Full Text Journal Articles by
Author Christian Renaud

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Oropharyngeal Carriage of Kingella kingae and Transient Synovitis of the Hip in Young Children: A Case-Control Study.

Jocelyn Gravel, Sergio Manzano, Marie-Lyne Nault, Émilie Vallières, Fabien Rallu, Christian Renaud,

<h4>Background</h4>Transient synovitis of the hip affects mostly preschool children, and its etiology is unknown. Kingella kingae has been identified recently as a common etiologic agent of osteoarticular infections (OAI) in young children and could potentially be associated to transient synovitis of the hip. The main objective of this study was ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, Publish Ahead of Print:]

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Predictive value of repeated cerebrospinal fluid parameters in the outcomes of bacterial meningitis in infants <90 days of age.

Joseph Y Ting, Ashley Roberts, Sarah Khan, Ari Bitnun, Michael Hawkes, Michelle Barton, Jennifer Bowes, Jason Brophy, Lynda Ouchenir, Christian Renaud, Andrée-Anne Boisvert, Jane McDonald, Joan L Robinson,

<h4>Background</h4>There are variations in recommendations from different guidelines regarding the indications for repeat lumbar puncture (LP) in young infants with the diagnosis of bacterial meningitis.<h4>Objective</h4>To evaluate the frequency of repeat LPs and the characteristics of cerebrospinal fluid (CSF) parameters in repeated sampling and their predictive values for adverse outcomes in ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0238056]

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Enteroviral and Herpes Simplex Virus  Central Nervous System Infections in Infants <90 Days Old: A Paediatric Investigators’ Collaborative Network on Infections in Canada (PICNIC) Study

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

<h4>Background: </h4> The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. <h4>Methods:</h4> In this cross-sectional retrospective study, seven centers from the Pediatric ... Read more >>

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Enteroviral and herpes simplex virus central nervous system infections in infants < 90 days old: a Paediatric Investigators' Collaborative Network on Infections in Canada (PICNIC) study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan L Robinson,

BACKGROUND:The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. METHODS:In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):252]

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Prenatal findings, neonatal symptoms and neurodevelopmental outcome of congenital cytomegalovirus infection in a university hospital in Montreal, Quebec.

Anne-Frédérique Minsart, Françoise Rypens, Mina Smiljkovic, Fatima Kakkar, Christian Renaud, Valérie Lamarre, Marc Boucher, Isabelle Boucoiran,

Background Outcome of congenital cytomegalovirus (cCMV) infection in the absence of routine CMV screening and third-trimester scan in North America is scarcely documented. The aim of this study was to assess the severe outcomes related to cCMV according to the indication for screening. Methods This was a retrospective study of ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2020, 48(3):234-241]

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Pregnancies Among the First Generation of Survivors of Perinatal HIV Infection.

Marie-Julie Trahan, Marc Boucher, Christian Renaud, Christos Karatzios, Marie-Elaine Metras, Silvie Valois, Doris G Ransy, Valérie Lamarre, Fatima Kakkar,

OBJECTIVE:Little is known about pregnancy outcomes among women who have acquired human immunodeficiency virus (HIV) through perinatal infection and survived into adulthood. The objectives of this study were to describe pregnancy outcomes among women with perinatal HIV infection (PHIV) in Canada and to identify potential challenges in the prevention of ... Read more >>

J Obstet Gynaecol Can (Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC)
[2020, 42(4):446-452]

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Maternal infections.

Isabelle Boucoiran, Fatima Kakkar, Christian Renaud,

Congenital infections are infections transmitted from mother to child during pregnancy (transplacentally) or delivery (peripartum). They have the potential to adversely affect fetal development and long-term neurodevelopmental outcome through inflammatory, destructive, developmental, or teratogenic lesions of the brain. Because the fetal/neonatal brain has a limited capacity to respond to injury, ... Read more >>

Handb Clin Neurol (Handbook of clinical neurology)
[2020, 173:401-422]

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Blood viral load in the diagnostic workup of congenital cytomegalovirus infection.

Mina Smiljkovic, Jean-Baptiste Le Meur, Brigitte Malette, Isabelle Boucoiran, Anne-Frédérique Minsart, Valérie Lamarre, Bruce Tapiero, Christian Renaud, Fatima Kakkar,

BACKGROUND:There is limited data on the role of cytomegalovirus (CMV) blood quantitative polymerase chain reaction (qPCR) in the diagnostic workup of congenital CMV (cCMV) infection. OBJECTIVES:The objective of this study was to determine if CMV blood qPCR at the time diagnosis could differentiate between symptomatic and asymptomatic infants according to ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2020, 122:104231]

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Head ultrasound, CT or MRI? The choice of neuroimaging in the assessment of infants with congenital cytomegalovirus infection.

Mina Smiljkovic, Christian Renaud, Bruce Tapiero, Valérie Lamarre, Fatima Kakkar,

<h4>Background</h4>Despite growing interest in universal screening for congenital CMV infection (cCMV), and data to support treatment for cases with central nervous system (CNS) involvement, there is limited regarding the optimal imaging modalities to identify CNS involvement. The objective of this study was to assess the concordance between head ultrasound (US) ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):180]

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Reevaluating immunization delays after red blood cell transfusion.

Alexandra Zabeida, Marc H Lebel, Christian Renaud, Marc Cloutier, Nancy Robitaille,

BACKGROUND:Current American and Canadian guidelines recommend delaying live vaccine immunization by 5 to 6 months after transfusion of red blood cells (RBCs) due to potential interference by serum antibodies. Due to lack of data, the recommendations may be unfounded and prevent valuable vaccination opportunities for children with frequent blood transfusions. The ... Read more >>

Transfusion (Transfusion)
[2019, 59(9):2806-2811]

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44 Viral Central Nervous System Infections in Canadian Infants <90 Days Old: Encephalitis as a Predictor of Neurodevelopmental Morbidity.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

AbstractBackgroundHerpes simplex virus (HSV) and enterovirus (EV) are important causes of central nervous system (CNS) infections in young infants. Though long-term morbidity has been linked to HSV, there is still limited data on outcomes of other viral CNS infections in young infants.Objectives1) Conduct a descriptive analysis of viral CNS infections ... Read more >>

Paediatr Child Health (Paediatrics & child health)
[2019, 24(Suppl 2):e18-e18]

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18F-Flurodeoxyglucose positron emission tomography with computed tomography (FDG PET/CT) findings in children with encephalitis and comparison to conventional imaging.

Sophie Turpin, Patrick Martineau, Marc-André Levasseur, Inge Meijer, Jean-Claude Décarie, Julie Barsalou, Christian Renaud, Hélène Decaluwe, Elie Haddad, Raymond Lambert,

<h4>Purpose</h4>FDG PET/CT is emerging as a new tool for the evaluation of acute encephalitis (AE). However, to date, there are no exclusively pediatric studies on the use of FDG PET for suspected AE. The objective of this study was to compare qualitative and quantitative brain PET to conventional brain imaging ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2019, 46(6):1309-1324]

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1601. Effect of Preemptive Rituximab Therapy on Epstein–Barr Reactivation in Allogenic Hematopoietic Stem Cell Pediatric Transplants.

Gaud Catho, Daniel Scheel, Pierre Teira, Christian Renaud, Lisa Kakinami, Philippe Ovetchkine, Julie Autmizguine,

AbstractBackgroundChildren with Epstein–Barr virus (EBV) viremia after hematopoietic stem cell transplantation (HSCT) are at increased risk of post-transplant lymphoproliferative disease (PTLD). Our aim was to assess whether pre-emptive rituximab reduced EBV-viral load (EBV-VL) and the risk of developing PTLD.MethodsWe retrospectively included all children who had a positive EBV-VL within 12 ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S502-S502]

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Evaluation of the Abbott ARCHITECT™ cytomegalovirus IgM/IgG, rubella IgM/IgG, and syphilis treponemal antibodies enzyme immunoassays in a mother and child health center population.

Simon Grandjean Lapierre, Emilie Vallières, Leila Rabaamad, Manon Labrecque, Caroline Chartrand, Christian Renaud,

This study evaluated the concordance of Architect™ chemiluminescent microparticle immunoassays with Captia™ ELISA for cytomegalovirus (CMV) IgM and IgG, with Enzygnost™ and Captia™ ELISA for rubella IgM and IgG and with Trep-Sure™ ELISA for syphilis treponemal antibodies in a mixed pediatric and obstetrical population. Total agreement between assays and Kappa ... Read more >>

Diagn Microbiol Infect Dis (Diagnostic microbiology and infectious disease)
[2019, 94(3):231-235]

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2342. Treatment Implications of Herpes Simplex Virus Central Nervous System Infection in Canadian Infants <90 Days Old: A Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) Study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason C Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane Mcdonald, André-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

AbstractBackgroundIn the pre-acyclovir era, HSV CNS infection was associated with very high morbidity and mortality. Since antiviral drugs recommended for therapy and long-term prophylaxis improve outcomes, clinicians need to be able to clinically detect young infants most likely to have HSV to facilitate early initiation of therapy. Limited data exist ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S696-S696]

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115. Results of a Targeted Neonatal Screening Program for Congenital Cytomegalovirus Infection in Montreal, Quebec

Christian Renaud, Mina Smiljkovic, Isabelle Boucoiran, Silvie Valois, Bruce Tapiero, Valérie Lamarre, Fatima Kakkar,

Abstract Background There remains considerable debate on the role of symptomatic, targeted vs. universal screening of newborns for congenital cytomegalovirus infection (cCMV). Here we report on a hospital-based targeted screening program for (1) infants who failed their newborn hearing screen and (2) infants of HIV-infected women, and compare this to ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S3-S4]

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Use of Cytomegalovirus-Specific Hyperimmunoglobulins in Pregnancy: A Retrospective Cohort.

Anne-Frédérique Minsart, Mina Smiljkovic, Christian Renaud, Marie-Pierre Gagné, Valérie Lamarre, Fatima Kakkar, Marc Boucher, Isabelle Boucoiran,

<h4>Objective</h4>There is no consensus on the use of cytomegalovirus (CMV)-specific hyperimmunoglobulins (CSHIGs) for suspected congenital CMV infections during pregnancy, but this therapy is currently used in some countries. The objectives of this study were to describe tolerability and pregnancy outcome following treatment with monthly intravenous CSHIG and compare rates of ... Read more >>

J Obstet Gynaecol Can (Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC)
[2018, 40(11):1409-1416]

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THE EPIDEMIOLOGY AND CLINICAL FEATURES OF SEPTIC ARTHRITIS CASES SECONDARY TO KINGELLA KINGAE IN COMPARISON TO SEPTIC ARTHRITIS FROM OTHER PATHOGENS.

Jessica ElBared, Émilie Vallières, Christian Renaud, Jocelyn Gravel, Caroline Chartrand, Fabien Rallu, YongMu Ouyang,

AbstractBACKGROUNDIn Europe (Kk) is considered as a significant pathogen in osteoarticular infections (OAI) in young children. Some authors suggest that a significant portion of ‘culture negative septic arthritis’ may be secondary to the inability to isolate using conventional methods. However, its pathogenic role and prevalence remain controversial in North ... Read more >>

Paediatr Child Health (Paediatrics & child health)
[2018, 23(Suppl 1):e45-e45]

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Reevaluating Immunization Delays Post Red Blood Cell Transfusion

Alexandra Zabeida, Nancy Robitaille, Marc Lebel, Christian Renaud,

Abstract <h4>BACKGROUND</h4> Current Canadian guidelines recommend to delay the measles, mumps, rubella (MMR) and varicella live attenuated vaccines by 6 months following transfusion of unwashed red blood cells (RBC) due to potential interference by serum antibodies. Thus, patients chronically transfused with RBC commonly suffer from a delay or absence of ... Read more >>

Paediatr Child Health (Paediatrics & child health)
[2018, 23(Suppl 1):e58-e58]

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A concordance study of the Altona RealStar Varicella-Zoster virus real-time quantitative PCR and in-house conventional qualitative PCR.

Simon Grandjean Lapierre, Karel Boissinot, Christian Renaud,

This study compared the Altona RealStar™ VZV Kit 1.0 real time quantitative VZV PCR with in-house qualitative conventional VZV PCR on cerebrospinal fluid, mucocutaneous, and other uncommon clinical specimens. Overall, positive and negative agreement percentages were respectively 97.9% (95%CI: 93.8-99.6), 100.0% (95%CI: 93.1-100.0), and 96.3% (95%CI: 89.4-99.2) while Cohen's kappa ... Read more >>

J Med Virol (Journal of medical virology)
[2018, 90(2):334-337]

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Association between oropharyngeal carriage of Kingella kingae and osteoarticular infection in young children: a case-control study.

Jocelyn Gravel, Dimitri Ceroni, Laurence Lacroix, Christian Renaud, Guy Grimard, Eleftheria Samara, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano,

<h4>Background</h4><i>Kingella kingae</i> has been increasingly identified in patients with osteoarticular infections. Our main objective was to evaluate the association between carriage of <i>K. kingae</i> in the oropharynx of preschool children and osteoarticular infections.<h4>Methods</h4>We conducted this prospective case-control study in 2 tertiary care pediatric hospitals (Canada and Switzerland) between 2014 and ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2017, 189(35):E1107-E1111]

Cited: 8 times

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Head Ultrasound or MRI? The Role of Neuroimaging in the Assessment of Symptomatic and Asymptomatic Infants with Congenital Infection.

Mina Smiljkovic, Christian Renaud, Bruce Tapiero, Valerie Lamarre, Fatima Kakkar,

AbstractBackgroundDespite interest in universal screening for congenital CMV infection (cCMV), there is little consensus on the management of asymptomatic newborns, and on the role or type of neuroimaging to be performed in infected infants. The objective of this study was to assess the concordance between head ultrasound (US) and magnetic ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S691-S691]

Cited: 0 times

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Time to Positivity of Blood Cultures in Infants 0 to 90 Days Old Presenting to the Emergency Department: Is 36 Hours Enough?

Claire E Lefebvre, Christian Renaud, Caroline Chartrand,

<h4>Background</h4>Continuous monitoring blood culture systems (CMBCS) now allow for more rapid detection of microbial growth. We aimed to determine whether a 36-hour period was sufficient to detect all blood cultures positive for pathogenic bacteria in infants 0 to 90 days old undergoing a septic workup in the emergency department of ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2017, 6(1):28-32]

Cited: 3 times

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The Epidemiology, Management, and Outcomes of Bacterial Meningitis in Infants.

Lynda Ouchenir, Christian Renaud, Sarah Khan, Ari Bitnun, Andree-Anne Boisvert, Jane McDonald, Jennifer Bowes, Jason Brophy, Michelle Barton, Joseph Ting, Ashley Roberts, Michael Hawkes, Joan L Robinson,

<h4>Objectives</h4>The pathogens that cause bacterial meningitis in infants and their antimicrobial susceptibilities may have changed in this era of increasing antimicrobial resistance, use of conjugated vaccines, and maternal antibiotic prophylaxis for group B <i>Streptococcus</i> (GBS). The objective was to determine the optimal empirical antibiotics for bacterial meningitis in early infancy.<h4>Methods</h4>This ... Read more >>

Pediatrics (Pediatrics)
[2017, 140(1):]

Cited: 18 times

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Diagnosis and management of infants with congenital cytomegalovirus infection.

Soren Gantt, Ari Bitnun, Christian Renaud, Fatima Kakkar, Wendy Vaudry,

Congenital cytomegalovirus infection (cCMV) is the most common congenital infection, occurring in approximately 0.5% of live births. Most infected newborns are asymptomatic, but up to 20% develop sensorineural hearing loss or other permanent neurologic sequelae. The presentation of newborns with symptomatic cCMV is highly variable, and the infection is usually ... Read more >>

Paediatr Child Health (Paediatrics & child health)
[2017, 22(2):72-74]

Cited: 5 times

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