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Author Christian Bauer

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The German National Case Collection for Familial Pancreatic Carcinoma (FaPaCa)—Knowledge Gained in 20 Years.

Detlef Klaus Bartsch, Elvira Matthäi, Ioannis Mintziras, Christian Bauer, Jens Figiel, Mercede Sina-Boemers, Thomas M Gress, Peter Langer, Emily P Slater,

<h4>Background</h4>Familial pancreatic carcinoma (FPC) is a rare hereditary tumor syndrome with a heterogeneous clinical phenotype. The study of FPC also contributes to a better understanding of the more common sporadic pancreatic ductal adenocarcinoma (PDAC). We report on the past 20 years' experience of the German National Case Collection for Familial ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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High fidelity simulation to assess task load index and performance: a prospective observational study

Jérémy Favre-Félix, Mikhail Dziadzko, Christian Bauer, Antoine Duclos, Jean-Jacques Lehot, Thomas Rimmelé, Marc Lilot,

<h4>Background: </h4> The NASA Task Load IndeX (NASA-TLX) is a questionnaire widely used in aviation. This index might help for attesting the quality of a scenario in high-fidelity simulation (HFS) in healthcare. The main purpose of this study was to observe whether the score of NASA-TLX for critical care simulated ... Read more >>

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Multiple Sclerosis Data Alliance - A global multi-stakeholder collaboration to scale-up real world data research.

Liesbet M Peeters, Tina Parciak, Dipak Kalra, Yves Moreau, Elisabeth Kasilingam, Pieter van Galen, Christoph Thalheim, Bernard Uitdehaag, Patrick Vermersch, Niels Hellings, Piet Stinissen, Bart Van Wijmeersch, Amin Ardeshirdavani, Ashkan Pirmani, Edward De Brouwer, Christian Robert Bauer, Dagmar Krefting, Stephanie Ribbe, Rod Middleton, Alexander Stahmann, Giancarlo Comi,

The Multiple Sclerosis Data Alliance (MSDA), a global multi-stakeholder collaboration, is working to accelerate research insights for innovative care and treatment for people with multiple sclerosis (MS) through better use of real-world data (RWD). Despite the increasing reliance on RWD, challenges and limitations complicate the generation, collection, and use of ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2021, 47:102634]

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Hydrogen from Wood Gasification with CCS - a Technoenvironmental Analysis of Production and Use as Transport Fuel

Cristina Antonini, Karin Treyer, Emanuele Moioli, christian bauer, Marco Mazzotti,

<p>In the presented work, we performed an integrated techno-environmental assessment of hydrogen production from woody biomass gasification, combined with CO<sub>2</sub> capture and storage (CCS). We have included three different types of gasification technologies for syngas production. CO<sub>2</sub> is captured from the syngas with conventional amine-based technology. Based on our integrated ... Read more >>

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IL-18 but Not IL-1 Signaling Is Pivotal for the Initiation of Liver Injury in Murine Non-Alcoholic Fatty Liver Disease.

Simon Hohenester, Veronika Kanitz, Tobias Schiergens, Claudia Einer, Jutta Nagel, Ralf Wimmer, Florian P Reiter, Alexander L Gerbes, Enrico N De Toni, Christian Bauer, Lesca Holdt, Doris Mayr, Christian Rust, Max Schnurr, Hans Zischka, Andreas Geier, Gerald Denk,

Non-alcoholic fatty liver disease (NAFLD) is rising in prevalence, and a better pathophysiologic understanding of the transition to its inflammatory phenotype (NASH) is key to the development of effective therapies. To evaluate the contribution of the NLRP3 inflammasome and its downstream effectors IL-1 and IL-18 in this process, we applied ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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Echinococcus multilocularis infection in horses in Poland.

Krzysztof Tomczuk, Jörg Hirzmann, Kernt Köhler, Klaudiusz Szczepaniak, Maria Studzinska, Marta Demkowska-Kutrzepa, Monika Roczeń-Karczmarz, Christian Bauer,

A cross-sectional survey was performed to obtain first information on the prevalence of Echinococcus multilocularis infection in slaughter horses from central, eastern and southern Poland, a country with a highly endemic occurrence of this tapeworm in red foxes. White tough nodular lesions being 3-10 mm in size, sharply demarcated and spherically ... Read more >>

Vet Parasitol Reg Stud Reports (Veterinary parasitology, regional studies and reports)
[2020, 22:100486]

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The POLD1R689W variant increases the sensitivity of colorectal cancer cells to ATR and CHK1 inhibitors.

Albert Job, Marina Tatura, Cora Schäfer, Veronika Lutz, Hanna Schneider, Brigitte Lankat-Buttgereit, Alexandra Zielinski, Kerstin Borgmann, Christian Bauer, Thomas M Gress, Malte Buchholz, Eike Gallmeier,

Inhibition of the kinase ATR, a central regulator of the DNA damage response, eliminates subsets of cancer cells in certain tumors. As previously shown, this is at least partly attributable to synthetic lethal interactions between ATR and POLD1, the catalytic subunit of the polymerase δ. Various POLD1 variants have been ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):18924]

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Pterygodermatites nycticebi infections in golden lion tamarins (Leontopithecus rosalia rosalia) and aye-ayes (Daubentonia madagascariensis) from a German zoo.

Liliana M R Silva, Iris Voelker, Christina Geiger, Nicole Schauerte, Joerg Hirzmann, Christian Bauer, Anja Taubert, Carlos Hermosilla,

In a golden lion tamarin (Leontopithecus rosalia rosalia) colony kept indoors in a German zoo, two animals presented a sudden onset of reduced general condition, lethargy, and diarrhea. At animal capture for clinical examination, adult nematode stages were observed after stress-induced defecation. Despite treatment, two golden lion tamarins died in ... Read more >>

Zoo Biol (Zoo biology)
[2021, 40(1):59-64]

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Endoscopic ultrasound-fine needle biopsies of pancreatic lesions: Prospective study of histology quality using Franseen needle.

Petros Stathopoulos, Anika Pehl, Lutz Philipp Breitling, Christian Bauer, Tobias Grote, Thomas Mathias Gress, Carsten Denkert, Ulrike Walburga Denzer,

<h4>Background</h4>The introduction of fine needle biopsies (FNB) to clinical practice presents a changing trend towards histology in the endoscopic ultrasound-guided tissue acquisition (EUS-TA).<h4>Aim</h4>To evaluate the clinical performance of a new FNB needle, the 22-gauge (22G) Franseen needle, when sampling pancreatic solid lesions.<h4>Methods</h4>Consecutive patients with an indication for EUS-TA for the ... Read more >>

World J Gastroenterol (World journal of gastroenterology)
[2020, 26(37):5693-5704]

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The Immune Microenvironment in Pancreatic Cancer.

Magdalena Huber, Corinna U Brehm, Thomas M Gress, Malte Buchholz, Bilal Alashkar Alhamwe, Elke Pogge von Strandmann, Emily P Slater, Jörg W Bartsch, Christian Bauer, Matthias Lauth,

The biology of solid tumors is strongly determined by the interactions of cancer cells with their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) represents a paradigmatic example for the multitude of possible tumor-stroma interactions. PDAC has proven particularly refractory to novel immunotherapies, which is a fact ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(19):]

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How to Save a Life From Macroscopic Fat Embolism: A Narrative Review of Treatment Options.

Aqeel Lari, Abeer Abdulshakoor, Elie Zogheib, Nizar Assaf, Ali Mojallal, Abdul-Reda Lari, Christian Bauer, Raphael Sinna,

Macroscopic fat embolism (MAFE) has grabbed the attention of the plastic surgery community in recent years because of its high mortality rate. Many articles on preventing MAFE during gluteal fat grafting are available in the literature. However, total prevention is difficult: a number of factors, both technical and human, mean ... Read more >>

Aesthet Surg J (Aesthetic surgery journal)
[2020, 40(10):1098-1107]

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Motor fatigue is associated with asymmetric connectivity properties of the corticospinal tract in multiple sclerosis.

Christian Bauer, Tim B Dyrby, Finn Sellebjerg, Kathrine Skak Madsen, Olivia Svolgaard, Morten Blinkenberg, Hartwig Roman Siebner, Kasper Winther Andersen,

Multiple Sclerosis (MS) is characterized by demyelination and neurodegeneration of the central nervous system and causes excessive fatigue in more than 80% of the patients. The pathophysiologic mechanisms causing fatigue are still largely unknown. In 46 right-handed patients with relapsing-remitting MS and 25 right-handed controls, we performed diffusion MRI and ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 28:102393]

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Bovine Babesiosis Diagnosed in Formalin-Fixed, Paraffin-Embedded Tissues by Using In Situ Hybridization.

Kirsten Hülskötter, Vanessa M Pfankuche, Lydia van Dyck, Martin Höltershinken, Andrea Springer, Fabienne Lienhart, Sandra Ermel, Jürgen Rehage, Martina Hoedemarker, Christina Strube, Jörg Hirzmann, Christian Bauer, Wolfgang Baumgärtner, Annika Lehmbecker, Peter Wohlsein,

Bovine babesiosis, caused by <i>Babesia divergens</i>, is in general a rare disease in Europe. Nonetheless, local outbreaks can cause severe economic damage, and postmortem identification represents a diagnostic challenge. During a recent outbreak in May 2018 in northern Germany, 21 animals of a herd of 150 cattle died within 40 ... Read more >>

Vet Pathol (Veterinary pathology)
[2020, 57(6):812-820]

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Breeding Habitat Preferences of Major Culicoides Species (Diptera: Ceratopogonidae) in Germany.

Doreen Werner, Sarah Groschupp, Christian Bauer, Helge Kampen,

Biting midges of the genus <i>Culicoides</i> (Diptera, Ceratopognidae) are demonstrably or putatively involved in the transmission of both bluetongue (BTV) and Schmallenberg viruses (SBV) in Central Europe. Although these insects are ubiquitous in Europe, relatively little is known about their requirements in terms of breeding habitats and substrates. <i>Culicoides</i> species ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(14):]

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Multisite Technical and Clinical Performance Evaluation of Quantitative Imaging Biomarkers from 3D FDG PET Segmentations of Head and Neck Cancer Images.

Brian J Smith, John M Buatti, Christian Bauer, Ethan J Ulrich, Payam Ahmadvand, Mikalai M Budzevich, Robert J Gillies, Dmitry Goldgof, Milan Grkovski, Ghassan Hamarneh, Paul E Kinahan, John P Muzi, Mark Muzi, Charles M Laymon, James M Mountz, Sadek Nehmeh, Matthew J Oborski, Binsheng Zhao, John J Sunderland, Reinhard R Beichel,

Quantitative imaging biomarkers (QIBs) provide medical image-derived intensity, texture, shape, and size features that may help characterize cancerous tumors and predict clinical outcomes. Successful clinical translation of QIBs depends on the robustness of their measurements. Biomarkers derived from positron emission tomography images are prone to measurement errors owing to differences ... Read more >>

Tomography (Tomography (Ann Arbor, Mich.))
[2020, 6(2):65-76]

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Which factors influence the accuracy of knee ROM data of the BPMpathway e-rehabilitation system? A concurrent validity study with healthy subjects

Carlos J. Marques, Christian Bauer, Dafne Grimaldo, Alexander Ehlert, Timo Weber, Steffen Tabling, Alex Mendes, Jürgen Lorenz, Frank Lampe,

<h4>Aims and Objectives:</h4> As the population in different countries ages, there is an expected increase in the demand for TKA procedures in the coming decades. This increasing demand will face the healthcare systems and health care providers with new challenges. After TKA physiotherapy and exercise lead to short term improvements ... Read more >>

Orthop J Sports Med (Orthopaedic journal of sports medicine)
[2020, 8(5 suppl4):]

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Quantitative Imaging Informatics for Cancer Research.

Andrey Fedorov, Reinhard Beichel, Jayashree Kalpathy-Cramer, David Clunie, Michael Onken, Jörg Riesmeier, Christian Herz, Christian Bauer, Andrew Beers, Jean-Christophe Fillion-Robin, Andras Lasso, Csaba Pinter, Steve Pieper, Marco Nolden, Klaus Maier-Hein, Markus D Herrmann, Joel Saltz, Fred Prior, Fiona Fennessy, John Buatti, Ron Kikinis,

<h4>Purpose</h4>We summarize Quantitative Imaging Informatics for Cancer Research (QIICR; U24 CA180918), one of the first projects funded by the National Cancer Institute (NCI) Informatics Technology for Cancer Research program.<h4>Methods</h4>QIICR was motivated by the 3 use cases from the NCI Quantitative Imaging Network. 3D Slicer was selected as the platform for ... Read more >>

JCO Clin Cancer Inform (JCO clinical cancer informatics)
[2020, 4:444-453]

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Sensor Positioning Influences the Accuracy of Knee Rom Data of an E-Rehabilitation System: A Preliminary Study with Healthy Subjects.

Carlos J Marques, Christian Bauer, Dafne Grimaldo, Steffen Tabeling, Timo Weber, Alexander Ehlert, Alexandre H Mendes, Juergen Lorenz, Frank Lampe,

E-rehabilitation is the term used to define medical rehabilitation programs that are implemented at home with the use of information and communication technologies. The aim was to test whether sensor position and the sitting position of the patient influence the accuracy of knee range of movement (ROM) data displayed by ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(8):]

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Smell and taste dysfunction in patients with COVID-19.

Michael S Xydakis, Puya Dehgani-Mobaraki, Eric H Holbrook, Urban W Geisthoff, Christian Bauer, Charlotte Hautefort, Philippe Herman, Geoffrey T Manley, Dina M Lyon, Claire Hopkins,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(9):1015-1016]

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The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults.

Anne Theil Gylling, Christian Skou Eriksen, Ellen Garde, Cathrine Lawaetz Wimmelmann, Nina Linde Reislev, Theresa Bieler, Andreas Kraag Ziegler, Kasper Winther Andersen, Christian Bauer, Kasper Dideriksen, Maria Baekgaard, Kenneth Hudlebusch Mertz, Monika Lucia Bayer, Mads Bloch-Ibenfeldt, Carl-Johan Boraxbekk, Hartwig Roman Siebner, Erik Lykke Mortensen, Michael Kjaer,

BACKGROUND:Physical muscle function and brain hippocampus size declines with age, accelerating after the age of 60. Strength training over a few months improves physical function, but less is known about how long-term strength training affects physical function and hippocampus volume. Therefore, we aimed to investigate the effect of 1-year strength ... Read more >>

Exp Gerontol (Experimental gerontology)
[2020, 136:110939]

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Energy System Pathways with Low Environmental Impacts and Limited Costs: Minimizing Climate Change Impacts Produces Environmental Cobenefits and Challenges in Toxicity and Metal Depletion Categories.

Laurent Vandepaer, Evangelos Panos, Christian Bauer, Ben Amor,

Environmental indicators based on the life cycle assessment method are integrated into an energy system model. This integration allows for the generation of comprehensive environmental assessments of future energy systems and for determining energy scenarios with less environmental impacts and moderate cost increases. In Switzerland, which is used as a ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2020, 54(8):5081-5092]

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A 3D deep convolutional neural network approach for the automated measurement of cerebellum tracer uptake in FDG PET-CT scans.

Xiaofan Xiong, Timothy J Linhardt, Weiren Liu, Brian J Smith, Wenqing Sun, Christian Bauer, John J Sunderland, Michael M Graham, John M Buatti, Reinhard R Beichel,

<h4>Purpose</h4>The purpose of this work was to assess the potential of deep convolutional neural networks in automated measurement of cerebellum tracer uptake in F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) scans.<h4>Methods</h4>Three different three-dimensional (3D) convolutional neural network architectures (U-Net, V-Net, and modified U-Net) were implemented and compared regarding their performance ... Read more >>

Med Phys (Medical physics)
[2020, 47(3):1058-1066]

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Applying FAIRness: Redesigning a Biomedical Informatics Research Data Management Pipeline.

Marcel Parciak, Theresa Bender, Ulrich Sax, Christian Robert Bauer,

BACKGROUND: Managing research data in biomedical informatics research requires solid data governance rules to guarantee sustainable operation, as it generally involves several professions and multiple sites. As every discipline involved in biomedical research applies its own set of tools and methods, research data as well as applied methods tend to branch ... Read more >>

Methods Inf Med (Methods of information in medicine)
[2019, 58(6):229-234]

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Provenance Solutions for Medical Research in Heterogeneous IT-Infrastructure: An Implementation Roadmap.

Marcel Parciak, Christian Bauer, Theresa Bender, Robert Lodahl, Björn Schreiweis, Erik Tute, Ulrich Sax,

Research data generated in large projects raise challenges about not only data analytics but also data quality assessments and data governance. The provenance of a data set - that is the history of data sets - holds information relevant to technicians and non-technicians and is able to answer questions regarding ... Read more >>

Stud Health Technol Inform (Studies in health technology and informatics)
[2019, 264:298-302]

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[Simulation of difficult airway management for residents: prospective comparative study].

Marc Lilot, Jean-Noel Evain, Alban Vincent, Guillain Gaillard, Dominique Chassard, Laurent Mattatia, Jacques Ripart, Lucas Denoyel, Christian Bauer, Philip Robinson, Antoine Duclos, Jean-Jacques Lehot, Thomas Rimmelé,

<h4>Background and objectives</h4>Procedural simulation training for difficult airway management offers acquisition opportunities. The hypothesis was that 3 hours of procedural simulation training for difficult airway management improves: acquisition, behavior, and patient outcomes as reported 6 months later.<h4>Methods</h4>This prospective comparative study took place in two medical universities. Second-year residents of anesthesiology ... Read more >>

Rev Bras Anestesiol (Revista brasileira de anestesiologia)
[2019, 69(4):358-368]

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