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Author Chonnamet Techasaensiri

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Immunogenicity of Vero Cell Culture-derived Japanese Encephalitis Vaccine in Pediatric and Young Hematopoietic Stem Cell Transplantation Recipients.

Surapat Assawawiroonhakarn, Nopporn Apiwattanakul, Samart Pakakasama, Suradej Hongeng, Usanarat Anurathapan, Sutee Yoksan, Chompunuch Klinmalai, Pattarana Sae-Chew, Chonnamet Techasaensiri,

<h4>Background</h4>Children and young adults undergoing hematopoietic stem cell transplantation (HSCT) typically lose their immunity to vaccine-preventable diseases, including Japanese encephalitis (JE). Revaccination against JE in this population has not been well characterized.<h4>Methods</h4>This prospective study evaluated the immunogenicity of inactivated Vero cell culture-derived JE vaccine in children and young adults (<25 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, Publish Ahead of Print:]

Cited: 0 times

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Pneumococcal disease in Thailand.

Amgad Gamil, Kulkanya Chokephaibulkit, Wanatpreeya Phongsamart, Chonnamet Techasaensiri, Barameht Piralam, Ruangwit Thamaree,

This review examines the epidemiology of pneumococcal disease, serotype prevalence, antibiotic resistance, and national vaccination recommendations in Thailand. The incidence of invasive pneumococcal disease (IPD) and annualized hospitalization rates for pneumococcal bacteremia in Thailand were highest in children aged <5years and the elderly. The most prevalent serotype is serotype 6B, ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, 102:429-436]

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High prevalence of multidrug-resistant gram-negative bacterial infection following pediatric liver transplantation.

Chanita Phichaphop, Nopporn Apiwattanakul, Chonnamet Techasaensiri, Chatmanee Lertudomphonwanit, Suporn Treepongkaruna, Chollasak Thirapattaraphan, Sophida Boonsathorn,

Bacterial infection has been identified as one of the most significant complications of liver transplantation (LT). Multidrug-resistant (MDR) gram-negative bacteria (GNB) infection remains problematic issue following LT in the adults. However, data in children are scarce. We aimed to examine the prevalence and associated factors of MDR-GNB infection among pediatric ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(45):e23169]

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Immune responses to hepatitis B vaccination after hematopoietic stem cell transplantation in pediatric and young adult patients.

Krittiya Chaichotjinda, Usanarat Anurathapan, Sophida Boonsathorn, Sujittra Chaisavaneeyakorn, Suporn Treepongkaruna, Chonnamet Techasaensiri, Nopporn Apiwattanakul,

<b>Background: </b>Hematopoietic stem cell transplantation (HSCT) recipients require hepatitis B (HBV) revaccination. Hepatitis B surface antibody (anti-HBs) seroconversion rates after revaccination range from 64% to 79% in these patients. The seroconversion rate and factors associated with non-seroconversion have not been clearly elucidated in pediatric and young adult recipients after HSCT.<br><br><b>Objectives: ... Read more >>

Clin Transplant (Clinical transplantation)
[2020, 34(10):e14024]

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Viral Tropism in Human Immunodeficiency Virus Type 1-Infected Children and Adolescents in Thailand.

Natt Arayapong, Ekawat Pasomsub, Rujikorn Kanlayanadonkit, Jiraporn Keatkla, Chonnamet Techasaensiri, Angsana Phuphuakrat, Somnuek Sungkanuparph, Nopporn Apiwattanakul, Sujittra Chaisavaneeyakorn,

BACKGROUND:Maraviroc, a C-C chemokine receptor 5 (CCR5) antagonist, has been used as an alternative antiretroviral drug in treatment-experienced adults and children infected by CCR5-tropic human immunodeficiency virus type 1 (HIV-1) isolates. Prior to widespread use of this drug, rates of HIV-1 coreceptor tropism and factors associated with coreceptor tropism had ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2020, :]

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Outcomes of Empirical Antimicrobial Therapy for Pediatric Community-onset Febrile Urinary Tract Infection in the Era of Increasing Antimicrobial Resistance.

Worawit Kantamalee, Pitak Santanirand, Pawaree Saisawat, Sophida Boonsathorn, Chonnamet Techasaensiri, Nopporn Apiwattanakul,

<h4>Background</h4>Urinary tract infection (UTI) is a common cause of fever in children. Despite the increasing numbers of extended-spectrum beta-lactamase-producing organisms in the community, the empirical therapy of choice is still third-generation cephalosporins. This study was performed to investigate whether inappropriate empirical therapy (IAT) of community-onset UTI results in adverse clinical ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(2):121-126]

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Analysis of Ganciclovir-Resistant Cytomegalovirus Infection Caused by the UL97 Gene Mutation in Codons 460 and 520 in Pediatric Patients: A Case Series.

Sophida Boonsathorn, Ekawat Pasomsub, Chonnamet Techasaensiri, Nopporn Apiwattanakul,

<h4>Background</h4>Drug-resistant cytomegalovirus (CMV) infection has been increasingly recognized. However, there are limited data in pediatric patients. In this study, the prevalence and factors associated with CMV infection with UL97 mutations in pediatric patients treated with ganciclovir but not responding to treatment were evaluated.<h4>Methods</h4>This retrospective study was conducted from January 2013 ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(11):ofz480]

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1509. Outcomes of Empirical Antimicrobial Therapy for Pediatric Community-Onset Febrile Urinary Tract Infection in the Era of Increasing Antimicrobial Resistance.

Worawit Kantamalee, Chonnamet Techasaensiri, Nopporn Apiwattanakul, Sophida Boonsathorn, Pawaree Saisawat, Pitak Santanirand,

AbstractBackgroundUrinary tract infection (UTI) is a common cause of fever in children. Since infections caused by extended-spectrum β-lactamase (ESBL)-producing organism in the community have increased, alternative empirical antimicrobials to carbapenems have been studied. We conducted this study to compare clinical outcomes between group receiving empirical antimicrobials to which organisms were ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S549-S549]

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Impact of an Antibiotic Stewardship Program on Antibiotic Prescription for Acute Respiratory Tract Infections in Children: A Prospective Before-After Study.

Nalinee Aoybamroong, Worawit Kantamalee, Kunlawat Thadanipon, Chonnamet Techasaensiri, Kumthorn Malathum, Nopporn Apiwattanakul,

We assessed the effectiveness of an antibiotic stewardship program (ASP) on antibiotic prescriptions for acute respiratory tract infection (ARTI) in a medical school. Our ASP included delivering an antibiotic use guideline via e-mail and LINE (an instant messaging app) to faculty staff, fellows, and residents, and posting of the guideline ... Read more >>

Clin Pediatr (Phila) (Clinical pediatrics)
[2019, 58(11-12):1166-1174]

Cited: 1 time

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An updated cost-effectiveness analysis of pneumococcal conjugate vaccine among children in Thailand.

Piyameth Dilokthornsakul, Kirati Kengkla, Surasak Saokaew, Unchalee Permsuwan, Chonnamet Techasaensiri, Tawee Chotpitayasunondh, Nathorn Chaiyakunapruk,

<h4>Background</h4>A previous cost-effectiveness analysis (CEA) showed that Pneumococcal Conjugate Vaccine (PCV) 10 and PCV13 were not cost-effective for universal immunization among children in Thailand. Given recent changes in the evidence of efficacy, herd effects and price, a CEA of PCVs should be revisited. This study aimed to determine the cost-effectiveness ... Read more >>

Vaccine (Vaccine)
[2019, 37(32):4551-4560]

Cited: 1 time

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Monitoring of cytomegalovirus infection in non-transplant pediatric acute lymphoblastic leukemia patients during chemotherapy.

Nonthapan Phasuk, Jiraporn Keatkla, Sasivimol Rattanasiri, Chonnamet Techasaensiri, Usanarat Anurathapan, Nopporn Apiwattanakul,

Cytomegalovirus (CMV) infection is a significant cause of morbidity and mortality in the posttransplant setting; however, it is increasingly recognized in pediatric leukemia during chemotherapy. This study assessed the prevalence and associated factors of CMV infection in pediatric non-transplant leukemia patients.This was a cross-sectional study of 50 pediatric acute lymphoblastic ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(4):e14256]

Cited: 2 times

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B cell subset alteration and the expression of tissue homing molecules in dengue infected patients.

Kovit Pattanapanyasat, Ladawan Khowawisetsut, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Kanchana Tangnararatchakit, Nopporn Apiwattanakul, Chonnamet Techasaensiri, Premrutai Thitilertdecha, Tipaporn Sae-Ung, Nattawat Onlamoon,

<h4>Background</h4>B cells play an essential role during dengue viral infection. While a major expansion of antibody secreting cells (ASCs) was observed, the importance of these increased frequencies of ASCs remains unclear. The alteration of B cell subsets may result from the expression of tissue specific homing molecules leading to their ... Read more >>

J Biomed Sci (Journal of biomedical science)
[2018, 25(1):64]

Cited: 0 times

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Typhoidal Salmonella Trends in Thailand.

Chonnamet Techasaensiri, Amruta Radhakrishnan, Daina Als, Usa Thisyakorn,

Typhoid and paratyphoid fever remain endemic diseases in Thailand with wide variation in subnational incidence trends. We examined these trends alongside contextual factors to study potential interactions and guide control strategies for this disease. Culture-confirmed typhoid and paratyphoid fever data from 2003 to 2014 were collected from the Ministry of ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2018, 99(3_Suppl):64-71]

Cited: 3 times

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Viral-specific T-cell response in hemorrhagic cystitis after haploidentical donor stem cell transplantation.

Nopporn Apiwattanakul, Suradej Hongeng, Usanarat Anurathapan, Samart Pakakasama, Supanart Srisala, Chonnamet Techasaensiri, Borje S Andersson,

Viral hemorrhagic cystitis (HC) after hematopoietic stem cell transplantation (HSCT) can be devastating. Standard treatment modalities have not been well established, but immune reconstitution may be necessary for sustained viral clearance. We studied five pediatric patients who developed viral HC after haplo-identical HSCT. All patients developed virus-specific CD4- and CD8-positive ... Read more >>

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2017, 19(6):]

Cited: 2 times

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Post-licensure, phase IV, safety study of a live attenuated Japanese encephalitis recombinant vaccine in children in Thailand.

Tawee Chotpitayasunondh, Pornpimol Pruekprasert, Thanyawee Puthanakit, Chitsanu Pancharoen, Auchara Tangsathapornpong, Peninnah Oberdorfer, Pope Kosalaraksa, Olarn Prommalikit, Suwimon Tangkittithaworn, Phirangkul Kerdpanich, Chonnamet Techasaensiri, Joanna Korejwo, Sunate Chuenkitmongkol, Guy Houillon,

<h4>Background</h4>Japanese encephalitis is a mosquito-borne viral disease endemic in most countries in Asia. A recombinant live, attenuated Japanese encephalitis virus vaccine, JE-CV, is licensed in 14 countries, including Thailand, for the prevention of Japanese encephalitis in adults and children.<h4>Methods</h4>This was a prospective, phase IV, open-label, multicentre, safety study of JE-CV ... Read more >>

Vaccine (Vaccine)
[2017, 35(2):299-304]

Cited: 4 times

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Pediatric extended spectrum β-lactamase infection: Community-acquired infection and treatment options.

Napapailin Sethaphanich, Pitak Santanirand, Sasivimol Rattanasiri, Chonnamet Techasaensiri, Sujittra Chaisavaneeyakorn, Nopporn Apiwattanakul,

<h4>Background</h4>Infection caused by extended spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in pediatric patients has been increasing and spreading to the community, compromising the options for effective antibiotics. This retrospective study was conducted to identify which antibiotics ESBL-producing Enterobacteriaceae remain susceptible to. In addition, the prevalence of community-acquired infection caused by these organisms, ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2016, 58(5):338-346]

Cited: 2 times

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Pharmacokinetics of atazanavir/ritonavir among HIV-infected Thai children concomitantly taking tenofovir disoproxil fumarate.

Torsak Bunupuradah, Chonnamet Techasaensiri, Siriwan Keadpudsa, Narukjaporn Thammajaruk, Amornrat Srimuan, Thaintip Sahakijpicharn, Wasana Prasitsuebsai, Jintanat Ananworanich, Thanyawee Puthanakit, ,

BACKGROUND: Atazanavir/ritonavir (ATV/r) is a recommended once-daily protease inhibitor. Tenofovir disoproxil fumarate (TDF) can reduce ATV exposure. The authors studied ATV pharmacokinetic (PK) parameters among children who received atazanavir/ritonavir co-administered with TDF. METHODS: HIV-infected children aged 6-18 years with a body weight of 25-50 kg were eligible. Branded ATV 200 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2014, 33(12):e316-9]

Cited: 2 times

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Serotype-specific changes in invasive pneumococcal disease after pneumococcal conjugate vaccine introduction: a pooled analysis of multiple surveillance sites.

Daniel R Feikin, Eunice W Kagucia, Jennifer D Loo, Ruth Link-Gelles, Milo A Puhan, Thomas Cherian, Orin S Levine, Cynthia G Whitney, Katherine L O'Brien, Matthew R Moore, ,

<h4>Background</h4>Vaccine-serotype (VT) invasive pneumococcal disease (IPD) rates declined substantially following introduction of 7-valent pneumococcal conjugate vaccine (PCV7) into national immunization programs. Increases in non-vaccine-serotype (NVT) IPD rates occurred in some sites, presumably representing serotype replacement. We used a standardized approach to describe serotype-specific IPD changes among multiple sites after PCV7 ... Read more >>

PLoS Med (PLoS medicine)
[2013, 10(9):e1001517]

Cited: 192 times

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Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensure.

Timothy L McCavit, Charles T Quinn, Chonnamet Techasaensiri, Zora R Rogers,

Invasive pneumococcal disease (IPD) in children with sickle cell disease has decreased with prophylactic penicillin, pneumococcal polysaccharide vaccine, and pneumococcal protein-conjugate vaccine usage. We report 10 IPD cases since pneumococcal protein-conjugate vaccine licensure, including a recent surge of non-vaccine serotypes. IPD continues to be a serious risk in sickle cell ... Read more >>

J Pediatr (The Journal of pediatrics)
[2011, 158(3):505-507]

Cited: 41 times

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Viral coinfections in children with invasive pneumococcal disease.

Benyachalee Techasaensiri, Chonnamet Techasaensiri, Asuncion Mejías, George H McCracken, Octavio Ramilo,

<h4>Background</h4>Respiratory viruses contribute to the seasonal pattern of invasive pneumococcal disease (IPD), but the impact of viral coinfections on the clinical characteristics and outcomes of patients with IPD have not been well defined.<h4>Objective</h4>This study was designed to describe and compare the clinical presentations and outcomes of patients with IPD with ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2010, 29(6):519-523]

Cited: 31 times

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Epidemiology and evolution of invasive pneumococcal disease caused by multidrug resistant serotypes of 19A in the 8 years after implementation of pneumococcal conjugate vaccine immunization in Dallas, Texas.

Chonnamet Techasaensiri, Allison F Messina, Kathy Katz, Naveed Ahmad, Rong Huang, George H McCracken,

<h4>Background</h4>The heptavalent pneumococcal conjugate vaccine (PCV7) has significantly reduced vaccine-type invasive pneumococcal disease (IPD) in children. An increasing percentage of IPD cases are now caused by nonvaccine serotypes. The purpose of our observational study was to define the epidemiology of pneumococcal disease in Dallas, TX children for 8 years after ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2010, 29(4):294-300]

Cited: 30 times

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Variation in colonization, ADP-ribosylating and vacuolating cytotoxin, and pulmonary disease severity among mycoplasma pneumoniae strains.

Chonnamet Techasaensiri, Claudia Tagliabue, Marianna Cagle, Pooya Iranpour, Kathy Katz, Thirumalai R Kannan, Jacqueline J Coalson, Joel B Baseman, R Doug Hardy,

<h4>Rationale</h4>Mycoplasma pneumoniae was recently discovered to produce an ADP-ribosylating and vacuolating cytotoxin, designated CARDS toxin, which is hypothesized to be a primary pathogenic mechanism responsible for M. pneumoniae-induced pulmonary inflammation. It is unknown if cytotoxin production varies with M. pneumoniae strain or if variation in cytotoxin production affects pulmonary disease ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2010, 182(6):797-804]

Cited: 30 times

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Analysis of pulmonary inflammation and function in the mouse and baboon after exposure to Mycoplasma pneumoniae CARDS toxin.

R Doug Hardy, Jacqueline J Coalson, Jay Peters, Adriana Chaparro, Chonnamet Techasaensiri, Angelene M Cantwell, T R Kannan, Joel B Baseman, Peter H Dube,

Mycoplasma pneumoniae produces an ADP-ribosylating and vacuolating toxin known as the CARDS (Community Acquired Respiratory Distress Syndrome) toxin that has been shown to be cytotoxic to mammalian cells in tissue and organ culture. In this study we tested the ability of recombinant CARDS (rCARDS) toxin to elicit changes within the ... Read more >>

PLoS One (PloS one)
[2009, 4(10):e7562]

Cited: 50 times

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Correction: Analysis of Pulmonary Inflammation and Function in the Mouse and Baboon after Exposure to Mycoplasma pneumoniae CARDS Toxin

R. Doug Hardy, Jacqueline J. Coalson, Jay Peters, Adriana Chaparro, Chonnamet Techasaensiri, Luis D. Giavedoni, Angelene M. Cantwell, T. R. Kannan, Joel B. Baseman, Peter H. Dube,

PLoS One (PloS one)
[2009, 4(12):]

Cited: 0 times

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Four novel and three recurrent mutations of the BTK gene and pathogenic effects of putative splice mutations.

Duangrurdee Wattanasirichaigoon, Suwat Benjaponpitak, Chonnamet Techasaensiri, Wasu Kamchaisatian, Pakit Vichyanond, Sucheela Janwityanujit, Lulin Choubtum, Sayomporn Sirinavin,

X-linked agammaglobulinemia is caused by mutations in the human BTK gene, leading to recurrent pyogenic infections. We describe four novel and three known BTK-mutations in seven patients from seven (six Thai and one Burmese) families. All but one were sporadic cases. Patients 1 and 2 had recurrent mutations in exon ... Read more >>

J Hum Genet (Journal of human genetics)
[2006, 51(11):1006-1014]

Cited: 3 times

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