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Author Cheryl S Rosenfeld

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Disruption of global hypothalamic microRNA (miR) profiles and associated behavioral changes in California mice (Peromyscus californicus) developmentally exposed to endocrine disrupting chemicals.

Sarabjit Kaur, Jessica A Kinkade, Madison T Green, Rachel E Martin, Tess E Willemse, Nathan J Bivens, A Katrin Schenk, William G Helferich, Brian C Trainor, Joseph Fass, Matthew Settles, Jiude Mao, Cheryl S Rosenfeld,

Developmental exposure to endocrine disrupting chemicals (EDCs), e.g., bisphenol A (BPA) or genistein (GEN), causes longstanding epigenome effects. MicroRNAs (miRs) regulate which mRNAs will be translated to proteins and thereby serve as the final checkpoint in epigenetic control. Scant amount is known, however, whether EDCs affect neural miRNA (miR) patterns. ... Read more >>

Horm Behav (Hormones and behavior)
[2020, 128:104890]

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Maternal oxycodone treatment causes pathophysiological changes in the mouse placenta.

Madison T Green, Rachel E Martin, Jessica A Kinkade, Robert R Schmidt, Nathan J Bivens, Geetu Tuteja, Jiude Mao, Cheryl S Rosenfeld,

INTRODUCTION:Pregnant women are increasingly being prescribed and abusing opioid drugs. As the primary communication organ between mother and conceptus, the placenta may be vulnerable to opioid effects but also holds the key to better understanding how these drugs affect long-term offspring health. We hypothesized that maternal treatment with oxycodone (OXY), ... Read more >>

Placenta (Placenta)
[2020, 100:96-110]

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Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.

Jerrold J Heindel, Scott Belcher, Jodi A Flaws, Gail S Prins, Shuk-Mei Ho, Jiude Mao, Heather B Patisaul, William Ricke, Cheryl S Rosenfeld, Ana M Soto, Frederick S Vom Saal, R Thomas Zoeller,

"Consortium Linking Academic and Regulatory Insights on BPA Toxicity" (CLARITY-BPA) was a comprehensive "industry-standard" Good Laboratory Practice (GLP)-compliant 2-year chronic exposure study of bisphenol A (BPA) toxicity that was supplemented by hypothesis-driven independent investigator-initiated studies. The investigator-initiated studies were focused on integrating disease-associated, molecular, and physiological endpoints previously found by ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Author Correction: Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood.

Sarabjit Kaur, Saurav J Sarma, Brittney L Marshall, Yang Liu, Jessica A Kinkade, Madison M Bellamy, Jiude Mao, William G Helferich, A Katrin Schenk, Nathan J Bivens, Zhentian Lei, Lloyd W Sumner, John A Bowden, Jeremy P Koelmel, Trupti Joshi, Cheryl S Rosenfeld,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):12524]

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Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood.

Sarabjit Kaur, Saurav J Sarma, Brittney L Marshall, Yang Liu, Jessica A Kinkade, Madison M Bellamy, Jiude Mao, William G Helferich, A Katrin Schenk, Nathan J Bivens, Zhentian Lei, Lloyd W Sumner, John A Bowden, Jeremy P Koelmel, Trupti Joshi, Cheryl S Rosenfeld,

Xenoestrogens are chemicals found in plant products, such as genistein (GEN), and in industrial chemicals, e.g., bisphenol A (BPA), present in plastics and other products that are prevalent in the environment. Early exposure to such endocrine disrupting chemicals (EDC) may affect brain development by directly disrupting neural programming and/or through ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):10902]

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Endocrine disruption of gene expression and microRNA profiles in hippocampus and hypothalamus of California mice: Association of gene expression changes with behavioural outcomes.

Mary C Butler, Camryn N Long, Jessica A Kinkade, Madison T Green, Rachel E Martin, Brittney L Marshall, Tess E Willemse, A Katrin Schenk, Jiude Mao, Cheryl S Rosenfeld,

The hypothalamus and hippocampus are sensitive to early exposure to endocrine disrupting chemicals (EDCs). Two EDCs that have raised particular concerns are bisphenol A (BPA), a widely prevalent chemical in many common household items, and genistein (GEN), a phyto-oestrogen present in soy and other plants. We hypothesised that early exposure ... Read more >>

J Neuroendocrinol (Journal of neuroendocrinology)
[2020, 32(5):e12847]

Cited: 1 time

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The placenta-brain-axis.

Cheryl S Rosenfeld,

All mammalian species depend on the placenta, a transient organ, for exchange of gases, nutrients, and waste between the mother and conceptus. Besides serving as a conduit for such exchanges, the placenta produces hormones and other factors that influence maternal physiology and fetal development. To meet all of these adaptations, ... Read more >>

J Neurosci Res (Journal of neuroscience research)
[2021, 99(1):271-283]

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Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice.

Dusti A Shay, Rebecca J Welly, Scott A Givan, Nathan Bivens, Jill Kanaley, Brittney L Marshall, Dennis B Lubahn, Cheryl S Rosenfeld, Victoria J Vieira-Potter,

Aromatase catalyzes conversion of testosterone to estradiol and is expressed in a variety of tissues, including the brain. Suppression of aromatase adversely affects metabolism and physical activity behavior, but mechanisms remain uncertain. The hypothesis tested herein was that whole body aromatase deletion would cause gene expression changes in the nucleus ... Read more >>

Horm Behav (Hormones and behavior)
[2020, 121:104719]

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Bisphenol A and bisphenol S disruptions of the mouse placenta and potential effects on the placenta-brain axis.

Jiude Mao, Ashish Jain, Nancy D Denslow, Mohammad-Zaman Nouri, Sixue Chen, Tingting Wang, Ning Zhu, Jin Koh, Saurav J Sarma, Barbara W Sumner, Zhentian Lei, Lloyd W Sumner, Nathan J Bivens, R Michael Roberts, Geetu Tuteja, Cheryl S Rosenfeld,

Placental trophoblast cells are potentially at risk from circulating endocrine-disrupting chemicals, such as bisphenol A (BPA). To understand how BPA and the reputedly more inert bisphenol S (BPS) affect the placenta, C57BL6J mouse dams were fed 200 μg/kg body weight BPA or BPS daily for 2 wk and then bred. ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(9):4642-4652]

Cited: 2 times

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Nontargeted fecal metabolomics: an emerging tool to probe the role of the gut microbiome in host health.

Saurav J Sarma, Zhentian Lei, Cheryl S Rosenfeld, Aaron Ericsson, Lloyd W Sumner,

Bioanalysis (Bioanalysis)
[2020, 12(6):351-353]

Cited: 1 time

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Placental serotonin signaling, pregnancy outcomes, and regulation of fetal brain development†.

Cheryl S Rosenfeld,

The placenta is a transient organ but essential for the survival of all mammalian species by allowing for the exchanges of gasses, nutrients, and waste between maternal and fetal placenta. In rodents and humans with a hemochorial placenta, fetal placenta cells are susceptible to pharmaceutical agents and other compounds, as ... Read more >>

Biol Reprod (Biology of reproduction)
[2020, 102(3):532-538]

Cited: 1 time

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Hypothalamic transcriptome of tame and aggressive silver foxes (Vulpes vulpes) identifies gene expression differences shared across brain regions.

Cheryl S Rosenfeld, Jessica P Hekman, Jennifer L Johnson, Zhen Lyu, Madison T Ortega, Trupti Joshi, Jiude Mao, Anastasiya V Vladimirova, Rimma G Gulevich, Anastasiya V Kharlamova, Gregory M Acland, Erin E Hecht, Xu Wang, Andrew G Clark, Lyudmila N Trut, Susanta K Behura, Anna V Kukekova,

The underlying neurological events accompanying dog domestication remain elusive. To reconstruct the domestication process in an experimental setting, silver foxes (Vulpes vulpes) have been deliberately bred for tame vs aggressive behaviors for more than 50 generations at the Institute for Cytology and Genetics in Novosibirsk, Russia. The hypothalamus is an ... Read more >>

Genes Brain Behav (Genes, brain, and behavior)
[2020, 19(1):e12614]

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Mice lacking uterine enhancer of zeste homolog 2 have transcriptomic changes associated with uterine epithelial proliferation.

Ana M Mesa, Jiude Mao, Manjunatha K Nanjappa, Theresa I Medrano, Sergei Tevosian, Fahong Yu, Jessica Kinkade, Zhen Lyu, Yang Liu, Trupti Joshi, Duolin Wang, Cheryl S Rosenfeld, Paul S Cooke,

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that suppresses gene expression. Previously, we developed a conditional null model where EZH2 is knocked out in uterus. Deletion of uterine EZH2 increased proliferation of luminal and glandular epithelial cells. Herein, we used RNA-Seq in wild-type (WT) and EZH2 conditional ... Read more >>

Physiol Genomics (Physiological genomics)
[2020, 52(2):81-95]

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Effects of Phytoestrogens on the Developing Brain, Gut Microbiota, and Risk for Neurobehavioral Disorders.

Cheryl S Rosenfeld,

Many pregnant and nursing women consume high amounts of soy and other plant products that contain phytoestrogens, such as genistein (GEN) and daidzein. Infants may also be provided soy based formulas. With their ability to bind and activate estrogen receptors (ESR) in the brain, such compounds can disrupt normal brain ... Read more >>

Front Nutr (Frontiers in nutrition)
[2019, 6:142]

Cited: 1 time

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Early genistein exposure of California mice and effects on the gut microbiota-brain axis.

Brittney L Marshall, Yang Liu, Michelle J Farrington, Jiude Mao, William G Helferich, A Katrin Schenk, Nathan J Bivens, Saurav J Sarma, Zhentian Lei, Lloyd W Sumner, Trupti Joshi, Cheryl S Rosenfeld,

Human offspring encounter high amounts of phytoestrogens, such as genistein (GEN), through maternal diet and soy-based formulas. Such chemicals can exert estrogenic activity and thereby disrupt neurobehavioral programming. Besides inducing direct host effects, GEN might cause gut dysbiosis and alter gut metabolites. To determine whether exposure to GEN affects these ... Read more >>

J Endocrinol (The Journal of endocrinology)
[2019, 242(2):139-157]

Cited: 5 times

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Mice lacking membrane estrogen receptor 1 are protected from reproductive pathologies resulting from developmental estrogen exposure†.

Manjunatha K Nanjappa, Theresa I Medrano, Ana M Mesa, Madison T Ortega, Paul D Caldo, Jiude Mao, Jessica A Kinkade, Ellis R Levin, Cheryl S Rosenfeld, Paul S Cooke,

Both membrane and nuclear fractions of estrogen receptor 1 (ESR1) mediate 17β-estradiol (E2) actions. Mice expressing nuclear (n)ESR1 but lacking membrane (m)ESR1 (nuclear-only estrogen receptor 1 [NOER] mice) show reduced E2 responsivity and reproductive abnormalities culminating in adult male and female infertility. Using this model, we investigated whether reproductive pathologies ... Read more >>

Biol Reprod (Biology of reproduction)
[2019, 101(2):392-404]

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Opposing effects of S-equol supplementation on metabolic and behavioral parameters in mice fed a high-fat diet.

Erin N Bax, Karlee E Cochran, Jiude Mao, Charles E Wiedmeyer, Cheryl S Rosenfeld,

Phytoestrogens, such as daidzein and genistein, may be used to treat various hormone-dependent disorders. Daidzein can be metabolized by intestinal microbes to S-equol. However, not all individuals possess bacteria producing this metabolite, resulting in categorization of equol vs nonequol producers. Past human and rodent studies have suggested that supplementation of ... Read more >>

Nutr Res (Nutrition research (New York, N.Y.))
[2019, 64:39-48]

Cited: 1 time

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Soy-Induced Fecal Metabolome Changes in Ovariectomized and Intact Female Rats: Relationship with Cardiometabolic Health.

Victoria J Vieira-Potter, Tzu-Wen L Cross, Kelly S Swanson, Saurav J Sarma, Zhentian Lei, Lloyd W Sumner, Cheryl S Rosenfeld,

Phytoestrogens are plant-derived compounds found in a variety of foods, most notably, soy. These compounds have been shown to improve immuno-metabolic health, yet mechanisms remain uncertain. We demonstrated previously that dietary phytoestrogen-rich soy (SOY) rescued metabolic dysfunction/inflammation following ovariectomy (OVX) in female rats; we also noted remarkable shifts in gut ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):16896]

Cited: 1 time

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Endocrine disruption through membrane estrogen receptors and novel pathways leading to rapid toxicological and epigenetic effects.

Cheryl S Rosenfeld, Paul S Cooke,

Estrogen binding to estrogen receptors (ESR) triggers signaling cascades within cells. Historically, a major emphasis has been characterizing estrogen-induced genomic actions resulting from binding to nuclear estrogen receptor 1 (nESR1). However, recent evidence indicates the first receptors estrogens encounter as they enter a cell, membrane ESR1 (mESR1), also play crucial ... Read more >>

J Steroid Biochem Mol Biol (The Journal of steroid biochemistry and molecular biology)
[2019, 187:106-117]

Cited: 2 times

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Cognitive Effects of Aromatase and Possible Role in Memory Disorders.

Cheryl S Rosenfeld, Dusti A Shay, Victoria J Vieira-Potter,

Diverse cognitive functions in many vertebrate species are influenced by local conversion of androgens to 17β-estradiol (E2) by aromatase. This enzyme is highly expressed in various brain regions across species, with some inter-species variation in terms of regional brain expression. Since women with breast cancer and men and women with ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2018, 9:610]

Cited: 3 times

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Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses.

Dusti A Shay, Victoria J Vieira-Potter, Cheryl S Rosenfeld,

Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals, aromatase is expressed in the testes, ovaries, brain, and other tissues. While estrogen is traditionally associated with reproduction and sexual behavior in females, our current understanding broadens this perspective to include such biological functions as metabolism and cognition. ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2018, 11:374]

Cited: 3 times

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Gene expression and DNA methylation changes in the hypothalamus and hippocampus of adult rats developmentally exposed to bisphenol A or ethinyl estradiol: a CLARITY-BPA consortium study.

Ana Cheong, Sarah A Johnson, Emily C Howald, Mark R Ellersieck, Luísa Camacho, Sherry M Lewis, Michelle M Vanlandingham, Jun Ying, Shuk-Mei Ho, Cheryl S Rosenfeld,

Bisphenol A (BPA), an endocrine disrupting chemical (EDC), is a ubiquitous pollutant. As part of the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA), we sought to determine whether exposure of Sprague-Dawley rats to 2,500 μg/kg/day BPA (BPA) or 0.5 μg/kg/day ethinyl estradiol (EE) from gestational day 6 through postnatal ... Read more >>

Epigenetics (Epigenetics)
[2018, 13(7):704-720]

Cited: 5 times

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Hypothalamic gene expression changes in F1 California mice (Peromyscus californicus) parents developmentally exposed to bisphenol A or ethinyl estradiol.

Sarah A Johnson, Mark R Ellersieck, Cheryl S Rosenfeld,

Bisphenol A (BPA) is a pervasive industrial chemical used in many common household items. To examine how early exposure to BPA and ethinyl estradiol (EE, estrogen in birth control pill) might affect biparental care, effects of these chemicals in male and female California mice (Peromyscus californicus), who are monogamous and ... Read more >>

(Heliyon)
[2018, 4(6):e00672]

Cited: 4 times

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Multigenerational effects of bisphenol A or ethinyl estradiol exposure on F2 California mice (Peromyscus californicus) pup vocalizations.

Sarah A Johnson, Michelle J Farrington, Claire R Murphy, Paul D Caldo, Leif A McAllister, Sarabjit Kaur, Catherine Chun, Madison T Ortega, Brittney L Marshall, Frauke Hoffmann, Mark R Ellersieck, A Katrin Schenk, Cheryl S Rosenfeld,

Rodent pups use vocalizations to communicate with one or both parents in biparental species, such as California mice (Peromyscus californicus). Previous studies have shown California mice developmentally exposed to endocrine disrupting chemicals, bisphenol A (BPA) or ethinyl estradiol (EE), demonstrate later compromised parental behaviors. Reductions in F1 parental behaviors might ... Read more >>

PLoS One (PloS one)
[2018, 13(6):e0199107]

Cited: 3 times

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Seminal fluid metabolome and epididymal changes after antibiotic treatment in mice.

Cheryl S Rosenfeld, Angela B Javurek, Sarah A Johnson, Zhentian Lei, Lloyd W Sumner, Rex A Hess,

Paternal environment can induce detrimental developmental origins of health and disease (DOHaD) effects in resulting offspring and even future descendants. Such paternal-induced DOHaD effects might originate from alterations in a possible seminal fluid microbiome (SFM) and composite metabolome. Seminal vesicles secrete a slightly basic product enriched with fructose and other ... Read more >>

Reproduction (Reproduction (Cambridge, England))
[2018, 156(1):1-10]

Cited: 1 time

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