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Author Chiara Bucciarelli Ducci

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Imaging Findings of COVID-19-Related Cardiovascular Complications

Eleni Nakou, Estefania De Garate, Kate Liang, Matthew Williams, Dudley J. Pennell, Chiara Bucciarelli-Ducci,

Other than respiratory disease, patients with coronavirus disease 2019 (COVID-19) commonly have cardiovascular manifestations, which are recognised as significant risk factors for increased mortality. COVID-19 patients may present with a wide spectrum of clinical presentations ranging from asymptomatic heart disease detected incidentally by cardiac investigations (troponin, BNP, imaging) to cardiogenic ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Cardiovascular Magnetic Resonance Parametric Mapping Techniques: Clinical Applications and Limitations.

Eleni Nakou, Rishi K Patel, Marianna Fontana, Chiara Bucciarelli-Ducci,

<h4>Purpose of review</h4>Parametric mapping represents a significant innovation in cardiovascular magnetic resonance (CMR) tissue characterisation, allowing the quantification of myocardial changes based on changes on T1, T2 and T2* relaxation times and extracellular volume (ECV). Its clinical use is rapidly expanding, but it requires availability of dedicated equipment as well ... Read more >>

Curr Cardiol Rep (Current cardiology reports)
[2021, 23(12):185]

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Clinical Impact of Cardiovascular Magnetic Resonance in Cancer Patients With Suspected Cardiomyopathy.

Giv Heidari-Bateni, Jean-Bernard Durand, Cezar Iliescu, Greg Gladish, Anita Deswal, Amit R Patel, Peter Kim, Juhee Song, Saamir Hassan, Nicolas Palaskas, Lauren A Baldassarre, Chiara Bucciarelli-Ducci, Juan Lopez-Mattei,

<b>Objectives:</b> To assess the clinical impact of Cardiovascular Magnetic Resonance (CMR) in clinical decision making of cancer patients with a suspected cardiomyopathy in a tertiary cancer center. <b>Background:</b> Cardiomyopathies of diverse etiologies are frequently encountered in a Cardio-Oncology practice. The clinical impact of CMR after a presumptive diagnosis of cardiomyopathy ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:734820]

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Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy.

Rohin Francis, Jun Chong, Manish Ramlall, Chiara Bucciarelli-Ducci, Tim Clayton, Matthew Dodd, Thomas Engstrøm, Richard Evans, Vanessa M Ferreira, Marianna Fontana, John P Greenwood, Rajesh K Kharbanda, Won Yong Kim, Tushar Kotecha, Jacob T Lønborg, Anthony Mathur, Ulla Kristine Møller, James Moon, Alexander Perkins, Roby D Rakhit, Derek M Yellon, Hans Erik Bøtker, Heerajnarain Bulluck, Derek J Hausenloy,

The effect of limb remote ischaemic conditioning (RIC) on myocardial infarct (MI) size and left ventricular ejection fraction (LVEF) was investigated in a pre-planned cardiovascular magnetic resonance (CMR) substudy of the CONDI-2/ERIC-PPCI trial. This single-blind multi-centre trial (7 sites in UK and Denmark) included 169 ST-segment elevation myocardial infarction (STEMI) ... Read more >>

Basic Res Cardiol (Basic research in cardiology)
[2021, 116(1):59]

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Stone Heart.

Estefania De Garate, Anna Baritussio, Alessandra Scatteia, Christopher Lawton, Chiara Bucciarelli-Ducci,

We describe a rare case of infiltrative cardiomyopathy characterized by multiple low-signal myocardial lesions consistent with nodular calcifications. A retrospectively detailed clinical history and the use of multimodality imaging enabled us to identify the final diagnosis. (<b>Level of Difficulty: Advanced.</b>). ... Read more >>

JACC Case Rep (JACC. Case reports)
[2021, 3(13):1509-1511]

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Mitral regurgitation quantification by cardiac magnetic resonance imaging (MRI) remains reproducible between software solutions

Ciaran Grafton-Clarke, George Thornton, Benjamin Fidock, Gareth Archer, Rod Hose, Rob van der Geest, Liang Zhong, Andrew Swift, James Wild, Estefania De Gárate, Chiara Bucciarelli-Ducci, Sven Plein, Thomas Treibel, Marcus Flather, Vassilios Vassiliou, Pankaj Garg,

Background: The reproducibility of mitral regurgitation (MR) quantification by cardiovascular magnetic resonance (CMR) imaging using different software solutions remains unclear. This research aimed to investigate the reproducibility of MR quantification between two software solutions: MASS (version 2019 EXP, LUMC, Netherlands) and CAAS (version 5.2, Pie Medical Imaging). Methods: CMR data ... Read more >>

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Diagnostic pathways in myocardial infarction with non-obstructive coronary artery disease (MINOCA).

Giovanni Occhipinti, Chiara Bucciarelli-Ducci, Davide Capodanno,

When acute myocardial injury is found in a clinical setting suggestive of myocardial ischaemia, the event is labelled as acute myocardial infarction (AMI), and the absence of coronary stenosis angiographically 50% or greater leads to the working diagnosis of myocardial infarction with non-obstructive coronary arteries (MINOCA). The initial diagnosis of ... Read more >>

Eur Heart J Acute Cardiovasc Care (European heart journal. Acute cardiovascular care)
[2021, 10(7):813-822]

Cited: 1 time

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Reconsidering safety and reducing barriers to MRI in patients with cardiac implantable electronic devices.

Chiara Bucciarelli-Ducci, Panos Vardas,

Eur Heart J (European heart journal)
[2021, :]

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The evolving role of cardiac imaging in patients with myocardial infarction and non-obstructive coronary arteries.

Rocco A Montone, Ik-Kyung Jang, John F Beltrame, Rosa Sicari, Maria Chiara Meucci, Michael Bode, Nicola Gaibazzi, Giampaolo Niccoli, Chiara Bucciarelli-Ducci, Filippo Crea,

Myocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) represents a heterogeneous clinical conundrum accounting for about 6%-8% of all acute MI who are referred for coronary angiography. Current guidelines and consensus documents recommend that these patients are appropriately diagnosed, uncovering the causes of MINOCA, so that specific therapies can be ... Read more >>

Prog Cardiovasc Dis (Progress in cardiovascular diseases)
[2021, 68:78-87]

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Long-term outcome of myocardial scarring and deformation with cardiovascular magnetic resonance in out of hospital cardiac arrest survivors.

Anna Baritussio, Giovanni Biglino, Alessandra Scatteia, Estefania De Garate, Amardeep Ghosh Dastidar, Alberto Palazzuoli, Iwan Harries, Julian W Strange, Ihab Diab, Chiara Bucciarelli-Ducci,

<h4>Aims</h4>Cardiovascular magnetic resonance (CMR) is increasingly recognized as a diagnostic and prognostic tool in out of hospital cardiac arrest (OHCA) survivors. After assessing CMR findings early after ventricular fibrillation (VF) OHCA, we sought to explore the long-term outcome of myocardial scarring and deformation.<h4>Methods and results</h4>We included 121 consecutive VF OHCA ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal. Cardiovascular Imaging)
[2021, 22(10):1149-1156]

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Cardiac tamponade secondary to Dressler's syndrome.

Stephanie Connaire, Elena Elchinova, Chiara Bucciarelli-Ducci, Philip Campbell,

A 56-year-old woman presented to hospital with chest pain. Following review and investigations in the medical assessment unit, she was diagnosed with costochondritis and discharged home. She represented 10 days later and was mottled and hypotensive with a high lactate, raised inflammatory markers, an acute kidney injury and bilateral loin ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(8):]

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Cardiovascular magnetic resonance characterisation of anthracycline cardiotoxicity in adults with normal left ventricular ejection fraction.

Iwan Harries, Bostjan Berlot, Natasha Ffrench-Constant, Matthew Williams, Kate Liang, Estefania De Garate, Anna Baritussio, Giovanni Biglino, Juan Carlos Plana, Chiara Bucciarelli-Ducci,

<h4>Background</h4>Anthracycline therapy may lead to changes in cardiac structure and function not detectable by solely evaluating left ventricular ejection fraction (LVEF).<h4>Objectives</h4>We hypothesized that cardiovascular magnetic resonance (CMR) would identify structural and functional myocardial abnormalities in anthracycline-treated cancer survivors with normal LVEF, compared to a matched control population.<h4>Methods</h4>Forty-five cancer survivors (56 ± 16 yrs., ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 343:180-186]

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Impact of COVID-19 on the imaging diagnosis of cardiac disease in Europe.

Michelle Claire Williams, Leslee Shaw, Cole B Hirschfeld, Pal Maurovich-Horvat, Bjarne L Nørgaard, Gianluca Pontone, Amelia Jimenez-Heffernan, Valentin Sinitsyn, Vladimir Sergienko, Alexey Ansheles, Jeroen J Bax, Ronny Buechel, Elisa Milan, Riemer H J A Slart, Edward Nicol, Chiara Bucciarelli-Ducci, Yaroslav Pynda, Nathan Better, Rodrigo Cerci, Sharmila Dorbala, Paolo Raggi, Todd C Villines, Joao Vitola, Eli Malkovskiy, Benjamin Goebel, Yosef Cohen, Michael Randazzo, Thomas N B Pascual, Maurizio Dondi, Diana Paez, Andrew J Einstein, ,

<h4>Objectives</h4>We aimed to explore the impact of the COVID-19 pandemic on cardiac diagnostic testing and practice and to assess its impact in different regions in Europe.<h4>Methods</h4>The online survey organised by the International Atomic Energy Agency Division of Human Health collected information on changes in cardiac imaging procedural volumes between March ... Read more >>

Open Heart (Open heart)
[2021, 8(2):]

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Evidence and Applicability of Stress Cardiovascular Magnetic Resonance in Detecting Coronary Artery Disease: State of the Art.

Anna Baritussio, Alessandra Scatteia, Santo Dellegrottaglie, Chiara Bucciarelli-Ducci,

Cardiovascular magnetic resonance is increasingly used in clinical practice, as it has emerged over the years as an invaluable imaging technique for diagnosis and prognosis, with clear-cut applications in managing patients with both ischemic and non-ischemic heart disease. In this review, we focus on the evidence and clinical application of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(15):]

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Prognostic value of perfusion cardiovascular magnetic resonance with adenosine triphosphate stress in stable coronary artery disease.

Ming-Yen Ng, Chi Yeung Chin, Pui Min Yap, Eric Yuk Fai Wan, JoJo Siu Han Hai, Stephen Cheung, Hung Fat Tse, Chiara Bucciarelli-Ducci, Dudley John Pennell, Kai-Hang Yiu,

<h4>Background</h4>Adenosine triphosphate (ATP) has been predominantly used in the Asia-Pacific region for stress perfusion cardiovascular magnetic resonance (CMR). We evaluated the prognosis of patients stressed using ATP, for which there are no current data.<h4>Methods</h4>We performed a retrospective longitudinal study from January 2016 to December 2020 and included 208 subjects with ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2021, 23(1):75]

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Treatment of Barth Syndrome by Cardiolipin Manipulation (CARDIOMAN) With Bezafibrate: Protocol for a Randomized Placebo-Controlled Pilot Trial Conducted in the Nationally Commissioned Barth Syndrome Service.

Lucy Dabner, Guido E Pieles, Colin G Steward, Julian P Hamilton-Shield, Andrew R Ness, Chris A Rogers, Chiara Bucciarelli-Ducci, Rosemary Greenwood, Lucy Ellis, Karen Sheehan, Barnaby C Reeves,

<h4>Background</h4>Barth syndrome is a rare, life-threatening, X-linked recessive genetic disease that predominantly affects young males and is caused by abnormal mitochondrial lipid metabolism. Currently, there is no definitive treatment for Barth syndrome other than interventions to ameliorate acute symptoms, such as heart failure, cardiac arrhythmias, neutropenia, and severe muscle fatigue. ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2021, 10(5):e22533]

Cited: 1 time

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Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART-a UK, multicentre, observational study.

Miroslawa Gorecka, Gerry P McCann, Colin Berry, Vanessa M Ferreira, James C Moon, Christopher A Miller, Amedeo Chiribiri, Sanjay Prasad, Marc R Dweck, Chiara Bucciarelli-Ducci, Dana Dawson, Marianna Fontana, Peter W Macfarlane, Alex McConnachie, Stefan Neubauer, John P Greenwood, ,

<h4>Background</h4>Although coronavirus disease 2019 (COVID-19) is primarily a respiratory illness, myocardial injury is increasingly reported and associated with adverse outcomes. However, the pathophysiology, extent of myocardial injury and clinical significance remains unclear.<h4>Methods</h4>COVID-HEART is a UK, multicentre, prospective, observational, longitudinal cohort study of patients with confirmed COVID-19 and elevated troponin (sex-specific > 99th ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2021, 23(1):77]

Cited: 3 times

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Cardiovascular magnetic resonance in women with cardiovascular disease: position statement from the Society for Cardiovascular Magnetic Resonance (SCMR).

Karen G Ordovas, Lauren A Baldassarre, Chiara Bucciarelli-Ducci, James Carr, Juliano Lara Fernandes, Vanessa M Ferreira, Luba Frank, Sophie Mavrogeni, Ntobeko Ntusi, Ellen Ostenfeld, Purvi Parwani, Alessia Pepe, Subha V Raman, Hajime Sakuma, Jeanette Schulz-Menger, Lilia M Sierra-Galan, Anne Marie Valente, Monvadi B Srichai,

This document is a position statement from the Society for Cardiovascular Magnetic Resonance (SCMR) on recommendations for clinical utilization of cardiovascular magnetic resonance (CMR) in women with cardiovascular disease. The document was prepared by the SCMR Consensus Group on CMR Imaging for Female Patients with Cardiovascular Disease and endorsed by ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2021, 23(1):52]

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Cardiovascular Care of the Oncology Patient During COVID-19: An Expert Consensus Document From the ACC Cardio-Oncology and Imaging Councils.

Lauren A Baldassarre, Eric H Yang, Richard K Cheng, Jeanne M DeCara, Susan Dent, Jennifer E Liu, Lawrence G Rudski, Jordan B Strom, Paaladinesh Thavendiranathan, Ana Barac, Vlad G Zaha, Chiara Bucciarelli-Ducci, Samer Ellahham, Anita Deswal, Carrie Lenneman, Hector R Villarraga, Anne H Blaes, Roohi Ismail-Khan, Bonnie Ky, Monika J Leja, Marielle Scherrer-Crosbie,

In response to the coronavirus disease 2019 (COVID-19) pandemic, the Cardio-Oncology and Imaging Councils of the American College of Cardiology offers recommendations to clinicians regarding the cardiovascular care of cardio-oncology patients in this expert consensus statement. Cardio-oncology patients-individuals with an active or prior cancer history and with or at risk ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2021, 113(5):513-522]

Cited: 4 times

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Transient recurrent takotsubo cardiomyopathy mimicking apical hypertrophic cardiomyopathy.

Matthew G L Williams, Kate Liang, Chiara Bucciarelli-Ducci,

Eur Heart J Cardiovasc Imaging (European heart journal. Cardiovascular Imaging)
[2021, 22(6):e72]

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Development, validation, and implementation of biomarker testing in cardiovascular medicine state-of-the-art: proceedings of the European Society of Cardiology-Cardiovascular Round Table.

Perry Elliott, Martin R Cowie, Jennifer Franke, André Ziegler, Charalambos Antoniades, Jeroen Bax, Chiara Bucciarelli-Ducci, Frank A Flachskampf, Christian Hamm, Magnus T Jensen, Hugo Katus, Alan Maisel, Theresa McDonagh, Clemens Mittmann, Pieter Muntendam, Eike Nagel, Giuseppe Rosano, Raphael Twerenbold, Faiez Zannad,

Many biomarkers that could be used to assess ejection fraction, heart failure, or myocardial infarction fail to translate into clinical practice because they lack essential performance characteristics or fail to meet regulatory standards for approval. Despite their potential, new technologies have added to the complexities of successful translation into clinical ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2021, 117(5):1248-1256]

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The corrected left ventricular ejection fraction: a potential new measure of ventricular function.

Jonathan Carl Luis Rodrigues, Benjamin Rooms, Katie Hyde, Stephen Rohan, Angus K Nightingale, Julian Paton, Nathan Manghat, Chiara Bucciarelli-Ducci, Mark Hamilton, Henggui Zhang, David H MacIver,

Left ventricular ejection fraction (LVEF) has a limited role in predicting outlook in heart diseases including heart failure. We quantified the independent geometric factors that determine LVEF using cardiac MRI and sought to provide an improved measure of ventricular function by adjusting for such independent variables. A mathematical model was ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2021, 37(6):1987-1997]

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Standard and emerging CMR methods for mitral regurgitation quantification.

Benjamin Fidock, Gareth Archer, Natasha Barker, Alaa Elhawaz, Abdallah Al-Mohammad, Alexander Rothman, Rod Hose, Ian R Hall, Ever Grech, Norman Briffa, Nigel Lewis, Rob J van der Geest, Jun-Mei Zhang, Liang Zhong, Andrew J Swift, James M Wild, Estefania De Gárate, Chiara Bucciarelli-Ducci, Jeroen J Bax, Sven Plein, Saul Myerson, Pankaj Garg,

<h4>Background</h4>There are several methods to quantify mitral regurgitation (MR) by cardiovascular magnetic resonance (CMR). The interoperability of these methods and their reproducibility remains undetermined.<h4>Objective</h4>To determine the agreement and reproducibility of different MR quantification methods by CMR across all aetiologies.<h4>Methods</h4>Thirty-five patients with MR were recruited (primary MR = 12, secondary MR = 10 and MVR = 13). ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 331:316-321]

Cited: 1 time

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Quality assurance of quantitative cardiac T1-mapping in multicenter clinical trials - A T1 phantom program from the hypertrophic cardiomyopathy registry (HCMR) study.

Qiang Zhang, Konrad Werys, Iulia A Popescu, Luca Biasiolli, Ntobeko A B Ntusi, Milind Desai, Stefan L Zimmerman, Dipan J Shah, Kyle Autry, Bette Kim, Han W Kim, Elizabeth R Jenista, Steffen Huber, James A White, Gerry P McCann, Saidi A Mohiddin, Redha Boubertakh, Amedeo Chiribiri, David Newby, Sanjay Prasad, Aleksandra Radjenovic, Dana Dawson, Jeanette Schulz-Menger, Heiko Mahrholdt, Iacopo Carbone, Ornella Rimoldi, Stefano Colagrande, Linda Calistri, Michelle Michels, Mark B M Hofman, Lisa Anderson, Craig Broberg, Flett Andrew, Javier Sanz, Chiara Bucciarelli-Ducci, Kelvin Chow, David Higgins, David A Broadbent, Scott Semple, Tarik Hafyane, Joanne Wormleighton, Michael Salerno, Taigang He, Sven Plein, Raymond Y Kwong, Michael Jerosch-Herold, Christopher M Kramer, Stefan Neubauer, Vanessa M Ferreira, Stefan K Piechnik,

<h4>Background</h4>Quantitative cardiovascular magnetic resonance T1-mapping is increasingly used for myocardial tissue characterization. However, the lack of standardization limits direct comparability between centers and wider roll-out for clinical use or trials.<h4>Purpose</h4>To develop a quality assurance (QA) program assuring standardized T1 measurements for clinical use.<h4>Methods</h4>MR phantoms manufactured in 2013 were distributed, including ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 330:251-258]

Cited: 4 times

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Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity.

Andrew R Harper, Anuj Goel, Christopher Grace, Kate L Thomson, Steffen E Petersen, Xiao Xu, Adam Waring, Elizabeth Ormondroyd, Christopher M Kramer, Carolyn Y Ho, Stefan Neubauer, , Rafik Tadros, James S Ware, Connie R Bezzina, Martin Farrall, Hugh Watkins,

Hypertrophic cardiomyopathy (HCM) is a common, serious, genetic heart disorder. Rare pathogenic variants in sarcomere genes cause HCM, but with unexplained phenotypic heterogeneity. Moreover, most patients do not carry such variants. We report a genome-wide association study of 2,780 cases and 47,486 controls that identified 12 genome-wide-significant susceptibility loci for ... Read more >>

Nat Genet (Nature genetics)
[2021, 53(2):135-142]

Cited: 15 times

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