficient clearance of apoptotic cells, named efferocytosis, is a fundamental physiological process for tissue development and homeostasis. The contribution of non-professional phagocytes like fibroblasts to efferocytosis has been established, although the underlying mechanisms are not well understood. We recently demonstrated that horizontal DNA transfer can occur through the uptake of ... Read more >>

Biol. Cell (Biology of the cell)
[2016, 108(7):189-204]

Cited: 11 times

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[HPV DNA genotyping: A study of anogenital, head and neck and skin cancers in a population from west Algerian. HPV detection in different cancers from an Algerian population].

Amira Nahet, Lamia Boublenza, Hafida Hassaine, Nabila Masdoua, Jean-Luc Prétet, Essaada Belglaiaa, Christiane Mougin,

To investigate the prevalence of human papillomaviruses (HPV) in cancers located at different sites in patients from west Algerian and collected between 2010 and 2014.Extracted DNA from archival formaldehyde-fixed and paraffin-embedded tissues was provided from 39 anogenital cancers, 10 head and neck cancers and 36 skin cancers. The viral DNA was detected using the ... Read more >>

Bull Cancer (Bulletin du cancer)
[2016, 103(5):455-460]

Cited: 1 time

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Human papillomavirus genotypes among women with or without HIV infection: an epidemiological study of Moroccan women from the Souss area.

Essaada Belglaiaa, Hicham Elannaz, Bouchra Mouaouya, Mohamed Aksim, Mariette Mercier, Jean-Luc Prétet, Said Chouham, Christiane Mougin,

Data on Human PapillomaVirus (HPV) infection are scarce in Morocco. The objective of the study was to determine the prevalence of HPV and cervical cytology abnormalities in women from the Souss area, Morocco.Two hundred and thirty two women who attended the Hassan II hospital (Agadir, Morocco) were recruited in this ... Read more >>

Infect. Agents Cancer (Infectious agents and cancer)
[2015, 10:44]

Cited: 3 times

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Long-term storage and safe retrieval of human papillomavirus DNA using FTA elute cards.

Heidi Barth, Adrien Morel, Christiane Mougin, Gerlinde Averous, Michèle Legrain, Muriel Fender, Simone Risch, Samira Fafi-Kremer, Michel Velten, Pierre Oudet, Jean-Jacques Baldauf, Françoise Stoll-Keller,

Biobanking or collection and storage of specimens for future research purposes have become an essential tool in many fields of biomedical research and aims to provide a better understanding of disease mechanisms as well as the identification of disease-specific biomarkers that can navigate in complex diseases. In this study, we ... Read more >>

J. Virol. Methods (Journal of virological methods)
[2016, 229:60-65]

Cited: 7 times

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[Analysis of MGMT methylation with the therascreen(®) MGMT Pyro(®) Kit (Qiagen). A method verification].

Alexandra Luquain, Sandrine Magnin, David Guenat, Jean-Luc Prétet, Gabriel Viennet, Séverine Valmary-Degano, Christiane Mougin,

Promoter methylation of the MGMT gene, encoding the enzyme O6-methylguanine-ubiquitous methyltransferase, is a theranostic good prognosis marker of glioblastomas treated with alkylating chemotherapy (temozolomide, Temodal(®)). Among the methylation analysis techniques, pyrosequencing is a reproducible and sensitive quantitative method. As part of the accreditation of the hospital platform of molecular genetics ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2015, 73(6):665-670]

Cited: 1 time

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BRAF mutation screening in melanoma: is sentinel lymph node reliable?

Charlée Nardin, Eve Puzenat, Jean Luc Prétet, Marie Paule Algros, Alexandre Doussot, Marc Puyraveau, Christiane Mougin, François Aubin,

As the detection of the BRAF V600E mutation has a direct impact on treatment decision, an accurate screening for BRAF mutations in patients with advanced or metastatic melanoma is mandatory. Nevertheless, BRAF oncogene mutation status between different samples from the same patient has been studied with conflicting results. This study ... Read more >>

Melanoma Res. (Melanoma research)
[2015, 25(4):328-334]

Cited: 4 times

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High prevalence of abnormal cervical smears in a hospital cohort of French women beyond the upper age limit screening program.

Alexandra Luquain, Essaada Belglaiaa, David Guenat, Sindy Vrecko, Didier Riethmuller, Séverine Valmary-Degano, Isabelle Bedgedjian, Said Chouham, Jean-Luc Prétet, Christiane Mougin,

To determine the prevalence of cytological abnormalities and high risk Human PapillomaVirus (hrHPV) in cervical smears from French women aged over 65 years who attended the referent Gynecology Clinic of the Besançon University Hospital.Between 2002 and 2012, 796 French women aged 66-99 years were cotested for cytology and hrHPV by ... Read more >>

Prev Med (Preventive medicine)
[2015, 81:157-162]

Cited: 1 time

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New HPV16 viral biomarkers to understand the progression of cervical lesions towards cancer.

Jean-Luc Prétet, David Guenat, Didier Riethmuller, Christiane Mougin,

Indian J. Med. Res. (The Indian journal of medical research)
[2014, 139(4):487-489]

Cited: 1 time

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Prevalence and risk factors of human papillomavirus infection types 16/18/45 in a cohort of French females aged 15-23 years.

Ariane Baudu, Jean-Luc Prétet, Didier Riethmuller, Morgane Chotard, Christiane Mougin, Mariette Mercier,

Investigation of the prevalence and risk factors of human papillomavirus (HPV) infection is the basis for developing prophylactic strategies against cervical cancer, especially for young women. This study aimed to assess the prevalence and risk factors of HPV infection among a cohort of sexually active young French women eligible for ... Read more >>

J Epidemiol Glob Health (Journal of epidemiology and global health)
[2014, 4(1):35-43]

Cited: 5 times

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Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells.

Fabienne Hirchaud, François Hermetet, Mourboul Ablise, Sylvie Fauconnet, Dominique A Vuitton, Jean-Luc Prétet, Christiane Mougin,

Flavonoids have antitumoral properties and may be attractive candidates as anticancer therapy. Isoliquiritigenin which is a constituent of licorice (Glycyrrhiza inflata), a plant commonly used in traditional Uyghur medicine in Xinjiang, China, was studied for antiproliferative and apoptotic activity in human cervical cancer cells, Ca Ski, SiHa, HeLa, and C-33A. ... Read more >>

Planta Med. (Planta medica)
[2013, 79(17):1628-1635]

Cited: 13 times

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Real-time duplex PCR for simultaneous HPV 16 and HPV 18 DNA quantitation.

Elise Jacquin, Maëlle Saunier, Frédéric Mauny, Elisabeth Schwarz, Christiane Mougin, Jean-Luc Prétet,

HPV 16 and HPV 18 are responsible for more than 75% of cervical cancers and high HPV 16 loads are associated with both prevalent and incident lesions. The objective of the present study was to develop a method allowing the detection and quantitation of HPV 16 and 18 DNA to ... Read more >>

J. Virol. Methods (Journal of virological methods)
[2013, 193(2):498-502]

Cited: 4 times

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