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Author Cheol Kwak

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Kidney VISTA prevents IFNγ-IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury.

Min-Gang Kim, Donghwan Yun, Chae Lin Kang, Minki Hong, Juhyeon Hwang, Kyung Chul Moon, Chang Wook Jeong, Cheol Kwak, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Dong-Sup Lee, Seung Seok Han,

Severe glomerular injury ultimately leads to tubulointerstitial fibrosis which determines patient outcome, but the immunological molecules connecting these two processes remain unresolved. The present study addressed whether V-domain Ig suppressor of T cell activation (VISTA), constitutively expressed in kidney macrophages, plays a protective role in tubulointerstitial fibrotic transformation after acute ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, :]

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Next-generation Proteomics-Based Discovery, Verification, and Validation of Urine Biomarkers for Bladder Cancer Diagnosis.

Jungyo Suh, Dohyun Han, Ja Hyeon Ku, Hyeon Hoe Kim, Cheol Kwak, Chang Wook Jeong,

<h4>Purpose</h4>We aimed to identify, verify, and validate a multiplex urinary biomarker-based prediction model for diagnosis and surveillance of urothelial carcinoma of bladder, using high-throughput proteomics methods.<h4>Materials and methods</h4>Label-free quantification of data-dependent and data-independent acquisition of 12 and 24 individuals was performed in each of the discovery and verification phases using ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2021, :]

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Estimated Glomerular Filtration Rate as a Prognostic Factor in Urothelial Carcinoma of the Upper Urinary Tract: A Systematic Review and Meta-Analysis.

Min Hyuk Kim, Hyeong Dong Yuk, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku,

Preoperative renal function is associated with worse outcomes in patients undergoing radical nephroureterectomy (RNU). The purpose of this systemic review and meta-analysis was to determine the association of preoperative renal function with oncological outcome in patients who underwent RNU. We searched articles published up to March 2021 in PubMed, Scopus, ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(18):]

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Comparison of radical prostatectomy and external beam radiotherapy in high-risk prostate cancer.

Seok-Joo Chun, Jin Ho Kim, Ja Hyeon Ku, Cheol Kwak, Eun Sik Lee, Suzy Kim,

<h4>Purpose</h4>We evaluated clinical outcomes of high-risk prostate cancer patients receiving external beam radiotherapy (EBRT) or radical prostatectomy (RP).<h4>Materials and methods</h4>Patients were classified as high-risk prostate cancer and received definitive treatment between 2005 and 2015. Patients with previous pelvic radiotherapy, positive lymph node or distant metastasis were excluded. The primary outcomes ... Read more >>

Radiat Oncol J (Radiation oncology journal)
[2021, 39(3):231-238]

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Pyuria as a Predictive Marker of Bacillus Calmette-Guérin Unresponsiveness in Non-Muscle Invasive Bladder Cancer.

Jungyo Suh, Hyeong Dong Yuk, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku,

This study aims to investigate the clinical role of preoperative pyuria for predicting bacillus Calmette-Guérin (BCG) unresponsiveness in non-muscle invasive bladder cancer (NMIBC). We performed a logistic regression analysis on 453 patients with NMIBC who were treated with BCG immunotherapy after a transurethral resection of bladder tumours, to evaluate predictive ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(17):]

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Prostate-specific membrane antigen-mediated theragnostics in prostate cancer.

Seung-Hwan Jeong, Cheol Kwak,

Investig Clin Urol (Investigative and clinical urology)
[2021, 62(5):497-499]

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Machine learning-based prediction of acute kidney injury after nephrectomy in patients with renal cell carcinoma.

Yeonhee Lee, Jiwon Ryu, Min Woo Kang, Kyung Ha Seo, Jayoun Kim, Jungyo Suh, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Chang Wook Jeong, Sang Chul Lee, Cheol Kwak, Sejoong Kim, Seung Seok Han,

The precise prediction of acute kidney injury (AKI) after nephrectomy for renal cell carcinoma (RCC) is an important issue because of its relationship with subsequent kidney dysfunction and high mortality. Herein we addressed whether machine learning (ML) algorithms could predict postoperative AKI risk better than conventional logistic regression (LR) models. ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):15704]

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Prognostic factors for overall survival in patients with clear cell metastatic renal cell carcinoma: Model development and external validation with Memorial Sloan Kettering Cancer Center model and the international metastatic renal cell carcinoma database consortium model.

Dongrul Shin, Chang Wook Jeong, Cheryn Song, Minyong Kang, Seong Il Seo, Jung Kwon Kim, Hakmin Lee, Jinsoo Chung, Sung-Hoo Hong, Eu Chang Hwang, Cheol Kwak, Jae Young Park,

<h4>Abstract</h4>To develop a new prognostic model for the overall survival of patients with clear cell metastatic renal cell carcinoma (mRCC) using Korean Renal Cancer Study Group (KRoCS) database and compared it with 2 renowned prognostic models: the Memorial Sloan Kettering Cancer Center (MSKCC) and the international metastatic renal cell carcinoma ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(31):e26826]

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A comparison of the survival outcomes of robotic-assisted radical prostatectomy and radiation therapy in patients over 75 years old with non-metastatic prostate cancer: A Korean multicenter study.

Young Hwii Ko, Sung-Woo Park, U-Syn Ha, Jae Young Joung, Seung-Hwan Jeong, Seok-Soo Byun, Seong Soo Jeon, Cheol Kwak,

<h4>Purpose</h4>To compare overall survivals (OSs) and cancer-specific survivals (CSSs) after robotic-assisted radical prostatectomy (RARP) and radiation therapy (RT), the latter of which has long been recommended primarily for elderly patients (≥75 years) with non-metastatic prostate cancer (PCa), given the Korean male life span of 79.7 years (2018).<h4>Materials and methods</h4>Retrospective data ... Read more >>

Investig Clin Urol (Investigative and clinical urology)
[2021, 62(5):535-544]

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Efficacy of the Treatment of Intraperitoneal Bladder Perforation during Transurethral Resection of Bladder Tumor with the Urethral Catheter Alone: Retrospective Analysis of over 15 Years Using the Clinical Data Warehouse System.

Junghoon Lee, Jungyo Suh, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku,

<h4>Introduction</h4>We investigated the efficacy of a urethral catheter alone for intraperitoneal perforation during transurethral resection of bladder tumor (TURBT).<h4>Patients and methods</h4>We retrospectively evaluated the medical records of 4,543 patients who underwent TURBT from January 2000 to December 2017 using the Clinical Data Warehouse system. The clinicopathologic characteristics, recurrence-free survival, and ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-9]

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A Retrospective, Multicenter, Long-Term Follow-Up Analysis of the Prognostic Characteristics of Recurring Non-Metastatic Renal Cell Carcinoma After Partial or Radical Nephrectomy.

Sung Han Kim, Boram Park, Eu Chang Hwang, Sung-Hoo Hong, Chang Wook Jeong, Cheol Kwak, Seok Soo Byun, Jinsoo Chung,

This study aimed to compare the cancer-specific survival (CSS) and overall survival (OS) of nephrectomized patients with non-metastatic renal cell carcinoma (nmRCC) and local recurrence without distant metastasis (LR group), those with metastasis without local recurrence (MET group), and those with both local recurrence and metastasis (BOTH group). This retrospective ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:653002]

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PDLIM2 Suppression Inhibit Proliferation and Metastasis in Kidney Cancer.

Hyeong-Dong Yuk, Kyoung-Hwa Lee, Hye-Sun Lee, Seung-Hwan Jeong, Yongseok Kho, Chang-Wook Jeong, Hyeon-Hoe Kim, Ja-Hyeon Ku, Cheol Kwak,

We evaluated the expression of PDLIM2 in human kidney cancer cell lines from primary or metastatic origins and found that PDLIM2 expression was highly elevated in metastatic kidney cancers. We evaluated the effect of PDLIM2 inhibition by RNA interference method. PDLIM2 knockdown showed the decreased proliferation and metastatic character in ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(12):]

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Stratifying risk for multiple, recurrent, and large (≥3 cm) Ta, G1/G2 tumors in non-muscle-invasive bladder cancer.

Jungyo Suh, Jae Hyun Jung, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku,

<h4>Purpose</h4>The current stratification of risk groups regarding recurrence and progression of non-muscle-invasive bladder cancer (NMIBC) is problematic. We aimed to assess the long-term outcome and risk of multiple, recurrent, and large (≥3 cm) Ta, G1/G2 tumors after transurethral resection of the bladder tumor (TURBT).<h4>Materials and methods</h4>We categorized 1,621 patients with ... Read more >>

Investig Clin Urol (Investigative and clinical urology)
[2021, 62(4):408-415]

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Prediction of Pathologic Findings with MRI-Based Clinical Staging Using the Bayesian Network Modeling in Prostate Cancer: A Radiation Oncologist Perspective.

Chan Woo Wee, Bum-Sup Jang, Jin Ho Kim, Chang Wook Jeong, Cheol Kwak, Hyun Hoe Kim, Ja Hyeon Ku, Seung Hyup Kim, Jeong Yeon Cho, Sang Youn Kim,

<h4>Purpose</h4>This study aimed to develop a model for predicting pathologic extracapsular extension (ECE) and seminal vesicle invasion (SVI) while integrating magnetic resonance imaging-based T-staging (cTMRI, cT1c-cT3b).<h4>Materials and methods</h4>A total of 1,915 who underwent radical prostatectomy between 2006-2016 met the inclusion/exclusion criteria. We performed a multivariate logistic regression analysis as well ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2021, :]

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The clinical impact of strict criteria for active surveillance of prostate cancer in Korean population: Results from a prospective cohort.

Jungyo Suh, Hyeong Dong Yuk, Minyong Kang, Bum Sik Tae, Ja Hyeon Ku, Hyeon Hoe Kim, Cheol Kwak, Chang Wook Jeong,

<h4>Purpose</h4>To evaluate the clinical impact of strict selection criteria for active surveillance (AS) of prostate cancer in a Korean population.<h4>Materials and methods</h4>A single-center, prospectively collected AS cohort from December 2016 to February 2019 was used. Following pre-determined criteria, patients were categorized into "strict AS" and "non-strict AS" groups. Clinicopathological progression-free ... Read more >>

Investig Clin Urol (Investigative and clinical urology)
[2021, 62(4):430-437]

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Evaluation of functional outcome of bilateral kidney tumors after sequential surgery.

Jung Kwon Kim, Hwanik Kim, Hakmin Lee, Jong Jin Oh, Sangchul Lee, Sung Kyu Hong, Cheol Kwak, Seok-Soo Byun,

<h4>Background</h4>There are limited data concerning patients treated with sequential bilateral kidney surgery. Current guidelines still lack an optimal surgical sequencing approach. We evaluated renal functional outcomes after sequential partial nephrectomy (PN) and radical nephrectomy (RN) in patients with bilateral renal cell carcinoma (RCC).<h4>Methods</h4>A propensity score matched cohort of 267 patients ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):592]

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Comprehensive metabolomic profiling in early IgA nephropathy patients reveals urine glycine as a prognostic biomarker.

Sehoon Park, Jueun Lee, Seung Hee Yang, Hajeong Lee, Joo Young Kim, Minkyoung Park, Kyu Hong Kim, Jong Joo Moon, Semin Cho, Soojin Lee, Yaerim Kim, Hajeong Lee, Jung Pyo Lee, Chang Wook Jeong, Cheol Kwak, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Geum-Sook Hwang, Dong Ki Kim,

Identification of a urinary metabolite biomarker with diagnostic or prognostic significance for early immunoglobulin A nephropathy (IgAN) is needed. We performed nuclear magnetic resonance-based metabolomic profiling and identified 26 metabolites in urine samples. We collected urine samples from 201, 77, 47, 36 and 136 patients with IgAN, patients with membranous ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, 25(11):5177-5190]

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Head-to-Head Comparison of 68Ga-NOTA (68Ga-NGUL) and 68Ga-PSMA-11 in Patients with Metastatic Prostate Cancer: A Prospective Study.

Minseok Suh, Hyung-Jun Im, Hyun Gee Ryoo, Keon Wook Kang, Jae Min Jeong, Sneha Prakash, Sanjana Ballal, Madhav P Yadav, Chandrasekhar Bal, Chang Wook Jeong, Cheol Kwak, Gi Jeong Cheon,

<sup>68</sup>Ga-NOTA Glu-Urea-Lys (NGUL) is a novel prostate-specific membrane antigen (PSMA)-targeting tracer used for PET/CT imaging. This study aimed to compare performance in the detection of primary and metastatic lesions and to compare biodistribution between <sup>68</sup>Ga-NGUL and <sup>68</sup>Ga-PSMA-11 in the same patients with prostate cancer. <b>Methods:</b> Eleven patients with metastatic prostate ... Read more >>

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2021, 62(10):1457-1460]

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Prognostic significance of pathologic nodal positivity in non-metastatic patients with renal cell carcinoma who underwent radical or partial nephrectomy.

Sung Han Kim, Boram Park, Eu Chang Hwang, Sung-Hoo Hong, Chang Wook Jeong, Cheol Kwak, Seok Soo Byun, Jinsoo Chung,

This retrospective, five-multicenter study was aimed to evaluate the prognostic impact of pathologic nodal positivity on recurrence-free (RFS), metastasis-free (MFS), overall (OS), and cancer-specific (CSS) survivals in patients with non-metastatic renal cell carcinoma (nmRCC) who underwent either radical or partial nephrectomy with/without LN dissection. A total of 4236 nmRCC patients ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):3079]

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Author Correction: Immune cell composition in normal human kidneys.

Jun-Gyu Park, Myeongsu Na, Min-Gang Kim, Su Hwan Park, Hack June Lee, Dong Ki Kim, Cheol Kwak, Yon Su Kim, Sunghoe Chang, Kyung Chul Moon, Dong-Sup Lee, Seung Seok Han,

Sci Rep (Scientific reports)
[2021, 11(1):4313]

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Targeted therapy response in early versus late recurrence of renal cell carcinoma after surgical treatment: A propensity score-matched study using the Korean Renal Cancer Study Group database.

Chan Ho Lee, Jinsoo Chung, Cheol Kwak, Chang Wook Jeong, Seong Il Seo, Minyong Kang, Sung-Hoo Hong, Cheryn Song, Jae Young Park, Eu Chang Hwang, Hakmin Lee, Ja Yoon Ku, Won Ik Seo, Seock Hwan Choi, Hong Koo Ha, ,

<h4>Objectives</h4>To investigate the clinicopathological features and outcomes of targeted therapy in patients with recurrence of renal cell carcinoma in <5 years or ≥5 years after the surgical treatment for renal cell carcinoma.<h4>Methods</h4>Patients with metastatic renal cell carcinoma treated with targeted therapy in a multicenter database were retrospectively characterized according to time from ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, 28(4):417-423]

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MLL5, a histone modifying enzyme, regulates androgen receptor activity in prostate cancer cells by recruiting co-regulators, HCF1 and SET1.

Kyoung-Hwa Lee, Byung-Chan Kim, Chang Wook Jeong, Ja Hyeon Ku, Hyeon Hoe Kim, Cheol Kwak,

In prostate cancer, the androgen receptor (AR) transcription factor is a major regulator of cell proliferation and metastasis. To identify new AR regulators, we focused on Mixed lineage leukemia 5 (MLL5), a histone-regulating enzyme, because significantly higher MLL5 expression was detected in prostate cancer tissues than in matching normal tissues. ... Read more >>

BMB Rep (BMB reports)
[2020, 53(12):634-639]

Cited: 1 time

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Efficacy of neoadjuvant atezolizumab treatment in patients with advanced urothelial bladder cancer according to the BASQ classification: a study protocol for an open-label, two-cohort, phase II trial.

Hyeong Dong Yuk, Chang Wook Jeong, Cheol Kwak, Hyeon Kim, Kyung Chul Moon, Ja Hyeon Ku,

<h4>Introduction</h4>Atezolizumab is a programmed death ligand-1 inhibitor for urothelial bladder cancer treatment. Atezolizumab has become the standard therapy for patients with urothelial bladder cancer who are not responding to cisplatin-based chemotherapy and is also used as a first-line treatment in cisplatin-ineligible patients. However, the efficacy of atezolizumab as a neoadjuvant ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e035530]

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Treatment strategy for papillary renal cell carcinoma type 2: a case series of seven patients treated based on next generation sequencing data.

Ji-Yeon Kim, Hyoung-Oh Jeong, Dae Seog Heo, Bhumsuk Keam, Kyung Chul Moon, Cheol Kwak, Jinho Jang, Seunghoon Kim, Jong-Il Kim, Semin Lee, Se-Hoon Lee,

<h4>Background</h4>Papillary renal cell carcinoma type 2 (PRCC2) is refractory to systemic treatment and has a dismal prognosis. Previous studies showed that genetic alterations in PRCC2 were heterogeneous regardless of germline or somatic mutations. In this study, we aimed to perform precision treatment of PRCC2 based on genetic information.<h4>Methods</h4>We performed exome ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2020, 8(21):1389]

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Immune cell composition in normal human kidneys.

Jun-Gyu Park, Myeongsu Na, Min-Gang Kim, Su Hwan Park, Hack June Lee, Dong Ki Kim, Cheol Kwak, Yon Su Kim, Sunghoe Chang, Kyung Chul Moon, Dong-Sup Lee, Seung Seok Han,

An understanding of immunological mechanisms in kidney diseases has advanced using mouse kidneys. However, the profiling of immune cell subsets in human kidneys remains undetermined, particularly compared with mouse kidneys. Normal human kidneys were obtained from radically nephrectomised patients with urogenital malignancy (n = 15). Subsequently, human kidney immune cell subsets were ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):15678]

Cited: 3 times

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