Full Text Journal Articles by
Author Christian Maasch

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Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis.

Holger Müller-Redetzky, Ute Kellermann, Sandra-Maria Wienhold, Birgitt Gutbier, Jasmin Lienau, Katharina Hellwig, Katrin Reppe, Eleftheria Letsiou, Thomas Tschernig, Markus Scholz, Peter Ahnert, Christian Maasch, Kai Hoehlig, Sven Klussmann, Axel Vater, Theresa C Firsching, Judith Hoppe, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory functions and is associated with tissue damage in various inflammatory conditions. The authors hypothesized that C5a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):795-807]

Cited: 0 times

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Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.

Laure Yatime, Christian Maasch, Kai Hoehlig, Sven Klussmann, Gregers R Andersen, Axel Vater,

L-Oligonucleotide aptamers (Spiegelmers) consist of non-natural L-configured nucleotides and are of particular therapeutic interest due to their high resistance to plasma nucleases. The anaphylatoxin C5a, a potent inflammatory mediator generated during complement activation that has been implicated with organ damage, can be efficiently targeted by Spiegelmers. Here, we present the ... Read more >>

Nat Commun (Nature communications)
[2015, 6:6481]

Cited: 20 times

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Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy.

Manolis Mavroidis, Constantinos H Davos, Stelios Psarras, Aimilia Varela, Nikolaos C Athanasiadis, Michalis Katsimpoulas, Ioanna Kostavasili, Christian Maasch, Axel Vater, J Peter van Tintelen, Yassemi Capetanaki,

Inflammation may contribute to disease progression in arrhythmogenic cardiomyopathy (ACM). However, its role in this process is unresolved. Our goal was to delineate the pathogenic role of the complement system in a new animal model of ACM and in human disease. Using cardiac histology, echocardiography, and electrocardiography, we have demonstrated ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2015, 110(3):27]

Cited: 12 times

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Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.

Dominik Oberthür, John Achenbach, Azat Gabdulkhakov, Klaus Buchner, Christian Maasch, Sven Falke, Dirk Rehders, Sven Klussmann, Christian Betzel,

We report the crystal structure of a 40 mer mirror-image RNA oligonucleotide completely built from nucleotides of the non-natural L-chirality in complex with the pro-inflammatory chemokine L-CLL2 (monocyte chemoattractant protein-1), a natural protein composed of regular L-amino acids. The L-oligonucleotide is an L-aptamer (a Spiegelmer) identified to bind L-CCL2 with ... Read more >>

Nat Commun (Nature communications)
[2015, 6:6923]

Cited: 28 times

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SDF-1 inhibition targets the bone marrow niche for cancer therapy.

Aldo M Roccaro, Antonio Sacco, Werner G Purschke, Michele Moschetta, Klaus Buchner, Christian Maasch, Dirk Zboralski, Stefan Zöllner, Stefan Vonhoff, Yuji Mishima, Patricia Maiso, Michaela R Reagan, Silvia Lonardi, Marco Ungari, Fabio Facchetti, Dirk Eulberg, Anna Kruschinski, Axel Vater, Giuseppe Rossi, Sven Klussmann, Irene M Ghobrial,

Bone marrow (BM) metastasis remains one of the main causes of death associated with solid tumors as well as multiple myeloma (MM). Targeting the BM niche to prevent or modulate metastasis has not been successful to date. Here, we show that stromal cell-derived factor-1 (SDF-1/CXCL12) is highly expressed in active ... Read more >>

Cell Rep (Cell reports)
[2014, 9(1):118-128]

Cited: 40 times

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The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization.

Julia Hoellenriegel, Dirk Zboralski, Christian Maasch, Nathalie Y Rosin, William G Wierda, Michael J Keating, Anna Kruschinski, Jan A Burger,

The CXC chemokine ligand (CXCL12, or stromal cell-derived factor-1 as previously known) plays a critical role for homing and retention of chronic lymphocytic leukemia (CLL) cells in tissues such as the bone marrow (BM). In tissues, stromal cells constitutively secrete and present CXCL12 via cell-surface-bound glycosaminoglycans (GAGs), thereby attracting CLL ... Read more >>

Blood (Blood)
[2014, 123(7):1032-1039]

Cited: 71 times

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A mixed mirror-image DNA/RNA aptamer inhibits glucagon and acutely improves glucose tolerance in models of type 1 and type 2 diabetes.

Axel Vater, Simone Sell, Przemyslaw Kaczmarek, Christian Maasch, Klaus Buchner, Ewa Pruszynska-Oszmalek, Pawel Kolodziejski, Werner G Purschke, Krzysztof W Nowak, Mathias Z Strowski, Sven Klussmann,

Excessive secretion of glucagon, a functional insulin antagonist, significantly contributes to hyperglycemia in type 1 and type 2 diabetes. Accordingly, immunoneutralization of glucagon or genetic deletion of the glucagon receptor improved glucose homeostasis in animal models of diabetes. Despite this strong evidence, agents that selectively interfere with endogenous glucagon have ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2013, 288(29):21136-21147]

Cited: 29 times

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The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.

Frank Schwoebel, Lucas T van Eijk, Dirk Zboralski, Simone Sell, Klaus Buchner, Christian Maasch, Werner G Purschke, Martin Humphrey, Stefan Zöllner, Dirk Eulberg, Frank Morich, Peter Pickkers, Sven Klussmann,

Anemia of chronic inflammation is the most prevalent form of anemia in hospitalized patients. A hallmark of this disease is the intracellular sequestration of iron. This is a consequence of hepcidin-induced internalization and subsequent degradation of ferroportin, the hepcidin receptor and only known iron-export protein. This study describes the characterization ... Read more >>

Blood (Blood)
[2013, 121(12):2311-2315]

Cited: 62 times

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Polyetheylenimine-polyplexes of Spiegelmer NOX-A50 directed against intracellular high mobility group protein A1 (HMGA1) reduce tumor growth in vivo.

Christian Maasch, Axel Vater, Klaus Buchner, Werner G Purschke, Dirk Eulberg, Stefan Vonhoff, Sven Klussmann,

High mobility group A1 (HMGA1) proteins belong to a group of architectural transcription factors that are overexpressed in a range of human malignancies, including pancreatic adenocarcinoma. They promote anchorage-independent growth and epithelial-mesenchymal transition and are therefore suggested as potential therapeutic targets. Employing in vitro selection techniques against a chosen fragment ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2010, 285(51):40012-40018]

Cited: 18 times

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SDF-I binding nucleic acids

WERNER PURSCHKE, FLORIAN JAROSCH, DIRK EULBERG, SVEN KLUSSAMANN, KLAUS BUCHNER, CHRISTIAN MAASCH, NICOLE DINSE,

The present invention is related to a nucleic acid molecule, preferably binding to SDF-I, selected from the group comprising type A nucleic acid molecules, type B nucleic acid molecules, type C nucleic acid molecules and nucleic acid molecules having a nucleic acid sequence according to any of SEQ.ID.No. 142, SEQ.ID.No. ... Read more >>

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Physicochemical stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for therapeutic applications.

Christian Maasch, Klaus Buchner, Dirk Eulberg, Stefan Vonhoff, Sven Klussmann,

Spiegelmers are structured mirror-image oligonucleotides that are designed to bind and inhibit pharmacologically relevant target molecules. The synthesis and purification of mirror-image oligonucleotides is comparable to the manufacturing of standard oligonucleotides that consist of naturally configured nucleotides. Due to the use of the non-natural L-nucleotides in Spiegelmers, these oligonucleotides show ... Read more >>

Nucleic Acids Symp Ser (Oxf) (Nucleic acids symposium series (2004))
[2008, (52):61-62]

Cited: 7 times

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Novel use of enantiomer

FLORIAN JAROSCH, CHRISTIAN MAASCH, SVEN KLUSSMANN, AXEL VATER, DIRK EULBERG, WERNER PURSCHKE, KLAUS BUCHNER,

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MCP-1 binding nucleic acids

WERNER PURSCHKE, FLORIAN JAROSCH, DIRK EULBERG, SVEN KLUSSMANN, KLAUS BUCHNER, CHRISTIAN MAASCH,

The present invention is related to a nucleic acid, preferably binding to MCP-I, selected from the group comprising type IA nucleic acids, type IB nucleic acids, type 2 nucleic acids, type 3 nucleic acids, type 4 nucleic acids and nucleic acids having a nucleic acid sequence according to any of ... Read more >>

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Nucleic acids specifically binding bioactive ghrelin

SVEN KLUSSMANN, STEFFEN HELMLING, DIRK EULBERG, CHRISTIAN MAASCH, KLAUS BUCHNER,

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Ghrelin binding nucleic acids

FLORIAN JAROSCH, DIRK EULBERG, CHRISTIAN MAASCH, STEFFEN HELMLING, SVEN KLUSSMANN,

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Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer.

Steffen Helmling, Christian Maasch, Dirk Eulberg, Klaus Buchner, Werner Schröder, Christian Lange, Stefan Vonhoff, Britta Wlotzka, Matthias H Tschöp, Stefan Rosewicz, Sven Klussmann,

Employing in vitro selection techniques, we have generated biostable RNA-based compounds, so-called Spiegelmers, that specifically bind n-octanoyl ghrelin, the recently discovered endogenous ligand for the type 1a growth hormone secretagogue (GHS) receptor. Ghrelin is a potent stimulant of growth hormone release, food intake, and adiposity. We demonstrate that our lead ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2004, 101(36):13174-13179]

Cited: 65 times

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