Full Text Journal Articles by
Author Christian Dierkes


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[Very rare cases of periprosthetic malignant neoplasms : Data from 4000 cases of endoprosthetic joint replacements from the histopathologic implant register].

Kevin Keidel, Marc Thomsen, Christian Dierkes, Holger Haas, Ingo Arnold, Karl-Dieter Heller, Vincent Krenn, Martin Liebisch, Mike Otto, Thorsten Gehrke, Veit Krenn,

BACKGROUND:In 2016, the AG 11 (work group for implant-material-intolerance) of the German society for Orthopaedics and Orthopaedic Surgery (DGOOC) created a histopathologic implant register (HIR). The goal was to conduct a retrospective data analysis based on the revised SLIM-consensus-classification, which defines eight different failure mechanisms. QUESTIONS:The analysis of 4000 cases of endoprosthetic joint replacements ... Read more >>

Orthopade (Der Orthopade)
[2020, 49(3):248-254]

Cited: 1 time

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Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis.

Marian Kampschulte, Christiane Stöckl, Alexander C Langheinrich, Ulrike Althöhn, Rainer M Bohle, Gabriele A Krombach, Philipp Stieger, Yuri Churin, Sandra Kremer, Christian Dierkes, Timo Rath, Elke Roeb, Martin Roderfeld,

Nonalcoholic fatty liver disease has been linked to cardiovascular diseases and atherosclerosis. The aim of the current study was to characterize the hepatic pathology leading to fibrosis and tumors in a murine model of atherosclerosis. Male apolipoprotein E/low-density lipoprotein receptor double-knockout mice (AL) mice were fed with a high fat ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2014, 94(11):1273-1282]

Cited: 16 times

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Scar sarcoidosis on a finger mimicking a rapidly growing soft tissue tumour: a case report.

Marcel-Philipp Henrichs, Arne Streitbürger, Georg Gosheger, Carsten Surke, Christian Dierkes, Jendrik Hardes,

<h4>Background</h4>Scar sarcoidosis is a rare and uncommon but specific cutaneous manifestation of sarcoidosis. In general it arises in pre-existing scars deriving from mechanical traumas. As most surgeons dealing with scars might not be aware of cutaneous sarcoidosis and its different types of appearance the appropriate staging and treatment might be ... Read more >>

BMC Res Notes (BMC research notes)
[2012, 5:545]

Cited: 3 times

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Bone marrow transplantation improves hepatic fibrosis in Abcb4-/- mice via Th1 response and matrix metalloproteinase activity.

Martin Roderfeld, Timo Rath, Sravanthi Pasupuleti, Marc Zimmermann, Caterina Neumann, Yuri Churin, Christian Dierkes, Robert Voswinckel, Peter J Barth, Daniel Zahner, Jürgen Graf, Elke Roeb,

<h4>Objective</h4>Reports on the effects of bone marrow-derived cells on hepatic fibrosis are contradictory. Impaired fibrosis but increased inflammation has recently been demonstrated 10 weeks after bone marrow transplantation (BM-Tx) in Abcb4-/- mice. It is hypothesised that BM-Tx might have long-term therapeutic potential by altering the immunological and matrix remodelling processes ... Read more >>

Gut (Gut)
[2012, 61(6):907-916]

Cited: 14 times

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Innovative immunohistochemistry identifies MMP-9 expressing macrophages at the invasive front of murine HCC.

Martin Roderfeld, Timo Rath, Frank Lammert, Christian Dierkes, Jürgen Graf, Elke Roeb,

<h4>Aim</h4>To investigate the proteolytic contribution of tumor-associated macrophages (TAM) in tumor invasion, we analyzed whether TAM at the invasive front of small HCC in Abcb4(-/-)-mice show an enhanced expression of MMP-9.<h4>Methods</h4>Liver cryosections of the hepatocellular carcinoma (HCC) invasive front from 12 mo old Abcb4(-/-)-mice were stained for collagen type I ... Read more >>

World J Hepatol (World journal of hepatology)
[2010, 2(5):175-179]

Cited: 20 times

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Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma.

Jan Smida, Daniel Baumhoer, Michael Rosemann, Axel Walch, Stefan Bielack, Christopher Poremba, Klaus Remberger, Eberhard Korsching, Wolfram Scheurlen, Christian Dierkes, Stefan Burdach, Gernot Jundt, Michael J Atkinson, Michaela Nathrath,

<h4>Purpose</h4>Osteosarcoma, the most common primary malignant tumor of the bone, is characterized by complex karyotypes with numerous structural and numerical alterations. Despite attempts to establish molecular prognostic markers at the time of diagnosis, the most accepted predictive factor remains the histologic evaluation of necrosis after neoadjuvant chemotherapy. The present approach ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2010, 16(16):4256-4267]

Cited: 58 times

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Atherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE-/-/LDL-/- double knockout mice.

Alexander C Langheinrich, Marian Kampschulte, Franziska Scheiter, Christian Dierkes, Philip Stieger, Rainer M Bohle, Wolfgang Weidner,

<h4>Background</h4>The apoE-/-/LDL-/- double knockout mice are bearing considerable structural homology to human atherosclerosis. We hypothesized, that advanced lesion formation in the renal artery is associated with kidney alterations in these mice.<h4>Methods</h4>Kidneys from apoE-/-/LDL-/- double knockout mice at the age of 80 weeks (n = 6) and C57/BL control mice (n ... Read more >>

BMC Nephrol (BMC nephrology)
[2010, 11:18]

Cited: 10 times

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In vitro evaluation of the sinus sagittalis superior thrombosis model in the rat using 3D micro- and nanocomputed tomography.

Alexander Claus Langheinrich, Mesut Yeniguen, Anne Ostendorf, Simone Marhoffer, Christian Dierkes, Susanne von Gerlach, Max Nedelmann, Marian Kampschulte, Georg Bachmann, Erwin Stolz, Tibo Gerriets,

<h4>Introduction</h4>Thrombosis of the cerebral veins and sinus are common causes of stroke. Animal models help us to understand the underlying pathophysiology of this condition. Therefore, the purpose of our study was to evaluate a well-established model for sinus sagittalis (SSS) thrombosis using micro- and nanocomputed tomography (CT) imaging.<h4>Methods</h4>SSS thrombosis was ... Read more >>

Neuroradiology (Neuroradiology)
[2010, 52(9):815-821]

Cited: 7 times

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Bone marrow transplantation demonstrates medullar origin of CD34+ fibrocytes and ameliorates hepatic fibrosis in Abcb4-/- mice.

Martin Roderfeld, Timo Rath, Robert Voswinckel, Christian Dierkes, Hartmut Dietrich, Daniel Zahner, Jürgen Graf, Elke Roeb,

<h4>Unlabelled</h4>Bone marrow (BM)-derived stem cells and CD34(+) fibrocytes are associated with fibrogenesis in several organs. In an Abcb4(-/-) mouse model for sclerosing cholangitis alpha-smooth muscle actin-positive (alpha-SMA(+)) myofibroblasts are thought to play a pivotal role in hepatic fibrogenesis. The aim of this study was 2-fold: (1) to demonstrate that the ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2010, 51(1):267-276]

Cited: 47 times

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[Interindividual variability, pathological changes and decomposition as an impediment to the morphological determination of human specificity of bone finds].

Marcel A Verhoff, Nele Rensing, Kerstin Kreutz, Christian Dierkes, Frank Ramsthaler,

Playing children discovered several teeth close to the wall surrounding a village church. A subsequent police search yielded further teeth, three neurocranial fragments, a metacarpal bone and the fragment of a long tubular bone. The circumstances along with the results of the investigation and the morphological findings suggested historical bones ... Read more >>

Arch Kriminol (Archiv fur Kriminologie)
[2008, 221(3-4):99-112]

Cited: 0 times

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Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors.

Leander Ermert, Christian Dierkes, Monika Ermert,

<h4>Purpose</h4>Prostanoids are important mediators of pulmonary vaso- and bronchotone regulation and strongly influence inflammatory reactivity. The product of cyclooxygenase (Cox), prostaglandin H(2), is further metabolized via downstream enzymes into the different effective metabolites. The specific cellular equipment with certain downstream enzymes crucially determines the cellular reactivity by generation of functionally ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2003, 9(5):1604-1610]

Cited: 62 times

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Cyclooxygenase-2-dependent and thromboxane-dependent vascular and bronchial responses are regulated via p38 mitogen-activated protein kinase in control and endotoxin-primed rat lungs.

Monika Ermert, Daniel Kuttner, Nils Eisenhardt, Christian Dierkes, Werner Seeger, Leander Ermert,

Mitogen-activated protein kinases (MAPKs) are part of an intracellular signaling machinery consisting of three known distinct pathways, each leading to activation of a different protein kinase: p38, ERK (extracellular signal-regulated kinase), or JNK (c-Jun N-terminal kinase). We investigated the role of the p38 MAPK pathway in the phenomenon of lung ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2003, 83(3):333-347]

Cited: 4 times

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