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2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease.

Hye-Kyung Jung, Chung Hyun Tae, Kyung Ho Song, Seung Joo Kang, Jong Kyu Park, Eun Jeong Gong, Jeong Eun Shin, Hyun Chul Lim, Sang Kil Lee, Da Hyun Jung, Yoon Jin Choi, Seung In Seo, Joon Sung Kim, Jung Min Lee, Beom Jin Kim, Sun Hyung Kang, Chan Hyuk Park, Suck Chei Choi, Joong Goo Kwon, Kyung Sik Park, Moo In Park, Tae Hee Lee, Seung Young Kim, Young Sin Cho, Han Hong Lee, Kee Wook Jung, Do Hoon Kim, Hee Seok Moon, Hirota Miwa, Chien-Lin Chen, Sutep Gonlachanvit, Uday C Ghoshal, Justin C Y Wu, Kewin T H Siah, Xiaohua Hou, Tadayuki Oshima, Mi-Young Choi, Kwang Jae Lee, ,

Gastroesophageal reflux disease (GERD) is a condition in which gastric contents regurgitate into the esophagus or beyond, resulting in either troublesome symptoms or complications. GERD is heterogeneous in terms of varied manifestations, test findings, and treatment responsiveness. GERD diagnosis can be established with symptomatology, pathology, or physiology. Recently the Lyon ... Read more >>

J Neurogastroenterol Motil (Journal of neurogastroenterology and motility)
[2021, 27(4):453-481]

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Editorial: time to retire Rome IV and the Montreal definition? Authors' reply.

Ming-Wun Wong, Chien-Lin Chen,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(8):1083-1084]

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Effects of menthol on esophageal motility in humans: Studies using high-resolution manometry.

Wei-Yi Lei, Shu-Wei Liang, Jui-Sheng Hung, Ming-Wun Wong, Tso-Tsai Liu, Chih-Hsun Yi, Lin Lin, William C Orr, Chien-Lin Chen,

<h4>Background/aim</h4>The cold receptor, transient receptor potential melastatin 8 (TRPM8), has been reported to be expressed in esophageal vagal afferents. Esophageal infusion of menthol modulates esophageal perception in reflux patients via TRPM8, but the effects of menthol on esophageal motility are not well investigated. This study aimed to test the hypothesis ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, :e14267]

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Effects of codeine on esophageal peristalsis in humans using high resolution manometry.

Chien-Lin Chen, Ming-Wun Wong, Jui-Sheng Hung, Shu-Wei Liang, Tso-Tsai Liu, Chih-Hsun Yi, Lin Lin, William C Orr, Wei-Yi Lei,

<h4>Background and aim</h4>Opioid receptors agonists have been demonstrated to impair lower esophageal sphincter (LES) relaxation and induce spastic esophageal dysmotility, but little was known for their impact on distension-induced secondary peristalsis. The aim of the study was to investigate the hypothesis whether acute administration of codeine can influence physiological characteristics ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2021, :]

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Oesophageal hypervigilance and visceral anxiety relate to reflux symptom severity and psychological distress but not to acid reflux parameters.

Ming-Wun Wong, Tso-Tsai Liu, Chih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Charles Cock, Taher Omari, Chandra Prakash Gyawali, Shu-Wei Liang, Lin Lin, Chien-Lin Chen,

<h4>Background</h4>The pathogenesis of gastro-oesophageal reflux disease (GERD) is complex and multifactorial. The oesophageal hypervigilance and anxiety scale (EHAS) is a novel cognitive-affective evaluation of visceral sensitivity.<h4>Aims</h4>To investigate the interrelationship between EHAS and reflux symptom severity, psychological stress, acid reflux burden, phenotypes, and oesophageal mucosal integrity in patients with GERD.<h4>Methods</h4>Patients with ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(7):923-930]

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Factors associated with high compliance behaviour against COVID-19 in the early phase of pandemic: a cross-sectional study in 12 Asian countries.

Chun En Chua, Guan Sen Kew, Alla Demutska, Sabrina Quek, Evelyn Xiu Ling Loo, Hao Gui, Scott Wong, Hui Xing Lau, En Xian Sarah Low, Tze Liang Loh, Shien Lung Ooi, Emily C W Hung, M Masudur Rahman, Uday Ghoshal, Hei Wong, Cynthia K Y Cheung, Ari F Syam, Niandi Tan, Yinglian Xiao, Jin-Song Liu, Fang Lu, Chien-Lin Chen, Yeong Yeh Lee, Ruter M Maralit, Yong-Sung Kim, Tadayuki Oshima, Hiroto Miwa, Junxiong Pang, Kewin Tien Ho Siah,

<h4>Introduction</h4>Regardless of having effective vaccines against COVID-19, containment measures such as enhanced physical distancing and good practice of personal hygiene remain the mainstay of controlling the COVID-19 pandemic. Countries across Asia have imposed these containment measures to varying extents. However, residents in different countries would have a differing degree of ... Read more >>

BMJ Open (BMJ open)
[2021, 11(8):e046310]

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Esophageal mucosal sensory nerves and potential mechanoreceptors in patients with ineffective esophageal motility.

Akinari Sawada, Wei-Yi Lei, Mengyu Zhang, Chung Lee, Ahsen Ustaoglu, Chien-Lin Chen, Daniel Sifrim,

<h4>Background</h4>Ineffective esophageal motility (IEM) is the most common motility disorder. However, little is known about its pathophysiology. Vagal afferent nerves convey esophageal intraluminal bolus information to solitary nucleus, which is likely to be involved with esophageal primary and secondary peristalsis (SP). We hypothesized that altered mucosal sensory afferents underlie the ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, :e14205]

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Prion-like Conformational Editing of SMN2 Proteins Rescues Spinal Muscular Atrophy

I-Fan Wang, Chen-Hung Ting, Li-Kai Tsai, Hsiang-Yu Chang, Hsing-Jung Lai, Chien-Lin Chen,

Spinal muscular atrophy (SMA) causes the loss of motor neurons and progressive muscle weakness. In 95% of patients with SMA, both alleles of the survival motor neuron 1 ( SMN1 ­) gene are deleted or the gene contains missense mutations. A nearly identical copy of SMN1 , SMN2 , is ... Read more >>

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Profile of the Change in Depression during Proton-Pump Inhibitor Therapy in Patients with Gastroesophageal Reflux Disease: Influence of the Mucosal Break.

Chia-Liang Wu, Chien-Lin Chen, Shu-Hui Wen,

Given the frequent concomitance between depression and gastroesophageal reflux disease (GERD), it is important to evaluate the change of depression in patients with GERD, especially considering the presence of esophageal mucosal breaks (MB). This study aimed to examine the change in the levels of depression in patients with GERD during ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(11):]

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Esophageal acid burden in reflux patients with normal endoscopy: Does esophageal peristalsis matter?

Ming-Wun Wong, Jui-Sheng Hung, Tso-Tsai Liu, Chih-Hsun Yi, Wei-Yi Lei, Shu-Wei Liang, William C Orr, Chien-Lin Chen,

<h4>Background</h4>A majority of patients with gastroesophageal reflux disease (GERD) have normal endoscopy. We aimed to investigate whether esophageal primary and secondary peristalsis influence esophageal reflux parameters in patients with normal endoscopy.<h4>Methods</h4>We enrolled consecutive patients with typical reflux symptoms and normal endoscopy. All patients underwent High resolution manometry (HRM) and 24-h ... Read more >>

J Formos Med Assoc (Journal of the Formosan Medical Association = Taiwan yi zhi)
[2021, :]

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Association between well-being and compliance with COVID-19 preventive measures by healthcare professionals: A cross-sectional study.

Shimoni Urvish Shah, Evelyn Xiu Ling Loo, Chun En Chua, Guan Sen Kew, Alla Demutska, Sabrina Quek, Scott Wong, Hui Xing Lau, En Xian Sarah Low, Tze Liang Loh, Ooi Shien Lung, Emily C W Hung, M Masudur Rahman, Uday C Ghoshal, Sunny H Wong, Cynthia K Y Cheung, Ari F Syam, Niandi Tan, Yinglian Xiao, Jin-Song Liu, Fang Lu, Chien-Lin Chen, Yeong Yeh Lee, Ruter M Maralit, Yong-Sung Kim, Tadayuki Oshima, Hiroto Miwa, Kewin Tien Ho Siah, Junxiong Pang,

<h4>Importance</h4>Knowledge and attitude influence compliance and individuals' practices. The risk and protective factors associated with high compliance to these preventive measures are critical to enhancing pandemic preparedness.<h4>Objective</h4>This survey aims to assess differences in mental health, knowledge, attitudes, and practices (KAP) of preventive measures for COVID-19 amongst healthcare professionals (HCP) and ... Read more >>

PLoS One (PloS one)
[2021, 16(6):e0252835]

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Two-stage prediction model for in-hospital mortality of patients with influenza infection.

Chan-Wa Cheong, Chien-Lin Chen, Chih-Huang Li, Chen-June Seak, Hsiao-Jung Tseng, Kuang-Hung Hsu, Chip-Jin Ng, Cheng-Yu Chien,

<h4>Background</h4>Infleunza is a challenging issue in public health. The mortality and morbidity associated with epidemic and pandemic influenza puts a heavy burden on health care system. Most patients with influenza can be treated on an outpatient basis but some required critical care. It is crucial for frontline physicians to stratify ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2021, 21(1):451]

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Conversion of Pectin-Containing By-Products to Pectinases by Bacillus amyloliquefaciens and Its Applications on Hydrolyzing Banana Peels for Prebiotics Production.

Chien Thang Doan, Chien-Lin Chen, Van Bon Nguyen, Thi Ngoc Tran, Anh Dzung Nguyen, San-Lang Wang,

The utilization of pectin-containing by-products may be useful in a variety of fields. This study aims to establish the processing of pectin-containing by-products to produce pectinases using <i>Bacillus amyloliquefaciens</i> TKU050 strain. In this study, several kinds of agricultural pectin-containing by-products from banana (banana peel), rice (rice bran), orange (orange peel), ... Read more >>

Polymers (Basel) (Polymers)
[2021, 13(9):]

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Shoulder strap fixation of LUCAS-2 to facilitate continuous CPR during non-supine (stair) stretcher transport of OHCAs patients.

Chen-Bin Chen, Kuan-Fu Chen, Cheng-Yu Chien, Chan-Wei Kuo, Zhong Ning Leonard Goh, Chen-Ken Seak, Joanna Chen-Yeen Seak, Chen-June Seak, ,

Early recognition and rapid initiation of high-quality cardiopulmonary resuscitation (CPR) are key to maximising chances of achieving successful return of spontaneous circulation in patients with out-of-hospital cardiac arrests (OHCAs), as well as improving patient outcomes both inside and outside hospital. Mechanical chest compression devices such as the LUCAS-2 have been ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):9858]

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Analysis of contractile segment impedance during straight leg raise maneuver using high-resolution impedance manometry increases diagnostic yield in reflux disease.

Ming-Wun Wong, Tso-Tsai Liu, Chih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Taher Omari, Charles Cock, Shu-Wei Liang, Chandra Prakash Gyawali, Chien-Lin Chen,

<h4>Background</h4>Contractile segment impedance (CSI) obtained from high-resolution impedance manometry (HRIM) is a measure of mucosal integrity that predicts gastroesophageal reflux disease (GERD). While straight leg raise (SLR) maneuver augments esophageal peristaltic vigor, it remains unclear whether SLR affects CSI values. This study was aimed to evaluate whether CSI with SLR ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, :e14135]

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The Effects of Silver-Releasing Foam Dressings on Diabetic Foot Ulcer Healing.

Yu-Chi Wang, Hsiao-Chen Lee, Chien-Lin Chen, Ming-Chun Kuo, Savitha Ramachandran, Rong-Fu Chen, Yur-Ren Kuo,

Diabetic foot ulcers (DFUs) are a serious complication in diabetic patients and lead to high morbidity and mortality. Numerous dressings have been developed to facilitate wound healing of DFUs. This study investigated the wound healing efficacy of silver-releasing foam dressings versus silver-containing cream in managing outpatients with DFUs. Sixty patients ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(7):]

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Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors.

Ahsen Ustaoglu, Akinari Sawada, Chung Lee, Wei-Yi Lei, Chien-Lin Chen, Richard Hackett, Daniel Sifrim, Madusha Peiris, Philip Woodland,

The underlying causes of heartburn, characteristic symptom of gastroesophageal reflux disease (GERD), remain incompletely understood. Superficial afferent innervation of the esophageal mucosa in nonerosive reflux disease (NERD) may drive nociceptive reflux perception, but its acid-sensing role has not yet been established. Transient receptor potential vanilloid subfamily member-1 (TRPV1), transient receptor ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2021, 320(5):G804-G815]

Cited: 1 time

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Impact of the coronavirus disease 2019 pandemic on irritable bowel syndrome.

Sabrina Xin Zi Quek, Evelyn Xiu Ling Loo, Alla Demutska, Chun En Chua, Guan Sen Kew, Scott Wong, Hui Xing Lau, En Xian Sarah Low, Tze Liang Loh, Ooi Shien Lung, Emily C W Hung, M Masudur Rahman, Uday C Ghoshal, Sunny H Wong, Cynthia K Y Cheung, Ari F Syam, Niandi Tan, Yinglian Xiao, Jin-Song Liu, Fang Lu, Chien-Lin Chen, Yeong Yeh Lee, Ruter M Maralit, Yong-Sung Kim, Tadayuki Oshima, Hiroto Miwa, Junxiong Pang, Kewin Tien Ho Siah,

<h4>Background and aim</h4>Gastrointestinal manifestations of the coronavirus disease 2019 (COVID-19) pandemic may mimic irritable bowel syndrome (IBS), and social distancing measures may affect IBS patients negatively. We aimed to study the impact of COVID-19 on respondents with self-reported IBS.<h4>Methods</h4>We conducted an anonymized survey from May to June 2020 in 33 ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2021, 36(8):2187-2197]

Cited: 4 times

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Two-stage Prediction Model for in-hospital Mortality of Patients With Influenza Infection

Chan-Wa Cheong, Chien-Lin Chen, Chih-Huang Li, Chen-June Seak, Hsiao-Jung Tseng, Kuang-Hung Hsu, Chip-Jin Ng, Cheng-Yu Chien,

<h4>Background: </h4> Infleunza is a challenging issue in public health. The mortality and morbidity associated with epidemic and pandemic influenza puts a heavy burden on health care system. Most patients with influenza can be treated on an outpatient basis but some required critical care. It is crucial for frontline physicians ... Read more >>

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An Uncommon Ectopic Duodenal Varices Hemorrhage in Cirrhotic Patient Managed With the Enteroscope.

Hsiang-Yu Hsu, Ming-Wun Wong, Chien-Lin Chen,

Am J Med Sci (The American journal of the medical sciences)
[2021, 362(3):e25]

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First record of the rare stenopodidean shrimp Odontozona spongicola (Alcock amp; Anderson, 1899) (Decapoda: Stenopodidea: Stenopodidae) from Indonesia.

Chien-Lin Chen, Tin-Yam Chan,

The stenopodidean shrimp Odontozona spongicola (Alcock Anderson, 1899) collected by the South Java Deep-Sea Biodiversity Expedition 2018 (SJADES 2018) is a new record from Indonesia. The specimen of O. spongicola recently listed from the South China Sea is also formally reported here in. The characteristcs and coloration of this rare ... Read more >>

Zootaxa (Zootaxa)
[2021, 4915(4):zootaxa.4915.4.8]

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Knowledge, Attitude, and Practice Survey of Gastroparesis in Asia by Asian Neurogastroenterology and Motility Association.

Tadayuki Oshima, Kewin T H Siah, Yong Sung Kim, Tanisa Patcharatrakul, Chien-Lin Chen, Sanjiv Mahadeva, Hyojin Park, Min-Hu Chen, Ching-Liang Lu, Xiaohua Hou, Duc T Quach, Ari F Syam, M Masudur Rahman, Yinglian Xiao, Liu Jinsong, Andrew S B Chua, Hiroto Miwa,

<h4>Background/aims</h4>Gastroparesis is identified as a subject that is understudied in Asia. The scientific committee of the Asian Neurogastroenterology and Motility Association performed a Knowledge, Attitude, and Practices survey on gastroparesis among doctors in Asia.<h4>Methods</h4>The questionnaire was created and developed through a literature review of current gastroparesis works of literature by ... Read more >>

J Neurogastroenterol Motil (Journal of neurogastroenterology and motility)
[2021, 27(1):46-54]

Cited: 1 time

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Acid suppressants use and the risk of dementia: A population-based propensity score-matched cohort study.

Chia-Liang Wu, Wei-Yi Lei, Jaw-Shing Wang, Ching-En Lin, Chien-Lin Chen, Shu-Hui Wen,

In this population-based propensity score matched (PSM) cohort study, we aimed to investigate the risk of developing dementia with the use of acid suppressants, including proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2 antagonists). Cohorts of PPI users (n = 2,778), H2 antagonist users (n = 6,165), and non-users ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0242975]

Cited: 2 times

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Impact of ineffective esophageal motility on secondary peristalsis: Studies with high-resolution manometry.

Wei-Yi Lei, Tso-Tsai Liu, Jen-Hung Wang, Chih-Hsun Yi, Jui-Sheng Hung, Ming-Wun Wong, Chandra Prakash Gyawali, Chien-Lin Chen,

<h4>Background/aim</h4>The aim was to investigate whether there is a difference in secondary peristalsis on high-resolution manometry (HRM) among gastroesophageal reflux disease (GERD) patients with and without ineffective esophageal motility (IEM), and healthy individuals.<h4>Methods</h4>Twenty-eight GERD patients and seventeen healthy controls were included. Secondary peristalsis was stimulated by a rapid injection of ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(4):e14024]

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Effect of prucalopride on sildenafil-induced inhibition of esophageal peristalsis in healthy adults.

Ming-Wun Wong, Tso-Tsai Liu, Chih-Hsun Yi, Jui-Sheng Hung, Wei-Yi Lei, Shu-Wei Liang, William C Orr, Chien-Lin Chen,

<h4>Background and aim</h4>Prucalopride, a high-affinity 5-hydroxytryptamine 4 receptor agonist, promotes esophageal peristalsis, while phosphodiesterase type 5 inhibitor sildenafil inhibits esophageal peristalsis. The present study was aimed to evaluate whether prucalopride would augment esophageal peristalsis subsequent to the application of sildenafil.<h4>Methods</h4>Seventeen healthy adults underwent high-resolution manometry by a catheter with one ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2021, 36(6):1556-1561]

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