Full Text Journal Articles by
Author Christian Heiss

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Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae.

Sabine Stoetzel, Deeksha Malhan, Ute Wild, Christian Helbing, Fathi Hassan, Sameh Attia, Klaus D Jandt, Christian Heiss, Thaqif El Khassawna,

Osseointegration is a prerequisite for the long-term success of implants. Titanium implants are preferred for their biocompatibility and mechanical properties. Nonetheless, the need for early and immediate loading requires enhancing these properties by adding bioactive coatings. In this preclinical study, extracellular matrix properties and cellular balance at the implant/bone interface ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 23(1):]

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OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images.

Gavrielle R Untracht, Rolando S Matos, Nikolaos Dikaios, Mariam Bapir, Abdullah K Durrani, Teemapron Butsabong, Paola Campagnolo, David D Sampson, Christian Heiss, Danuta M Sampson,

Optical coherence tomography angiography (OCTA) performs non-invasive visualization and characterization of microvasculature in research and clinical applications mainly in ophthalmology and dermatology. A wide variety of instruments, imaging protocols, processing methods and metrics have been used to describe the microvasculature, such that comparing different study outcomes is currently not feasible. ... Read more >>

PLoS One (PloS one)
[2021, 16(12):e0261052]

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Metabotypes of flavan-3-ol colonic metabolites after cranberry intake: elucidation and statistical approaches.

Pedro Mena, Claudia Favari, Animesh Acharjee, Saisakul Chernbumroong, Letizia Bresciani, Claudio Curti, Furio Brighenti, Christian Heiss, Ana Rodriguez-Mateos, Daniele Del Rio,

<h4>Purpose</h4>Extensive inter-individual variability exists in the production of flavan-3-ol metabolites. Preliminary metabolic phenotypes (metabotypes) have been defined, but there is no consensus on the existence of metabotypes associated with the catabolism of catechins and proanthocyanidins. This study aims at elucidating the presence of different metabotypes in the urinary excretion of ... Read more >>

Eur J Nutr (European journal of nutrition)
[2021, :]

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Lipid-lowering and anti-thrombotic therapy in patients with peripheral arterial disease: European Atherosclerosis Society/European Society of Vascular Medicine Joint Statement.

Jill J F Belch, Marianne Brodmann, Iris Baumgartner, Christoph J Binder, Manuela Casula, Christian Heiss, Thomas Kahan, Paolo Parini, Pavel Poredos, Alberico L Catapano, Lale Tokgözoğlu,

Patients with peripheral arterial disease (PAD) are at very high risk of cardiovascular events, but risk factor management is usually suboptimal. This Joint Task Force from the European Atherosclerosis Society and the European Society of Vascular Medicine has updated evidence on the management on dyslipidaemia and thrombotic factors in patients ... Read more >>

Atherosclerosis (Atherosclerosis)
[2021, 338:55-63]

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Lipid-lowering and anti-thrombotic therapy in patients with peripheral arterial disease.

Jill J F Belch, Marianne Brodmann, Iris Baumgartner, Christoph J Binder, Manuela Casula, Christian Heiss, Thomas Kahan, Paolo Parini, Pavel Poredos, Alberico L Catapano, Lale Tokgözoğlu,

Patients with peripheral arterial disease (PAD) are at very high risk of cardiovascular events, but risk factor management is usually suboptimal. This Joint Task Force from the European Atherosclerosis Society and the European Society of Vascular Medicine has updated evidence on the management on dyslipidaemia and thrombotic factors in patients ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2021, 50(6):401-411]

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Impact of high on-treatment platelet reactivity after angioplasty in patients with critical limb ischemia.

Lucas Busch, Manuel Stern, René M'Pembele, Lisa Dannenberg, Philipp Mourikis, Michael Gröne, Göksen Özaslan, Yvonne Heinen, Christian Heiss, Roberto Sansone, Ragnar Huhn, Malte Kelm, Amin Polzin,

<h4>Objectives</h4>Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard of care in patients with peripheral artery disease (PAD) after percutaneous transluminal angioplasty (PTA). However, high on treatment platelet reactivity (HTPR) to DAPT is frequent and associated with major adverse limb events (MALE) in PAD patients. Nevertheless, association of MALE ... Read more >>

Vascul Pharmacol (Vascular pharmacology)
[2021, :106925]

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Structure of Lipopolysaccharide from Liberibacter crescens Is Low Molecular Weight and Offers Insight into Candidatus Liberibacter Biology.

Ian M Black, Christian Heiss, Mukesh Jain, Artur Muszyński, Russell W Carlson, Dean W Gabriel, Parastoo Azadi,

Huanglongbing (HLB) disease, also known as citrus greening disease, was first reported in the US in 2005. Since then, the disease has decimated the citrus industry in Florida, resulting in billions of dollars in crop losses and the destruction of thousands of acres of citrus groves. The causative agent of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(20):]

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Mortality, Risk Factors and Risk Assessment after Periprosthetic Femoral Fractures-A Retrospective Cohort Study.

Thaqif El Khassawna, Gero Knapp, Nadja Scheibler, Deeksha Malhan, Nike Walter, Christoph Biehl, Volker Alt, Christian Heiss, Markus Rupp,

Periprosthetic femoral fracture (PFF) is a devastating complication. Here, the authors aimed to determine the influence of the timing of surgery as a risk factor for mortality and poor postoperative outcome in patients suffering from PFF. A retrospective descriptive analysis of patients treated for PFF between January 2010 and March ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(19):]

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Resonance vibration interventions in the femur: Experimental-numerical modelling approaches.

Alexandre Presas, David Valentin, Joseph Deering, Marian Kampschulte, Bosco Yu, Kathryn Grandfield, Elisa Mele, Christoph Biehl, Gabriele A Krombach, Christian Heiss, Wolfram A Bosbach,

<h4>Motive</h4>External vibration excitation might be key to many novel non-surgical interventions for pathologies in the musculoskeletal system and in other parts of the human organism. Lack of understanding about vibration patterns, their controllability, and reproducibility are three limitations of ongoing research. This study establishes a bovine vibration model and animal ... Read more >>

J Mech Behav Biomed Mater (Journal of the mechanical behavior of biomedical materials)
[2021, 124:104850]

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Corrigendum to: Progress in aorta and peripheral cardiovascular disease research.

Lucia Mazzolai, Adriano Alatri, Alessandra Bura Rivière, Marco De Carlo, Christian Heiss, Christine Espinola-Klein, Oliver Schlager, Henrik Sillesen, Daniel Staub, José F Rodriguez-Palomares, Aline Verstraeten, Victor Aboyans, ,

Cardiovasc Res (Cardiovascular research)
[2021, 117(10):2262]

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Bone Status in a Mouse Model of Experimental Autoimmune-Orchitis.

Fabian Hemm, Monika Fijak, Jan Belikan, Marian Kampschulte, Thaqif El Khassawna, Adrian Pilatz, Christian Heiss, Katrin Susanne Lips,

Investigations in male patients with fertility disorders revealed a greater risk of osteoporosis. The rodent model of experimental autoimmune-orchitis (EAO) was established to analyze the underlying mechanisms of male infertility and causes of reduced testosterone concentration. Hence, we investigated the impact of testicular dysfunction in EAO on bone status. Male ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(15):]

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Angioplasty of Flow-Limiting Stenosis Reduces Aortic and Brachial Blood Pressure in Patients With Peripheral Artery Disease.

Lucas Busch, Yvonne Heinen, Manuel Stern, Georg Wolff, Göksen Özaslan, Konstantina Tzetou, Roberto Sansone, Christian Heiss, Malte Kelm,

Background Arterial hypertension affects cardiovascular outcome in patients with peripheral artery disease (PAD). We hypothesized that angioplasty of peripheral arterial stenoses decreases aortic (aBP) and brachial blood pressure (bBP). Methods and Results In an index cohort (n=30), we simultaneously measured aBP, bBP, augmentation index (AIx), and aortic pulse wave velocity ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(14):e019724]

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Progress in aorta and peripheral cardiovascular disease research.

Lucia Mazzolai, Adriano Alatri, Alessandra Bura Rivière, Marco De Carlo, Christian Heiss, Christine Espinola-Klein, Oliver Schlager, Henrik Sillesen, Daniel Staub, José F Rodriguez-Palomares, Aline Verstraeten, Victor Aboyans, ,

Although coronavirus disease 2019 seems to be the leading topic in research number of outstanding studies have been published in the field of aorta and peripheral vascular diseases likely affecting our clinical practice in the near future. This review article highlights key research on vascular diseases published in 2020. Some ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2021, 117(9):2045-2053]

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Low carotid intima media thickness excludes lower limb peripheral artery disease.

Christoph Kalka, Denise Surberg, Iris Baumgartner, Nicolas Diehm, Christian Heiss,

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2021, 50(4):317-318]

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Titel Treatment of Hand and Wrist Fractures with the Stryker Hand Plating System

Christoph Biehl, Sabine Stötzel, Lydia Schock, Gabor Szalay, Christian Heiss,

<h4>Background: </h4> 10% of all fractures occur in the fingers and metacarpal region. Early mobilization with preservation of grip function is the goal of any therapy for these injuries. Osteosyntheses with plates are used in complex fractures that do not allow any other treatment. The aim of this retrospective study ... Read more >>

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Experimental Evidence that (-)-Epicatechin and Anthocyanins Modulate Glucagon-Like Peptide-1 Metabolism: Relevant For Humans?

Christian Heiss, Ana Rodriguez-Mateos,

J Nutr (The Journal of nutrition)
[2021, 151(6):1365-1366]

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[Surgical treatment of the ulnar styloid process using an angle-stable hook plate in fractures and symptomatic nonunions].

Gero Knapp, Florian Möller, Christian Heiß, Matthias Mülke, Gabor Szalay,

<h4>Objective</h4>Anatomical reduction of dislocated fractures using an angle-stable hook plate. Surgical revision of symptomatic nonunions with the aim of bone regeneration.<h4>Indications</h4>Dislocated fractures of the ulnar styloid process with involvement of the ulnar fovea. Combined fractures with instability of the distal radioulnar joint and symptomatic nonunions.<h4>Contraindications</h4>Undisplaced fractures of the ulnar styloid ... Read more >>

Oper Orthop Traumatol (Operative Orthopadie und Traumatologie)
[2021, 33(5):430-435]

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Liposuction treatment improves disease-specific quality of life in lipoedema patients.

Torsten Schlosshauer, Christian Heiss, Ann-Kathrin von Hollen, Stefano Spennato, Ulrich M Rieger,

This study examined the disease-specific quality of life (QoL) in lipoedema patients undergoing treatment for the condition with liposuction. We conducted a retrospective analysis of all patients (n = 69) who underwent liposuction for treatment of lipoedema between 2004 and 2019, and gathered data on patient age, body mass index, the number ... Read more >>

Int Wound J (International wound journal)
[2021, 18(6):923-931]

Cited: 1 time

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Maximization of Open Hospital Capacity under Shortage of SARS-CoV-2 Vaccines-An Open Access, Stochastic Simulation Tool.

Wolfram A Bosbach, Martin Heinrich, Rainer Kolisch, Christian Heiss,

<i>Motive.</i> The Covid-19 pandemic has led to the novel situation that hospitals must prioritize staff for a vaccine rollout while there is acute shortage of the vaccine. In spite of the availability of guidelines from state agencies, there is partial confusion about what an optimal rollout plan is. This study ... Read more >>

Vaccines (Basel) (Vaccines)
[2021, 9(6):]

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DXA reference values of the humanoid sheep model in preclinical studies.

Christoph Biehl, Jakob Schmitt, Sabine Stoetzel, Deeksha Malhan, Fathi Hassan, Gero Knapp, Christian Heiss, Thaqif El Khassawna,

<h4>Background</h4>Merino land sheep are a popular pre-clinical large animal model in research on systemic skeletal diseases such as osteoporosis. Interpretation of studies is difficult because many reference parameters are missing or not established. This study aims to determine the reference parameters of the skeletal system (peak bone mass = PBM, ... Read more >>

PeerJ (PeerJ)
[2021, 9:e11183]

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Central and peripheral arterial diseases in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kirsten L Johansen, Pranav S Garimella, Caitlin W Hicks, Philip A Kalra, Dearbhla M Kelly, Sven Martens, Kunihiro Matsushita, Pantelis Sarafidis, Manish M Sood, Charles A Herzog, Michael Cheung, Michel Jadoul, Wolfgang C Winkelmayer, Holger Reinecke, ,

Chronic kidney disease (CKD) affects about 10% of all populations worldwide, with about 2 million people requiring dialysis. Although patients with CKD are at high risk of cardiovascular disease and events, they are often underrepresented or excluded in clinical trials, leading to important knowledge gaps about how to treat these ... Read more >>

Kidney Int (Kidney international)
[2021, 100(1):35-48]

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Long-Term Results of the Modular Physiological Wrist Prosthesis (MPW®) in Patients with Inflammatory Diseases.

Christoph Biehl, Martin Stoll, Martin Heinrich, Lotta Biehl, Jochen Jung, Christian Heiss, Gabor Szalay,

The wrist is among the predilection sites of over 90% of cases of rheumatoid arthritis (RA). In advanced cases, total wrist arthroplasty (TWA) is an alternative to arthrodesis. The aim of this study is to present the long-term results of the modular physiological wrist prosthesis (MPW<sup>®</sup>) and to match them ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(4):]

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Implant resonance and the mechanostat theory: Applications of therapeutic ultrasound for porous metallic scaffolds.

Joseph Deering, Alexandre Presas, Bosco Yu, David Valentin, Christian Heiss, Wolfram A Bosbach, Kathryn Grandfield,

The development of treatment strategies for improving secondary stability at the bone-implant interface is a challenge. Porous implants are one solution for improving long-term implant stability, but the osteoconduction process of implants into the bone can be slow. Strain-driven osteogenesis from the mechanostat theory offers insight into pathways for post-operative ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2021, 125:112070]

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Surgical treatment outcome after serial debridement of infected nonunion-A retrospective cohort study.

Markus Rupp, Stefanie Kern, Nike Walter, Lydia Anastasopoulou, Reinhard Schnettler, Christian Heiss, Volker Alt,

<h4>Purpose</h4>Reported outcome after multiple staged surgical treatment of infected nonunion is scarce. We, therefore, asked: (1) What is the clinical outcome in infected nonunion patients after multiple staged revision surgery? (2) Are different pathogens evidenced after surgical treatment in patients who have undergone more or less surgeries?<h4>Methods</h4>All enrolled patients were ... Read more >>

Eur J Orthop Surg Traumatol (European journal of orthopaedic surgery & traumatology : orthopedie traumatologie)
[2022, 32(1):183-189]

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Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model.

Markus Rupp, Christoph Biehl, Deeksha Malhan, Fathi Hassan, Sameh Attia, Sebastian Rosch, Annemarie B Schäfer, Erin McMahon, Marian Kampschulte, Christian Heiss, Thaqif El Khassawna,

Osteoporosis is a common metabolic disorder diagnosed by lower bone density and higher risk of fracture. Fragility fractures because of osteoporosis are associated with high mortality rate. Deep understanding of fracture healing in osteoporosis is important for successful treatment. Therefore, the FDA approved the use of small and large animal ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(3):]

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