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A hydrophobic semiconducting metal-organic framework assembled from silver chalcogenide wires.

Jia-Yin Wang, Wen-Hua Li, Zhong Wei, Chong Zhang, Ya-Hui Li, Xi-Yan Dong, Gang Xu, Shuang-Quan Zang,

Silver chalcogenide wires are assembled for the first time using a linear fluorinated carboxylate ligand into a metal-organic framework (MOF) with multifunctional properties. Fluorinated ligands in the host framework endow the MOF with excellent hydrophobicity. More interestingly, it displays typical semiconductivity due to the ordered nanoarray of non-discrete helical (-Ag-S-)n ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(14):2091-2094]

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Enhanced photocatalytic activity of g-C3N4/MnO composites for hydrogen evolution under visible light.

Na Mao, Xiaomin Gao, Chong Zhang, Chang Shu, Wenyan Ma, Feng Wang, Jia-Xing Jiang,

In this work, a range of g-C3N4/MnO composites were constructed using g-C3N4 nanosheets modified with MnO, and the photocatalytic performance for hydrogen evolution was evaluated by using these as-prepared g-C3N4/MnO composites as photocatalysts. It was found that the photocatalytic activity of the g-C3N4/MnO composites for hydrogen evolution is significantly enhanced ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(39):14864-14872]

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Effectiveness-Analysis of one-stage Operation for Combined Ankle Fracture and III Degree Lateral Ligament Injury: A Retrospective Study of 23 Cases

Chunquan Zhu, Linglong Deng, Chong Zhang, Guorong Yu, Li Yu,

Abstract Background: Ankle fracture is often accompanied by injuries of lateral collateral ligaments, which results in ankle instability and traumatic arthritis in the later period, causing pain and discomfort in patients. However, the repair of the lateral collateral ligament is still inconclusive. The aim of this study was to investigate ... Read more >>

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Hydrazinocurcumin and 5-fluorouracil enhance apoptosis and restrain tumorigenicity of HepG2 cells via disrupting the PTEN-mediated PI3K/Akt signaling pathway.

Ye Zhou, Meng Zhang, Zhilei Zhang, Yuming Jia, Chong Zhang, Li Peng,

Hydrazinocurcumin (HZC), a curcumin analogue, serves as a tumor suppressor in breast cancer and lung cancer. In this study, we investigate the role and mechanism of HZC in regulating HepG2 cell apoptosis and tumorigenicity, and its synergistic effects with 5-fluorouracil (5-Fu). HepG2 cells were treated with HZC and/or 5-Fu to ... Read more >>

Biomed. Pharmacother. (Biomedicine & Pharmacotherapy)
[2020, 129:109851]

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Coronatine is More Potent than Jasmonates in Regulating Arabidopsis Circadian Clock

Min Gao, Chong Zhang, Hua Lu,

Abstract Recent studies establish a crucial role of the circadian clock in regulating plant defense against pathogens. Whether pathogens modulate host circadian clock as a potential strategy to suppress host innate immunity is not well understood. Coronatine is a toxin produced by the bacterial pathogen Pseudomonas syringae that is known ... Read more >>

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Effects of hydrogeochemical conditions on the distribution of pesticides in the karst river system.

Tian Zhou, Fuyang Huang, Chong Zhang, Zeyan Li, Fei Liu,

Karst aquifer systems are tended to be polluted compared to other types of aquifers because pollutants are able to enter aquifers through developed conduit systems. To identify the effects of hydrogeochemical conditions on the distribution of pesticides in a karst river system in Kaiyang, southwest China, a typical pollution mode ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, :]

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Neural-specific distribution of transmembrane protein TMEM240 and formation of TMEM240-Body.

Qiongqiong Hu, Guangyou Wang, Xin Chen, Liulei Zhang, Wei Zhao, Yan Jiang, Chong Zhang, Jin Sun, Hao Xu, Hulun Li, Qingfei Kong, Jiarui Zhao, Xinrong Li, Xiaoyu Zhang, Weiqi Lv, Yumei Liu, Gaiqing Yang, Lili Mu, Jinghua Wang,

Mutation in TMEM240 is suggested to cause SCA21, but the specific mechanism has not been clarified. The subcellular localization, specific biological function, and corresponding mechanism of action of TMEM240 have also not been delineated. In this study, the mRNA and protein expression of TMEM240 were assessed using qPCR and western ... Read more >>

Int. J. Biol. Macromol. (International journal of biological macromolecules)
[2020, 161:692-703]

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Screening COVID-19 with Chest CT in Preference to RT-PCR: Based on Mortality Analysis

Yuanlong Xie, Minhao Wu, Chong Zhang, Yufan Zhu, Kun Li, Meng Wu, Zhouming Deng, Xiaobin Zhu, Lin Cai,

Abstract Corona Virus Disease 2019 (COVID-19) became the outbreak of infectious diseases emergency worldwide. It remains unknown whether the RT-PCR test results was associated with the prognosis of COVID-19 patients or not. In this study, a total number of 495 patients with typical chest CT feature and symptom consistent with ... Read more >>

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The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer.

Zengshu Xing, Sailian Li, Zhenxiang Liu, Chong Zhang, Meijiang Meng, Zhiming Bai,

Prostate cancer is a kind of male malignant tumor, which has brought tremendous health threat to men. Prostate cancer is difficult to be cured because of high incidence and metastasis rate. Thereby, it is of great urgency to elucidate the underlying molecular mechanism of prostate cancer for the treatment of ... Read more >>

Biosci. Rep. (Bioscience reports)
[2020, :]

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Characterisation of a subpopulation of CD133+ cancer stem cells from Chinese patients with oral squamous cell carcinoma.

Zhen Ma, Chong Zhang, Xiaotong Liu, Fang Fang, Shiqi Liu, Xianxiang Liao, Shicheng Tao, Huaming Mai,

Cancer stem cells (CSCs) play a critical role in cancer development and growth. The aim of this study was to identify and isolate CSCs from populations of primary oral squamous cell carcinoma (OSCC) cells, which were obtained from OSCC specimens and identified by cell morphology and immunohistochemical staining for keratin. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8875]

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Smad3 gene C-terminal phosphorylation site mutation aggravates CCl4 -induced inflammation in mice.

Hanyan Ding, Meng Fang, Yongfang Gong, Dong Li, Chong Zhang, Guanghua Wen, Chao Wu, Jingjing Yang, Yan Yang,

The expression of C-terminal phosphorylated Smad3 (pSmad3C) is down-regulated with the progression of liver disease. Thus, we hypothesized that pSmad3C expression may be negatively related to liver disease. To develop novel therapeutic strategies, a suitable animal model is required that will allow researchers to study the effect of Smad3 domain-specific ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, 24(12):7044-7054]

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Volar Locked Plating Versus Closed Reduction and Casting for Acute, Displaced Distal Radial Fractures in the Elderly: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Andrew R Stephens, Angela P Presson, Mary M McFarland, Chong Zhang, Kai Sirniö, Marjolein A M Mulders, Niels W L Schep, Andrew R Tyser, Nikolas H Kazmers,

BACKGROUND:It remains unclear whether volar locked plating (VLP) yields a better functional outcome than closed reduction and casting (CRC) for elderly patients with an acute, displaced distal radial fracture. Our purpose was to conduct a systematic review and meta-analysis of randomized controlled trials comparing outcomes of VLP and CRC for ... Read more >>

J Bone Joint Surg Am (The Journal of bone and joint surgery. American volume)
[2020, :]

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DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bcl-2 inhibitors.

Yangling Li, Dongmei Zhou, Shuang Xu, Mingjun Rao, Zuoyan Zhang, Linwen Wu, Chong Zhang, Nengming Lin,

Objective: Mcl-1 overexpression confers acquired resistance to Bcl-2 inhibitors in non-small cell lung cancer (NSCLC), but no direct Mcl-1 inhibitor is currently available for clinical use. Thus, novel therapeutic strategies are urgently needed to target Mcl-1 and sensitize the anti-NSCLC activity of Bcl-2 inhibitors. Methods: Cell proliferation was measured using ... Read more >>

Cancer Biol Med (Cancer biology & medicine)
[2020, 17(2):387-400]

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Reply to: Evaluating two different models of peanut's origin.

Weijian Zhuang, Xiyin Wang, Andrew H Paterson, Hua Chen, Meng Yang, Chong Zhang, Pengchuan Sun, Yixiong Zheng, Lihui Wang, Wenping Xie, Wenting Chu, Huiwen Fu, Rajeev K Varshney,

Nat. Genet. (Nature genetics)
[2020, 52(6):560-563]

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Aspirin sensitizes osimertinib-resistant NSCLC cells in vitro and in vivo via Bim-dependent apoptosis induction.

Rui Han, Shuai Hao, Conghua Lu, Chong Zhang, Caiyu Lin, Li Li, Yubo Wang, Chen Hu, Yong He,

Osimertinib, a third-generation irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), provides marked clinical benefit for patients with EGFR-activating mutations. Unfortunately, limited treatments exist for patients who acquire osimertinib resistance. We observed two 'special' patients who regained an antitumor response with osimertinib plus aspirin treatment. As previous data indicate ... Read more >>

Mol Oncol (Molecular oncology)
[2020, 14(6):1152-1169]

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The correlation between Aromatase (CYP19A1) and Bladder cancer in Chinese Han Population

Shufang Zhang, Chong Zhang, Xiaohong Wen, Shunlan Wang, Haowei He, Linlin Zheng, Mei Chen, Fei Wang,

Abstract BackgroundSeveral P450 metabolic enzymes genes have been discovered that affect the genetic susceptibility of bladder cancer. While, there is no report about CYP19A1 gene polymorphism on the susceptibility of bladder cancer. So, we performed a case–control study to investigate the association between polymorphisms in CYP19A1 gene and the susceptibility ... Read more >>

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Design, synthesis, and biological evaluation of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents.

Li-Qiang Wu, Xin Ma, Chong Zhang, Zhao-Peng Liu,

A novel series of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents were designed, synthesized, biologically evaluated. Compounds 3n, 3o and 3j proved to be good NQO1 substrates that showed increased metabolic rates relative to that of β-lapachone. In addition, 3n, 3o and 3j potently inhibited the growth of NQO1-rich breast cancer MCF-7 cell, ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 198:112396]

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Patient and Institutional Characteristics Influence the Decision to Use Extracorporeal Cardiopulmonary Resuscitation for In-Hospital Cardiac Arrest.

Joseph E Tonna, Craig H Selzman, Saket Girotra, Angela P Presson, Ravi R Thiagarajan, Lance B Becker, Chong Zhang, Heather T Keenan, ,

BACKGROUND Outcomes from extracorporeal cardiopulmonary resuscitation (ECPR) are felt to be influenced by selective use, but the characteristics of those receiving ECPR are undefined. We demonstrate the relationship between individual patient and hospital characteristics and the probability of ECPR use. METHODS AND RESULTS We performed an observational analysis of adult ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(9):e015522]

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Mapping the spreading routes of lymphatic metastases in human colorectal cancer.

Chong Zhang, Lin Zhang, Tianlei Xu, Ruidong Xue, Liang Yu, Yuelu Zhu, Yunlong Wu, Qingqing Zhang, Dongdong Li, Shuohao Shen, Dongfeng Tan, Fan Bai, Haizeng Zhang,

Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). How tumor cells disseminate within the lymphatic network remains largely unknown. Here, we analyze the subclonal structure of 94 tumor samples, covering the primary tumors, lymph node metastases (LNMs), and liver metastases from 10 CRC ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1993]

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High-density SNP map facilitates fine mapping of QTLs and candidate genes discovery for Aspergillus flavus resistance in peanut (Arachis hypogaea).

Shahid Ali Khan, Hua Chen, Ye Deng, Yuhua Chen, Chong Zhang, Tiecheng Cai, Niaz Ali, Gandeka Mamadou, Dongyang Xie, Baozhu Guo, Rajeev K Varshney, Weijian Zhuang,

KEY MESSAGE:Two novel resistant QTLs mapped and candidate genes identified for Aspergillus flavus resistance in cultivated peanut using SLAF-seq. Aflatoxin contamination in peanuts caused by Aspergillus flavus is a serious food safety issue for human health around the world. Host plant resistance to fungal infection and reduction in aflatoxin are ... Read more >>

Theor. Appl. Genet. (TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik)
[2020, 133(7):2239-2257]

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Increased stability and intracellular antioxidant activity of chlorogenic acid depend on its molecular interaction with wheat gluten hydrolysate.

Dong He, Xue Peng, Yi-Fan Xing, Yi Wang, Wen Zeng, Nan Su, Chong Zhang, Dian-Nan Lu, Xin-Hui Xing,

Gastrointestinal stability and cell entry efficiency affect the biological accessibility of chlorogenic acid (CGA). Here, wheat gluten hydrolysate (WGH) was proven to improve the stability of CGA during simulated gastrointestinal digestion, promote the intestinal epithelial cell entry efficiency of CGA, and increase its intracellular antioxidant activity. The interaction between WGH ... Read more >>

Food Chem (Food chemistry)
[2020, 325:126873]

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A multi-centered, retrospective, descriptive study on 107 dead patients with COVID-19

chong zhang, Minhao Wu, Xiaobin Zhu, meng wu, yufan zhu, kun li, zhouming deng, yuanlong xie, lin cai,

Abstract Since the emergence of Corona Virus Disease 2019 (COVID-19) in Wuhan city, Hubei Province, China, it has caused thousands of deaths. As the ongoing outbreak of COVID-19 around the world, the number of deaths will definitely continue to increase. We aimed to further describe the clinical characteristics of dead ... Read more >>

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Irgm1 knockout indirectly inhibits regeneration after skeletal muscle injury in mice.

Liulei Zhang, Guangyou Wang, Xin Chen, Chong Zhang, Yan Jiang, Wei Zhao, Hulun Li, Jin Sun, Xinrong Li, Hao Xu, Yuting Weng, Xiaoyu Zhang, Lixuan Hou, Qingfei Kong, Yumei Liu, Hongwei Xu, Lili Mu, Jinghua Wang,

Immunity-related GTPase family M1 protein (lRGM1) plays an important role in host resistance to infection, immune inflammation, and tumors, and it is expressed in various tissues and cells, including the central nervous system, cardiovascular system, bone marrow-derived cells, glioma, and melanoma. However, the effect of IRGM1 in the muscles has ... Read more >>

Int. Immunopharmacol. (International Immunopharmacology)
[2020, 84:106515]

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Theoretical Investigation of Energetic Salts with Pentazolate Anion.

Hao-Ran Wang, Chong Zhang, Bing-Cheng Hu, Xue-Hai Ju,

Energetic salts based on pentazolate anion (cyclo-N5-) have attracted much attention due to their high nitrogen contents. However, it is an enormous challenge to efficiently screen out an appropriate cation that can match well with cyclo-N5-. The vertical electron affinity (VEA) of the cations and vertical ionization potential (VIP) of ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(8):]

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Ran promotes the proliferation and migration ability of head and neck squamous cell carcinoma cells.

Chong Zhang, Xida Zhao, Weidong Du, Jing Shen, Siqi Li, Zijia Li, Zengxu Wang, Fayu Liu,

HNSCC is an aggressive tumor that often recurrence and metastasis. Although the treatment of HNSCC has improved over the past few decades, it is easy to recurrence even after comprehensive treatment. Ran is a small Ras-related GTPase belonging to the Ras superfamily. Recently, Ran has been proven to be an ... Read more >>

Pathol. Res. Pract. (Pathology, research and practice)
[2020, 216(6):152951]

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