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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Surviving Critical Illness: The First Turn on the Long and Winding Road Back to Normalcy.

Christa Schorr, Brendan Gill,

Crit Care Med (Critical care medicine)
[2021, 49(11):1988-1991]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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50 Years of Sepsis Investigation/Enlightenment Among Adults-The Long and Winding Road.

R Phillip Dellinger, Mitchell M Levy, Christa A Schorr, Sean R Townsend,

Crit Care Med (Critical care medicine)
[2021, 49(10):1606-1625]

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Rapid Development and Deployment of an Intensivist-Led Venovenous Extracorporeal Membrane Oxygenation Cannulation Program.

Michael Kouch, Adam Green, Emily Damuth, Christopher Noel, Jason Bartock, Michael Rosenbloom, Christa Schorr, Robert Rios, Nancy Loperfido, Nitin Puri,

<h4>Objectives</h4>To determine the safety and efficacy of a rapidly deployed intensivist-led venovenous extracorporeal membrane oxygenation cannulation program in a preexisting extracorporeal membrane oxygenation program.<h4>Design</h4>A retrospective observational before-and-after study of 40 patients undergoing percutaneous cannulation for venovenous extracorporeal membrane oxygenation in an established cannulation program by cardiothoracic surgeons versus a rapidly ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States.

Julia L Jezmir, Maheetha Bharadwaj, Alexander Chaitoff, Bradford Diephuis, Conor P Crowley, Sandeep P Kishore, Eric Goralnick, Louis T Merriam, Aimee Milliken, Chanu Rhee, Nicholas Sadovnikoff, Sejal B Shah, Shruti Gupta, David E Leaf, William B Feldman, Edy Y Kim, ,

Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the ... Read more >>

Cell Rep Med (Cell reports. Medicine)
[2021, 2(9):100376]

Cited: 1 time

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Effects of Compliance With the Early Management Bundle (SEP-1) on Mortality Changes Among Medicare Beneficiaries With Sepsis: A Propensity Score Matched Cohort Study.

Sean R Townsend, Gary S Phillips, Reena Duseja, Lemeneh Tefera, Derek Cruikshank, Robert Dickerson, H Bryant Nguyen, Christa A Schorr, Mitchell M Levy, R Phillip Dellinger, William A Conway, Warren S Browner, Emanuel P Rivers,

<h4>Background</h4>US hospitals have reported compliance with the SEP-1 quality measure to Medicare since 2015. Finding an association between compliance and outcomes is essential to gauge measure effectiveness.<h4>Research question</h4>What is the association between compliance with SEP-1 and 30-day mortality among Medicare beneficiaries?<h4>Study design and methods</h4>Studying patient-level data reported to Medicare by ... Read more >>

Chest (Chest)
[2021, :]

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Obesity, inflammatory and thrombotic markers, and major clinical outcomes in critically ill patients with COVID-19 in the US.

Allon N Friedman, John Guirguis, Rajat Kapoor, Shruti Gupta, David E Leaf, Lava R Timsina, ,

<h4>Objective</h4>This study aimed to determine whether obesity is independently associated with major adverse clinical outcomes and inflammatory and thrombotic markers in critically ill patients with COVID-19.<h4>Methods</h4>The primary outcome was in-hospital mortality in adults with COVID-19 admitted to intensive care units across the US. Secondary outcomes were acute respiratory distress syndrome ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2021, 29(10):1719-1730]

Cited: 1 time

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Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

, , , Patrick R Lawler, Ewan C Goligher, Jeffrey S Berger, Matthew D Neal, Bryan J McVerry, Jose C Nicolau, Michelle N Gong, Marc Carrier, Robert S Rosenson, Harmony R Reynolds, Alexis F Turgeon, Jorge Escobedo, David T Huang, Charlotte A Bradbury, Brett L Houston, Lucy Z Kornblith, Anand Kumar, Susan R Kahn, Mary Cushman, Zoe McQuilten, Arthur S Slutsky, Keri S Kim, Anthony C Gordon, Bridget-Anne Kirwan, Maria M Brooks, Alisa M Higgins, Roger J Lewis, Elizabeth Lorenzi, Scott M Berry, Lindsay R Berry, Aaron W Aday, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Todd W Costantini, Sophie de Brouwer, Lennie P G Derde, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Sebastian García-Madrona, Timothy D Girard, Lucas C Godoy, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Naomi M Hamburg, Rashan Haniffa, George Hanna, Nicholas Hanna, Sheila M Hegde, Carolyn M Hendrickson, R Duncan Hite, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Vivek N Iyer, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei L Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Vidya Krishnan, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Jose L Lopez-Sendon Moreno, Sylvain A Lother, Saurabh Malhotra, Miguel Marcos, Andréa Saud Marinez, John C Marshall, Nicole Marten, Michael A Matthay, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Steven C Moore, Raquel Morillo Guerrero, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Brenda Nunez-Garcia, Ambarish Pandey, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Yessica S Pérez González, Mauricio Pompilio, Matthew E Prekker, John G Quigley, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler Olombrada Santos, Lewis Satterwhite, Christina T Saunders, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Manu Shankar-Hari, John P Sheehan, Aneesh B Singhal, Dayna Solvason, Simon J Stanworth, Tobias Tritschler, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, Bryan J Wells, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Fernando G Zampieri, Derek C Angus, Colin J McArthur, Steven A Webb, Michael E Farkouh, Judith S Hochman, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.<h4>Methods</h4>In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):790-802]

Cited: 17 times

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Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.

, , , Ewan C Goligher, Charlotte A Bradbury, Bryan J McVerry, Patrick R Lawler, Jeffrey S Berger, Michelle N Gong, Marc Carrier, Harmony R Reynolds, Anand Kumar, Alexis F Turgeon, Lucy Z Kornblith, Susan R Kahn, John C Marshall, Keri S Kim, Brett L Houston, Lennie P G Derde, Mary Cushman, Tobias Tritschler, Derek C Angus, Lucas C Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E Farkouh, Maria M Brooks, Roger J Lewis, Lindsay R Berry, Elizabeth Lorenzi, Anthony C Gordon, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W Costantini, Sophie de Brouwer, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Heather F Eng, Jorge Escobedo, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Joshua D Froess, Zhuxuan Fu, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Timothy D Girard, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Rashan Haniffa, Sheila M Hegde, Carolyn M Hendrickson, Alisa M Higgins, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, David T Huang, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A Lother, Nicole Marten, Andréa Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Jose C Nicolau, Brenda Nunez-Garcia, John J Park, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Mauricio Pompilio, John G Quigley, Robert S Rosenson, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler O Santos, Lewis Satterwhite, Christina T Saunders, Jake Schreiber, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Aneesh B Singhal, Arthur S Slutsky, Dayna Solvason, Simon J Stanworth, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Yongqi Zhong, Scott M Berry, Colin J McArthur, Matthew D Neal, Judith S Hochman, Steven A Webb, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.<h4>Methods</h4>In an open-label, adaptive, multiplatform, randomized clinical trial, critically ill patients with severe Covid-19 were randomly assigned to a pragmatically defined ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):777-789]

Cited: 23 times

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Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Respiratory Failure.

Kusum S Mathews, Howard Soh, Shahzad Shaefi, Wei Wang, Sonali Bose, Steven Coca, Shruti Gupta, Salim S Hayek, Anand Srivastava, Samantha K Brenner, Jared Radbel, Adam Green, Anne Sutherland, Amanda Leonberg-Yoo, Alexandre Shehata, Edward J Schenck, Samuel A P Short, Miguel A Hernán, Lili Chan, David E Leaf, ,

<h4>Objectives</h4>Therapies for patients with respiratory failure from coronavirus disease 2019 are urgently needed. Early implementation of prone positioning ventilation improves survival in patients with acute respiratory distress syndrome, but studies examining the effect of proning on survival in patients with coronavirus disease 2019 are lacking. Our objective was to estimate ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(7):1026-1037]

Cited: 4 times

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d-dimer and Death in Critically Ill Patients With Coronavirus Disease 2019.

Samuel A P Short, Shruti Gupta, Samantha K Brenner, Salim S Hayek, Anand Srivastava, Shahzad Shaefi, Harkarandeep Singh, Benjamin Wu, Aranya Bagchi, Hanny Al-Samkari, Rajany Dy, Katherine Wilkinson, Neil A Zakai, David E Leaf, ,

<h4>Objectives</h4>Hypercoagulability may be a key mechanism for acute organ injury and death in patients with severe coronavirus disease 2019, but the relationship between elevated plasma levels of d-dimer, a biomarker of coagulation activation, and mortality has not been rigorously studied. We examined the independent association between d-dimer and death in ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(5):e500-e511]

Cited: 2 times

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Identification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19.

Charles R Vasquez, Shruti Gupta, Todd A Miano, Meaghan Roche, Jesse Hsu, Wei Yang, Daniel N Holena, John P Reilly, Sarah J Schrauben, David E Leaf, Michael G S Shashaty, ,

<h4>Background</h4>Subphenotypes have been identified in patients with sepsis and ARDS and are associated with different outcomes and responses to therapies.<h4>Research question</h4>Can unique subphenotypes be identified among critically ill patients with COVID-19?<h4>Study design and methods</h4>Using data from a multicenter cohort study that enrolled critically ill patients with COVID-19 from 67 hospitals ... Read more >>

Chest (Chest)
[2021, 160(3):929-943]

Cited: 0 times

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Hospital-Level Variation in Death for Critically Ill Patients with COVID-19.

Matthew M Churpek, Shruti Gupta, Alexandra B Spicer, William F Parker, John Fahrenbach, Samantha K Brenner, David E Leaf, ,

<h4>Rationale</h4>Variation in hospital mortality has been described for coronavirus disease 2019 (COVID-19), but the factors that explain these differences remain unclear.<h4>Objective</h4>Our objective was to utilize a large, nationally representative dataset of critically ill adults with COVID-19 to determine which factors explain mortality variability.<h4>Methods</h4>In this multicenter cohort study, we examined adults ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, :]

Cited: 5 times

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Establishing a Peer Support Program for Survivors of COVID-19: A Report From the Critical and Acute Illness Recovery Organization.

Aluko A Hope, Andrea Annie Johnson, Joanne McPeake, Hali Felt, Carla M Sevin, Mark E Mikkelsen, Theodore J Iwashyna, Caroline Lassen-Greene, Kimberley J Haines, Sachin Agarwal, Rita N Bakhru, Leanne M Boehm, Brad W Butcher, Kelly Drumright, Tammy L Eaton, Elizabeth Hibbert, Karen Sara Hoehn, David Hornstein, Heather Imperato-Shedden, James C Jackson, Janet A Kloos, Anna Lewis, Joel Meyer, Ashley Montgomery-Yates, Veronica Rojas, Christa Schorr, Dorothy Wade, Cydni Williams,

Am J Crit Care (American journal of critical care : an official publication, American Association of Critical-Care Nurses)
[2021, :e1-e5]

Cited: 0 times

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Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry.

Juan Pablo Domecq, Amos Lal, Christopher R Sheldrick, Vishakha K Kumar, Karen Boman, Scott Bolesta, Vikas Bansal, Michael O Harhay, Michael A Garcia, Margit Kaufman, Valerie Danesh, Sreekanth Cheruku, Valerie M Banner-Goodspeed, Harry L Anderson, Patrick S Milligan, Joshua L Denson, Catherine A St Hill, Kenneth W Dodd, Greg S Martin, Ognjen Gajic, Allan J Walkey, Rahul Kashyap, ,

<h4>Objectives</h4>To describe the outcomes of hospitalized patients in a multicenter, international coronavirus disease 2019 registry.<h4>Design</h4>Cross-sectional observational study including coronavirus disease 2019 patients hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 infection between February 15, 2020, and November 30, 2020, according to age and type of organ support therapies.<h4>Setting</h4>About 168 hospitals ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):437-448]

Cited: 5 times

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Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19.

Shahzad Shaefi, Samantha K Brenner, Shruti Gupta, Brian P O'Gara, Megan L Krajewski, David M Charytan, Sobaata Chaudhry, Sara H Mirza, Vasil Peev, Mark Anderson, Anip Bansal, Salim S Hayek, Anand Srivastava, Kusum S Mathews, Tanya S Johns, Amanda Leonberg-Yoo, Adam Green, Justin Arunthamakun, Keith M Wille, Tanveer Shaukat, Harkarandeep Singh, Andrew J Admon, Matthew W Semler, Miguel A Hernán, Ariel L Mueller, Wei Wang, David E Leaf, ,

<h4>Purpose</h4>Limited data are available on venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe hypoxemic respiratory failure from coronavirus disease 2019 (COVID-19).<h4>Methods</h4>We examined the clinical features and outcomes of 190 patients treated with ECMO within 14 days of ICU admission, using data from a multicenter cohort study of 5122 critically ill ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(2):208-221]

Cited: 13 times

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Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19.

Hanny Al-Samkari, Shruti Gupta, Rebecca Karp Leaf, Wei Wang, Rachel P Rosovsky, Samantha K Brenner, Salim S Hayek, Hanna Berlin, Rajat Kapoor, Shahzad Shaefi, Michal L Melamed, Anne Sutherland, Jared Radbel, Adam Green, Brian T Garibaldi, Anand Srivastava, Amanda Leonberg-Yoo, Alexandre M Shehata, Jennifer E Flythe, Arash Rashidi, Nitender Goyal, Lili Chan, Kusum S Mathews, S Susan Hedayati, Rajany Dy, Stephanie M Toth-Manikowski, Jingjing Zhang, Mary Mallappallil, Roberta E Redfern, Amar D Bansal, Samuel A P Short, Mark G Vangel, Andrew J Admon, Matthew W Semler, Kenneth A Bauer, Miguel A Hernán, David E Leaf, ,

<h4>Background</h4>Hypercoagulability may be a key mechanism of death in patients with coronavirus disease 2019 (COVID-19).<h4>Objective</h4>To evaluate the incidence of venous thromboembolism (VTE) and major bleeding in critically ill patients with COVID-19 and examine the observational effect of early therapeutic anticoagulation on survival.<h4>Design</h4>In a multicenter cohort study of 3239 critically ill ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(5):622-632]

Cited: 17 times

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Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19.

Shruti Gupta, Wei Wang, Salim S Hayek, Lili Chan, Kusum S Mathews, Michal L Melamed, Samantha K Brenner, Amanda Leonberg-Yoo, Edward J Schenck, Jared Radbel, Jochen Reiser, Anip Bansal, Anand Srivastava, Yan Zhou, Diana Finkel, Adam Green, Mary Mallappallil, Anthony J Faugno, Jingjing Zhang, Juan Carlos Q Velez, Shahzad Shaefi, Chirag R Parikh, David M Charytan, Ambarish M Athavale, Allon N Friedman, Roberta E Redfern, Samuel A P Short, Simon Correa, Kapil K Pokharel, Andrew J Admon, John P Donnelly, Hayley B Gershengorn, David J Douin, Matthew W Semler, Miguel A Hernán, David E Leaf, ,

<h4>Importance</h4>Therapies that improve survival in critically ill patients with coronavirus disease 2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 receptor, may counteract the inflammatory cytokine release syndrome in patients with severe COVID-19 illness.<h4>Objective</h4>To test whether tocilizumab decreases mortality in this population.<h4>Design, setting, and participants</h4>The data for ... Read more >>

JAMA Intern Med (JAMA internal medicine)
[2021, 181(1):41-51]

Cited: 112 times

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Skill retention with ultrasound curricula.

Lawrence Matthews, Krysta Contino, Charlotte Nussbaum, Krystal Hunter, Christa Schorr, Nitin Puri,

<h4>Background</h4>Implementation of a point of care ultrasound curricula is valuable, but optimal integration for internal medicine residency is unclear. The purpose of this study was to evaluate if a structured ultrasound curriculum vs. structured ultrasound curriculum plus supervised thoracic ultrasounds would improve internal medicine residents' skill and retention 6 and ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0243086]

Cited: 0 times

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Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States.

Jennifer E Flythe, Magdalene M Assimon, Matthew J Tugman, Emily H Chang, Shruti Gupta, Jatan Shah, Marie Anne Sosa, Amanda DeMauro Renaghan, Michal L Melamed, F Perry Wilson, Javier A Neyra, Arash Rashidi, Suzanne M Boyle, Shuchi Anand, Marta Christov, Leslie F Thomas, Daniel Edmonston, David E Leaf, ,

<h4>Rationale & objective</h4>Underlying kidney disease is an emerging risk factor for more severe coronavirus disease 2019 (COVID-19) illness. We examined the clinical courses of critically ill COVID-19 patients with and without pre-existing chronic kidney disease (CKD) and investigated the association between the degree of underlying kidney disease and in-hospital outcomes.<h4>Study ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2021, 77(2):190-203.e1]

Cited: 32 times

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AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.

Shruti Gupta, Steven G Coca, Lili Chan, Michal L Melamed, Samantha K Brenner, Salim S Hayek, Anne Sutherland, Sonika Puri, Anand Srivastava, Amanda Leonberg-Yoo, Alexandre M Shehata, Jennifer E Flythe, Arash Rashidi, Edward J Schenck, Nitender Goyal, S Susan Hedayati, Rajany Dy, Anip Bansal, Ambarish Athavale, H Bryant Nguyen, Anitha Vijayan, David M Charytan, Carl E Schulze, Min J Joo, Allon N Friedman, Jingjing Zhang, Marie Anne Sosa, Eric Judd, Juan Carlos Q Velez, Mary Mallappallil, Roberta E Redfern, Amar D Bansal, Javier A Neyra, Kathleen D Liu, Amanda D Renaghan, Marta Christov, Miklos Z Molnar, Shreyak Sharma, Omer Kamal, Jeffery Owusu Boateng, Samuel A P Short, Andrew J Admon, Meghan E Sise, Wei Wang, Chirag R Parikh, David E Leaf, ,

<h4>Background</h4>AKI is a common sequela of coronavirus disease 2019 (COVID-19). However, few studies have focused on AKI treated with RRT (AKI-RRT).<h4>Methods</h4>We conducted a multicenter cohort study of 3099 critically ill adults with COVID-19 admitted to intensive care units (ICUs) at 67 hospitals across the United States. We used multivariable logistic ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2021, 32(1):161-176]

Cited: 36 times

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Society of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness.

Mark E Mikkelsen, Mary Still, Brian J Anderson, O Joseph Bienvenu, Martin B Brodsky, Nathan Brummel, Brad Butcher, Alison S Clay, Hali Felt, Lauren E Ferrante, Kimberley J Haines, Michael O Harhay, Aluko A Hope, Ramona O Hopkins, Megan Hosey, Catherine Terri L Hough, James C Jackson, Annie Johnson, Babar Khan, Nazir I Lone, Pamela MacTavish, Joanne McPeake, Ashley Montgomery-Yates, Dale M Needham, Giora Netzer, Christa Schorr, Becky Skidmore, Joanna L Stollings, Reba Umberger, Adair Andrews, Theodore J Iwashyna, Carla M Sevin,

<h4>Background</h4>After critical illness, new or worsening impairments in physical, cognitive, and/or mental health function are common among patients who have survived. Who should be screened for long-term impairments, what tools to use, and when remain unclear.<h4>Objectives</h4>Provide pragmatic recommendations to clinicians caring for adult survivors of critical illness related to screening ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(11):1670-1679]

Cited: 16 times

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Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US.

Shruti Gupta, Salim S Hayek, Wei Wang, Lili Chan, Kusum S Mathews, Michal L Melamed, Samantha K Brenner, Amanda Leonberg-Yoo, Edward J Schenck, Jared Radbel, Jochen Reiser, Anip Bansal, Anand Srivastava, Yan Zhou, Anne Sutherland, Adam Green, Alexandre M Shehata, Nitender Goyal, Anitha Vijayan, Juan Carlos Q Velez, Shahzad Shaefi, Chirag R Parikh, Justin Arunthamakun, Ambarish M Athavale, Allon N Friedman, Samuel A P Short, Zoe A Kibbelaar, Samah Abu Omar, Andrew J Admon, John P Donnelly, Hayley B Gershengorn, Miguel A Hernán, Matthew W Semler, David E Leaf, ,

<h4>Importance</h4>The US is currently an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, yet few national data are available on patient characteristics, treatment, and outcomes of critical illness from COVID-19.<h4>Objectives</h4>To assess factors associated with death and to examine interhospital variation in treatment and outcomes for patients with COVID-19.<h4>Design, setting, and ... Read more >>

JAMA Intern Med (JAMA internal medicine)
[2020, 180(11):1436-1447]

Cited: 234 times

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