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HIV-1 Drug Resistance in ART-Naïve Individuals in Myanmar.

Mei Ye, Xin Chen, Yu Wang, Yan-Heng Zhou, Wei Pang, Chiyu Zhang, Yong-Tang Zheng,

Background:Estimating the prevalence and characterizing the transmission of HIV-1 drug resistance in treatment-naïve individuals are very important in the prevention and control of HIV/AIDS. As one of the areas most affected by HIV/AIDS, few data are currently available for HIV-1 drug resistance in antiretroviral therapy (ART)-naïve individuals in Myanmar, which ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2020, 13:1123-1132]

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Correction to: Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2.

Renfei Lu, Xiuming Wu, Zhenzhou Wan, Yingxue Li, Lulu Zuo, Jianru Qin, Xia Jin, Chiyu Zhang,

The corrected legend is given below. ... Read more >>

Virol Sin (Virologica Sinica)
[2020, :]

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A Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2.

Renfei Lu, Xiuming Wu, Zhenzhou Wan, Yingxue Li, Xia Jin, Chiyu Zhang,

COVID-19 has become a major global public health burden, currently causing a rapidly growing number of infections and significant morbidity and mortality around the world. Early detection with fast and sensitive assays and timely intervention are crucial for interrupting the spread of the COVID-19 virus (SARS-CoV-2). Using a mismatch-tolerant amplification ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(8):]

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The Phylodynamics of Seasonal Influenza A/H1N1pdm Virus in China Between 2009 and 2019.

Yingying Ma, Kai Liu, Yong Yin, Jianru Qin, Yan-Heng Zhou, Juan Yang, Shenwei Li, Leo L. M. Poon, Chiyu Zhang,

Since its first introduction into China in 2009, influenza A/H1N1pdm virus has undergone a rapid expansion and replaced the classical seasonal A(H1N1) virus. To characterize the ongoing evolution and national transmission dynamics of this virus, we analyzed 335 complete genome, 1259 HA, and 1043 NA sequences of the A/H1N1pdm strains ... Read more >>

Front Microbiol (Frontiers in Microbiology)
[2020, 11:]

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Laos is Affected by HIV CRF01_AE and the Newly Identified CRF97_01B.

Xin Chen, Mei Ye, Yu Wang, Chiyu Zhang, Yong-Tang Zheng,

Laos is the only landlocked country in Southeast Asia and borders Thailand, Myanmar and Cambodia, the three countries in this region that have been hardest hit by human immunodeficiency virus (HIV). Laos has been regarded as a low-HIV-prevalence country for decades. To understand the status of HIV in Laos in ... Read more >>

Virol Sin (Virologica Sinica)
[2020, :]

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Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2.

Renfei Lu, Xiuming Wu, Zhenzhou Wan, Yingxue Li, Lulu Zuo, Jianru Qin, Xia Jin, Chiyu Zhang,

Virol Sin (Virologica Sinica)
[2020, :]

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HIV drug resistance and antiretroviral therapy programs in Henan, China-authors' reply.

Lulu Zuo, Jianru Qin, Qinggang Xu, Chiyu Zhang,

EClinicalMedicine (EClinicalMedicine)
[2020, 19:100272]

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Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017).

Lulu Zuo, Kai Liu, Honglian Liu, Yihong Hu, Zhijie Zhang, Jianru Qin, Qinggang Xu, Ke Peng, Xia Jin, Jian-Hua Wang, Chiyu Zhang,

Background:The emergence and spread of HIV-1 drug resistance may compromise HIV control globally. In response to HIV/AIDS epidemic, China launched national HIV/AIDS treatment program in 2003, and started to accumulate drug resistance data since 2001. In this study we aimed to assess the level, trend and distribution of HIV-1 drug ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2020, 18:100238]

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A quite sensitive fluorescent loop-mediated isothermal amplification for rapid detection of respiratory syncytial virus.

Yihong Hu, Zhenzhou Wan, Yonglin Mu, Yi Zhou, Jia Liu, Ke Lan, Chiyu Zhang,

INTRODUCTION:Human respiratory syncytial virus (hRSV) is a common respiratory virus closely related to respiratory tract infection (RTI). Rapid and accurate detection of hRSV is urgently needed to reduce the high morbidity and mortality due to hRSV infection. METHODOLOGY:Here, we established a highly sensitive and specific reverse-transcription loop-mediated isothermal amplification (RT-LAMP) ... Read more >>

J Infect Dev Ctries (Journal of infection in developing countries)
[2019, 13(12):1135-1141]

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National Epidemiology and Evolutionary History of Four Hand, Foot and Mouth Disease-Related Enteroviruses in China from 2008 to 2016.

Xuemin Fu, Zhenzhou Wan, Yanpeng Li, Yihong Hu, Xia Jin, Chiyu Zhang,

Hand, foot and mouth disease (HFMD) is a major public health concern in China. The most predominant enteroviruses that cause HFMD have traditionally been attributed to enterovirus A71 (EVA71) and coxsackievirus A16 (CVA16). Since its first large outbreak in 2008, the dominant HFMD pathogens are constantly changing. In 2013 and ... Read more >>

Virol Sin (Virologica Sinica)
[2020, 35(1):21-33]

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Gemykibivirus Genome in Lower Respiratory Tract of Elderly Woman With Unexplained Acute Respiratory Distress Syndrome.

Jian Wang, Yanpeng Li, Xi He, Jinmin Ma, Wenxin Hong, Fengyu Hu, Lingzhai Zhao, Qiongfang Li, Jianhui Zhang, Chiyu Zhang, Fuchun Zhang,

Using metagenomics analysis, we are the first to identify the presence of a small, circular, single-stranded Gemykibivirus (GkV) genome from the respiratory tract of an elderly woman with severe acute respiratory distress syndrome. Our results suggest that further studies on whether GkVs infect humans and cause respiratory disease are needed. ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 69(5):861-864]

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High proportion of coxsackievirus B3 genotype A in hand, foot and mouth disease in Zhenjiang, China, 2011-2016.

Xuemin Fu, Lingxiang Mao, Zhenzhou Wan, Rong Xu, Yingying Ma, Li Shen, Xia Jin, Chiyu Zhang,

BACKGROUND:Hand, foot and mouth disease (HFMD) is usually caused by EVA71 and CVA16 except for a few cases that are caused by non-EVA71 non-CAV16 enteroviruses. Coxsackievirus B3 (CVB3) is mostly associated with myocarditis, occasionally with HFMD. METHODS:The partial VP1 gene of enteroviruses were amplified and sequenced from 610 throat swabs ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2019, 87:1-7]

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Self-Sorting of 10-µm-Long Single-Walled Carbon Nanotubes in Aqueous Solution.

Peng Wang, Benjamin Barnes, Xiaojian Wu, Haoran Qu, Chiyu Zhang, Yang Shi, Robert J Headrick, Matteo Pasquali, YuHuang Wang,

Single-walled carbon nanotubes (SWCNTs) are a class of 1D nanomaterials that exhibit extraordinary electrical and optical properties. However, many of their fundamental studies and practical applications are stymied by sample polydispersity. SWCNTs are synthesized in bulk with broad structural (chirality) and geometrical (length and diameter) distributions; problematically, all known post-synthetic ... Read more >>

Adv. Mater. Weinheim (Advanced materials (Deerfield Beach, Fla.))
[2019, 31(33):e1901641]

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Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children.

Yanpeng Li, Xuemin Fu, Jinmin Ma, Jianhui Zhang, Yihong Hu, Wei Dong, Zhenzhou Wan, Qiongfang Li, Yi-Qun Kuang, Ke Lan, Xia Jin, Jian-Hua Wang, Chiyu Zhang,

Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):2288]

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A Mismatch-Tolerant Reverse Transcription Loop-Mediated Isothermal Amplification Method and Its Application on Simultaneous Detection of All Four Serotype of Dengue Viruses.

Yi Zhou, Zhenzhou Wan, Shuting Yang, Yingxue Li, Min Li, Binghui Wang, Yihong Hu, Xueshan Xia, Xia Jin, Na Yu, Chiyu Zhang,

Loop-mediated isothermal amplification (LAMP) has been widely used in the detection of pathogens causing infectious diseases. However, mismatches between primers (especially in the 3'-end) and templates significantly reduced the amplification efficiency of LAMP, and limited its application to genetically diverse viruses. Here, we reported a novel mismatch-tolerant LAMP assay and ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:1056]

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Identification of a New HCV Subtype 6xg Among Injection Drug Users in Kachin, Myanmar.

Mei Ye, Xin Chen, Yu Wang, Lin Duo, Chiyu Zhang, Yong-Tang Zheng,

Characterizing hepatitis C virus (HCV) genetic diversity not only allows us to trace its origin and evolutionary history, but also provides valuable insights into diagnosis, prevention and therapy of HCV infection. Although eight HCV genotypes and 86 subtypes have been classified, there are still some HCV variants that need to ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:814]

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A mismatch-tolerant RT-quantitative PCR: application to broad-spectrum detection of respiratory syncytial virus.

Yingxue Li, Zhenzhou Wan, Yihong Hu, Yi Zhou, Qin Chen, Chiyu Zhang,

Quantitative PCR (qPCR) is widely used to detect viruses. However, mismatches occurring in the 3'-end of the primers reduce amplification efficiency of qPCR and limit its capacity in detection of highly variable viruses. Here, we reported a mismatch-tolerant RT-qPCR with a small amount of additional high-fidelity DNA polymerase for simultaneous ... Read more >>

BioTechniques (BioTechniques)
[2019, 66(5):225-230]

Cited: 1 time

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No association of TP53 codon 72 and intron 3 16-bp duplication polymorphisms with breast cancer risk in Chinese Han women: new evidence from a population-based case-control investigation.

Weiming Hao, Xia Xu, Haifeng Shi, Chiyu Zhang, Xiaoxiang Chen,

BACKGROUND:Many studies have demonstrated that the genetic variants of tumor suppressor gene TP53 contribute to the prediction of breast cancer risk. However, most of them focused on Europeans and Americans; the investigations about Asians, especially Chinese women, are scarce. Thus, the aim of this study was to explore the influence ... Read more >>

Eur. J. Med. Res. (European journal of medical research)
[2018, 23(1):47]

Cited: 1 time

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Non-Chinese Immigrants: Challenge Faced by Yunnan of China to Achieve the 90-90-90 Goals.

Xin Chen, Lin Duo, Mei Ye, Chiyu Zhang, Yong-Tang Zheng,

Virol Sin (Virologica Sinica)
[2018, 33(3):291-293]

Cited: 6 times

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Author Correction: A novel quantitative PCR mediated by high-fidelity DNA polymerase.

Mengling Zhang, Kyle Liu, Yihong Hu, Yi Lin, Yang Li, Ping Zhong, Xia Jin, Xiaoli Zhu, Chiyu Zhang,

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):6142]

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The dynamics of the hand, foot and mouth disease epidemic from 2008 to 2016 in Zhenjiang city, China.

Lingxiang Mao, Xuemin Fu, Jing Wu, Li Shen, Jiaqi Gu, Zhaohu Yuan, Jianguo Chen, Xinran Zou, Chiyu Zhang,

AIM:To investigate the hand, foot and mouth disease (HFMD) epidemic in Zhenjiang, China from 2008 to 2016. MATERIALS & METHODS:A total of 37,202 HFMD cases were investigated and 3707 nasopharyngeal swabs were detected for enterovirus RNA using RT-quantitative PCR. RESULTS:We first reported a mixed pattern of HFMD seasonal epidemic with ... Read more >>

Future Microbiol (Future microbiology)
[2018, 13:1029-1040]

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Burmese injecting drug users in Yunnan play a pivotal role in the cross-border transmission of HIV-1 in the China-Myanmar border region.

Xin Chen, Yan-Heng Zhou, Mei Ye, Yu Wang, Lin Duo, Wei Pang, Chiyu Zhang, Yong-Tang Zheng,

Injecting drug users (IDUs) are the major risk group for HIV-1 infection in the China-Myanmar border area. There are a large number of Burmese IDUs living in Yunnan (Yunnan-mIDUs) who might be associated with the cross-border transmission of HIV-1. From 2010 to 2013, 617 Yunnan-mIDUs were recruited from three counties ... Read more >>

Virulence (Virulence)
[2018, 9(1):1195-1204]

Cited: 5 times

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Metagenomic analysis identified co-infection with human rhinovirus C and bocavirus 1 in an adult suffering from severe pneumonia.

Yanpeng Li, Xilong Deng, Fengyu Hu, Jian Wang, Ying Liu, Huang Huang, Jinmin Ma, Jianhui Zhang, Fuchun Zhang, Chiyu Zhang,

J. Infect. (The Journal of infection)
[2018, 76(3):311-313]

Cited: 1 time

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A novel quantitative PCR mediated by high-fidelity DNA polymerase.

Mengling Zhang, Kyle Liu, Yihong Hu, Yi Lin, Yang Li, Ping Zhong, Xia Jin, Xiaoli Zhu, Chiyu Zhang,

The biggest challenge for accurate diagnosis of viral infectious disease is the high genetic variability of involved viruses, which affects amplification efficiency and results in low sensitivity and narrow spectrum. Here, we developed a new simple qPCR mediated by high-fidelity (HF) DNA polymerase. The new method utilizes an HFman probe ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):10365]

Cited: 1 time

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